| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
- Gustavsson, Anders, et al.
(författare)
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Corrigendum to “Cost of disorders of the brain in Europe 2010” [Eur. Neuropsychopharmacol. 21 (2011) 718–779]
- 2012
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Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 22:3, s. 237-238
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Tidskriftsartikel (refereegranskat)abstract
- The spectrum of disorders of the brain is large, covering hundreds of disorders that are listed in either the mental or neurological disorder chapters of the established international diagnostic classification systems. These disorders have a high prevalence as well as short- and long-term impairments and disabilities. Therefore they are an emotional, financial and social burden to the patients, their families and their social network. In a 2005 landmark study, we estimated for the first time the annual cost of 12 major groups of disorders of the brain in Europe and gave a conservative estimate of €386 billion for the year 2004. This estimate was limited in scope and conservative due to the lack of sufficiently comprehensive epidemiological and/or economic data on several important diagnostic groups. We are now in a position to substantially improve and revise the 2004 estimates. In the present report we cover 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items. We therefore present much improved cost estimates. Our revised estimates also now include the new EU member states, and hence a population of 514 million people.
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| 3. |
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| 4. |
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| 5. |
- Jonsson, Jacob, et al.
(författare)
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Optical characterization of fritted glass for architectural applications
- 2009
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Ingår i: Optical materials (Amsterdam). - : Elsevier BV. - 0925-3467 .- 1873-1252. ; 31:6, s. 949-958
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Tidskriftsartikel (refereegranskat)abstract
- Fritted glass is commonly used as a light diffusing element in modern buildings. Traditionally it has been used for aesthetic purposes but it can also be used for energy savings by incorporating it in novel daylighting systems? To answer such questions the light scattering properties must be properly characterized.This paper contains measurements of different varieties of fritted glass, ranging from the simplest direct-hemispherical measurements to angle-resolved goniometer measurements. Modeling the light scattering to obtain the full bidirectional scattering distribution function (BSDF) extends the measured data, making it useful in simulation programs such as Window 6 and Radiance. Surface profilometry results and SEM micrographs are included to demonstrate the surface properties of the samples studied.
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| 6. |
- Nilsson, Annica M, et al.
(författare)
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Method for more accurate transmittance measurements of low-angle scattering samples using an integrating sphere with an entry port beam diffuser
- 2011
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Ingår i: Applied Optics. - 1559-128X .- 2155-3165. ; 50:7, s. 999-1006
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Tidskriftsartikel (refereegranskat)abstract
- For most integrating sphere measurements, the difference in light distribution between a specular reference beam and a diffused sample beam can result in significant errors. The problem becomes especially pronounced in integrating spheres that include a port for reflectance or diffuse transmittance measurements. The port is included in many standard spectrophotometers to facilitate a multipurpose instrument, however, absorption around the port edge can result in a detected signal that is too low. The absorption effect is especially apparent for low-angle scattering samples, because a significant portion of the light is scattered directly onto that edge. In this paper, a method for more accurate transmittance measurements of low-angle light-scattering samples is presented. The method uses a standard integrating sphere spectrophotometer, and the problem with increased absorption around the port edge is addressed by introducing a diffuser between the sample and the integrating sphere during both reference and sample scan. This reduces the discrepancy between the two scans and spreads the scattered light over a greater portion of the sphere wall. The problem with multiple reflections between the sample and diffuser is successfully addressed using a correction factor. The method is tested for two patterned glass samples with low-angle scattering and in both cases the transmittance accuracy is significantly improved.
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| 7. |
- Aidas, Kestutis, et al.
(författare)
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The Dalton quantum chemistry program system
- 2014
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Ingår i: WIREs Computational Molecular Science. - : Wiley. - 1759-0876 .- 1759-0884. ; 4:3, s. 269-284
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Tidskriftsartikel (refereegranskat)abstract
- Dalton is a powerful general-purpose program system for the study of molecular electronic structure at the Hartree-Fock, Kohn-Sham, multiconfigurational self-consistent-field, MOller-Plesset, configuration-interaction, and coupled-cluster levels of theory. Apart from the total energy, a wide variety of molecular properties may be calculated using these electronic-structure models. Molecular gradients and Hessians are available for geometry optimizations, molecular dynamics, and vibrational studies, whereas magnetic resonance and optical activity can be studied in a gauge-origin-invariant manner. Frequency-dependent molecular properties can be calculated using linear, quadratic, and cubic response theory. A large number of singlet and triplet perturbation operators are available for the study of one-, two-, and three-photon processes. Environmental effects may be included using various dielectric-medium and quantum-mechanics/molecular-mechanics models. Large molecules may be studied using linear-scaling and massively parallel algorithms. Dalton is distributed at no cost from for a number of UNIX platforms.
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| 8. |
- Albert, Malin, et al.
(författare)
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Aetiology and outcome in hospitalized cardiac arrest patients.
- 2023
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Ingår i: European Heart Journal Open. - 2752-4191. ; 3:4
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To study aetiologies of in-hospital cardiac arrests (IHCAs) and their association with 30-day survival.METHODS AND RESULTS: Observational study with data from national registries. Specific aetiologies (n = 22) of IHCA patients between April 2018 and December 2020 were categorized into cardiac vs. non-cardiac and six main aetiology categories: myocardial ischemia, other cardiac causes, pulmonary causes, infection, haemorrhage, and other non-cardiac causes. Main endpoints were proportions in each aetiology, 30-day survival, and favourable neurological outcome (Cerebral Performance Category scale 1-2) at discharge. Among, 4320 included IHCA patients (median age 74 years, 63.1% were men), approximate 50% had cardiac causes with a 30-day survival of 48.4% compared to 18.7% among non-cardiac causes (P < 0.001). The proportion in each category were: myocardial ischemia 29.9%, pulmonary 21.4%, other cardiac causes 19.6%, other non-cardiac causes 11.6%, infection 9%, and haemorrhage 8.5%. The odds ratio (OR) for 30-day survival compared to myocardial ischemia for each category were: other cardiac causes OR 1.48 (CI 1.24-1.76); pulmonary causes OR 0.36 (CI 0.3-0.44); infection OR 0.25 (CI 0.18-0.33); haemorrhage OR 0.22 (CI 0.16-0.3); and other non-cardiac causes OR 0.56 (CI 0.45-0.69). IHCA caused by myocardial ischemia had the best favourable neurological outcome while those caused by infection had the lowest OR 0.06 (CI 0.03-0.13).CONCLUSION: In this nationwide observational study, aetiologies with cardiac and non-cardiac causes of IHCA were evenly distributed. IHCA caused by myocardial ischemia and other cardiac causes had the strongest associations with 30-day survival and neurological outcome.
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| 9. |
- Albert, Malin, et al.
(författare)
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Hospitalized patients' attitudes towards participating in a randomized control trial in case of a cardiac arrest.
- 2024
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Ingår i: Resuscitation Plus. - 2666-5204. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- No previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial "Vasopressin and Steroids in addition to Adrenaline in cardiac arrest" (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).Hospitalized patients, men≥18 and women≥50years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.Patients admitted to hospital were asked to give informed consent of inclusion in VAST-A in case of an IHCA during their hospital stay. Patients were also asked why they approved or declined inclusion as well as baseline characteristics questions.1,064 patients were asked about willingness to participate in the VAST-A trial, of these 902 (84.8%) patients approved inclusion. A subgroup of 411 patients were, except willingness, also asked about motives to participate or not and basic characteristics. The main reason for approving inclusion was to contribute to research (n=328, 83.9%). The main reason for declining inclusion was concerns regarding testing the drug treatment (n=6, 30%).Among hospitalized patients the vast majority gave informed consent to inclusion in an ongoing randomized cardiac arrest drug trial. The main reason for approving inclusion was to contribute to research.
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| 10. |
- Albert, Malin, et al.
(författare)
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Hospitalized patients’ attitudes towards participating in a randomized control trial in case of a cardiac arrest
- 2024
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Ingår i: Resuscitation Plus. - 2666-5204. ; 18
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundNo previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial “Vasopressin and Steroids in addition to Adrenaline in cardiac arrest” (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).ObjectivesHospitalized patients, men ≥ 18 and women ≥ 50 years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.MethodsPatients admitted to hospital were asked to give informed consent of inclusion in VAST-A in case of an IHCA during their hospital stay. Patients were also asked why they approved or declined inclusion as well as baseline characteristics questions.Results1,064 patients were asked about willingness to participate in the VAST-A trial, of these 902 (84.8%) patients approved inclusion. A subgroup of 411 patients were, except willingness, also asked about motives to participate or not and basic characteristics. The main reason for approving inclusion was to contribute to research (n = 328, 83.9%). The main reason for declining inclusion was concerns regarding testing the drug treatment (n = 6, 30%).ConclusionAmong hospitalized patients the vast majority gave informed consent to inclusion in an ongoing randomized cardiac arrest drug trial. The main reason for approving inclusion was to contribute to research.
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| 11. |
- Angioni, C., et al.
(författare)
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Gyrokinetic study of turbulent convection of heavy impurities in tokamak plasmas at comparable ion and electron heat fluxes
- 2017
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 57:2
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Tidskriftsartikel (refereegranskat)abstract
- In tokamaks, the role of turbulent transport of heavy impurities, relative to that of neoclassical transport, increases with increasing size of the plasma, as clarified by means of general scalings, which use the ITER standard scenario parameters as reference, and by actual results from a selection of discharges from ASDEX Upgrade and JET. This motivates the theoretical investigation of the properties of the turbulent convection of heavy impurities by nonlinear gyrokinetic simulations in the experimentally relevant conditions of comparable ion and electron heat fluxes. These conditions also correspond to an intermediate regime between dominant ion temperature gradient turbulence and trapped electron mode turbulence. At moderate plasma toroidal rotation, the turbulent convection of heavy impurities, computed with nonlinear gyrokinetic simulations, is found to be directed outward, in contrast to that obtained by quasi-linear calculations based on the most unstable linear mode, which is directed inward. In this mixed turbulence regime, with comparable electron and ion heat fluxes, the nonlinear results of the impurity transport can be explained by the coexistence of both ion temperature gradient and trapped electron modes in the turbulent state, both contributing to the turbulent convection and diffusion of the impurity. The impact of toroidal rotation on the turbulent convection is also clarified.
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| 12. |
- Arnqvist, Goran, et al.
(författare)
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Falsk marknadsföring om hållbart skogsbruk
- 2022
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Ingår i: Svenska Dagbladet Debatt. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Dagens svenska skogsbruk är inte ekologiskt hållbart. Att saluföra det som hållbart är därför – för att tala klarspråk – falsk marknadsföring, skriver forskare.
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| 13. |
- Batistoni, P., et al.
(författare)
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Technical preparations for the in-vessel 14 MeV neutron calibration at JET
- 2017
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Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 117, s. 107-114
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Tidskriftsartikel (refereegranskat)abstract
- The power output of fusion devices is measured from their neutron yields which relate directly to the fusion yield. In this paper we describe the devices and methods that have been prepared to perform a new in situ 14 MeV neutron calibration at JET in view of the new DT campaign planned at JET in the next years. The target accuracy of this calibration is 10% as required for ITER, where a precise neutron yield measurement is important, e.g., for tritium accountancy. In this paper, the constraints and early decisions which defined the main calibration approach are discussed, e.g., the choice of 14 MeV neutron source and the deployment method. The physics preparations, source issues, safety and engineering aspects required to calibrate directly the JET neutron detectors are also discussed. The existing JET remote-handling system will be used to deploy the neutron source inside the JET vessel. For this purpose, compatible tooling and systems necessary to ensure safe and efficient deployment have been developed. The scientific programme of the preparatory phase is devoted to fully characterizing the selected 14 MeV neutron generator to be used as the calibrating source, obtain a better understanding of the limitations of the calibration, optimise the measurements and other provisions, and to provide corrections for perturbing factors (e.g., anisotropy of the neutron generator, neutron energy spectrum dependence on emission angle). Much of this work has been based on an extensive programme of Monte-Carlo calculations which provide support and guidance in developing the calibration strategy.
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| 14. |
- Berggren, Lars, et al.
(författare)
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Optical absorption in lithiated tungsten oxide thin films : Experiment and theory
- 2007
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 102:8, s. 083538-
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Tidskriftsartikel (refereegranskat)abstract
- Amorphous tungsten oxide exhibits electrochromism when intercalated with protons, lithium, sodium, and other ions. Thin films of the material were prepared by dc magnetron sputtering and then electrochemically intercalated with lithium. The optical absorption in the wavelength range of 300-2500 nm was measured for a number of lithium concentrations. The optical absorption shows a maximum for lithium/tungsten ratios of 0.3-0.5. The optical spectra can be fitted by a superposition of three Gaussian peaks, representing the three possible electronic transitions between W6+, W5+, and W4+ sites. The variation of the peak strength with lithium concentration is consistent with an extended site-saturation theory.
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| 15. |
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| 16. |
- Berglund, Ellinor, et al.
(författare)
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Effect of Smartphone Dispatch of Volunteer Responders on Automated External Defibrillators and Out-of-Hospital Cardiac Arrests : The SAMBA Randomized Clinical Trial
- 2023
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Ingår i: JAMA cardiology. - : American Medical Association (AMA). - 2380-6583 .- 2380-6591. ; 8:1, s. 81-88
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Tidskriftsartikel (refereegranskat)abstract
- Importance Smartphone dispatch of volunteer responders to nearby out-of-hospital cardiac arrests (OHCAs) has emerged in several emergency medical services, but no randomized clinical trials have evaluated the effect on bystander use of automated external defibrillators (AEDs).Objective To evaluate if bystander AED use could be increased by smartphone-aided dispatch of lay volunteer responders with instructions to collect nearby AEDs compared with instructions to go directly to patients with OHCAs to start cardiopulmonary resuscitation (CPR).Design, Setting, and Participants This randomized clinical trial assessed a system for smartphone dispatch of volunteer responders to individuals experiencing OHCAs that was triggered at emergency dispatch centers in response to suspected OHCAs and randomized 1:1. The study was conducted in 2 main Swedish regions: Stockholm and Västra Götaland between December 2018 and January 2020. At study start, there were 3123 AEDs in Stockholm and 3195 in Västra Götaland and 24 493 volunteer responders in Stockholm and 19 117 in Västra Götaland. All OHCAs in which the volunteer responder system was activated by dispatchers were included. Excluded were patients with no OHCAs, those with OHCAs not treated by the emergency medical services, and those with OHCAs witnessed by the emergency medical services.Interventions Volunteer responders were alerted through the volunteer responder system smartphone application and received map-aided instructions to retrieve nearest available public AEDs on their way to the OHCAs. The control arm included volunteer responders who were instructed to go directly to the OHCAs to perform CPR.Main Outcomes and Measures Overall bystander AED attachment, including those attached by volunteer responders and lay volunteers who did not use the smartphone application.Results Volunteer responders were activated for 947 patients with OHCAs. Of those, 461 were randomized to the intervention group (median [IQR] age of patients, 73 [61-81] years; 295 male patients [65.3%]) and 486 were randomized to the control group (median [IQR] age of patients, 73 [63-82] years; 312 male patients [65.3%]). Primary outcome of AED attachment occurred in 61 patients (13.2%) in the intervention arm vs 46 patients (9.5%) in the control arm (difference, 3.8% [95% CI, −0.3% to 7.9%]; P = .08). The majority of AEDs were attached by lay volunteers who were not using the smartphone application (37 in intervention arm, 28 in control). There were no significant differences in secondary outcomes. Among the volunteer responders using the application, crossover was 11% and compliance to instructions was 31%. Volunteer responders attached 38% (41 of 107) of all AEDs and provided 45% (16 of 36) of all defibrillations and 43% (293 of 666) of all CPR.Conclusions and Relevance In this study, smartphone dispatch of volunteer responders to OHCAs to retrieve nearby AEDs vs instructions to directly perform CPR did not significantly increase volunteer AED use. High baseline AED attachement rate and crossover may explain why the difference was not significant.Trial Registration ClinicalTrials.gov Identifier: NCT02992873
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| 17. |
- Berglund, Ellinor, et al.
(författare)
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Wellbeing, emotional response and stress among lay responders dispatched to suspected out-of-hospital cardiac arrests
- 2022
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Ingår i: Resuscitation. - : Elsevier Ireland Ltd. - 0300-9572 .- 1873-1570. ; 170, s. 352-360
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Tidskriftsartikel (refereegranskat)abstract
- Background: Systems for smartphone dispatch of lay responders to perform cardio-pulmonary resuscitation (CPR) and bring automated external defibrillators to out-of-hospital cardiac arrests (OHCAs) are advocated by recent international guidelines and emerging worldwide. Objectives: This study aimed to investigate the emotional responses, posttraumatic stress reactions and levels of wellbeing among smartphone-alerted lay responders dispatched to suspected OHCAs. Methods: Lay responders were stratified by level of exposure: unexposed (Exp-0), tried to reach (Exp-1), and reached the suspected OHCA (Exp-2). Participants rated their emotional responses online, at 90 minutes and at 4–6 weeks after an incident. Level of emotional response was measured in two dimensions of core affect: “alertness” – from deactivation to activation, and “pleasantness” – from unpleasant to pleasant. At 4–6 weeks, WHO wellbeing index and level of posttraumatic stress (PTSD) were also rated. Results: Altogether, 915 (28%) unexposed and 1471 (64%) exposed responders completed the survey. Alertness was elevated in the exposed groups: Exp-0: 6.7 vs. Exp-1: 7.3 and Exp-2: 7.5, (p < 0.001) and pleasantness was highest in the unexposed group: 6.5, vs. Exp-1: 6.3, and Exp-2: 6.1, (p < 0.001). Mean scores for PTSD at follow-up was below clinical cut-off, Exp-0: 9.9, Exp-1: 8.9 and Exp-2: 8.8 (p = 0.065). Wellbeing index showed no differences, Exp-0: 78.0, Exp-1: 78.5 and Exp-2: 79.9 (p = 0.596). Conclusion: Smartphone dispatched lay responders rated the experience as high-energy and mainly positive. No harm to the lay responders was seen. The exposed groups had low posttraumatic stress scores and high-level general wellbeing at follow-up. © 2021
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| 18. |
- Bernardo, J., et al.
(författare)
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Ion temperature and toroidal rotation in JET's low torque plasmas
- 2016
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 87:11
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on the procedure developed as the best method to provide an accurate and reliable estimation of the ion temperature T-i and the toroidal velocity v(phi) from Charge-eXchange Recombination Spectroscopy (CXRS) data from intrinsic rotation experiments at the Joint European Torus with the carbon wall. The low impurity content observed in such plasmas, resulting in low active CXRS signal, alongside low Doppler shifts makes the determination of Ti and v(phi) particularly difficult. The beam modulation method will be discussed along with the measures taken to increase photon statistics and minimise errors from the absolute calibration and magneto-hydro-dynamics effects that may impact the CXRS passive emission.
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| 19. |
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| 20. |
- Bisoffi, Andrea, et al.
(författare)
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Hybrid cancellation of ripple disturbances arising in AC/DC converters
- 2017
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Ingår i: Automatica. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0005-1098 .- 1873-2836. ; 77, s. 344-352
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Tidskriftsartikel (refereegranskat)abstract
- In AC/DC converters, a peculiar periodic nonsmooth waveform arises, the so-called ripple. In this paper we propose a novel model that captures this nonsmoothness by means of a hybrid dynamical system performing state jumps at certain switching instants, and we illustrate its properties with reference to a three phase diode bridge rectifier. As the ripple corrupts an underlying desirable signal, we propound two observer schemes ensuring asymptotic estimation of the ripple, the first with and the second without knowledge of the switching instants. Our theoretical developments are well placed in the context of recent techniques for hybrid regulation and constitute a contribution especially for our second observer, where the switching instants are estimated. Once asymptotic estimation of the ripple is achieved, the ripple can be conveniently canceled from the desirable signal, and thanks to the inherent robustness properties of the proposed hybrid formulation, the two observer schemes require only that the desirable signal is slowly time varying compared to the ripple. Exploiting this fact, we illustrate the effectiveness of our second hybrid observation law on experimental data collected from the Joint European Torus tokamak.
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| 21. |
- Bolshakova, I., et al.
(författare)
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Experimental evaluation of stable long term operation of semiconductor magnetic sensors at ITER relevant environment
- 2015
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 55:8
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Tidskriftsartikel (refereegranskat)abstract
- The paper deals with radiation resistant sensors and their associated measuring instrumentation developed in the course of R and D activities carried out in the framework of an international collaboration. The first trial tests of three-dimensional (3D) probes with Hall sensors have been performed in European tokamaks TORE SUPRA (2004) and JET (2005). Later in 2009 six sets of 3D probes were installed in JET and now continue to operate. The statistical analysis performed in 2014 on the basis of the JET database have demonstrated stable long term operation of all 18 sensors of 3D probes. The results of measurements conducted at the neutron fluxes of nuclear reactors have demonstrated the operability of the sensors up to high neutron fluences of F > 10(18)n , cm(-2) that exceeds the maximum one for the locations of steady state sensors in ITER over its total lifetime.
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| 22. |
- Boltruczyk, G., et al.
(författare)
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Development of MPPC-based detectors for high count rate DT campaigns at JET
- 2017
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Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 123, s. 940-944
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Tidskriftsartikel (refereegranskat)abstract
- The products of fusion reactions at JET are measured using different diagnostic techniques. One of the methods is based on measurements of gamma-rays, originating from reactions between fast ions and plasma impurities. During the forthcoming deuterium-tritium (DT) campaign a particular attention will be paid to 4.44 MeV gamma-rays emitted in the Be-9(alpha,n gamma)C-12 reaction. Gamma-ray detectors foreseen for measurements in DT campaigns have to be able to register spectra at high count rates, up to approximately 500 kHz. For the Gamma-ray Camera at JET a new setup will be based on scintillators with a short decay time, e.g., CeBr3, and a multi-pixel photon counter (MPPC). We present two methods of output signal shortening in modules based on MPPC. A short detector output signal is necessary in order to minimize the number of pile up events at high count rates. One method uses a passive RC circuit with a pole zero cancellation, whereas an active transimpedance amplifier is used in the other one. Due to the strong dependence of MPPC properties on temperature variation, a special device MTCD@NCBJ was designed and produced to stabilize the gain in MPPC-based scintillation detectors. We show that this device guarantees stable working conditions.
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| 23. |
- Borodin, D., et al.
(författare)
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Improved ERO modelling for spectroscopy of physically and chemically assisted eroded beryllium from the JET-ILW
- 2016
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Ingår i: Nuclear Materials and Energy. - : ELSEVIER. - 2352-1791. ; 9, s. 604-609
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Tidskriftsartikel (refereegranskat)abstract
- Physical and chemical assisted physical sputtering were characterised by the Be I and Be II line and BeD band emission in the observation chord measuring the sightline integrated emission in front of the inner beryllium limiter at the torus midplane. The 3D local transport and plasma-surface interaction Monte-Carlo modelling (ERO code [18]) is a key for the interpretation of the observations in the vicinity of the shaped solid Be limiter. The plasma parameter variation (density scan) in limiter regime has provided a useful material for the simulation benchmark. The improved background plasma parameters input, the new analytical expression for particle tracking in the sheath region and implementation of the BeD release into ERO has helped to clarify some deviations between modelling and experiments encountered in the previous studies [4,5]. Reproducing the observations provides additional confidence in our 'ERO-min' fit for the physical sputtering yields for the plasma-wetted areas based on simulated data.
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| 24. |
- Borodkina, I., et al.
(författare)
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An Analytical Expression for the Electric Field and Particle Tracing in Modelling of Be Erosion Experiments at the JET ITER-like Wall
- 2016
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Ingår i: Contributions to Plasma Physics. - : WILEY-V C H VERLAG GMBH. - 0863-1042 .- 1521-3986. ; 56:6-8, s. 640-645
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Tidskriftsartikel (refereegranskat)abstract
- A new analytical approximation for the electric potential profile in the presence of an oblique magnetic field and the analytical solution for the particle motion just before the impact with a plasma-facing surface are presented. These approximations are in good agreement with fluid solutions and the corresponding PIC simulations. These expressions were applied to provide effective physical erosion yields for Be, which have in a second step been used in ERO code simulations of spectroscopy at Be limiters of the JET ITER-like wall. These new analytical expressions lead to an increase of the effective physical sputtering yields of Be by deuteron impact up to 30% in comparison with earlier pure numerical simulations. (
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| 25. |
- Bourdelle, C., et al.
(författare)
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L to H mode transition : parametric dependencies of the temperature threshold
- 2015
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 55:7
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Tidskriftsartikel (refereegranskat)abstract
- The L to H mode transition occurs at a critical power which depends on various parameters, such as the magnetic field, the density, etc. Experimental evidence on various tokamaks (JET, ASDEX-Upgrade, DIII-D, Alcator C-Mod) points towards the existence of a critical temperature characterizing the transition. This criterion for the L-H transition is local and is therefore easier to be compared to theoretical approaches. In order to shed light on the mechanisms of the transition, simple theoretical ideas are used to derive a temperature threshold (T-th). They are based on the stabilization of the underlying turbulence by a mean radial electric field shear. The nature of the turbulence varies as the collisionality decreases, from resistive ballooning modes to ion temperature gradient and trapped electron modes. The obtained parametric dependencies of the derived T-th are tested versus magnetic field, density, effective charge. Various robust experimental observations are reproduced, in particular T-th increases with magnetic field B and increases with density below the density roll-over observed on the power threshold.
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| 26. |
- Bourdelle, C., et al.
(författare)
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WEST Physics Basis
- 2015
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 55:6
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Tidskriftsartikel (refereegranskat)abstract
- With WEST (Tungsten Environment in Steady State Tokamak) (Bucalossi et al 2014 Fusion Eng. Des. 89 907-12), the Tore Supra facility and team expertise (Dumont et al 2014 Plasma Phys. Control. Fusion 56 075020) is used to pave the way towards ITER divertor procurement and operation. It consists in implementing a divertor configuration and installing ITER-like actively cooled tungsten monoblocks in the Tore Supra tokamak, taking full benefit of its unique long-pulse capability. WEST is a user facility platform, open to all ITER partners. This paper describes the physics basis of WEST: the estimated heat flux on the divertor target, the planned heating schemes, the expected behaviour of the L-H threshold and of the pedestal and the potential W sources. A series of operating scenarios has been modelled, showing that ITER-relevant heat fluxes on the divertor can be achieved in WEST long pulse H-mode plasmas.
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| 27. |
- Boyer, Helen, et al.
(författare)
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JET Tokamak, preparation of a safety case for tritium operations
- 2016
-
Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 109, s. 1308-1312
-
Tidskriftsartikel (refereegranskat)abstract
- A new Safety Case is required to permit tritium operations on JET during the forthcoming DTE2 campaign. The outputs, benefits and lessons learned associated with the production of this Safety Case are presented. The changes that have occurred to the Safety Case methodology since the last JET tritium Safety Case are reviewed. Consideration is given to the effects of modifications, particularly ITER related changes, made to the JET and the impact these have on the hazard assessments as well as normal operations. Several specialized assessments, including recent MELCOR modelling, have been undertaken to support the production of this Safety Case and the impact of these assessments is outlined. Discussion of the preliminary actions being taken to progress implementation of this Safety Case is provided, highlighting new methods to improve the dissemination of the key Safety Case results to the plant operators. Finally, the work required to complete this Safety Case, before the next tritium campaign, is summarized. (C) 2016 EURATOM. Published by Elsevier B.V. All rights reserved.
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| 28. |
- Brose, Ulrich, et al.
(författare)
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Body sizes of consumers and their resources
- 2005
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Ingår i: Ecology. - : Ecological Society of America. - 0012-9658 .- 1939-9170. ; 86:9, s. 2545-2545
-
Tidskriftsartikel (refereegranskat)abstract
- Trophic information—who eats whom—and species’ body sizes are two of the most basic descriptions necessary to understand community structure as well as ecological and evolutionary dynamics. Consumer–resource body size ratios between predators and their prey, and parasitoids and their hosts, have recently gained increasing attention due to their important implications for species’ interaction strengths and dynamical population stability. This data set documents body sizes of consumers and their resources. We gathered body size data for the food webs of Skipwith Pond, a parasitoid community of grass-feeding chalcid wasps in British grasslands; the pelagic community of the Benguela system, a source web based on broom in the United Kingdom; Broadstone Stream, UK; the Grand Caric¸aie marsh at Lake Neuchaˆtel, Switzerland; Tuesday Lake, USA; alpine lakes in the Sierra Nevada of California; Mill Stream, UK; and the eastern Weddell Sea Shelf, Antarctica. Further consumer–resource body size data are included for planktonic predators, predatory nematodes, parasitoids, marine fish predators, freshwater invertebrates, Australian terrestrial consumers, and aphid parasitoids. Containing 16 807 records, this is the largest data set ever compiled for body sizes of consumers and their resources. In addition to body sizes, the data set includes information on consumer and resource taxonomy, the geographic location of the study, the habitat studied, the type of the feeding interaction (e.g., predacious, parasitic) and the metabolic categories of the species (e.g., invertebrate, ectotherm vertebrate). The present data set was gathered with the intent to stimulate research on effects of consumer–resource body size patterns on food-web structure, interaction-strength distributions, population dynamics, and community stability. The use of a common data set may facilitate cross-study comparisons and understanding of the relationships between different scientific approaches and models.
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| 29. |
- Budny, R. V., et al.
(författare)
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Alpha heating, isotopic mass, and fast ion effects in deuterium-tritium experiments
- 2018
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 58:9
-
Tidskriftsartikel (refereegranskat)abstract
- Alpha heating experiments in the Tokamak Fusion Test Reactor (TFTR) and in the Joint European Torus (JET) 1997 DTE1 campaign arc reexamined. In TFTR supershots central electron heating of both deuterium only and deuterium-tritium supershots was dominated by thermal ion-electron heat transfer rate p(ie). The higher T-e in deuterium-tritium supershots was mainly due to higher T-i largely caused by isotopic mass effects of neutral beam-thermal ion heating. The thermal ion-electron heating dominated the electron heating in the center. The ratio of the predicted alpha to total electron heating rates f(alp) is less than 0.30. Thus alpha heating (and possible favorable isotopic mass scaling of the thermal plasma) were too small to be measured reliably. The JET alpha heating Hot-Ion H-mode discharges had lower T-i/T-e, and thus had lower p(ie) and the deuterium-tritium DT discharges had higher f(alp), than in TFTR. There were not enough comparable discharges to verify alpha heating. The high performance phases consisted of rampup to brief flattop durations. At equal times during the rampup phase central T-e and T-i were linearly correlated with the thermal hydrogcnic isotopic mass < A >(hyd) which co-varied with beam ion pressure, the tritium fraction of neutral beam power, and the time delay to the first significant sawteeth which interrupted the T-e increases. For both devices the expected alpha healing rate and the null hypothesis of no alpha heating arc consistent with the measurements within the measurement and modeling uncertainties.
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| 30. |
- Budny, R. V., et al.
(författare)
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Core fusion power gain and alpha heating in JET, TFTR, and ITER
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:5
-
Tidskriftsartikel (refereegranskat)abstract
- Profiles of the ratio of fusion power and the auxiliary heating power (MT are calculated for the TFTR and JET discharges with the highest neutron emission rates, and arc predicted for ITER. Core values above 1.3 for JET and 0.8 for TFTR are obtained, Values above 20 are predicted for ITER baseline plasmas.
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| 31. |
- Budtz-Lilly, Jacob, et al.
(författare)
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European Multicentric Experience With Fenestrated-branched ENDOvascular Stent Grafting After Previous FAILed Infrarenal Aortic Repair The EU-FBENDO-FAIL Registry
- 2023
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Ingår i: Annals of Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0003-4932 .- 1528-1140. ; 278:2, s. E389-E395
-
Tidskriftsartikel (refereegranskat)abstract
- Objective:To report the mid-term outcomes of fenestrated-branched endovascular aneurysm repair (F-BEVAR) following a failed previous endovascular aneurysm repair (pEVAR) or previous open aneurysm repair (pOAR).Methods:Data from consecutive patients who underwent F-BEVAR for pEVAR or pOAR from 2006 to 2021 from 17 European vascular centers were analyzed. Endpoints included technical success, major adverse events, 30-day mortality, and 5-year estimates of survival, target vessel primary patency, freedom from reinterventions, type I/III endoleaks, and sac growth >5 mm.Background:Treatment of a failed previous abdominal aortic aneurysm repair is a complex undertaking. F-BEVAR is becoming an increasingly attractive option, although comparative data are limited regarding associated risk factors, indications for treatment, and various outcomes.Results:There were 526 patients included, 268 pOAR and 258 pEVAR. The median time from previous repair to F-BEVAR was 7 (interquartile range, 4-12) years, 5 (3-8) for pEVAR, and 10 (6-14) for pOAR, P<0.001. Predominant indication for treatment was type Ia endoleak for pEVAR and progression of the disease for pOAR. Technical success was 92.8%, pOAR (92.2%), and pEVAR (93.4%), P=0.58. The 30-day mortality was 6.5% overall, 6.7% for pOAR, and 6.2% for pEVAR, P=0.81. There were 1853 treated target vessels with 5-year estimates of primary patency of 94.4%, pEVAR (95.2%), and pOAR (94.4%), P=0.03. Five-year estimates for freedom from type I/III endoleaks were similar between groups; freedom from reintervention was lower for pEVAR (38.3%) than for pOAR (56.0%), P=0.004. The most common indication for reinterventions was for type I/III endoleaks (37.5%).Conclusions:Repair of a failed pEVAR or pOARis safe and feasible with comparable technical success and survival rates. While successful treatment can be achieved, significant rates of reintervention should be anticipated, particularly for issues related to instability of target vessels/bridging stents.
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| 32. |
- Buratti, P., et al.
(författare)
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Diagnostic application of magnetic islands rotation in JET
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:7
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements of the propagation frequency of magnetic islands in JET are compared with diamagnetic drift frequencies, in view of a possible diagnostic application to the determination of markers for the safety factor profile. Statistical analysis is performed for a database including many well-diagnosed plasma discharges. Propagation in the plasma frame, i.e. with subtracted E x B Doppler shift, results to be in the ion diamagnetic drift direction, with values ranging from 0.8 (for islands at the q = 2 resonant surface) to 1.8 (for more internal islands) times the ion diamagnetic drift frequency. The diagnostic potential of the assumption of island propagation at exactly the ion diamagnetic frequency is scrutinised. Rational-q locations obtained on the basis of this assumption are compared with the ones measured by equilibrium reconstruction including motional Stark effect measurements as constraints. Systematic shifts and standard deviations are determined for islands with (poloidal, toroidal) periodicity indexes of (2, 1), (3, 2), (4, 3) and (5, 3) and possible diagnostic applications are indicated.
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| 33. |
- Carlsson, Fredrik, 1974-
(författare)
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Wood Fungi and Forest Fire
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Forest fires have been the major stand-replacing/modifying disturbance in boreal forests. To adapt to fire disturbance, different strategies have evolved. This thesis focuses on wood fungi, and the effect of forest fire on this organism group. In many ways it is a study on adaptation to forest fire, in concurrence with adaptation to dry open habitats. In Paper I we study increased heat resistance in mycelia from species prevalent in fire prone environments. Fungi were cultivated on fresh wood and exposed to different temperatures. Species prevalent in fire affected habitats had a much higher survival rate over all combinations of time and temperature compared to species associated with other environments. Based on this results the competitiveness was tested after temperature stress (paper II), three fire associated species, were tested against three non fire associated species. All fire associated species had a clear advantage after heat treatment, conquering a larger volume of wood than its competitor. In paper III we studied the effect of heat shock on decomposition rate, 18 species was tested. Species were cultivated and monitored for CO2 accumulation for 8 weeks and then heat shocked. All species including non fire associated species seemed to up-regulate decomposition after heat shock, this response was more pronounced in fire associated species. To look at the possible effect of forest fire on population structure (Paper IV), we developed 29 SNP/INDELs for Phlebiopsis. gigantea. We amplified the marker containing fragments in 132 individuals of P. gigantea in 6 populations, 3 which were found in areas affected by forest fire and 3 in unaffected areas. We found no genetic structure in accordance to forest fire. However we detected geographic structure, which stands in contrast to earlier studies. This might be due to the method, using SNP´s and number of individuals in the study. Finally we collected cross-sections of decayed logs to evaluate the number of fungal species domains that are likely to be hit when drilling a saw-dust sample in a log. We used these estimates to simulate how many species that will be found by a certain number of samples. We found that in 99% of the
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| 34. |
- Chiariello, Andrea Gaetano, et al.
(författare)
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A 3D electromagnetic model of the iron core in JET
- 2017
-
Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 123, s. 527-531
-
Tidskriftsartikel (refereegranskat)abstract
- The Magnet and Power Supplies system in JET includes a ferromagnetic core able to increase the transformer effect by improving the magnetic coupling with the plasma. The iron configuration is based on an inner cylindrical core and eight returning limbs; the ferromagnetic circuit is designed in such a way that the inner column saturates during standard operations [1]. The modelling of the magnetic circuit is a critical issue because of its impact on several applications, including equilibrium and reconstruction analysis required for control applications. The most used model in present applications is based on Equivalent Currents (ECs) placed on the iron boundary together with additional specific constraints, in a 2D axisymmetric frame. The (circular) ECs are chosen, by using the available magnetic measurements, to best represent the magnetic polarization effect [1]. Due to the axisymmetric assumption such approach is not well suited to deal with significant 3D effects, e.g. arising in operations with Error Field Correction Coils (EFCC). In this paper a new methodology is proposed, based on a set of 3D-shaped ECs and able to better model the actual 3D magnetization giving rise to a linear system to be solved. According to a well assessed approach [2], the 3D shape of ECs is represented by a set of elementary sources. The methodology has been successfully validated in a number of JET dry-run experiments where 3D effects are generated by EFCC currents. The new procedure has been designed to be easily coupled with equilibrium or reconstruction codes such as EFIT/V3FIT. The proposed model resulted to be very effective in representing 3D iron magnetization, especially if compared with typical 2D models.
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| 35. |
- Claesson, Andreas, et al.
(författare)
-
Simulation and education Outline and validation of a new dispatcher-assisted cardiopulmonary resuscitation educational bundle using the Delphi method
- 2024
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Ingår i: Resuscitation Plus. - : ELSEVIER. - 2666-5204. ; 17
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is time-dependent. To date, evidence-based training programmes for dispatchers are lacking. This study aimed to reach expert consensus on an educational bundle content for dispatchers to provide DA-CPR using the Delphi Method: An educational bundle was created by the Swedish Resuscitation Council consisting of three parts: e-learning on DA-CPR, basic life support training and audit of emergency out-of-hospital cardiac arrest calls. Thereafter, a two-round modified Delphi study was conducted between November 2022 and March 2023; 37 experts with broad clinical and/or scientific knowledge of DA-CPR were invited. In the first round, the experts participated in the e-learning module and answered a questionnaire with 13 closed and open questions, whereafter the e-learning part of the bundle was revised. In the second round, the revised e-learning part was evaluated using Likert scores (20 items). The predefined consensus level was set Results: Delphi rounds one and two were assessed by 20 and 18 of the invited experts, respectively. In round one, 18 experts (18 of 20, 90%) stated that they did not miss any content in the programme. In round two, the scale-level content validity index based on the average method (S-CVI/AVE, 0.99) and scale-level content validity index based on universal agreement (S-CVI/UA, 0.85) exceeded the threshold level of 80%. Conclusion: Expert consensus on the educational bundle content was reached using the Delphi method. Further work is required to evaluate its effect in real-world out-of-hospital cardiac arrest calls.
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| 36. |
- Clairet, F., et al.
(författare)
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Plasma turbulence measured with fast frequency swept reflectometry in JET H-mode plasmas
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:12
-
Tidskriftsartikel (refereegranskat)abstract
- In this work we present recent achievements to provide precise measurements of turbulence on JET H-mode plasmas using frequency sweeping reflectometry diagnostic. The plasma density fluctuations retrieved from swept reflected signals, first initiated with the Tore Supra reflectometry (Heuraux et al 2003 Rev. Sci. Instrum. 74 1501, Vermare et al 2006 Nucl. Fusion 46 S743, Gerbaud et al 2006 Rev. Sci. Instrum. 77 10E928), provides a radial profile of the density fluctuation level and its spectral structure. Using the complete set of the JET X-mode fast sweeping heterodyne reflectometers we have determined the temporal dynamic of the density fluctuation profile from the edge to the center during an H-mode discharge. At the L-H transition, the turbulence reduction seems to occur, at first, simultaneously from the edge to the center then deepens at the edge at rho similar to 0.95 and this deepening propagates toward the center with a steepening of the wavenumber spectra. During an edge localized mode (ELM) event, a substantial density fluctuations increase has been observed with a localized turbulent wave front propagating toward the center accompanying a particle transport. We also show that type-III ELMs sustain a steady and high level of plasma turbulence compare to type-I.
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| 37. |
- Coiling, Bethany, et al.
(författare)
-
Testing of tritium breeder blanket activation foil spectrometer during JET operations
- 2018
-
Ingår i: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 136, s. 258-264
-
Tidskriftsartikel (refereegranskat)abstract
- Accurate measurement of the nuclear environment within a test tritium breeding-blanket module of a fusion reactor is crucial to determine tritium production rates which are relevant to self-sufficiency of tritium fuel supply, tritium accountancy and also to the evaluation of localised power levels produced in blankets. This requires evaluation of the time-dependent spectral neutron flux within the test tritium breeding-blanket module under harsh radiation and temperature environments. The application of an activation foil-based spectrometer system to determine neutron flux density using a pneumatic transfer system in ITER has been studied, deployed and tested on the Joint European Torus (JET) machine in a recent deuterium - deuterium campaign for a selection of high purity activation foils. Deployment of the spectrometer system has provided important functional and practical testing of the detector measurement system, associated hardware and post processing techniques for the analysis of large data sets produced through the use of list mode data collection. The testing is invaluable for the optimisation of systems for future planned testing in tritium - tritium and deuterium - tritium conditions. Analysis of the time and energy spectra collected to date and the status of the development of methods for post processing are presented in this paper.
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| 38. |
- Conley, Daniel, et al.
(författare)
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Hypoxia is increasing in the coastal zone of the Baltic Sea
- 2011
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 45:16, s. 6777-6783
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Tidskriftsartikel (refereegranskat)abstract
- Hypoxia is a well-described phenomenon in the offshore waters of the Baltic Sea with both the spatial extent and intensity of hypoxia known to have increased due to anthropogenic eutrophication, however, an unknown amount of hypoxia is present in the coastal zone. Here we report on the widespread unprecedented occurrence of hypoxia across the coastal zone of the Baltic Sea. We have identified 115 sites that have experienced hypoxia during the period 1955-2009 increasing the global total to ca. 500 sites, with the Baltic Sea coastal zone containing over 20% of all known sites worldwide. Most sites experienced episodic hypoxia, which is a precursor to development of seasonal hypoxia. The Baltic Sea coastal zone displays an alarming trend with hypoxia steadily increasing with time since the 1950s effecting nutrient biogeochemical processes, ecosystem services, and coastal habitat.
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| 39. |
- Conroy, Sean, et al.
(författare)
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The global build-up to intrinsic ELM bursts and comparison with pellet triggered ELMs seen in JET
- 2017
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 57:2
-
Tidskriftsartikel (refereegranskat)abstract
- We focus on JET plasmas in which ELMs are triggered by pellets in the presence of ELMs which occur naturally. We perform direct time domain analysis of signals from fast radial field coils and toroidal full flux azimuthal loops. These toroidally integrating signals provide simultaneous high time resolution measurements of global plasma dynamics and its coupling to the control system. We examine the time dynamics of these signals in plasmas where pellet injection is used to trigger ELMs in the presence of naturally occurring ELMs. Pellets whose size and speed are intended to provide maximum local perturbation for ELM triggering are launched at pre-programmed times, without correlation to the occurrence times of intrinsic ELMs. Pellet rates were sufficiently low to prevent sustained changes of the underlying plasma conditions and natural ELM behaviour. We find a global signature of the build-up to natural ELMs in the temporal analytic phase of both the full flux loops and fast radial field coil signals. Before a natural ELM, the signal phases align to the same value on a similar to 2-5 ms timescale. This global build up to a natural ELM occurs whilst the amplitude of the full flux loop and fast radial field coil signals are at their background value: it precedes the response seen in these signals to the onset of ELMing. In contrast these signals do not clearly phase align before the ELM for ELMs which are the first to occur following pellet injection. This provides a direct test that can distinguish when an ELM is triggered by a pellet as opposed to occurring naturally. It further supports the idea [1-4] of a global build up phase that precedes natural ELMs; pellets can trigger ELMs even when the signal phase is at a value when a natural ELM is unlikely to occur.
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| 40. |
- Cooper, W. A., et al.
(författare)
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Free boundary equilibrium in 3D tokamaks with toroidal rotation
- 2015
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 55:6
-
Tidskriftsartikel (refereegranskat)abstract
- The three-dimensional VMEC equilibrium solver has been adapted to numerically investigate the approximate toroidal rotation model we have derived. We concentrate our applications on the simulation of JET snakes and MAST long-lived modes under free boundary conditions. Helical core solutions are triggered when exceeds a threshold value, typically 2.7% in JET-like plasmas. A large plasma current and edge bootstrap current can drive helical core formations at arbitrarily small in which the ideal saturated internal kink coexists with an ideal saturated external kink structure of opposite phase. The centrifugal force linked with the rotation has the effect of displacing the plasma column away from the major axis, but does not alter significantly the magnitude of the edge corrugation of the plasma. Error field correction coil currents in JET-like configurations increase the outer midplane distortions by 2 cm. The edge bootstrap current enhances the edge modulation of the plasma driven by the core snake deformations in MAST.
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| 41. |
- Corre, Y., et al.
(författare)
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Thermal analysis of protruding surfaces in the JET divertor
- 2017
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 57:6
-
Tidskriftsartikel (refereegranskat)abstract
- Tungsten (W) melting is a major concern for next step fusion devices. Two ELM induced tungsten melting experiments have been performed in JET by introducing two special target plate lamellae designed to receive excessively high ELM transient power loads. The first experiment was performed in JET in 2013 using a special lamella with a sharp leading edge gradually varying from h = 0.25 mm to 2.5 mm in order to maximise the temperature rise by exposure to the full parallel heat flux. ELM-induced transient melting has been successively achieved allowing investigation of the melt motion. However, using the available IR viewing geometry from the top, it was not possible to directly discriminate between the top and leading edge power loads. To improve the experimental validation of heat load and melt motion modelling codes, a new protruding W lamella with a 15 degrees slope facing the toroidal direction has been installed for the 2015-16 campaigns, allowing direct, spatially resolved observation of the top surface and reduced sensitivity of the analysis to the surface incidence angle of the magnetic field. This paper reports on the results of these more recent experiments, with specific focus on IR data analysis and heat flux calculations during L-mode discharges in order to investigate the behaviour of the W lamella with steady state heat load, which is a prerequisite for the more complex ELMing H-mode discharges (including both, steady and transient heat loads). It shows that, at least in L-mode, the assumption of optical heat flux projection is justified.
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| 42. |
- Curuia, Marian, et al.
(författare)
-
Upgrade of the tangential gamma-ray spectrometer beam-line for JET DT experiments
- 2017
-
Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 123, s. 749-753
-
Tidskriftsartikel (refereegranskat)abstract
- The JET tangential gamma-ray spectrometer is undergoing an extensive upgrade in order to make it compatible with the forthcoming deuterium-tritium (DT) experiments. The paper presents the results of the design for the main components for the upgrade of the spectrometer beam-line: tandem collimators, gamma-ray shields, and neutron attenuators. The existing tandem collimators will be upgraded by installing two additional collimator modules. Two gamma-ray shields will define the gamma-ray field of-view at the detector end of the spectrometer line-of-sight. A set of three lithium hydride neutron attenuators will be used to control the level of the fast neutron flux on the gamma-ray detector. The design of the upgraded spectrometer beam-line has been supported by extensive radiation (neutron and photon) transport calculations using both large volume and point radiation sources.
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| 43. |
- de la Luna, E., et al.
(författare)
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Understanding the physics of ELM pacing via vertical kicks in JET in view of ITER
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:2
-
Tidskriftsartikel (refereegranskat)abstract
- Experiments on JET, with both the previous carbon wall (JET-C) and the new Be/W wall (JET-ILW), have demonstrated the efficacy of using a fast vertical plasma motion (known as vertical kicks in JET) for active ELM control. In this paper we report on a series of experiments that have been recently conducted in JET-ILW with the goal of further improving the physics understanding of the processes governing the triggering of ELMs via vertical kicks. This is a necessary step to confidently extrapolate this ELM control method to ITER. Experiments have shown that ELMs can be reliably triggered provided a minimum vertical plasma displacement and velocity is imposed. The magnitude of the minimum displacement depends on the plasma parameters, being smaller for higher pedestal temperatures and lower collisionalities, which is encouraging in view of ITER. Modelling and stability analysis suggest that a localized current density induced by the vertical plasma movement close to the separatrix plays a major role in the ELM triggering mechanism, which is consistent with the experimental observations. The implications of these results for the extrapolation of this ELM control scheme to ITER are discussed.
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| 44. |
- de Vries, P. C., et al.
(författare)
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Scaling of the MHD perturbation amplitude required to trigger a disruption and predictions for ITER
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:2
-
Tidskriftsartikel (refereegranskat)abstract
- The amplitude of locked instabilities, likely magnetic islands, seen as precursors to disruptions has been studied using data from the JET, ASDEX Upgrade and COMPASS tokamaks. It was found that the thermal quench, that often initiates the disruption, is triggered when the amplitude has reached a distinct level. This information can be used to determine thresholds for simple disruption prediction schemes. The measured amplitude in part depends on the distance of the perturbation to the measurement coils. Hence the threshold for the measured amplitude depends on the mode location (i.e. the rational q-surface) and thus indirectly on parameters such as the edge safety factor, q(95), and the internal inductance, li(3), that determine the shape of the q-profile. These dependencies can be used to set the disruption thresholds more precisely. For the ITER baseline scenario, with typically q(95) = 3.2, li(3) = 0.9 and taking into account the position of the measurement coils on ITER, the maximum allowable measured locked mode amplitude normalized to engineering parameters was estimated to be a.B-ML(r
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| 45. |
- Dillenbeck, Emelie, et al.
(författare)
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The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable
- 2024
-
Ingår i: American Heart Journal. - : MOSBY-ELSEVIER. - 0002-8703 .- 1097-6744. ; 271, s. 97-108
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Tidskriftsartikel (refereegranskat)abstract
- Background Delayed hypothermia, initiated after hospital arrival, several hours after cardiac arrest with 8-10 hours to reach the target temperature, is likely to have limited impact on overall survival. However, the effect of ultrafast hypothermia, i.e., delivered intra-arrest or immediately after return of spontaneous circulation (ROSC), on functional neurologic outcome after out -of -hospital cardiac arrest (OHCA) is unclear. In two prior trials, prehospital trans -nasal evaporative intra-arrest cooling was safe, feasible and reduced time to target temperature compared to delayed cooling. Both studies showed trends towards improved neurologic recovery in patients with shockable rhythms. The aim of the PRINCESS2-study is to assess whether cooling, initiated either intra-arrest or immediately after ROSC, followed by in -hospital hypothermia, significantly increases survival with complete neurologic recovery as compared to standard normothermia care, in OHCA patients with shockable rhythms. Methods/design In this investigator -initiated, randomized, controlled trial, the emergency medical services (EMS) will randomize patients at the scene of cardiac arrest to either trans -nasal cooling within 20 minutes from EMS arrival with subsequent hypothermia at 33 degrees C for 24 hours after hospital admission (intervention), or to standard of care with no prehospital or in -hospital cooling (control). Fever ( > 37,7 degrees C) will be avoided for the first 72 hours in both groups. All patients will receive post resuscitation care and withdrawal of life support procedures according to current guidelines. Primary outcome is survival with complete neurologic recovery at 90 days, defined as modified Rankin scale (mRS) 0-1. Key secondary outcomes include survival to hospital discharge, survival at 90 days and mRS 0-3 at 90 days. In total, 1022 patients are required to detect an absolute difference of 9% (from 45 to 54%) in survival with neurologic recovery (80% power and one-sided alpha= 0,025, beta = 0,2) and assuming 2,5% lost to follow-up. Recruitment starts in Q1 2024 and we expect maximum enrolment to be achieved during Q4 2024 at 20-25 European and US sites. Discussion This trial will assess the impact of ultrafast hypothermia applied on the scene of cardiac arrest, as compared to normothermia, on 90 -day survival with complete neurologic recover y in OHCA patients with initial shockable rhythm. Trial registration NCT06025123. (Am Heart J 2024;271:97-108.)
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| 46. |
- Domanski, Henryk A, et al.
(författare)
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Core-needle biopsy performed by the cytopathologist : a technique to complement fine-needle aspiration of soft tissue and bone lesions
- 2005
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Ingår i: Cancer. - : Wiley. - 1097-0142 .- 0008-543X. ; 105:4, s. 229-239
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Fine-needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of musculoskeletal lesions; and, in many patients, a definitive diagnosis can be rendered from aspiration smears alone. The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies.METHODS: A consecutive series of 130 patients with soft tissue and bone lesions was examined by core-needle biopsy (CNB) performed by a cytopathologist in conjunction with FNAC. The findings of this combined diagnostic approach were compared with histologic diagnoses made on surgical biopsies and resected specimens from 86 patients. Adequate follow-up was available in all patients.RESULTS: FNAC combined with CNB correctly could identify 77 of 78 malignant lesions and 50 of 52 benign lesions. Only seven patients underwent incisional biopsy. The tumor subtype was determined correctly in 30 of 39 patients (77%) and the malignancy grade was determined in 35 of 39 patients (90%) with primary soft tissue and bone sarcomas compared with the biopsy or operative specimens.CONCLUSIONS: FNAC of musculoskeletal tumors/lesions complemented with CNB combined cytomorphology with tissue architecture and ancillary procedures. In the current study, obtaining FNAC as well as CNB at the same clinic visit and by the cytopathologist made preliminary diagnosis on the day of referral possible. This speeded diagnosis increased the number of correct diagnoses and usually enabled correct subtyping and malignancy grading of sarcomas.
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| 47. |
- D'Oria, Mario, et al.
(författare)
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Comparison of early and mid-term outcomes after fenestrated-branched endovascular aortic repair in patients with or without prior infrarenal repair
- 2021
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Ingår i: Journal of Endovascular Therapy. - : Sage Publications. - 1526-6028 .- 1545-1550. ; 29:4, s. 544-554
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The purpose of this study was to compare short- and mid-term outcomes of fenestrated-branched endovascular repair (F-BEVAR) of pararenal (PRAA)/thoracoabdominal (TAAA) aortic aneurysms in patients with or without prior endovascular/open (EVAR/OAR) infrarenal aortic repair.Methods: Data from consecutive F-BEVAR (2010-2019) at two high-volume aortic centers were retrospectively reviewed. Primary endpoints were technical success, 30-day mortality, and overall survival. Secondary endpoints included 30-day major adverse events (MAE), freedom from type I/III endoleaks, reinterventions, sac expansion, and target vessel (TV) primary patency.Results: A total of 222 consecutive patients were included for analysis; of these 58 (26.1%) had prior infrarenal repair (EVAR=33, OAR=25) and 164 (73.9%) had native PRAA/TAAA. At baseline, patients with prior infrarenal repair were older (mean age=75.1 vs 71.6 years, p=.005) and the proportion of females was lower (8.6% vs 29.3%, p=.002). Technical success was 97.8% (n=217) in the entire cohort, without any significant differences between study groups (94.8% vs 98.8%, p=.08). At 30 days, there were no significant differences between patients with prior infrarenal repair as compared with those without in rate of MAE (44.8% vs 54.9%, p=.59). The 5-year estimate of survival for those who underwent native aortic repair was 61.6%, versus 61.3% for those who had a previous repair (p=.67). The 5-year freedom from endoleaks I/III estimates were significantly lower in patients who had prior infrarenal repair as compared with patients undergoing treatment of native aneurysms (57.1% vs 66.1%, p=.03), mainly owing to TV-related endoleaks (ie, type IC and/or IIIC endoleaks). No significant differences were found between study groups in rates of reinterventions and TV primary patency. Five-year estimates of freedom from sac increase >5mm were significantly lower in patients who received F-BEVAR after previous infrarenal repair as compared with those who underwent treatment of native aneurysms (48.6% vs 77.5%, p=.002).Conclusions: F-BEVAR is equally safe and feasible for treatment of patients with prior infrarenal repair as compared with those undergoing treatment for native aneurysms. Increased rates of TV-related endoleaks were observed which could lead to lower freedom from aneurysm sac shrinkage during follow-up. Nevertheless, the 5-year rates of reinterventions and TV patency were similar, thereby indicating that overall effectiveness of treatment remained satisfactory at mid-term.
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| 48. |
- Dreisig, Karin, et al.
(författare)
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TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia
- 2021
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Ingår i: Pediatric Hematology and Oncology. - : Informa UK Limited. - 0888-0018 .- 1521-0669. ; 38:3, s. 227-238
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Tidskriftsartikel (refereegranskat)abstract
- © 2020 Taylor & Francis Group, LLC. Bone marrow minimal residual disease (MRD) is the strongest predictor of relapse in children with acute lymphoblastic leukemia (ALL). 6-mercaptopurine (6MP) in ALL therapy has wide inter-individual variation in disposition and is strongly influenced by polymorphisms in the thiopurine methyltransferase (TPMT) gene. In 952 patients treated according to the NOPHO ALL2008 protocol, we explored the association between thiopurine disposition, TPMT genotypes and MRD levels after consolidation therapy with 6MP, high-dose methotrexate (HD-MTX), asparaginase, and vincristine. The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/µg DNA, p = 0.002). In contrast, TPMT genotype did not associate with the end of consolidation MRD levels irrespective of randomization of the patients to fixed dose (25 mg/m2/day) or 6MP escalation (up to 50 or 75 mg/m2/day) during consolidation therapy.
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| 49. |
- Drenik, A., et al.
(författare)
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Analysis of the outer divertor hot spot activity in the protection video camera recordings at JET
- 2019
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Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 139, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Hot spots on the divertor tiles at JET result in overestimation of the tile surface temperature which causes unnecessary termination of pulses. However, the appearance of hot spots can also indicate the condition of the divertor tile surfaces. To analyse the behaviour of the hot spots in the outer divertor tiles of JET, a simple image processing algorithm is developed. The algorithm isolates areas of bright pixels in the camera image and compares them to previously identified hot spots. The activity of the hot spots is then linked to values of other signals and parameters in the same time intervals. The operation of the detection algorithm was studied in a limited pulse range with high hot spot activity on the divertor tiles 5, 6 and 7. This allowed us to optimise the values of the controlling parameters. Then, the wider applicability of the method has been demonstrated by the analysis of the hot spot behaviour in a whole experimental campaign.
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| 50. |
- Dumortier, P., et al.
(författare)
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Commissioning and first results of the reinstated JET ICRF ILA
- 2017
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Ingår i: Fusion engineering and design. - : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 123, s. 285-288
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Tidskriftsartikel (refereegranskat)abstract
- The JET ICRF ITER-like Antenna (ILA) has been operated at 33,42 and 47 MHz in 2008-2009 but stopped operation in 2009 due to the failure of one of the tuning capacitors inside the antenna. Tests on a spare capacitor showed that a micro-leak was caused by the cycle wear of a capacitor's internal bellows. The ILA was reinstated with a new operating scheme minimizing the full stroke requests of the capacitor. This contribution gives an overview of the works undertaken to reinstate the JET ILA up to the first results on plasma. The capacitors were replaced and high voltage tests of the capacitors were performed. An extensive calibration of all the measurements in the RF circuit was carried out. New simulation tools were created and control algorithms were implemented for the - toroidal and poloidal - phase control of the array as well as for the matching of the second stage. New protections are being implemented for the thermal and voltage protection of the capacitors. Low voltage matching tests were performed before the high power commissioning. Finally the first results on plasma are presented, showing that the new controls allow extending the range of the operation to lower (29 MHz) and higher (51 MHz) frequencies than previously achieved.
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