1. |
- Luth, Stefan, et al.
(författare)
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Combined X-Ray Computed Tomography and X-Ray Fluorescence Drill Core Scanning for 3-D Rock and Ore Characterization : Implications for the Lovisa Stratiform Zn-Pb Deposit and Its Structural Setting, Bergslagen, Sweden
- 2022
-
Ingår i: Economic geology and the bulletin of the Society of Economic Geologists. - : Society of Economic Geologists, Inc.. - 0361-0128 .- 1554-0774. ; 117:6, s. 1255-1273
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of a pilot study that integrates automated drill core scanning technology based on simultaneous X-ray computed tomography (XCT) and X-ray fluorescence (XRF) analyses to provide high-spatial-resolution (<0.2 mm) information on 3-D rock textures and structures, chemical composition, and density. Testing of its applicability for mineral exploration and research was performed by scanning and analyzing 1,500 m of drill core from the Paleoproterozoic Lovisa stratiform Zn-Pb sulfide deposit, which is part of a larger mineral system also including Cu-Co and Fe-(rare earth element) mineralization, hosted by the highly strained West Bergslagen boundary zone in south-central Sweden. The obtained scanning data complements data derived from structural field mapping, drill core logs, and chemical analysis as well as from multiscale 3-D geologic modeling at Lovisa. Data integration reveals macroand mesoscopic folding of S-0/S-1 by asymmetric steeply SE-plunging F-2 folds and N-striking vertical F-3 folds. Stretching lineations, measured directly from the scanning imagery, trend parallel to F-2 fold hinges and modeled ore shoots at the nearby Hakansboda Cu-Co and Strassa and Blanka Fe deposits. The textural character of the Lovisa ore zones is revealed in 3-D by XCT-XRF scanning and highlight remobilization of Zn and Pb from primary layering into ductile and brittle structures. The downhole bulk geochemical trends seen in scanning and traditional assay data are generally comparable but with systematic variations for some elements due to currently unresolved XRF spectral overlaps (e.g., Co and Fe). The 3-D deformation pattern at Lovisa is explained by D-2 sinistral transpression along the West Bergslagen boundary zone in response to regional north-south crustal shortening at ca. 1.84-1.81 Ga. Local refolding was caused by D-3 regional east-west crustal shortening resulting in dextral transpression along the West Bergslagen boundary zone, presumably at ca. 1.80-1.76 Ga. Based on polyphase ore textures and modeled ore shoots aligned to F-2 fold hinges, we postulate that D-2 and D-3 transpressive deformation exerted both a strong control on ore remobilization and the resulting orebody geometries at Lovisa and neighboring deposits within the West Bergslagen boundary zone. We conclude that the combined XCT-XRF drill core scanning technique provides a valuable tool for 3-D ore and rock characterization, generating continuous downhole data sets, with the potential for increasing precision and efficiency in mineral exploration and mining.
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2. |
- Wain, Louise V, et al.
(författare)
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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
- 2017
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:3, s. 416-425
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
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3. |
- Andersson, Stefan, et al.
(författare)
-
Metod- och kvalitetsbeskrivning för geografiskt fördelade emissioner till luft under 2017
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sverige rapporterar årligen nationella utsläpp till luft till UNFCCC (FN:s klimatkonvention) och CLRTAP (UNECE:s konvention om gränsöverskridande luftföroreningar), så kallade submissioner. Förutom emissioner på nationell nivå finns även behov av data med högre geografisk upplösning. För regional uppföljning av miljömålen behövs emissioner på kommun- och länsnivå.Detta dokument utgör en metod- och kvalitetsbeskrivning av geografiskt fördelade emissioner för åren 1990, 2000, 2005 samt 2010-2015. Emissionerna presenteras i 45 olika sektorer uppdelade på åtta huvudsektorer. Huvudsektorerna är El och uppvärmning, Industri (energi och processer), Transporter, Produktanvändning, Avfall och avlopp, Internationell luftfart och sjöfart, Jordbruk samt Arbetsmaskiner. Uppdelningen är förändrad jämfört med föregående år vad gäller industrins utsläpp samt utsläppen från energiförförsörjning, se avsnittet Förändringar i nationella totalemissioner samt sektorsindelning, jämfört med föregående år. De ämnen som ingår är växthusgaser, metaller, partiklar och övriga ämnen, totalt 29 ämnen.Arbetet med geografisk fördelning av Sveriges utsläpp till luft är sedan 2007 ett årligt projekt. Projektet har ett långsiktigt perspektiv med målsättningen att stegvis förbättra kvaliteten på geografiskt upplösta emissionsdata.
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4. |
- Andersson, Stefan, et al.
(författare)
-
Metod- och kvalitetsbeskrivning för geografiskt fördelade emissioner till luft (submission 2018)
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sverige rapporterar årligen nationella utsläpp till luft till UNFCCC (FN:s klimatkonvention) och CLRTAP (UNECE:s konvention om gränsöverskridande luftföroreningar), så kallade submissioner. Förutom emissioner på nationell nivå finns även behov av data med högre geografisk upplösning. För regional uppföljning av miljömålen behövs emissioner på kommun- och länsnivå. Detta dokument utgör en metod- och kvalitetsbeskrivning av geografiskt fördelade emissioner för åren 1990, 2000, 2005 samt 2010-2016, rapporterade i submission 2018.Emissionerna presenteras i 55 olika sektorer uppdelade på nio huvudsektorer. Huvudsektorerna är El och fjärrvärme, Egen uppvärmning av bostäder och lokaler, Industri (energi och processer), Transporter, Arbetsmaskiner, Produktanvändning (inkl. lösningsmedel), Jordbruk, Avfall (inkl. avlopp) samt Utrikes transporter. Uppdelningen är förändrad jämfört med föregående år. För huvudsektorn Utrikes transporter fördelas eller redovisas inga växthusgaser geografiskt.Den geografiska fördelningen utförs huvudsakligen enligt konceptet ”topdown”. Detta innebär att emissioner bryts ner från en nationell totalemission för att uppnå en högre rumslig upplösning på lokal nivå. Nedbrytningen till högre rumslig upplösning kräver en geografisk begränsning av emissionerna och statistik på regional nivå.Metoden för geografisk fördelning tillåter för vissa utsläppskällor en hög rumslig upplösning (t.ex. för vägtrafik och industriprocesser). För flera sektorer är emellertid resultaten otillförlitliga om de ska studeras med högre upplösning än kommunnivå (i vissa fall även länsnivå). Resultaten från den geografiska fördelningen lagras i årsvisa emissionsdatabaser i SMHIs tekniska system för luftvårdsarbete; Airviro. Ur Airviro exporteras emissionerna till Excel-tabeller på läns- och kommunnivå. Emissionerna presenteras även på karta, samt i diagram. Publicering av resultaten sker via www.rus.lst.se. En presentation riktad mot allmänheten ges även på http://utslappisiffror.naturvardsverket.se/.Arbetet med geografisk fördelning av Sveriges utsläpp till luft är sedan 2007 ett årligt projekt. Projektet har ett långsiktigt perspektiv med målsättningen att stegvis förbättra kvaliteten på geografiskt upplösta emissionsdata. Resultaten för alla sektorer presenteras med samma geografiska upplösning även om kvaliteten varierar. På grund av detta krävs det att användare av dessa emissionsdata går igenom kvalitetsbeskrivningen och bedömer om osäkerheterna är acceptabla för den aktuella tillämpningen. Genom retroaktiva omräkningar säkerställs att metodförändringar inte orsakar trendbrott. I vissa fall har dock tillgängliga grunddata (t.ex. statistik) förändrats, vilket kan leda till icke-reella trendbrott.
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5. |
- CARLSSON, STEFAN, 1987, et al.
(författare)
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Orgasm-Associated Urinary Incontinence and Sexual Life after Radical Prostatectomy.
- 2011
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Ingår i: The journal of sexual medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095.
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction. Involuntary release of urine during sexual climax, orgasm-associated urinary incontinence, occurs frequently after radical prostatectomy. We know little about its prevalence and its effect on sexual satisfaction. Aim. To determine the prevalence of orgasm-associated incontinence after radical prostatectomy and its effect on sexual satisfaction. Methods. Consecutive series, follow-up at one point in calendar time of men having undergone radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital, Stockholm, Sweden, 2002-2006. Of the 1,411 eligible men, 1,288 (91%) men completed a study-specific questionnaire. Main Outcome Measure. Prevalence rate of orgasm-associated incontinence. Results. Of the 1,288 men providing information, 691 were sexually active. Altogether, 268 men reported orgasm-associated urinary incontinence, of whom 230 (86%) were otherwise continent. When comparing them with the 422 not reporting the symptom but being sexually active, we found a prevalence ratio (with 95% confidence interval) of 1.5 (1.2-1.8) for not being able to satisfy the partner, 2.1 (1.1-3.5) for avoiding sexual activity because of fear of failing, 1.5 (1.1-2.1) for low orgasmic satisfaction, and 1.4 (1.2-1.7) for having sexual intercourse infrequently. Prevalence ratios increase in prostate-cancer survivors with a higher frequency of orgasm-associated urinary incontinence. Conclusion. We found orgasm-associated urinary incontinence to occur among a fifth of prostate cancer survivors having undergone radical prostatectomy, most of whom are continent when not engaged in sexual activity. The symptom was associated with several aspects of sexual life. Nilsson AE, Carlsson S, Johansson E, Jonsson MN, Adding C, Nyberg T, Steineck G, and Wiklund NP. Orgasm-associated urinary incontinence and sexual life after radical prostatectomy. J Sex Med **;**:**-**.
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6. |
- Docherty, Anna R, et al.
(författare)
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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.
- 2023
-
Ingår i: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 180:10, s. 723-738
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Tidskriftsartikel (refereegranskat)abstract
- Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures.This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses.Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10-8. These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10-80). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors.This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.
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7. |
- Evangelou, Evangelos, et al.
(författare)
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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
- 2011
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 70:2, s. 349-355
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Replication of the top hits was attempted with data from 10 additional replication datasets. Results With a cumulative sample size of 6709 cases and 44 439 controls, one genome-wide significant locus was identified on chromosome 7q22 for knee OA (rs4730250, p = 9.2 x 10(-9)), thereby confirming its role as a susceptibility locus for OA. Conclusion The associated signal is located within a large (500 kb) linkage disequilibrium block that contains six genes: PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like) and BCAP29 (B cell receptor-associated protein 29). Gene expression analyses of the (six) genes in primary cells derived from different joint tissues confirmed expression of all the genes in the joint environment.
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8. |
- Frangou, Sophia, et al.
(författare)
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Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
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Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
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9. |
- Hedbom, Hans, et al.
(författare)
-
A Comparison of the Security of Windows NT and UNIX
- 1998
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Konferensbidrag (refereegranskat)abstract
- This paper presents a brief comparison of two operating systems, Windows NT and UNIX. The comparison covers two different aspects. First, we compare the main security features of the two operating systems and then we make a comparison of a selection of vulnerabilities most of which we know have been used for making real intrusions. We found that Windows NT has slightly more rigorous security features than standard UNIX but the two systems display similar vulnerabilities. The conclusion is that there are no significant differences in the real level of security between these systems
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10. |
- Hedbom, Hans, et al.
(författare)
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Analysis of the Security of Windows NT
- 1998
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Rapport (refereegranskat)abstract
- This paper presents an analysis of the security in Windows NT 4.0, working in both stand-alone and networking mode. The objective of the work was to find out how secure this operating system actually is. A technical overview of the system, and in particular its security features is given. The system security was analyzed and practical intrusion attempts were made in order to verify vulnerabilities or to find new ones. All vulnerabilities are described in detail and classified according to a classification scheme. A comparison to commonly known UNIX weaknesses was made. It revealed generic similarities between the two systems to a surprisingly high degree. Finally a number of recommendations are given. The paper concludes that there are ample opportunities to improve the security of Windows NT. We have reason to believe that it is probably not higher than that of UNIX
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11. |
- Li, Yutang, et al.
(författare)
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The long-awaited synthesis and self-assembly of a small rigid C3-symmetric trilactam
- 2022
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Ingår i: Chemical Communications. - 1359-7345. ; 58:23, s. 3751-3754
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Tidskriftsartikel (refereegranskat)abstract
- The challenging synthesis of a fused C3-symmetric trilactam (1) was executed in racemic and enantiomerically pure form. The rigidity, symmetry and high density of hydrogen bonding motifs make 1 an attractive candidate for self-assembly study, which revealed different hydrogen bond patterns in the crystals of rac-1-d3 and (+)-(SSS)-1.
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12. |
- Maudsdotter, Lisa, 1984-, et al.
(författare)
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Lactobacilli reduce cell cytotoxicity caused by Streptococcus pyogenes by producing lactic acid that degrades the toxic component lipoteichoic acid
- 2011
-
Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 55:4, s. 1622-1628
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Tidskriftsartikel (refereegranskat)abstract
- Lactobacilli are known to prevent colonization by many pathogens; nevertheless, the mechanisms of their protective effect are largely unknown. In this work, we investigated the role of lactobacilli during infection of epithelial cells with group A streptococci (GAS). GAS cause a variety of illnesses ranging from noninvasive disease to more severe invasive infections, such as necrotizing fasciitis and toxic shock-like syndrome. Invasion of deeper tissues is facilitated by GAS-induced apoptosis and cell death. We found that lactobacilli inhibit GAS-induced host cell cytotoxicity and shedding of the complement regulator CD46. Further, survival assays demonstrated that lactic acid secreted by lactobacilli is highly bactericidal toward GAS. In addition, lactic acid treatment of GAS, but not heat killing, prior to infection abolishes the cytotoxic effects against human cells. Since lipoteichoic acid (LTA) of GAS is heat resistant and cytotoxic, we explored the effects of lactic acid on LTA. By applying such an approach, we demonstrate that lactic acid reduces epithelial cell damage caused by GAS by degrading both secreted and cell-bound LTA. Taken together, our experiments reveal a mechanism by which lactobacilli prevent pathogen-induced host cell damage.
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13. |
- Mullins, Niamh, et al.
(författare)
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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- 2022
-
Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 91:3, s. 313-327
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
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14. |
- Sahiström, Fredrik, et al.
(författare)
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Textural evolution of the Lovisa Zn-Pb-(Ag) deposit, Bergslagen, Sweden : insights from microscopy and 3D X-ray tomography
- 2019
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Ingår i: LIFE WITH ORE DEPOSITS ON EARTH, PROCEEDINGS OF THE 15TH SGA BIENNIAL MEETING, 2019, VOLS 1-4. - : SOC GEOLOGY APPLIED MINERAL DEPOSITS-SGA. - 9780852619629 ; , s. 443-446
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Konferensbidrag (refereegranskat)abstract
- The presently mined Lovisa deposit constitutes a c. 1.9 Ga, stratiform Zn-Pb-(Ag) sulphide mineralisation hosted by rhyolite-dominated meta volcanic rocks in the Bergslagen ore province, south central Sweden. The mineralised rock sequence at Lovisa has been subjected to polyphase ductile deformation, amphibolite facies regional metamorphism, and late-stage brittle deformation. The combined effects of these processes have produced a diversity of post-genetic ore textures within the sulphide horizons, including metablastic growth, piercements, ductile and brittle sulphide deformation, and durchbewegung and 'ball ore' textures. Here we report on the character and textural evolution of the Lovisa deposit in conjunction with regional metamorphism and deformation, utilising new data from ore- and electron microscopy combined with 3D tomography by means of novel XRT-XRF drill core scanning technique.
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15. |
- Scott, Robert A, et al.
(författare)
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No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
- 2012
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Ingår i: Diabetes. - Alexandria, VA : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 61:5, s. 1291-1296
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Tidskriftsartikel (refereegranskat)abstract
- Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
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16. |
- Styrkarsdottir, Unnur, et al.
(författare)
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GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 – 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10 −42 , β = −0.090) and confers risk of hip fracture (P = 1.0 × 10 −8 , OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.
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17. |
- Thorgeirsson, Thorgeir E, et al.
(författare)
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
- 2008
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 452:7187, s. 9-638
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Tidskriftsartikel (refereegranskat)abstract
- Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk factor for lung cancer (LC)(11-14) and is one of the main risk factors for peripheral arterial disease (PAD)(15-17). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking- related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genomewide association study that used low- quantity smokers as controls(18,19), and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene - environment interaction(20), highlighting the role of nicotine addiction in the pathology of other serious diseases.
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18. |
- Wierenga, Lara M., et al.
(författare)
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Greater male than female variability in regional brain structure across the lifespan
- 2022
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Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 470-499
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Tidskriftsartikel (refereegranskat)abstract
- For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
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19. |
- Williamson, Alice, et al.
(författare)
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
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Tidskriftsartikel (refereegranskat)abstract
- Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
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20. |
- Abdallah, J., et al.
(författare)
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A determination of the centre-of-mass energy at LEP2 using radiative two-fermion events
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 46:2, s. 295-305
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Tidskriftsartikel (refereegranskat)abstract
- Using e(+)e(-) -> mu(+)mu(-)(gamma) and e(+)e(-) -> q (q) over bar(gamma) events radiative to the Z pole, DELPHI has determined the centre-of-mass energy, root s, using energy and momentum constraint methods. The results are expressed as deviations from the nominal LEP centre-of-mass energy, measured using other techniques. The results are found to be compatible with the LEP Energy Working Group estimates for a combination of the 1997 to 2000 data sets.
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21. |
- Abdallah, J, et al.
(författare)
-
A measurement of the branching fractions of the b-quark into charged and neutral b-hadrons
- 2003
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 576:1-2, s. 29-42
-
Tidskriftsartikel (refereegranskat)abstract
- The production fractions of charged and neutral b-hadrons in b-quark events from Z(0) decays have been measured with the DELPHI detector at LEP. An algorithm has been developed, based on a neural network, to estimate the charge of the weakly-decaying b-hadron by distinguishing its decay products from particles produced at the primary vertex. From the data taken in the years 1994 and 1995, the fraction of (b) over bar -quarks fragmenting into positively charged weakly-decaying b-hadrons has been measured to be: f(+) = (42.09+/-0.82(stat)+/-0.89(syst))%. Subtracting the rates for charged Xi(b)(+) and Omega(b)(+) baryons gives the production fraction of B+ mesons: f(Bu) = (40.99+/-0.82(stat)+/-1.11 (syst)) %.
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22. |
- Abdallah, J., et al.
(författare)
-
A measurement of the tau hadronic branching ratios
- 2006
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 46:1, s. 1-26
-
Tidskriftsartikel (refereegranskat)abstract
- The exclusive and semi-exclusive branching ratios of the tau lepton hadronic decay modes (h(-)upsilon(tau), h(-)pi(0)upsilon(tau), h(-)pi(0)pi(0)upsilon(tau), h(-) >= 2 pi(0)nu(tau), 2h(-)h(+)upsilon(tau), 2h(-)h(+)>= 2 pi(0)upsilon(tau), 3h(-)2h(+)upsilon(tau) and 3h(-)2h(+) >= 1 pi(0)upsilon(tau)) were measured with data from the DELPHI detector at LEP.
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23. |
- Abdallah, J, et al.
(författare)
-
A precise measurement of the B+, B-0 and mean b-hadron lifetime with the DELPHI detector at LEP I
- 2004
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:3, s. 307-324
-
Tidskriftsartikel (refereegranskat)abstract
- Final results from the DELPHI Collaboration on the lifetime of B+ and B-0 mesons and the mean b-hadron lifetime, are presented using the data collected at the Z(0) peak in 1994 and 1995. Elaborate, inclusive, secondary vertexing methods have been employed to ensure a b-hadron reconstruction with good efficiency. To separate samples of B+ and B-0 mesons, high performance neural network techniques are used that achieve very high purity signals. The results obtained are: tau(B+) = 1.624+/-0.014 (stat)+/-0.018 (syst) ps tau(B)0 = 1.531+/-0.021 (stat)+/-0.031 (syst) ps tau(B+)/tau(B)0 = 1.060+/-0.021 (stat)+/-0.024 (syst) and for the average b-hadron lifetime: taub/tau(B)0 = 1.570+/-0.005 (stat)+/-0.008 (syst) ps.
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24. |
- Abdallah, J, et al.
(författare)
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A precise measurement of the tau lifetime
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 36:3, s. 283-296
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Tidskriftsartikel (refereegranskat)abstract
- The tau lepton lifetime has been measured with the e(+) e(-) --> tau(+) tau(-) events collected by the DELPHI detector at LEP in the years 1991 - 1995. Three different methods have been exploited, using both one-prong and three-prong tau decay channels. Two measurements have been made using events in which both taus decay to a single charged particle. Combining these measurements gave tau(tau) ( 1 prong) = 291.8 +/- 2.3(stat) +/- 1.5(sys) fs. A third measurement using taus which decayed to three charged particles yielded tau(tau) (3 prong) = 288.6 +/- 2.4(stat) +/- 1.3(sys) fs. These were combined with previous DELPHI results to measure the tau lifetime, using the full LEP1 data sample, to be tau(tau) = 290.9 +/- 1.4(stat) +/- 1.0(sys) fs.
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25. |
- Abdallah, J., et al.
(författare)
-
A study of b(b)over-bar production in e(+)e(-) collisions at root s=130-207 GeV
- 2009
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 60:1, s. 1-15
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements are presented of R-b, the ratio of the b (b) over bar cross-section to the q (q) over bar cross-section in e(+)e(-) collisions, and the forward-backward asymmetry A(FB)(b) at twelve energy points in the range root s = 130-207 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions.
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26. |
- Abdallah, J, et al.
(författare)
-
A study of the energy evolution of event shape distributions and their means with the DELPHI detector at LEP
- 2003
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 29:3, s. 285-312
-
Tidskriftsartikel (refereegranskat)abstract
- Infrared and collinear safe event shape distributions and their mean values are determined in e(+)e(-) collisions at centre-of-mass energies between 45 and 202GeV. A phenomenological analysis based on power correction models including hadron mass effects for both differential distributions and mean values is presented. Using power corrections, alpha(s) is extracted from the mean values and shapes. In an alternative approach, renormalisation group invariance (RGI) is used as an explicit constraint, leading to a consistent description of mean values without the need for sizeable power corrections. The QCD beta-function is precisely measured using this approach. From the DELPHI data on Thrust, including data from low energy experiments, one finds beta(0) = 7.86 +/- 0.32 for the one loop coefficient of the beta-function or, assuming QCD, n(f) = 4.75 +/- 0.44 for the number of active flavours. These values agree well with the QCD expectation of beta(0) = 7.67 and n(f) 5. A direct measurement of the full logarithmic energy slope excludes light gluinos with a mass below 5GeV.
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27. |
- Abdallah, J, et al.
(författare)
-
Bose-Einstein correlations in W+W- events at LEP2
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:2, s. 161-174
-
Tidskriftsartikel (refereegranskat)abstract
- Bose-Einstein correlations (BEC) between final state particles in the reaction e(+)e(-) -> W+ W- -> q(1)(q(2)) over barq(3)(q(4)over bar>) over bar) have been studied. Data corresponding to a total integrated luminosity of 550 pb(-1), recorded by the DELPHI detector at centre-of-mass energies ranging from 189 to 209 GeV, were analysed. An indication for inter-W BEC between like-sign particles has been found at the level of 2.4 standard deviations of the combined statistical and systematic uncertainties.
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28. |
- Abdallah, J, et al.
(författare)
-
Coherent soft particle production in Z decays into three jets
- 2005
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 605:1-2, s. 37-48
-
Tidskriftsartikel (refereegranskat)abstract
- Low-energy particle production perpendicular to the event plane in three-jet events produced in Z decays in e(+)e(-) annihilation is measured and compared to that perpendicular to the event axis in two-jet events. The topology dependence of the hadron production ratio is found to agree with a leading-order QCD prediction. This agreement and especially the need for the presence of a destructive interference term gives evidence for the coherent nature of gluon radiation. Hadron production in three-jet events is found to be directly proportional to a single topological scale function of the inter-jet angles. The slope of the dependence of the multiplicity with respect to the topological scale was measured to be 2.211 +/- 0.014(stat.) +/- 0.053(syst.) in good agreement with the expectation given by the colour-factor ratio C-A/C-F = 9/4. This result strongly supports the assumption of local parton-hadron duality, LPHD, at low hadron momentum.
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29. |
- Abdallah, J, et al.
(författare)
-
Determination of A(FB)(b) at the Z pole using inclusive charge reconstruction and lifetime tagging
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 40:1, s. 1-25
-
Tidskriftsartikel (refereegranskat)abstract
- A novel high precision method measures the b-quark forward-backward asymmetry at the Z pole on a sample of 3,560,890 hadronic events collected with the DELPHI detector in 1992 to 2000. An enhanced impact parameter tag provides a high purity b sample. For event hemispheres with a reconstructed secondary vertex the charge of the corresponding quark or anti-quark is determined using a neural network which combines in an optimal way the full available charge information from the vertex charge, the jet charge and from identified leptons and hadrons. The probability of correctly identifying b-quarks and anti-quarks is measured on the data themselves comparing the rates of double hemisphere tagged like-sign and unlike-sign events. The b-quark forward-backward asymmetry is determined from the differential asymmetry, taking small corrections due to hemisphere correlations and background contributions into account. The results for different centre-of-mass energies are: A(FB)(b) ( 89.449 GeV) = 0.0637 +/- 0.0143( stat.) +/- 0.0017( syst.), A(FB)(b) ( 91.231 GeV) = 0.0958 +/- 0.0032( stat.) +/- 0.0014( syst.), A(FB)(b) ( 92.990 GeV) = 0.1041 +/- 0.0115( stat.) +/- 0.0024( syst.). Combining these results yields the b-quark pole asymmetry A(FB)(b0) = 0.0972 +/- 0.0030( stat.) +/- 0.0014( syst.).
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30. |
- Abdallah, J, et al.
(författare)
-
Determination of heavy quark non-perturbative parametersfrom spectral moments in semileptonic B decays
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 45:1, s. 35-59
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Tidskriftsartikel (refereegranskat)abstract
- Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distribution, have been used to determine parameters which enter into the extraction of vertical bar V-cb vertical bar from the measurement of the inclusive b-hadron semileptonic decay width. The values obtained in the kinetic scheme are: m(b)(1 GeV) = 4.591 +/- 0.062 +/- 0.039 +/- 0.005 GeV/c(2), m(c)(1 GeV) = 1.170 +/- 0.093 +/- 0.055 +/- 0.005 GeV/c(2), m(pi)(2) (1 GeV) = 0.399 +/- 0.048 +/- 0.034 +/- 0.087 GeV2, (p) over tilde (3)(D) = 0.053 +/- 0.017 +/- 0.011 +/- 0.026 GeV3, and include corrections at order 1/m(b)(3). Using these results, and present measurements of the inclusive semileptonic decay partial width of b-hadrons at LEP, an accurate determination of vertical bar V-cb vertical bar is obtained: vertical bar V-cb vertical bar = 0.0421 x (1 +/- 0.014 (meas center dot) +/- 0.014 (fit) +/- 0.015 (th center dot)).
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31. |
- Abdallah, J., et al.
(författare)
-
Determination of the b quark mass at the M-Z scale with the DELPHI detector at LEP
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 46:3, s. 569-583
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Tidskriftsartikel (refereegranskat)abstract
- An experimental study of the normalized three-jet rate of b quark events with respect to light quarks events (light = l equivalent to u, d, s) has been performed using the CAMBRIDGE and DURHAM jet algorithms. The data used were collected by the DELPHI experiment at LEP on the Z peak from 1994 to 2000. The results are found to agree with theoretical predictions treating mass corrections at next-to-leading order. Measurements of the b quark mass have also been performed for both the b pole mass: M-b and the b running mass: m(b)(M-Z). Data are found to be better described when using the running mass. The measurement yields: m(b)(M-Z) = 2.85 +/- 0.18(stat) +/- 0.13(exp) +/- 0.19(had) +/- 0.12(theo) GeV/c(2). for the CAMBRIDGE algorithm. This result is the most precise measurement of the b mass derived from a high energy process. When compared to other b mass determinations by experiments at lower energy scales, this value agrees with the prediction of quantum chromodynamics for the energy evolution of the running mass. The mass measurement is equivalent to a test of the flavour independence of the strong coupling constant with an accuracy of 7 parts per thousand.
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32. |
- Abdallah, J, et al.
(författare)
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Determination of the e(+)e(-)->gamma gamma(gamma) cross-section at LEP 2
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 37:4, s. 405-419
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Tidskriftsartikel (refereegranskat)abstract
- A test of the benchmark QED process e(+) e(-) -->gammagamma(gamma) is reported, using the data collected with the DELPHI detector at LEP 2. The data analysed were recorded at centre-of-mass energies ranging from 161 GeV to 208 GeV and correspond to a total integrated luminosity of 656.4 pb(-1). The Born cross-section for the process e(+) e(-)-->gammagamma(gamma) was determined, confirming the validity of QED at the highest energies ever attained in electron-positron collisions. Lower limits on the parameters of a number of possible deviations from QED, predicted within theoretical frameworks expressing physics beyond the Standard Model, were derived.
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33. |
- Abdallah, J., et al.
(författare)
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Evidence for an excess of soft photons in hadronic decays of Z(0)
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 47:2, s. 273-294
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Tidskriftsartikel (refereegranskat)abstract
- Soft photons inside hadronic jets converted in front of the DELPHI main tracker (TPC) in events of qq disintegrations of the Z(0) were studied in the kinematic range 0.2 < E-y < I GeV and transverse momentum with respect to the closest jet direction P-T < 80 MeV/c. A clear excess of photons in the experimental data as compared to the Monte Carlo predictions is observed. This excess (uncorrected for the photon detection efficiency) is (1.17 +/- 0.06 +/- 0.27) x 10(-3) gamma/jet in the specified kinematic region, while the expected level of the inner hadronic bremsstrahlung (which is not included in the Monte Carlo) is (0.340 +/- 0.001 +/- 0.038) X 10(-3) gamma/jet. The ratio of the excess to the predicted bremsstrahlung rate is then (3.4 +/- 0.2 +/- 0.8), which is similar in strength to the anomalous soft photon signal observed in fixed target experiments with hadronic beams.
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34. |
- Abdallah, J, et al.
(författare)
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Final results from DELPHI on the searches for SM and MSSM neutral Higgs bosons
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 32:2, s. 145-183
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Tidskriftsartikel (refereegranskat)abstract
- These final results from DELPHI searches for the Standard Model (SM) Higgs boson, together with benchmark scans of the Minimal Supersymmetric Standard Model (MSSM) neutral Higgs bosons, used data taken at centre-of-mass energies between 200 and 209 GeV with a total integrated luminosity of 224 pb(-1). The data from 192 to 202 GeV are reanalysed with improved b-tagging for MSSM final states decaying to four b-quarks. The 95% confidence level lower mass bound on the Standard Model Higgs boson is 114.1 GeV/c(2). Limits are also given on the lightest scalar and pseudo-scalar Higgs bosons of the MSSM.
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35. |
- Abdallah, J, et al.
(författare)
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Flavour independent searchesfor hadronically decaying neutral Higgs bosons
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:2, s. 147-159
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes flavour independent searches for hadronically decaying neutral Higgs bosons in the data collected by the DELPHI experiment at LEP, at centre-of-mass energies between 189 and 209 GeV. The collected data-set corresponds to an integrated luminosity of around 610 pb(-1). The e(+)e(-) -> hA and e(+)e(-) -> hZand processes are considered, with direct Higgs boson decays into hadrons. No evidence for Higgs boson production is found, and cross-section limits are set as a function of the Higgs boson masses. No explicit assumptions are made on the underlying physics beyond the Standard Model, allowing interpretation of the data in a large class of models.
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36. |
- Abdallah, J., et al.
(författare)
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Higgs boson searches in CP-conserving and CP-violating MSSM scenarios with the DELPHI detector
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; C:54, s. 1-35
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the final interpretation of the results from DELPHI on the searches for Higgs bosons in the minimal supersymmetric extension of the Standard Model (MSSM). A few representative scenarios are considered, that include CP conservation and explicit CP violation in the Higgs sector. The experimental results encompass the searches for neutral Higgs bosons at LEP1 and LEP2 in final states as expected in the MSSM, as well as LEP2 searches for charged Higgs bosons and for neutral Higgs bosons decaying into hadrons independent of the quark flavour. The data reveal no significant excess with respect to background expectations. The results are translated into excluded regions of the parameter space in the various scenarios. In the CP-conserving case, these lead to limits on the masses of the lightest scalar and pseudoscalar Higgs bosons, h and A, and on tan beta. The dependence of these limits on the top quark mass is discussed. Allowing for CP violation reduces the experimental sensitivity to Higgs bosons. It is shown that this effect depends strongly on the values of the parameters responsible for CP violation in the Higgs sector.
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37. |
- Abdallah, J, et al.
(författare)
-
Inclusive b decays to wrong sign charmed mesons
- 2003
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 561:1-2, s. 26-40
-
Tidskriftsartikel (refereegranskat)abstract
- The production of wrong sign charmed mesons b --> (D) over bar X-(s), D-(s) = (D-0, D+, D-s), is studied using the data collected by the DELPHI experiment in the years 1994 and 1995. Charmed mesons in Z --> b (b) over bar events are exclusively reconstructed by searching for the decays D-0 --> K(-)pi(+), D+ --> K(-)pi(+)pi(+) and D-s(+) --> phipi(+) --> K(+)K(-)pi(+). The wrong sign contribution is extracted by using two discriminant variables: the charge of the b-quark at decay time, estimated from the charges of identified particles, and the momentum of the charmed meson in the rest frame of the b-hadron. The inclusive branching fractions of b-hadrons into wrong sign charm mesons are measured to be: B(b --> (D) over bar X-0) + B(b --> D-X) = (9.3 +/- 1.7(stat) +/- 1.3(syst) +/- 0.4(B))%, B(b --> Ds-X) = (10.1 +/- 1.0(stat) +/- 0.6(syst) +/- 2.8(B))% where the first error is statistical, the second and third errors are systematic. (C) 2003 Published by Elsevier Science B.V.
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38. |
- Abdallah, J., et al.
(författare)
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Investigation of colour reconnection in WW events with the DELPHI detector at LEP-2
- 2007
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 51:2, s. 249-269
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Tidskriftsartikel (refereegranskat)abstract
- In the reaction e(+)e(-) -> WW -> (q(1) (q) over bar (2))(q(3)(q) over bar (4)) the usual hadronization models treat the colour singlets q(1)(q) over bar (2) and q(3)(q) over bar (4) coming from two W bosons independently. However, since the. nal state partons may coexist in space and time, cross-talk between the two evolving hadronic systems may be possible during fragmentation through soft gluon exchange. This e. ect is known as colour reconnection. In this article the results of the investigation of colour reconnection e. ects in fully hadronic decays of W pairs in DELPHI at LEP are presented. Two complementary analyses were performed, studying the particle. ow between jets and W mass estimators, with negligible correlation between them, and the results were combined and compared to models. In the framework of the SK-I model, the value for its. parameter most compatible with the data was found to be: (SK)-S-kappa-I = 2.2(-1.3) (+2.5) corresponding to the probability of reconnection P-reco to be in the range 0.31 < P-reco < 0.68 at 68% confidence level with its best value at 0.52.
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39. |
- Abdallah, J., et al.
(författare)
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Masses, lifetimes and production rates of Xi(-) and Xi(+) at LEP 1
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 639:3-4, s. 179-191
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the Xi(-) and (Xi) over bar (+) masses, mass differences, lifetimes and lifetime differences are presented. The (Xi) over bar (+) sample used is much larger than those used previously for such measurements. In addition, the S production rates in Z -> b (b) over bar and Z -> q (q) over bar events are compared and the position xi* of the maximum of the distribution in Z -> q (q) over bar events is measured.
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40. |
- Abdallah, J., et al.
(författare)
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Measurement and interpretation of fermion-pair production at LEP energies above the Z resonance
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 45:3, s. 589-632
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents DELPHI measurements and interpretations of cross-sections, forward-backward asymmetries, and angular distributions, for the e(+)e(-) -> f (f) over bar process for centre-of-mass energies above the Z resonance, from root s similar to 130-207 GeV at the LEP collider. The measurements are consistent with the predictions of the Standard Model and are used to study a variety of models including the S-Matrix ansatz for e(+)e(-) -> f (f) over bar scattering and several models which include physics beyond the Standard Model: the exchange of Z' bosons, contact interactions between fermions, the exchange of gravitons in large extra dimensions and the exchange of (v) over tilde in R-parity violating supersymmetry.
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41. |
- Abdallah, J, et al.
(författare)
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Measurement of inclusive f(1) (1285) and f(1) (1420) production in Z decays with the DELPHI detector
- 2003
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 569:3-4, s. 129-139
-
Tidskriftsartikel (refereegranskat)abstract
- DELPHI results are presented on the inclusive production of two (K(K) over bar π)(0) states in the mass region 1.2-1.6 GeV/c(2) in hadronic Z decays at LEP I. The measured masses (widths) are 1274 +/- 6 MeV/c(2) (29 +/- 12 MeV/c(2)) and 1426 +/- 6 MeV/c(2) (51 +/- 14 MeV/c(2)), respectively. A partial-wave analysis of the (K(K) over bar π)(0) system shows that the first peak is consistent with the I-G (J(PC)) = 0(+)(1(++))/(0(-+))a(0)(980)pi and the second with the I-G (J(PC)) = 0(+)(1(++))K*(892)(K) over bar + c.c. assignments. The total hadronic production rates per hadronic Z decay are (0.165 +/- 0.051) and (0.056 +/- 0.012), respectively. These measurements are consistent with the two states being the f(1) (1285) and f(1) (1420) mesons. (C) 2003 Published by Elsevier B.V.
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42. |
- Abdallah, J, et al.
(författare)
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Measurement of the forward-backward asymmetries of e(+)e(-)-> Z -> b(b)over-bar and e(+)e(-)-> Z -> c(c)over-bar using prompt leptons
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 109-125
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Tidskriftsartikel (refereegranskat)abstract
- The forward-backward asymmetries of the processes e(+) e(-) --> Z --> b (b) over bar and e(+)e(-) --> Z --> c (c) over bar were measured from a sample of hadronic Z decays collected by the DELPHI experiment between 1993 and 1995. Enriched samples of b (b) over bar and c (c) over bar events were obtained using lifetime information. The tagging of b and c quarks in these samples was based on the semileptonic decay channels b/c --> X + mu and b/c --> X + e combined with charge flow information from the hemisphere opposite to the lepton. Combining the A(FB)(b (b) over bar) and A(FB)(c (c) over bar) measurements presented in this paper with published results based on 1991 and 1992 DELPHI data samples, the following pole asymmetries were obtained: A(FB)(0,b) = 0.1021 +/- 0.0052 (stat) +/- 0.0024 (syst) A(FB)(0,c) = 0.0728 +/- 0.0086 (stat) +/- 0.0063 (syst) The effective value of the weak mixing angle derived from these measurements is sin(2) theta(W,eff)(lept) = 0.23170 +/- 0.00097.
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43. |
- Abdallah, J, et al.
(författare)
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Measurement of the Lambda(0)(b) decay form factor
- 2004
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 585:1-2, s. 63-84
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Tidskriftsartikel (refereegranskat)abstract
- The form factor of A(o)(b) baryons is estimated using 3.46 x 10(6) hadronic Z decays collected by the DELPM experiment between 1992 and 1995. Charmed A(c)(+) baryons fully reconstructed in the pK(-)pi(+), pK(o)(s), and Api(+)pi(+)pi(-) modes, are associated to a c S lepton with opposite charge in order to select A(o)(b) --> A(c)(+)l(-)v(l) decays. From a combined likelihood and event rate fit to the b C distribution of the Isgur-Wise variable w, and using the Heavy Quark Effective Theory (HQET), the slope of the b-baryon form factor is measured to be p(2)=2.03+/-0.46(stat)(-1.00)(+0.72)(syst). The exclusive semileptonic branching fraction Br(A(b)(o) --> A(c)(+)l(-)v(l)) can be derived from p(2) and is found to be (5.0(-0.8)(+1.1)(stat)(-1.2)(+1.6) (syst))%. Limits on other branching fractions are also obtained. (C) 2004 Published by Elsevier B.V.
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44. |
- Abdallah, J, et al.
(författare)
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Measurement of the W-pair production cross-section and W branching ratios in e(+)e(-) collisions at root s=161-209 GeV
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 127-144
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Tidskriftsartikel (refereegranskat)abstract
- These final results on e(+) e(-) W+ W- production cross-section measurements at LEP2 use data collected by the DELPHI detector at centre-of-mass energies up to 209 GeV. Measurements of total cross-sections, W angular differential distributions and decay branching fractions, and the value of the CKM element |V-cs| are compared to the expectations of the Standard Model. These results supersede all values previously published by DELPHI.
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45. |
- Abdallah, J, et al.
(författare)
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Measurement of vertical bar Vcb vertical bar using the semileptonic decay (B)d(0))over-bar -> D*+l(-)(nu)over-barl
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:2, s. 213-232
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Tidskriftsartikel (refereegranskat)abstract
- Data from Z decays in DELPHI have been searched for <(B-d(o))over bar> --> D*+ l(-) (ν) over bar (l) with the D*+ decaying to D(0)pi(+) and D-0 --> K(-)pi(+), K(-)pi(+)pi(+)pi(-) or K- pi(+)(pi(0)). These events are used to measure the CKM matrix element V-cb and the form factor slope, rho(A1)(2): F-D*(1) V-cb = 0.0392 +/- 0.0018 +/- 0.0023; rho(A1)(2) = 1.32 +/- 0.15 +/- 0.33 corresponding to a branching fraction: BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.90 +/- 0.22 +/- 0.50)%. Combining these and previous DELPHI measurements gives: FD*(1)V-cb = 0.0377 +/- 0.0011 +/- 0.0019, rho(A1)(2) = 1.39 +/- 0.10 +/- 0.33 and BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.39 +/- 0.11 +/- 0.34)% Using F-D*(1) = 0.91 +/- 0.04, yields: V-cb = 0.0414 +/- 0.0012(stat.) +/- 0.0021(syst.) +/- 0.0018 (theory). The b-quark semileptonic branching fraction into a D*+ emitted from higher mass charmed excited states has also been measured to be: BR(b --> D*+ Xl(-)(ν) over bar (l)) = (0.67 +/- 0.08 +/- 0.10)%.
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46. |
- Abdallah, J, et al.
(författare)
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Rapidity-alignment and p(T) compensation of particle pairs in hadronic Z(0) decays
- 2002
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 533:3-4, s. 243-252
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Tidskriftsartikel (refereegranskat)abstract
- Observation is made of rapidity-alignment of K+K- and (p) over barp pairs which results from their asymmetric orientation in rapidity, with respect to the direction from primary quark to antiquark. The K+K- and (p) over barp data are consistent with predictions from the fragmentation string model. However, the (p) over barp data strongly disagree with the conventional implementation of the cluster model. The non-perturbative process of 'gluon splitting to diquarks' has to be incorporated into the cluster model for it to agree with the data. Local conservation of PT between particles nearby in rapidity (i.e., p(T) compensation) is analysed with respect to the thrust direction for pi(+)pi(-), K+K-, and (p) over barp pairs. In this case, the string model provides fair agreement with the data. The cluster model is incompatible with the data for all three particle pairs. The model with its central premiss of isotropically-decaying clusters predicts a p(T) correlation not seen in the data. (C) 2002 Elsevier Science B.V. All rights reserved.
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47. |
- Abdallah, J., et al.
(författare)
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Search for a fourth generation b '-quark at LEP-II at root s=196-209GeV
- 2007
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 50:3, s. 507-518
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Tidskriftsartikel (refereegranskat)abstract
- A search for the pair production of fourth generation b'-quarks was performed using data taken by the DELPHI detector at LEP-II. The analysed data were collected at centre-of-mass energies ranging from 196 to 209 GeV, corresponding to an integrated luminosity of 420 pb(-1). No evidence for a signal was found. Upper limits on BR(b'-> bZ) and BR(b'-> bZ) were obtained for b' masses ranging from 96 to 103 GeV/c(2) stop. These limits, together with the theoretical branching ratios predicted by a sequential four generations model, were used to constrain the value of R-CKM=vertical bar V-cb(') /V-tb'V-tb vertical bar there V-cb', V-tb' and V-tb are elements of the extended CKM matrix.
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48. |
- Abdallah, J, et al.
(författare)
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Search for an LSP gluino at LEP with the DELPHI detector
- 2003
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 26:4, s. 505-525
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Tidskriftsartikel (refereegranskat)abstract
- In some supersymmetric models, the gluino ((g) over tilde) is predicted to be light and stable. In that case, it would hadronize to form R-hadrons. In these models, the missing energy signature of the lightest supersymmetric particle is no longer valid, even if R-parity is conserved. Therefore, such a gluino is not constrained by hadron collider results, which looked for the decay (g) over tilde --> q (q) over bar(χ) over tilde (0)(1). Data collected by the DELPHI detector in 1994 at 91.2 GeV have been analysed to search for q (q) over bar(gg) over tilde events. No deviation from Standard Model predictions is observed and a gluino mass between 2 and 18 GeV/c(2) is excluded at the 95% confidence level in these models. Then, R-hadrons produced in the squark decays were searched for in the data collected by DELPHI at the centre-of-mass energies of 189 to 208 GeV, corresponding to an overall integrated luminosity of 609 pb(-1). The observed number of events is in agreement with the Standard Model predictions. Limits at 95% confidence level are derived on the squark masses from the excluded regions in the plane (m((q) over tilde1),m((g) over bar)): m((t) over tilde1) > 90 GeV/c(2) and m((b) over tilde1) > 96 GeV/c(2) for purely left squarks. m((t) over tilde1) > 87 GeV/c(2) and m((b) over tilde1) > 82 GeV/c(2) independent of the mixing angle.
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49. |
- Abdallah, J, et al.
(författare)
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Search for B-s(0)-(B-s(0))over-bar oscillations and a measurement of B-d(0)-(B-d(0))over-bar oscillations using events with an inclusively reconstructed vertex
- 2003
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 28:2, s. 155-173
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Tidskriftsartikel (refereegranskat)abstract
- Neutral B meson oscillations in the B-s(0) - <(B-s(0))over bar>, and B-d(0) - <(B-d(0))over bar> systems were studied using a sample of about 4.0 million hadronic Z decays recorded by the DELPHI detector between 1992 and 2000. Events with a high transverse momentum lepton were removed and a sample of 770 k events with an inclusively reconstructed vertex was selected. The mass difference between the two physical states in the B-d(0) - <(B-d(0))over bar>system was measured to be: Deltam(d) = (0.531 +/- 0.025(stat.) +/- 0.007(syst.))ps(-1). The following limit on the width difference of these states was also obtained: DeltaGamma(Bd)/Gamma(Bd) < 0.18 at 95% CL. As no evidence for B-s(0) -<(B-s(0))over bar> oscillations was found, a limit on the mass difference of the two physical states was given:, Deltam(s) > 5.0 ps(-1) at 95% CL. The corresponding sensitivity of this analysis is equal to 6.6 ps(-1).
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50. |
- Abdallah, J, et al.
(författare)
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Search for B-s(0)-(B-s(0))over-bar oscillations in DELPHI using high-p(t) leptons
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:1, s. 35-52
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Tidskriftsartikel (refereegranskat)abstract
- Oscillations in the B-s(0)- <(B-s(0))over bar> system were studied in events selected from about 4.3 million hadronic Z(0) decays registered by DELPHI between 1992 and 2000. This paper presents updates of two published analyses ([11, 12]). The first analysis, which utilizes leptons emitted with large momentum transverse to a jet, was improved by means of a better algorithm for the vertex reconstuction and a new algorithm for flavour-tagging at production time. The second analysis, which utilizes D-s-lepton events, was improved by optimizing the treatment of proper time resolution. No signal of B-s(0) oscillations was observed and limits on the mass difference between the physical B-s(0) states were obtained to be: Deltam(s)>8.0 ps-1 at the 95% C.L. with a sensitivity of Deltam(s)= 9.1 ps(-1) in the high p(t) lepton analysis and Deltam(s)>4.9 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=8.6 ps(-1) in the D-s-lepton analysis. Previously published results on these analyses are superseded. The combination of these results with those obtained in other independent analyses previously performed in DELPHI (D-s-hadron, exclusive B-s(0), inclusive vertex) gives: Deltam(s)>8.5 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=12.0 ps(-1).
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