| 1. |
- Donati, Michele, et al.
(författare)
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MAP2K1-Mutated Melanocytic Neoplasms With a SPARK-Like Morphology
- 2021
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Ingår i: American journal of dermatopathology. - : Wolters Kluwer. - 0193-1091 .- 1533-0311. ; 43:6, s. 412-417
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Tidskriftsartikel (refereegranskat)abstract
- Specific alterations involving MAPK genes (MAP3K8 fusions, MAP3K3 fusions) have been recently detected in a subgroup of spitzoid neoplasms that seem to constitute a distinctive clinicopathologic group, occur mostly in younger patients (median age 18 years) and present with atypical histologic features associated with frequent homozygous deletion of CDKN2A, qualifying a high proportion of them as Spitz melanoma (malignant Spitz tumor). Apart from lesions with spitzoid morphology harboring MAP3K8 or MAP3K3 fusion, a single case with MAP2K1 deletion has been identified. The authors report herein 4 melanocytic lesions with a MAP2K1 mutation, all showing similar microscopic appearances, including spitzoid cytology and dysplastic architectural features, resembling so-called SPARK nevus, suggesting that these lesions may represent another distinctive group.
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| 2. |
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| 3. |
- Alsiö, Johan, et al.
(författare)
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Inverse association of high-fat diet preference and anxiety-like behavior : a putative role for urocortin 2
- 2009
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Ingår i: Genes, Brain and Behavior. - 1601-1848 .- 1601-183X. ; 8:2, s. 193-202
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether the preference for a palatable high-fat diet (HFD) is associated with response to novelty and with anxiety-like behavior in rats and whether such fat preference correlates with gene expression of hypothalamic neuropeptides related to feeding. We subjected male rats to two tests of exploration of novel environments: the multivariate concentric square field (MCSF) and the elevated plus maze (EPM). The rats were then exposed to a 5-day test of preference for a palatable HFD versus reference diets. Messenger RNA (mRNA) levels of 21 neuropeptides were investigated by quantitative polymerase chain reaction. We found a strong positive correlation of HFD preference and open-arm activity in the EPM (% open-arm time, r(s) = 0.629, df = 26, P < 0.001). Thus, HFD preference was inversely associated with anxiety-like behavior. The same association was found for HFD preference and behavior in the MCSF (bridge entries, r(s) = 0.399, df = 23, P = 0.048). In addition, the HFD preference was positively correlated (r(s) = 0.433, df = 25, P = 0.021) with hypothalamic mRNA levels of urocortin 2 (Ucn 2). Moreover, behavior in the EPM was significantly correlated with expression levels of the receptor for Ucn 2, the corticotropin-releasing factor receptor 2, in the hypothalamus (r(s) = 0.382, df = 33, P = 0.022, pituitary (r(s) = 0.494, df = 31, P = 0.004) and amygdala (r(s) = 0.381, df = 30, P = 0.032). We conclude that preference for palatable HFD is inversely associated with anxiety and propose that Ucn 2 signaling may play a role in this association.
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| 4. |
- Ayres-de-Campos, Diogo, et al.
(författare)
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European Association of Perinatal Medicine (EAPM), European Board and College of Obstetricians and Gynaecologists (EBCOG), European Midwives Association (EMA). Joint position statement : Substandard and disrespectful care in labour - because words matter
- 2024
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Ingår i: European Journal of Obstetrics, Gynecology, and Reproductive Biology. - : Elsevier. - 0301-2115 .- 1872-7654 .- 2590-1613. ; 296, s. 205-207
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Tidskriftsartikel (refereegranskat)abstract
- Substandard or disrespectful care during labour should be of serious concern for healthcare professionals, as it can affect one of the most important events in a woman's life. Substandard care refers to the use of interventions that are not considered best -practice, to the inadequate execution of interventions, to situations where bestpractice interventions are withheld from patients, or there is lack of adequate informed consent. Disrespectful care refers to forms of verbal and non-verbal communication that affect patients' dignity, individuality, privacy, intimacy, or personal beliefs. There are many possible underlying causes for substandard and disrespectful care in labour, including difficulties in modifying behaviours, judgmental or paternalistic attitudes, personal interests and individualism, and a human tendency to make less arduous, less difficult, or less stressful clinical decisions. The term "obstetric violence" is used in some parts of the world to describe various forms of substandard and disrespectful care in labour, but suggests that it is mainly carried out by obstetricians and is a serious form of aggression, carried out with the intent to cause harm. We believe that this term should not be used, as it does not help to identify the underlying problem, its causes, or its correction. In addition, it is generally seen by obstetricians and other healthcare professionals as an unjust and offensive term, generating a defensive and less collaborative mindset. We reach out to all individuals and institutions sharing the common goal of improving women's experience during labour, to work together to address the underlying causes of substandard and disrespectful care, and to develop common strategies to deal with this problem, based on mutual comprehension, trust and respect
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| 5. |
- Bengtsson, Ylva, et al.
(författare)
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Ulriksdals slott under 350 år
- 1995
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Rapport (populärvet., debatt m.m.)abstract
- Studierna har utgått från Ulriksdals slott, uppfört av Jacob De la Gardie för 350 år sedan. Som kungligt slott har Ulriksdal genomgått ombyggnader under 1600 - och 1700-talet, men präglas idag mest av Karl XVs omfattande omdaning på 1850-talet och Gustav VI Adolfs lika genomgripande förändringar på 1920-talet.Slottet har bjudit på rika studiemöjligheter av stilideal, planlösning, interiörgestaltning, snickerikultur och stormtekniska system från hela 350-årsperioden. Genom noggranna uppmätningar och inventeringar på plats kopplade till arkivstudier har slottets komplicerade förändringshistoria kunnat analyseras,
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| 6. |
- Bexelius, Maria, et al.
(författare)
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27 forskare : Så kan EU:s murar rivas
- 2015
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Ingår i: Dagens samhälle. - : Sveriges kommuner och landsting. - 1652-6511. ; :20150923
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 7. |
- Bosch-Sijtsema, Petra, 1971, et al.
(författare)
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Hur vi använder digitala tekniker. En framtidsspaning i byggbranschen
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Detta forskningsprojekt har finansierats av CMB (Centrum för Management i Byggsektorn). Forskningsprojektet syftar till att identifiera digitala trender i den svenska byggbranschen. Det globala samhället är just nu inne i ett paradigmskifte, på samma sätt som samhället förändrades från ett jordbrukssamhälle till ett industrialiserat samhälle, ser vi nu en övergång från manuellt hanterad information till uppkopplad och digital; och i vissa fall ett samhälle som får se att den mänskliga intelligensen inte alltid är överlägsen. Denna omställning presenterar ett antal nya möjligheter för företag och organisationer men ställer också nya krav och efterfrågar ny kompetens. Detta utmanar byggbranschen och dess aktörer men öppnar upp möjligheten till ökad effektivitet, hållbarhet och konkurrenskraft. Under de senaste tio åren har få prognosstudier utförts för byggbranschen och med tanke på den snabba teknikutvecklingen är det relevant att studera dess nuvarande användning och potentiella möjligheter inom byggbranschen. Genom detta projekt vill vi försöka ge en ögonblicksbild av förståelsen för och användandet av ett antal utvalda digitala tekniker inom byggbranschen. Samtidigt vill vi också skapa en ökad medvetenhet om teknikerna för att på så sätt stötta branschen i dess strävan mot att digitaliseras. Projektet har följande delmål: 1. Kartlägga och analysera ett urval digitala tekniker som kommer att påverka byggbranschen. 2. Att för byggbranschen diskutera och analysera de digitala teknikerna och deras konsekvenser med hjälp av representanter verksamma inom branschen.
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| 8. |
- Bosch-Sijtsema, Petra, 1971, et al.
(författare)
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The hype factor of digital technologies in AEC
- 2021
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Ingår i: Construction Innovation. - 1477-0857 .- 1471-4175. ; 21:4, s. 899-916
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – This paper aims to focus on 11 digital technologies (i.e. building information modeling, artificial intelligence and machine learning, 3D scanning, sensors, robots/automation, digital twin, virtual reality, 3D printing, drones, cloud computing and self-driving vehicles) that are portrayed in future trend reports and hype curves. The study concentrates on the current usage and knowledge of digital technologies in the Swedish architecture, engineering and construction (AEC) industry to gain an insight in the possible expectations and future trajectory of these digital technologies. Design/methodology/approach – The study applies an abductive approach which is based on three different types of methods. These methods are a literature and document study which focused on 11 digital technologies, two workshops with industry (13 participants) and an online survey (N = 84). Findings – The paper contributes to a current state analysis of the Swedish AEC industry concerning digital technologies and discusses the trajectory of these technologies for the AEC industry. The paper identifies hype factors, in which the knowledge of a digital technology is related to its usage. From the hype factors, four zones that show different stages of digital technology usage and maturity in the industry are induced. Originality/value – The contribution of the paper is twofold. The paper shows insight into opportunities, the current barriers, use and knowledge of digital technologies for the different actors in the AEC industry. Furthermore, the study shows that the AEC industry is behind the traditional Gartner hype curves and contributes with defining four zones for digital technologies for the Swedish AEC industry: confusion, excitement, experimentation and integration.
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| 9. |
- Ek, Kristine, 1975, et al.
(författare)
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Multi-criteria decision analysis methods to support sustainable infrastructure construction
- 2019
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Ingår i: IABSE Symposium, Guimaraes 2019: Towards a Resilient Built Environment Risk and Asset Management - Report. ; , s. 1084-1091
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Konferensbidrag (refereegranskat)abstract
- The construction of infrastructure projects represents a large sustainability impact, both positive and negative. Increased positive and reduced negative impacts can be achieved through better design and planning of the construction. To make more sustainable choices, well‐defined predictive sustainability assessment methods are required. Multi‐criteria decision analysis (MCDA) is a well-suited method for predictive sustainability assessment. This paper evaluates two MCDA methods for sustainability assessment of infrastructure construction and exemplifies their application with two case studies. The aim of this paper is to discuss if the methods are suitable for identifying the most sustainable alternative during the procurement process of an infrastructure project. It is recommended that MCDA methods are further developed to comply with the recently published EN standard on sustainability assessment of civil engineering works.
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| 10. |
- Escott-Price, Valentina, et al.
(författare)
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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6, s. e94661-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
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| 11. |
- Gilligan, Melanie, 1979-
(författare)
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Treating the Abstract of Capital Concretely: Films Against Capitalism
- 2022
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- This practice-based PhD, Treating the Abstract of Capital Concretely: Films Against Capitalism, looks at how film can oppose the prevailing ideasof capitalist systems.The research asks: What qualities do films have that can be used as strategies against capitalism and what knowledge do these films produce? In an understanding that capitalism projects concepts onto the world, and that mainstream film can frame people’s lives through a reductive capitalist understanding, the research suggests that more politically powerful moving images need to be the focus to create societal change.Treating the Abstract of Capitalism Concretely: Films Against Capitalism, includes six aesthetic, political and conceptual video works, and an accompanying written handbook, that together consider capital as the relation between abstract laws of accumulation and concrete lived situations.Making moving image works against the capitalist system necessarily involves knowledge about capitalism, however, the research charts how the knowledge most central in filmmaking is often associative, affective and combines knowledge with practice. A variety of methodological approaches are pursued through practical and theoretical research about how films can oppose capitalism. This investigation is explored materially, through video projects that interrogate capitalist abstraction from inside social processes,in realities that people live. The video works present a critique of racial and patriarchal capitalism, while the written component presents a contextual discussion about films against capitalism.The PhD submission consists of six video projects: The Common Sense, The Bay Area Protests, Parts-wholes 2, Crowds, Home Together, and Health as Individual vs. Health as Social and a PDF handbook, Treating the Abstractof Capital Concretely: Films Against Capitalism. The written text puts forth theoretical and practical proposals for films against capitalism as well as a 3 script. Connections are here made between different understandings of abstraction, while bringing in ideas from political theory, as well as demonstrating allegory as a technique against capitalism in film.The video works and handbook are accessed via: https://www.films-against-capitalism.com
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| 12. |
- Hallingström, Maria, et al.
(författare)
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Mid-trimester amniotic fluid proteome’s association with spontaneous preterm delivery and gestational duration
- 2020
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 15:5
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Tidskriftsartikel (refereegranskat)abstract
- Background Amniotic fluid is clinically accessible via amniocentesis and its protein composition may correspond to birth timing. Early changes in the amniotic fluid proteome could therefore be associated with the subsequent development of spontaneous preterm delivery. Objective The main objective of this study was to perform unbiased proteomics analysis of the association between mid-trimester amniotic fluid proteome and spontaneous preterm delivery and gestational duration, respectively. A secondary objective was to validate and replicate the findings by enzyme-linked immunosorbent assay using a second independent cohort. Methods Women undergoing a mid-trimester genetic amniocentesis at Sahlgrenska University Hospital/Östra between September 2008 and September 2011 were enrolled in this study, designed in three analytical stages; 1) an unbiased proteomic discovery phase using LC-MS analysis of 22 women with subsequent spontaneous preterm delivery (cases) and 37 women who delivered at term (controls), 2) a validation phase of proteins of interest identified in stage 1, and 3) a replication phase of the proteins that passed validation using a second independent cohort consisting of 20 cases and 40 matched controls. Results Nine proteins were nominally significantly associated with both spontaneous preterm delivery and gestational duration, after adjustment for gestational age at sampling, but none of the proteins were significant after correction for multiple testing. Several of these proteins have previously been described as being associated with spontaneous PTD etiology and six of them were thus validated using enzyme linked immunosorbent assay. Two of the proteins passed validation; Neutrophil gelatinase-associated lipocalin and plasminogen activator inhibitor 1, but the results could not be replicated in a second cohort. Conclusions Neutrophil gelatinase-associated lipocalin and Plasminogen activator inhibitor 1 are potential biomarkers of spontaneous preterm delivery and gestational duration but the findings could not be replicated. The negative findings are supported by the fact that none of the nine proteins from the exploratory phase were significant after correction for multiple testing.
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| 13. |
- Hassan, Osama, 1969-, et al.
(författare)
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Lecablock, an Alternative Construction Material for the Exterior Walls of Passive House
- 2014
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Ingår i: Journal of Building Construction and Planning Research. - : Scientific Research Publishing. - 2328-4889 .- 2328-4897. ; 2:2, s. 96-108
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Tidskriftsartikel (refereegranskat)abstract
- In this paper it is attempted to investigate the Leca blocks as sustainable construction material forthe exterior walls of passive house. The building physical properties of Leca design wall structureare studied along with the environmental impact and load-bearing capacity. To compare the results,a similar analysis is carried out considering the traditional wooden wall construction of passivehouses. The results showed that Leca design wall structure can be an alternative sustainablesolution to the traditional wooden wall structure of passive house, mainly due to its low U-value,its ability to handle moisture, and comparable structural load-bearing capacity. However, thewooden wall structure is more environmentally friendly than the Leca blocks due to its loweremissions to the environment and reduced energy use, especially during the manufacturing process.
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| 14. |
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| 15. |
- Ho, Doris M.L., et al.
(författare)
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Overall approaches and experiences of first-time participants in the Nuclear Forensics International Technical Working Group’s Fourth Collaborative Material Exercise (CMX-4)
- 2018
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 315:2, s. 353-363
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Tidskriftsartikel (refereegranskat)abstract
- The Fourth Collaborative Material Exercise (CMX-4) of the Nuclear Forensics International Technical Working Group (ITWG) registered the largest participation for this exercise in nuclear forensics, with seven of the 17 laboratories participating for the first time. Each of the laboratories had their strategic role to play in its respective country, analyzing real-world samples using their in-house resources. The scenario was fictitious but was thoughtfully crafted to engage participants in nuclear forensic investigations. In this paper, participants from five of the first-time laboratories shared their individual experience in this exercise, from preparation to analysis of samples.
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| 16. |
- Jones, Lesley, et al.
(författare)
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Convergent genetic and expression data implicate immunity in Alzheimer's disease
- 2015
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
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Tidskriftsartikel (refereegranskat)abstract
- Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
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| 17. |
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| 18. |
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| 19. |
- Jonsson, Linus, 1986-, et al.
(författare)
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Changes in amotivation, external regulation, and intrinsic regulation predicted dropout from youth soccer during the COVID-19 pandemic
- 2023
-
Konferensbidrag (refereegranskat)abstract
- Background: Regular sport participation is essential for youths physical, mental, and social health. Research shows, however, that sports participation peaks at around 10-14 years of age before declining through adolescence. Soccer, which is the most popular youth sport in Sweden, is no exception to dropout problems during adolescence. Purpose of the study: The purpose was to examine longitudinal changes in youth soccer players motivational regulations during the first year of the Covid-19 pandemic in Sweden, and how longitudinal changes in motivational regulations predicts dropout from youth soccer.Methods: Self-reported data was collected from 325 youth soccer players between 11 and 17 years of age (M = 13.08) at the beginning of the season in 2019 (TI) and 2020 (T2) and dropout data was reported by the coaches at the end of the season in 2021 (T3). Latent change score analyses, using Bayesian estimator, was used to examine change in the players motivational regulations. Findings: There was a credible increase in amotivation (β = 0.14) and a credible decrease in identified regulation (β = -0.41) between T1 and T2. Changes in amotivation (β = 0.16), external regulation (β = 0.14), and intrinsic regulation (β = -0.15) between T1 and T2 were credible predictors of dropout from soccer at T3. Conclusion: To reduce the risk of dropout from youth soccer, during an ongoing pandemic, it is important to mitigate increases in amotivation and external regulation and to facilitate intrinsic motivation.
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| 20. |
- Jonsson, Linus, 1986-, et al.
(författare)
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Changes in amotivation was the only credible predictor of dropout in a sample of Swedish youth soccer players during the COVID-19 pandemic
- 2023
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Ingår i: 8th International Self-Determination Theory Conference. ; , s. 33-33
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Konferensbidrag (refereegranskat)abstract
- Background: Regular sport participation is essential for youths physical, mental, and social health. Research shows, however, that sports participation peaks at around 10-14 years of age before declining through adolescence. Soccer, which is the most popular youth sport in Sweden, is no exception to dropout problems during adolescence.Objectives: The purpose was to examine longitudinal changes in youth soccer players motivational regulations during the first year of the Covid-19 pandemic in Sweden, and how longitudinal changes in motivational regulations predicts dropout from youth soccer.Design: Three-wave survey. Methods: Self-reported data was collected from 325 youth soccer players between 11 and 17 years of age (M = 13.08) at the beginning of the season in 2019 (T1) and 2020 (T2) and dropout data was reported by the coaches at the end of the season in 2021 (T3). Latent change score analyses, using Bayesian estimator, was used to examine change in the players motivational regulations.Results: There was a credible increase in amotivation (β = 0.14) and a credible decrease in identified regulation (β = -0.41) between T1 and T2. Changes in amotivation (β = 0.15) between T1 and T2 were the only credible predictor of dropout from soccer at T3.Conclusions: To reduce the risk of dropout from youth soccer, during an ongoing pandemic, it is important to mitigate increases in amotivation.
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| 21. |
- Jonsson, Magnus, et al.
(författare)
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Carotid Endarterectomy After Intracranial Endovascular Thrombectomy for Acute Ischaemic Stroke in Patients with Carotid Artery Stenosis
- 2022
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier. - 1078-5884 .- 1532-2165. ; 63:3, s. 371-378
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Recent randomised controlled trials demonstrated the benefit of intracranial endovascular thrombectomy (EVT) in acute ischaemic stroke. There is no consensus, however, on how to treat concomitant extracranial carotid artery stenosis after EVT. The aim of this study was to evaluate the outcome in patients treated with carotid endarterectomy (CEA) after EVT, comparing complication rates among patients undergoing CEA for stroke without previous EVT.Methods: This was a registry study of all patients (n = 3 780) treated with CEA after stroke in Sweden and the capital Helsinki region, Finland, from January 2011 to September 2020. Sixty three patients (1.7%; 0.5% 2011, 4.3% 2019) underwent EVT prior to CEA. The primary outcome was 30 day stroke and death rate.Results: The EVT+CEA group had major stroke as the qualifying neurological event (QNE) in 79%, but just 5.9% had this in the CEA only group (p < .001). Intravenous thrombolysis was administered before EVT in 54% of patients in the EVT+CEA group, but in just 12% in those receiving CEA only (p < .001). The combined stroke and death rate at 30 days for EVT+CEA was 0.0% (95% confidence interval [CI] 0.0 - 5.7). One patient had a post-operative TIA, none had post-operative intracerebral or surgical site haemorrhage. CEA was performed within a median of seven days (interquartile range 4, 15) after QNE, and 75% had CEA <= 14 days from QNE. The main reason to postpone CEA was an infarct larger than one third of the middle cerebral artery territory. The stroke and death rate in patients treated with CEA only was 3.7% (95% CI 3.2 - 4.4), CEA was performed a median of eight days after QNE, and in 79.7% in <= 14 days. The three year survival after EVT+CEA was 93% (95% CI 85 - 100), compared with 87% (95% CI 86 - 88) after CEA only. Cox regression analysis adjusting for age showed no increased all cause mortality after EVT+CEA (HR 1.3, 95% CI 0.6 - 2.7, p = .52).Conclusion: These results indicate that CEA is safe to perform after previous successful EVT for acute ischaemic stroke. Results were comparable with those undergoing CEA only, despite the EVT+CEA patients having more severe stroke symptoms prior to surgery, and timing was similar.
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| 22. |
- Jonsson, T, et al.
(författare)
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Nonequilibrium dynamics in a three-dimensional spin glass
- 1999
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - 0163-1829. ; 59:13, s. 8770-8777
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Tidskriftsartikel (refereegranskat)abstract
- Nonequilibrium dynamics in a AE(11% Mn) spin glass has been studied by low frequency ac-susceptibility and magnetic relaxation experiments. The results unequivocally show that spin structures that memorize the cooling process are imprinted in the system.
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| 23. |
- Kiemeney, Lambertus A, et al.
(författare)
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A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
- 2010
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:5, s. 415-9
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Tidskriftsartikel (refereegranskat)abstract
- Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.
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| 24. |
- Klintman, Mikael, et al.
(författare)
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Academia and society in collaborative knowledge production towards urban sustainability : several schemes—three common crossroads
- 2022
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Ingår i: Environment, Development and Sustainability. - : Springer Science and Business Media LLC. - 1387-585X .- 1573-2975.
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Tidskriftsartikel (refereegranskat)abstract
- Arrangements for collaboration in knowledge production across academia, government, non-governmental organisations, and corporations have several names, such as citizen-science, community-based participatory research, engaged research and hybrid forums. The multiplicity of schemes does not lie only in the high number of names for various versions of collaborative knowledge production. Different scholars also use concepts in multiple ways, depending on their individual choices, mother disciplines, and the problem area in which collaboration occurs. At the same time, there is a lack of analytical tools that address the full range of collaborative research schemes and provide a systematic set of questions to learn about the schemes, challenges, and opportunities. Based on our review of academic journal articles highlighting collaborative research schemes, this paper aims to analyse three parameters which it is fair to say that virtually all arrangements of collaborative knowledge production ought to consider when making decisions, parameters that are often partially missed or misunderstood: (A) epistemic-procedural, (B) exclusive-inclusive and (C) aggregative-integrative. By examining the three parameters, their political theory origins, and how they connect to and challenge existing schemes of knowledge collaboration, we provide analytical tools that could facilitate processes of developing and scrutinising arrangements of collaborative research.
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| 25. |
- Kriström, Berit, et al.
(författare)
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A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.
- 2009
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 94:4, s. 1154-1161
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: The LIM homeobox 3 (LHX3) LIM-homeodomain transcription factor gene, found in both man and mouse, is required for development of the pituitary and motor neurons, and is also expressed in the auditory system. OBJECTIVE: The objective of this study was to determine the cause of, and further explore, the phenotype in six patients (aged 6 months to 22 yr) with combined pituitary hormone deficiency (CPHD), restricted neck rotation, scoliosis, and congenital hearing impairment. Three of the patients also have mild autistic-like behavior. DESIGN: Because patients with CPHD and restricted neck rotation have previously been shown to have mutations in the LHX3 gene, a candidate gene approach was applied, and the gene was sequenced. Neck anatomy was explored by computed tomography and magnetic resonance imaging, including three-dimensional reformatting. RESULTS: A novel, recessive, splice-acceptor site mutation was found. The predicted protein encoded by the mutated gene lacks the homeodomain and carboxyl terminus of the normal, functional protein. Genealogical studies revealed a common gene source for all six families dating back to the 17th century. Anatomical abnormalities in the occipito-atlantoaxial joints in combination with a basilar impression of the dens axis were found in all patients assessed. CONCLUSIONS: This study extends both the mutations known to be responsible for LHX3-associated syndromes and their possible phenotypical consequences. Previously reported traits include CPHD and restricted neck rotation; patients examined in the present study also show a severe hearing defect. In addition, the existence of cervical vertebral malformations are revealed, responsible for the rigid neck and the development of scoliosis.
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| 26. |
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| 27. |
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| 28. |
- Nordqvist, Petra
(författare)
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Exploring the Wood Adhesive Performance of Wheat Gluten
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The increasing environmental concern has reawakened an interest in materials based on renewable resources as replacement for petroleum-based materials. The main objective of this thesis was to explore plant proteins, more specifically wheat gluten, as a binder in wood adhesives intended for typical solid wood applications such as furniture and flooring. Alkaline and acidic dispersions of wheat gluten were used as wood adhesives to bond together beech wood substrates. Soy protein isolate was used as a reference. The tensile shear strengths of the substrates were measured for comparison of bond strength and resistance to cold water. AFM in colloidal probe mode was used to investigate nanoscale adhesion between cellulose and protein films. Wheat gluten was divided into the two protein classes; glutenins and gliadins, and their adhesive performance was compared with that of wheat gluten. Heat treatment and mild hydrolysis were investigated as means for improving bonding performance of wheat gluten. The treated wheat gluten samples were analysed by SE-HPLC and 13C-NMR to correlate molecular size distribution and structural changes with bonding performance. Soy protein isolate is superior to wheat gluten, especially in regards to water resistance. However, the bond strength of wheat gluten is improved when starved bond lines are avoided. The AFM analysis reveals higher interfacial adhesion between soy protein isolate and cellulose than between wheat gluten and cellulose. These results partly explain some of the differences in bonding performance between the plant proteins. Soy protein isolate contains more polar amino acid residues than wheat gluten and possibly interacts more strongly with cellulose. Furthermore, the bond performances of wheat gluten and glutenin are similar, while that of gliadin is inferior to the others, especially regarding water resistance. The extent of penetration of the dispersions into the wood material has a large impact on the results. The bonding performance of gliadin is similar to the others when over-penetration of the dispersion into the wood material is avoided. Moreover, the bond strength of the wheat gluten samples heated at 90°C was in general improved compared to that of wheat gluten. A small improvement was also obtained for some of the hydrolyzed wheat gluten samples (degree of hydrolysis: 0-0.6 %). The improvements in bonding performance for the heat treated samples are due to polymerization, while the improvements for the hydrolyzed samples are due to denaturation. The 13C-NMR analysis of the treated samples confirms some degree of denaturation.
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| 29. |
- Rafnar, Thorunn, et al.
(författare)
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European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
- 2011
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Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 20:21, s. 4268-81
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Tidskriftsartikel (refereegranskat)abstract
- Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC.
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| 30. |
- Ramebäck, Henrik, 1967, et al.
(författare)
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Gamma spectrometric measurement of uranium isotopic composition and mass in sintered UO 2 pellets using the efficiency transfer method
- 2023
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Ingår i: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 192, s. 110607-
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Tidskriftsartikel (refereegranskat)abstract
- Gamma spectrometric measurements to determine the isotopic composition and total uranium mass in UO2 pellets (D = 7.5 mm; H = 3.5 mm, ρ = 10 g/cm3) were carried out. The required efficiency curve was obtained by applying the efficiency transfer method from a calibration standard (D = 65 mm; H = 20 mm) of a slightly acidified water solution. The average isotopic composition of ten UO2 pellets was consistent with values of natural uranium given by IUPAC. The average relative bias for the 235U/238U amount ratio was -0.73% using the 1001 keV gamma line for 238U and 0.50% using the 63 keV gamma line (186 keV was always used for 235U). For the total uranium mass, the mean deviation as compared to mass determinations using a balance was 5.5% using the 1001 keV gamma line for 238U and 4.3% using the 63 keV gamma line.
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| 31. |
- Ramebäck, Henrik, 1967, et al.
(författare)
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On the accuracy of gamma spectrometric isotope ratio measurements of uranium
- 2016
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 815, s. 57-61
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Tidskriftsartikel (refereegranskat)abstract
- The isotopic composition of uranium was measured using high resolution gamma spectrometry. Two acid solutions and two samples in the form of UO2 pellets were measured. The measurements were done in close geometries, i.e. directly on the endcap of the high purity germanium detector (HPGe). Applying no corrections for count losses due to true coincidence summing (TCS) resulted in up to about 40% deviation in the abundance of U-235 from the results obtained with mass spectrometry. However, after correction for TCS, excellent agreement was achieved between the results obtained using two different measurement methods, or a certified value. Moreover, after corrections, the fitted relative response curves correlated excellently with simulated responses, for the different geometries, of the HPGe detector.
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| 32. |
- Russell Jonsson, Kenisha, 1980, et al.
(författare)
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The clustering of multiple health and lifestyle behaviors among Swedish adolescents: a person-oriented analysis
- 2023
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Ingår i: Frontiers In Public Health. - 2296-2565. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundKnowledge of the distribution, prevalence, and clustering of multiple health and lifestyle related behaviors (HLBs) among adolescents can inform the development of effective health-promoting policies and interventions. We assessed the clustering of multiple HLBs among 11, 13 and 15-year-old Swedish adolescents and examined the socioeconomic and demographic correlates for the identified clusters. MethodsWe used data from the 2017/2018 Swedish Health Behaviour in School-aged children (HBSC) study to conduct sex and age-stratified latent class analysis (LCA). The LCA was based on five HLBs: eating behavior and habits (EBH), physical activity (PA), tobacco usage (TU), alcohol consumption (AC) and sleeping habits and patterns (SHPs). Multinomial logistic regression models were used to assess the associations between the identified clusters and the socioeconomic and demographic characteristics of adolescents and their parents. ResultsHealth behaviors varied by sex and age. Four distinct clusters were identified based on sex: cluster 1 (Mixed eating behaviors and habits, physical activity and low alcohol consumption), cluster 2 (Healthy lifestyle behaviors), cluster 3 (Unhealthy lifestyle behaviors), and cluster 4 (Breakfast, low alcohol consumption and tobacco usage). In the age-stratified analyzes, three clusters were identified: cluster 1 (Unhealthy lifestyle behaviors), cluster 2 (Moderately healthy lifestyle behaviors) and cluster 3 (Healthy lifestyle behaviors). The multinomial analysis showed that sex, age, family situation and perceived family wealth were strong predictors of health behaviors. Unhealthy behaviors were most commonly associated with socioeconomic disadvantage, having a migrant background, and living in reconstructed families or single-parent households. ConclusionHealth behaviors vary significantly based on socioeconomic and demographic circumstances. Targeted policies and intervention programs are necessary to improve HLBs among vulnerable and at-risk adolescents.
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| 33. |
- Seror, Raphaèle, et al.
(författare)
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EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide.
- 2015
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Ingår i: RMD Open. - : BMJ. - 2056-5933. ; 1:1, s. 000022-000022
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Forskningsöversikt (refereegranskat)abstract
- The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS.
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| 34. |
- Spichtinger, Daniel, et al.
(författare)
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Key issues in European food science research: a review of the European Food Science Day 2009
- 2010
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Ingår i: Quality Assurance and Safety of Crops & Foods. - 1757-8361. ; 2:3, s. 114-119
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Forskningsöversikt (refereegranskat)abstract
- This paper is a report on the European Food Science Day (Brussels, 18 November 2009, organized by the CommNet network of food science communicators) and its outcomes. The article presents FP 7 as a key funding mechanism in European food and nutrition research and it puts research in this sector in a socio-economic context. The article then reviews the specific activities of several EU-funded projects in the field of risk, safety, and health, discussing key issues and research questions in these fields.
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| 35. |
- Stenseke, Marie, et al.
(författare)
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Kris i naturen – vår existens har blivit sårbar
- 2019
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Ingår i: Svenska Dagbladet, Stockholm. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Fler arter än någonsin i mänsklighetens historia hotas av utrotning och den biologiska mångfalden lokalt har förändrats kraftigt i en stor del av världens ekosystem. Grundläggande förändringar behövs både i samhället och för individer, för att bromsa den negativa trenden, skriver en rad debattörer.
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| 36. |
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| 37. |
- Thorstenson, Andreas, et al.
(författare)
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Diagnostic random bladder biopsies: reflections from a population-based cohort of 538 patients.
- 2010
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Ingår i: Scandinavian journal of urology and nephrology. - : Informa UK Limited. - 1651-2065 .- 0036-5599. ; 44:1, s. 11-19
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To assess whether diagnostic random bladder biopsies and the detection of concomitant carcinoma in situ (CIS) have an impact on the frequency of intravesical bacille Calmette–Guérin (BCG) instillations or radical cystectomy; and whether this affects the cancer-specific survival in patients with pTaG3 or pT1G1–G3 transitional cell carcinoma of the urinary bladder. Material and methods. A population-based cohort of 538 patients with newly diagnosed bladder cancer was prospectively registered in the Stockholm County during 1995 and 1996 and followed for more than 5 years. Results. Random biopsies were recommended in all patients but the decision to take biopsies was made by the treating urologist and hence performed in 326 out of 538 patients (61%), which revealed concomitant CIS in 47 patients(14%). Sixty out of 103 (58%) patients with pTaG3 or pT1G1–G3 tumours, in whom random biopsies were performed, received intravesical BCG compared with five out of 22 patients (23%) where random biopsies were not taken (p = 0.004). Moreover, 23 out of 103 patients (22%) with pTaG3 or pT1G1–G3 tumours in whom random biopsies were performed underwent radical cystectomy compared with none out of 22 patients (0%) without random biopsies (p = 0.013). The Cox proportional hazard ratio for death due to bladder cancer in patients with pTaG3 or pT1G1–G3 tumours among patients not having versus having undergone random biopsies was 2.5 (95% confidence interval 1.1–5.6). Conclusion. Patients diagnosed in Stockholm in 1995 or 1996 with pTaG3 or pT1G1–G3 bladder tumours having undergone random bladder biopsies more frequently underwent BCG treatment and radical cystectomy and had higher cancer-specific survival than patients who did not undergo random biopsies.
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| 38. |
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| 39. |
- Wagman, Petra, et al.
(författare)
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Occupational balance: A scoping review of current research and identified knowledge gaps
- 2015
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Ingår i: Journal of Occupational Science. - : Informa UK Limited. - 1442-7591 .- 2158-1576. ; 22:2, s. 160-169
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Forskningsöversikt (refereegranskat)abstract
- This article reports a comprehensive review of the research conducted regarding occupational balance. A scoping study method was used to explore and describe current research about occupational balance and to identify research gaps. Twenty-two articles published between 2009 and 2014 met the inclusion criteria. The articles reported studies conducted in eight countries on four continents, but the majority were conducted in Europe and North America. The articles contributed to knowledge about the concept itself, its importance, levels of occupational balance, and the relationship between occupational balance and health and well-being. They also described what is important for occupational balance or how to enhance/create/recreate it and differences between people. Several research gaps were identified which include the need for studies about perceptions of occupational balance among people beyond western societies. Furthermore, systematic research is warranted with regards to levels of occupational balance, and how to enhance it.
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