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1.	Acharya, Shikha, 1986, et al. (författare) Clinical characterization of women with burning mouth syndrome in a case-control study. 2018 Ingår i: Acta Odontologica Scandinavica. - : Informa UK Limited. - 1502-3850 .- 0001-6357. ; 76:4, s. 279-86 Tidskriftsartikel (refereegranskat)abstract Burning mouth syndrome (BMS) is a chronic orofacial pain disorder that is defined by a burning sensation in the oral mucosa. The aim of this study was to investigate the underlying factors, clinical characteristics and self-reported oral and general health factors associated with BMS.Fifty-six women with BMS (mean age: 67.7) and their age-matched controls were included in the study. A general questionnaire, an OHRQL index and BMS-specific questionnaires were used. Each subject underwent an oral examination.The mean severity of the BMS symptoms (VAS, 0-100) was 66.2 (SD 19.7). Overall, 45% of the patients reported taste disturbances. More of the patients than the controls rated their general health, oral health and life situation as 'less satisfactory'. The patients also reported more frequently on-going medications, diseases/disorders, xerostomia, allergy and skin diseases. Except for more bruxofacets among the patients, there were no significant differences regarding signs of parafunction. In a multiple logistic regression analysis, xerostomia and skin diseases showed the strongest prediction for BMS and no significant effect was found for medication, allergy or bruxofacets.Skin diseases and xerostomia but not parafunction were strongly associated with BMS. Our findings provide the basis for additional studies to elucidate the causal factors of BMS.
2.	Acharya, Shikha, 1986, et al. (författare) Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome 2018 Ingår i: Oral Diseases. - : Wiley. - 1354-523X. ; 24:8, s. 1468-1476 Tidskriftsartikel (refereegranskat)abstract Objective The aim of the study was to examine mucosal saliva and unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates and associated factors, in 56 female patients diagnosed with BMS and age-matched control women. Material and MethodsResultsMucosal saliva was assessed using the Periotron((R)) method and blood flow using laser Doppler flowmetry. Diseases, drug usage and xerostomia were registered using questionnaires. The patients with BMS displayed less lingual and whole saliva, and more hyposalivation, xerostomia diseases/disorders and drug usage, compared to the controls. Only a low SWS and xerostomia differed after adjusting for drugs and systemic diseases. Regression analyses suggested an importance of saliva affecting drugs for saliva on the tongue and for SWS, and the total number of drugs used for UWS. Lingual saliva and UWS were also associated with systemic diseases in the patients. Xerostomia was significantly associated with drug use and whole saliva for all subjects but not in separate analyses of the groups. ConclusionLess saliva in patients with BMS could be related to more systemic diseases and medication and not to the syndrome per se. Xerostomia in the patients was not related to any of these factors.
3.	Jontell, Mats, 1951, et al. (författare) An oral and psychosocial examination of patients with presumed oral galvanism 1982 Ingår i: Swedish Dental J. ; 9, s. 175-185 Tidskriftsartikel (refereegranskat)
4.	Mattsson, Ulf, 1955, et al. (författare) Digital image analysis of erythema development after experimental thermal injury to human skin: effect of postburn topical local anesthetics (EMLA). 1999 Ingår i: Anesthesia and analgesia. - 0003-2999. ; 88:5, s. 1131-6 Tidskriftsartikel (refereegranskat)abstract Local anesthetics inhibit edema and improve circulation in experimental burns. We evaluated the effect of topical local anesthetics on human skin burns in volunteers using computerized color analysis that allowed repeated noninvasive quantitative measurements. A standardized partial-thickness burn (1 cm2) was induced in one forearm of 10 healthy volunteers and in the opposite forearm a week later. The burned areas were treated with lidocaine/prilocaine cream (EMLA; Astra, Sweden) or a placebo cream for 1 h. The experimental skin area was photographed before and 1, 2, 4, and 12 h postburn. Digitized images were evaluated using normalized red-green-blue and Hue-Saturation-Intensity. Differences in erythema between skin treated with EMLA and placebo were not significant during the first 4 h postburn. However, 12 h postburn, a pronounced decrease in the degree of erythema was observed in EMLA-treated skin compared with placebo-treated skin. We conclude that topical local anesthetics administered for 1 h postburn significantly reduces the duration of erythema after a mild thermal injury, which suggests a potential use in clinical practice in the treatment of minor skin burns.
5.	Rödström, Per-Olof, 1955, et al. (författare) Cancer and oral lichen planus in a Swedish population. 2004 Ingår i: Oral oncology. - 1368-8375. ; 40:2, s. 131-8 Tidskriftsartikel (refereegranskat)abstract Oral lichen planus (OLP) is generally regarded as a premalignant condition. The objective of the present study was to assess the number of oral malignant tumours in a retrospective analysis of 1028 patients (mean age=55 years; range=18-86; female, n=667; men, n=351) who between 1978 to end of 1993 were diagnosed with OLP at the Faculty of Odontology, Göteborg University, Sweden. Patients with malignant tumours were identified through the Swedish Cancer Registry at the National Board of Health and Welfare, which annually reports the incidence of malignant neoplasms in the Swedish population. The incidence of oral squamous cancer (OSCC), other malignant tumours and survival in the study group was compared to the Swedish population. The total time with OLP in the study group amounted to 7009 person years, with a mean follow up of 6.8 years (SD=4.9). The observed incidence of OSCC was higher than the expected incidence in the study group. The difference was statistically significant (P<0.001). No statistically significant difference was found for any other malignant tumours than OSCC. Also, no statistically significant difference could be identified in survival between study group and the population. The results from the present study gives further support to the concept of a small but increased risk for development of squamous cell carcinoma in patients with OLP.
6.	Simark-Mattsson, Charlotte, 1955, et al. (författare) T cell receptor V-gene usage in oral lichen planus; increased frequency of T cell receptors expressing V alpha 2 and V beta 3. 1994 Ingår i: Clinical and experimental immunology. - 0009-9104. ; 98:3, s. 503-7 Tidskriftsartikel (refereegranskat)abstract In order to analyse the clonality of T cells in the inflammatory infiltrate of oral lichen planus (OLP), mucosal biopsies were obtained from seven patients with manifest disease. The biopsies were stained with MoAbs directed against 11 different T cell receptor (TCR) V-gene families, anti-CD4, anti-CD8 and IL-2 receptor (IL-2R). For comparison, the frequencies of the different TCR V-families were determined in biopsies from five patients with oral candidosis as well as in peripheral blood from three patients with OLP and from six healthy blood donors (HBD). The occurrence of the investigated TCR V-families varied between 0% and 7% in venous blood obtained from both HBD and OLP patients. T lymphocytes expressing the TCR V beta 3 and V alpha 2 in OLP biopsies were, however, detected in frequencies ranging between 18% and 40% of the total fraction of lymphocytes, a consistent finding for all the OLP infiltrates studied. The other nine TCR V-families examined appeared in low frequencies both in biopsies and in peripheral blood. V alpha 2+ and V beta 3+ cells were often localized adjacent to the basal membrane. In contrast, T cells in Candida-induced lesions did not express a biased TCR distribution, and most V-families studied appeared in frequencies of 0-6%. Thus, T lymphocytes in OLP lesions express a substantially higher frequency of TCR V alpha 2 and V beta 3 than expected from the distribution in blood. The clonal expansion of T cells observed in OLP suggests that a superantigen is involved in the pathogenesis of the disease. Whether this superantigen is of exogenous or endogenous origin needs to be investigated.
7.	Acharya, Shikha, 1986, et al. (författare) Reduced sialyl-Lewis(x) on salivary MUC7 from patients with burning mouth syndrome 2019 Ingår i: Molecular Omics. - : Royal Society of Chemistry (RSC). - 2515-4184. ; 15:5, s. 331-339 Tidskriftsartikel (refereegranskat)abstract We analysed and compared MUC7 O-glycosylation and inflammatory biomarkers in saliva from female patients with burning mouth syndrome (BMS) and gender/age-matched controls. Oligosaccharides from salivary MUC7 from BMS and controls were released. Inflammatory mediators were measured by multiplex proximity extension assay. Presence of sialyl-Lewis(x) (Si-Le(x)) epitope on MUC7 was confirmed using Western blot. MUC7 O-glycans and measured inflammatory biomarkers were found to be similar between BMS and controls. However, oligosaccharides sialyl-Lewis(x) (Si-Le(x)) was found to be reduced in samples from BMS patients. Positive correlation (combined patients and controls) was found between levels of C-C motif chemokine 19 (CCL-19) and the amount of core-2 oligosaccharides on MUC7 as well as fractalkine (CX3CL1) and level of sialylation. Patients with BMS were shown to represent a heterogeneous group in terms of inflammatory biomarkers. This indicates that BMS patients could be further stratified on the basis of low-level inflammation. The results furthermore indicate that reduced sialylation of MUC7, particularly Si-Le(x), may be an important feature in patients with BMS. However, the functional aspects and potential involvement in immune regulation of Si-Le(x) remains unclear. Our data suggests a chemokine driven alteration of MUC7 glycosylation.
8.	Al-Hashimi, Ibtisam, et al. (författare) Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. 2007 Ingår i: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier BV. - 1528-395X .- 1079-2104. ; 103 Suppl Tidskriftsartikel (refereegranskat)abstract Several therapeutic agents have been investigated for the treatment of oral lichen planus (OLP). Among these are corticosteroids, retinoids, cyclosporine, and phototherapy, in addition to other treatment modalities. A systematic review of clinical trials showed that particularly topical corticosteroids are often effective in the management of symptomatic OLP lichen planus. Systemic corticosteroids should be only considered for severe widespread OLP and for lichen planus involving other mucocutaneous sites. Because of the ongoing controversy in the literature about the possible premalignant character of OLP, periodic follow-up is recommended. There is a spectrum of oral lichen planus-like ("lichenoid") lesions that may confuse the differential diagnosis. These include lichenoid contact lesions, lichenoid drug reactions and lichenoid lesions of graft-versus-host disease. In regard to the approach to oral lichenoid contact lesions the value of patch testing remains controversial. Confirmation of the diagnosis of an oral lichenoid drug reaction may be difficult, since empiric withdrawal of the suspected drug and/or its substitution by an alternative agent may be complicated. Oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) are recognized to have an association with malignancy. Local therapy for these lesions rests in topical agents, predominantly corticosteroids.
9.	Ali, Y, et al. (författare) MedView-design and adoption of an interactive system for oral medicine. 2000 Ingår i: Studies in health technology and informatics. - 0926-9630 .- 1879-8365. ; 77, s. 3-7 Konferensbidrag (refereegranskat)abstract MedView is a joint project with participants from oral medicine and computer science. The aim of the project is to build a large database from patient examinations and produce computerized tools to extend, view, and analyze the contents of the database. The contents of the data base is based on a formalization of health-care processes and clinical knowledge in oral medicine harmonized within the network SOMNET. We give an overview of the current status of the MedView project and discuss background and future directions.
10.	Alves, Fabio de Abreu, et al. (författare) Immunohistopathology of the Newly Discovered Giant Papillae Tongue Disorder in Organ-Transplanted Children 2017 Ingår i: Transplantation. - : Lippincott Williams & Wilkins. - 0041-1337 .- 1534-6080. ; 101:6, s. 1441-1448 Tidskriftsartikel (refereegranskat)abstract Background. Giant papillae tongue disorder (GRID) is a newly discovered, long-lasting clinical disorder that may develop in organ-transplanted pediatric recipients. The key feature of this disorder is the unique tongue lesion, which comprises swollen fungiform papillae. The aim of this study was to characterize the immunohistopathology of this novel inflammatory condition. Methods. Six organ transplanted children with GRID were included in the study. Routine histopathology and immunohistochemical stainings for CD3, CD4, CD8, CD25, FOXP3, CD20, CD138, CD68, CD1a, CD15, CD23, and mast cell tryptase were performed. Results. Immunohistochemical analyses of the oral lesions revealed a subepithelial infiltrate that was primarily composed of CD3- and CD4-positive T cells, CD20-expressing B cells, macrophages, and CD138-positive plasma cells. The CD20-positive cells did not display the typical B cell morphology, having in general a more dendritic cell-like appearance. The CD138-expressing plasma cells were distinctly localized as a dense infiltrate beneath the accumulation of T cells and B cells. Increased numbers of CD1a-expressing Langerhans cells were detected both in the epithelium and connective tissue. Because no granulomas were observed and only single lesional eosinophils were detected, GPTD does not resemble a granulomatous or eosinophilic condition. Conclusions. We describe for the first time the immunopathological characteristics of a novel inflammatory disorder of the oral cavity, which may develop after solid organ transplantation in children.
11.	Bankvall, Maria, et al. (författare) A family-based genome-wide association study of recurrent aphthous stomatitis 2020 Ingår i: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 26:8, s. 1696-1705 Tidskriftsartikel (refereegranskat)abstract © 2020 The Authors. Oral Diseases published by John Wiley & Sons Ltd Objectives: The aetiology of recurrent aphthous stomatitis (RAS) remains unknown. Individuals may share features of genetic susceptibility, and there may also be a hereditary component. The aim was to identify patterns of association and segregation for genetic variants and to identify the genes and signalling pathways that determine the risk of developing RAS, through a family-based genome-wide association study (GWAS). Subjects and methods: DNA was extracted from buccal swabs of 91 individuals in 16 families and analysed in an Illumina core exome single nucleotide polymorphism (SNP) array. A family-based association test (dFAM) was used to derive SNP association values across all chromosomes. Results: None of the final 288,452 SNPs reached the genome-wide significant threshold of 5×10–8. The most significant pathways were the Ras and PI3K-Akt signalling pathways, pathways in cancer, circadian entrainment and the Rap 1 signalling pathway. Conclusions: This confirms that RAS is not monogenic but results as a consequence of interactions between multiple host genes and possibly also environmental factors. The present approach provides novel insights into the mechanisms underlying RAS and raises the possibility of identifying individuals at risk of acquiring this condition.
12.	Bankvall, Maria, et al. (författare) The engagement of oral-associated lymphoid tissues during oral versus gastric antigen administration 2016 Ingår i: Immunology. - : Wiley. - 0019-2805. ; 149:1, s. 98-110 Tidskriftsartikel (refereegranskat)abstract The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cavity. OVA was administered by the oral or gastric route to BALB/c mice that had received OVA-specific DO11.10+ CD4(+) T cells, stained with CellTrace Violet dye, through intravenous injection. Proliferating OVA-specific T cells were detected in the nose-associated lymphoid tissues (NALT) and the cervical, mesenteric and peripheral lymph nodes at different time-points following OVA exposure. OVA-specific T-cell proliferation was initially observed in the NALT 1hr after oral, but not gastric, administration. However, at day 1, proliferation at this site was also detected after gastric administration and profound proliferation was observed at all sites by day 4. For the oral route the degree of proliferation observed was lower in the peripheral lymph nodes by day 4 compared with the other sites. These results demonstrate a similar activation pattern achieved by the two routes. However, the NALT distinguishes itself as a site of rapid T-cell activation towards fed antigens irrespective of feeding regimen. To evaluate induction of tolerance a semi-effective OVA dose was used, to detect differences in the degree of tolerance achieved. This was performed in a model of OVA-induced airway hypersensitivity. No differences in tolerance induction were observed between the two administration routes.
13.	Bankvall, Maria, et al. (författare) The oral microbiota of patients with recurrent aphthous stomatitis. 2014 Ingår i: Journal of oral microbiology. - : Informa UK Limited. - 2000-2297. ; 6 Tidskriftsartikel (refereegranskat)abstract Specific pathogenic bacteria have been implicated in recurrent aphthous stomatitis (RAS), a chronic inflammatory condition characterised by ulcerations in the oral mucosa. However, the aetiology behind this condition still remains unclear.
14.	Bankvall, Maria, et al. (författare) Tissue-specific Differences in Immune Cell Subsets Located in the Naso-oropharyngeal-associated Lymphoid Tissues 2018 Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475. ; 87:1, s. 15-27 Tidskriftsartikel (refereegranskat)abstract Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient orally and nasally delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN and PLN. The APCs of the NALT more often belonged to the CD11c(+)CD11b(+) and the CD11c(neg)CD11b(+) subsets as compared to the other sites. Both of these APC populations showed little sign of activation, that is low expression of the markers CD40, CD86 and IAd. Instead, the APCs of the NALT more often co-expressed CX3CR1 and CD206, markers associated with a tolerogenic function. No increase in the proportion of regulatory T cells was observed in the NALT. Instead, the T cells frequently exhibited a memory/effector phenotype, expressing the homing markers 47, CCR4 and CCR9, but rarely the naive phenotype cell surface marker CD45RB. In contrast, the T cells at the other sites were mostly of the naive phenotype. In addition, cells from the NALT did not proliferate upon in vitro stimulation with Con A, whereas the cells from the other sites did. Taken together, these results suggest that the NALT is primarily an effector site rather than one for activation and differentiation, despite it being regarded as a site of induction.
15.	Berteus Forslund, Helene, 1952, et al. (författare) Number of teeth, body mass index, and dental anxiety in middle-aged Swedish women 2002 Ingår i: Acta Odontol Scand. - 0001-6357 .- 1502-3850. ; 60:6, s. 346-52 Tidskriftsartikel (refereegranskat)abstract Risk factors for poor dental health include obesity, low socio-economic status, poor dietary habits, and dental anxiety. The aim of this study was to explore the complex relation between body mass index (BMI) and number of teeth in middle-aged women taking education, dietary intake patterns, dental care utilization, and dental anxiety into account. Three groups of women (37-60 years): reference women (group I, BMI 23.8 +/- 3.1 kg/m2), obese women (group II, BMI 35.0 +/- 2.6 kg/m2), and severely obese women (group III, BMI 41.0 +/- 3.4 kg/m2) were included. Questionnaires were used to assess education, smoking, number of teeth, dental care utilization, dental anxiety, dietary intake, and meal patterns. Age, education, and smoking habits did not differ significantly between groups. However, there were significant global differences in number of teeth (27.2 +/- 3.4, 23.0 +/- 9.2, 24.7 +/- 5.9) and reported daily energy intake (9756 +/- 3363 kJ, 10344 +/- 3850 kJ, 11970 +/- 3786 kJ in groups I, II, and m, respectively). In a multiple regression model, a lower number of teeth was independently associated with higher age, higher BMI, lower education, irregular dental care, high dental anxiety, higher energy intake, and lower iron intake. These variables explained 25% of the variation in number of teeth. In conclusion, BMI is an independent predictor of number of teeth in middle-aged women when socio-economic, dietary, and psychological factors are taken into account.
16.	Brailo, V., et al. (författare) World Workshop on Oral Medicine VI: Utilization of Oral Medicine-specific software for support of clinical care, research, and education: current status and strategy for broader implementation 2015 Ingår i: Oral Surgery Oral Medicine Oral Pathology Oral Radiology. - : Elsevier BV. - 2212-4403. ; 120:2, s. 172-184 Tidskriftsartikel (refereegranskat)abstract Objectives. To assess the current scope and status of Oral Medicine-specific software (OMSS) utilized to support clinical care, research, and education in Oral Medicine and to propose a strategy for broader implementation of OMSS within the global Oral Medicine community. Study Design. An invitation letter explaining the objectives was sent to the global Oral Medicine community. Respondents were interviewed to obtain information about different aspects of OMSS functionality. Results. Ten OMSS tools were identified. Four were being used for clinical care, one was being used for research, two were being used for education, and three were multipurpose. Clinical software was being utilized as databases developed to integrate of different type of clinical information. Research software was designed to facilitate multicenter research. Educational software represented interactive, case-orientated technology designed for clinical training in Oral Medicine. Easy access to patient data was the most commonly reported advantage. Difficulty of use and poor integration with other software was the most commonly reported disadvantage. Conclusions. The OMSS presented in this paper demonstrate how information technology (IT) can have an impact on the quality of patient care, research, and education in the field of Oral Medicine. A strategy for broader implementation of OMSS is proposed.
17.	Bratel, John, 1953, et al. (författare) The effect of LongoVital on recurrent aphthous stomatitis in a controlled clinical trial. 2005 Ingår i: Oral health & preventive dentistry. - 1602-1622. ; 3:1, s. 3-8 Tidskriftsartikel (refereegranskat)abstract PURPOSE: The aim of this study was to evaluate the effect of daily intake of LongoVital (LV) (herbal vitamin tablets) in the prevention of RAS. MATERIALS AND METHODS: A group of 78 consecutively referred patients was enrolled to a three-months pretreatment period. Fifty subjects were then randomly allocated to an LV-group (n = 25) or a placebo group (N = 25). A double blind, stratified-randomised clinical case-control study was performed during six months. Number and size of the ulcers were registered by the patients using a standardized chart. The degree of discomfort was recorded on a 100 mm horizontal visual analogue scale (VAS-scale). RESULTS: The three-months pretreatment period revealed that the most dominant symptoms were pain (78%) followed by burning sensation (18%). No significant differences between the two groups were found during this period when a comparison was made at the end of the study. After the intervention period the number of aphthous ulcers/month decreased significantly in the LV-group (p = 0.02). The number of days in pain/month were also reduced (p < 0.001). If a 50% reduction of number of aphthous ulcers and days in pain were considered as clinically relevant, no statistical significant differences were found between the groups. CONCLUSION: Thus, no strong evidence was found that justified a recommendation of LV as a general drug for treatment of RAS.
18.	Bratel, John, 1953, et al. (författare) The frequency of different T-cell receptor V-families in oral lichen planus and lichenoid contact lesions: an immunohistochemical study. 1998 Ingår i: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. - 0904-2512. ; 27:9, s. 415-9 Tidskriftsartikel (refereegranskat)abstract Oral lichen planus (OLP) and lichenoid contact lesions (CL) are recognized as different pathological conditions of the oral mucosa. Cutaneous delayed-type hypersensitivity to mercury displayed by patients with CL but not by OLP patients supports the concept of different etiological mechanisms behind the two lesions. It is not possible to reveal this difference by histopathological assessments, and differences in clinical appearances are at present the only way to discriminate between the two conditions. It has recently been observed that T cells in OLP lesions express T-cell receptors (TCR) belonging to the Vbeta3 family in a higher frequency than expected from a random distribution, suggesting an involvement of superantigens as an etiologic factor behind this condition. In an effort to discriminate more clearly between OLP and CL, and to provide clues to the etiological mechanisms behind the two lesions, the TCR V-family distributions in the inflammatory infiltrates of OLP and CL were compared. Biopsies were taken from 10 patients with manifest OLP and 10 patients with CL. Frozen sections were incubated with antibodies against TCR Vbeta3, Valpha2 and Vbeta5a utilizing a standard immunoperoxidase technique. The frequency of Vbeta3.1 (clone 8F10) was calculated as 7%, and for Valpha2 less than 3%, and the results did not reveal any differences between OLP and CL regarding the frequencies of T-cell V-families. Thus, it was not possible to discriminate between OLP and CL by immunohistochemistry staining for different V families.
19.	Brennan, Michael, et al. (författare) Management of oral epithelial dysplasia: a review. 2007 Ingår i: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier BV. - 1528-395X .- 1079-2104. ; 103 Suppl Tidskriftsartikel (refereegranskat)abstract One of the goals of the fourth meeting of The World Workshop on Oral Medicine (WWOM IV) included a review of the pathophysiology and future directions for the clinical management of patients with oral epithelial dysplasia, excluding the lips and oropharynx. In the pathophysiology review of dysplasia since WWOM III (1998-2006), a wide range of molecular changes associated with progression of dysplasia to squamous cell carcinoma were found. These include loss of heterozygosity, dysregulation of apoptosis, aberrant DNA expression, and altered expression of numerous tissue markers. Based on the literature search, no single molecular pathway has been identified as the primary factor in progression of dysplasia to squamous cell carcinoma. A systematic review of medical (i.e., nonsurgical) management strategies for the treatment of dysplastic lesions has shown promising results in short-term resolution of dysplasia in the small number of studies that met eligibility criteria for review. However, because of the limited periods of follow-up reported in these studies, it remains unclear as whether resolution of dysplasia would actually be a long-term benefit of these interventions. This question is particularly germane when it is considered in the context of prevention of future development of squamous cell carcinoma. Because of the lack of randomized controlled trials that have shown effectiveness in the prevention of malignant transformation, no recommendations can be provided for specific surgical interventions of dysplastic oral lesions either.
20.	Bäckman, K, et al. (författare) Microbial-associated oral lichenoid reactions. 2007 Ingår i: Oral diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 13:4, s. 402-6 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE: The objective of the present study was to compare a new type of symptomatic lichenoid reaction, specifically located on the mucosal side of the lips, and associated with microorganisms, with a matched group presenting with reticular oral lichen planus (OLP) of the buccal mucosa. PATIENTS AND METHODS: The mean age for both groups was 66 years with a predominance of women (62%). The lichenoid reaction group (n = 25) presented with a reticular reaction pattern embracing various degrees of erythema. Patients presenting with OLP had similar lesions confined to the buccal mucosa but not on the mucosal side of the lips. RESULTS: In both groups, 80% were on any type of medication. However, 56% of the patients with lichenoid reactions medicated with more than three drugs compared with 29% (P < 0.05) in the OLP group. The former group more often used medicaments prescribed for cardiovascular diseases (48%vs 25%). Twenty-two of the patients with lichenoid reactions were treated with chlorhexidine. In 80% of these patients (n = 18), the lesions improved or completely healed, indicating a microbial association. CONCLUSION: Lichenoid reactions present on the mucosal side of the lips may be initiated by microbial plaque precipitated on the buccal surfaces of the anterior teeth.
21.	Coli, Pierluigi, 1964, et al. (författare) The effect of a dentifrice in the prevention of recurrent aphthous stomatitis. 2004 Ingår i: Oral health & preventive dentistry. - 1602-1622. ; 2:2, s. 133-41 Tidskriftsartikel (refereegranskat)abstract PURPOSE: A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the efficacy of an experimental dentifrice on the prevention of recurrent aphthous stomatitis (RAS). MATERIAL AND METHODS: A 3-month pretrial period was used to self-record data pertaining to the frequency, ulcer size, duration, and pain associated with ulcers. Thirty-six participants, who reported at least 3 RAS episodes or 30 days with RAS during the pretrial period, completed the study. Following a stratified randomization for age, sex and disease severity, the participants received the experimental dentifrice (T) or the placebo (C). The test period comprised 3 months of self-evaluation of number of ulcers, size and location. Pain related to RAS was estimated by the use of a Visual Analogue Scale (VAS). RESULTS: Symptoms were found to decrease in both groups when the pretrial and test periods were compared, although no statistical difference was reached in the C group. A statistically significant difference between the two time periods was obtained for the T group concerning the number of days with ulcers (p < 0.025) and VAS (p < 0.010). Of more clinical importance was the observation that 50% of the patients in the T group reported a more than 50% reduction in days with ulcers compared to 17% in the C group. CONCLUSIONS: The dentifrice may be used as a treatment strategy for a subgroup of patients with RAS in view of the low adverse effects and the benefit of using a treatment modality that is a part of daily routines.
22.	Dafar, Amal, et al. (författare) Factors associated with geographic tongue and fissured tongue 2016 Ingår i: Acta Odontologica Scandinavica. - : Informa UK Limited. - 0001-6357 .- 1502-3850. ; 74:3, s. 210-216 Tidskriftsartikel (refereegranskat)abstract Objectives: The primary objective of this study was to investigate the association of systemic diseases, use of medications, allergies and tobacco habits with geographic tongue (GT) and fissured tongue (FT) lesions. The secondary objectives were to evaluate the clinical characteristics of tongue lesions and to compare the overall results for referred and non-referred patients. Methodology: Non-referred patients with GT (GTgp; n=130) and FT (FTgp; n=62) were examined by general practitioners (gp) and compared to a control group without oral mucosal lesions (C; n=1029). Referred patients with GT (GTs; n=166) and FT (FTs; n=15) were examined by oral medicine specialists (s) and compared to GTgp and FTgp. Statistical analyses were performed using unpaired t-test or Fisher's exact test. A multiple logistic regression model was developed to control for age and gender as confounders. Results: Compared to the C group, GTgp patients used more anti-hypertensive medications and Swedish snus (p<0.01). The GTgp group consisted of older males (p<0.001) compared to C. Compared to the GTgp group, the GTs group was younger, more likely to have symptomatic lesions (p<0.0001) and comprised of more females. Among the groups examined, FT patients had the highest mean age. Conclusion: This study identified an association between GT and anti-hypertensive medications, as well as the use of Swedish snus. It also found differences in the activities and symptoms of the lesions between referred patients and their counterparts who were seen in general dental practice; these parameters influenced the results when these conditions were taken into account.
23.	Dafar, Amal, et al. (författare) Lingual microbiota profiles of patients with geographic tongue 2017 Ingår i: Journal of Oral Microbiology. - : Informa UK Limited. - 2000-2297. ; 9:1 Tidskriftsartikel (refereegranskat)abstract Geographic tongue (GT) is an oral mucosal lesion that affects the tongue. The association between GT and the bacterial colonization profiles of the tongue is not clear. Lingual swabs were collected from lesion sites and healthy sites of 35 patients with GT (19 males and 16 females; M-age = 54.3 +/- 16.1 years) and 22 controls (12 males and 10 females; M-age = 56.3 +/- 15.8 years). Bacterial DNA was extracted and sequenced by next-generation sequencing. At the phylum level, Fusobacteria were significantly less abundant, while Spirochaetes were significantly more abundant in GT patients compared to controls. At the operational taxonomic units level, multivariate analysis revealed distinct clusters for the three groups based on the lingual microbiota composition. Acinetobacter and Delftia were significantly associated with GT lesion and healthy sites. However, Microbacterium, Leptospira, Methylotenera, and Lactococcus were significantly associated with GT lesion sites. Additionally, Mogibacterium and Simonsiella were significantly associated with GT healthy sites and controls. The changes in the lingual microbiota profiles of patients with GT imply a shift in the lingual bacterial ecology. However, it remains unknown if this shift is a consequence of the lesions or of factors associated with the initiation and progression of the disease.
24.	Dafar, Amal, et al. (författare) Quantitative detection of epidermal growth factor and interleukin-8 in whole saliva of healthy individuals 2014 Ingår i: JIM - Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 408, s. 46-51 Tidskriftsartikel (refereegranskat)abstract Objectives: This study aims to create consensus concerning the use of a methodology by which the handling of saliva is standardized and quantitative detection of IL-8 and EGF in whole saliva is achieved. Our study involves evaluating the extent to which the pre-treatment of saliva samples with an anionic detergent – sodium dodecyl sulphate (SDS) – improved detection levels for IL-8 and EGF. Methods: Whole saliva samples (n = 28) were collected from healthy individuals and a protease inhibitor cocktail was added immediately. They were treated with either SDS or PBS for 20 min and were then applied to a sandwich ELISA. Results and conclusions: Saliva is a complex viscous fluid that requires degrading before the analysis of salivary biomarkers. We found that pre-treatment of samples with SDS significantly increased the detection levels for both EGF (293%) and IL-8 (346%) when compared with PBS-treated pairs (⁎⁎⁎P b 0.001). According to the results we recommend: (i) pre-treatment of whole saliva samples with SDS for quantitative analysis (ii) using secretory output instead of concentration in the presentation of results to avoid individual variations and (iii) taking into consideration gender, age and meal intake since these have an impact on the secretory output of salivary proteins.
25.	Dafar, Amal, et al. (författare) Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue 2017 Ingår i: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 23:6, s. 757-762 Tidskriftsartikel (refereegranskat)abstract © 2017 John Wiley & Sons A/S.Objectives: The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with geographic tongue (GT), as compared to control subjects. Methodology: An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers. Results: All patients with GT displayed significantly higher levels of IL-8 than the controls (P < 0.001). The young female patients also showed reduced levels of EGF (P < 0.05) and VEGF (P < 0.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension. Conclusion: We consider IL-8 an inflammatory mediator, which contributes to the acute inflammatory response found in GT. EGF and VEGF also seem to be involved in the pathophysiology of GT.
26.	Falkman, Göran, 1968, et al. (författare) Collaboration Patterns in a Medical Community of Practice 2008 Ingår i: Poster Session of EKAW 2008. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
27.	Falkman, Göran, 1968-, et al. (författare) Collaboration Patterns in an Online Community of Practice in Oral Medicine 2008 Ingår i: eHealth Beyond the Horizon – Get IT There. - Amsterdam : IOS Press. - 9781586038649 ; 136, s. 175-80 Konferensbidrag (refereegranskat)abstract SOMWeb is an online collaboration system based on Semantic Web technologies, which is used for knowledge sharing and dissemination within an oral medicine community in Sweden. Based on a previous study of the use of SOMWeb, general patterns of interaction and communicative activities involved in community collaboration have been identified. The patterns for one such activity, distance consultation, are described and modeled using techniques from the Pragmatic Web. It is also shown how patterns could inform system design
28.	Falkman, Göran, 1968-, et al. (författare) SOMWeb : A Semantic Web-Based System for Supporting Collaboration of Distributed Medical Communities of Practice 2008 Ingår i: Journal of Medical Internet Research. - : J M I R Publications, Inc.. - 1438-8871. ; 10:3, s. e25- Tidskriftsartikel (refereegranskat)abstract Background: Information technology (IT) support for remote collaboration of geographically distributed communities of practice (CoP) in health care must deal with a number of sociotechnical aspects of communication within the community. In the mid-1990s, participants of the Swedish Oral Medicine Network (SOMNet) began discussing patient cases in telephone conferences. The cases were distributed prior to the conferences using PowerPoint and email. For the technical support of online CoP, Semantic Web technologies can potentially fulfill needs of knowledge reuse, data exchange, and reasoning based on ontologies. However, more research is needed on the use of Semantic Web technologies in practice. Objectives: The objectives of this research were to (1) study the communication of distributed health care professionals in oral medicine; (2) apply Semantic Web technologies to describe community data and oral medicine knowledge; (3) develop an online CoP, Swedish Oral Medicine Web (SOMWeb), centered on user-contributed case descriptions and meetings; and (4) evaluate SOMWeb and study how work practices change with IT support.Methods: Based on Java, and using the Web Ontology Language and Resource Description Framework for handling community data and oral medicine knowledge, SOMWeb was developed using a user-centered and iterative approach. For studying the work practices and evaluating the system, a mixed-method approach of interviews, observations, and a questionnaire was used.Results: By May 2008, there were 90 registered users of SOMWeb, 93 cases had been added, and 18 meetings had utilized the system. The introduction of SOMWeb has improved the structure of meetings and their discussions, and a tenfold increase in the number of participants has been observed. Users submit cases to seek advice on diagnosis or treatment, to show an unusual case, or to create discussion. Identified barriers to submitting cases are lack of time, concern about whether the case is interesting enough, and showing gaps in one’s own knowledge. Three levels of member participation are discernable: a core group that contributes most cases and most meeting feedback; an active group that participates often but only sometimes contribute cases and feedback; and a large peripheral group that seldom or never contribute cases or feedback.Conclusions: SOMWeb is beneficial for individual clinicians as well as for the SOMNet community. The system provides an opportunity for its members to share both high quality clinical practice knowledge and external evidence related to complex oral medicine cases. The foundation in Semantic Web technologies enables formalization and structuring of case data that can be used for further reasoning and research. Main success factors are the long history of collaboration between different disciplines, the user-centered development approach, the existence of a “champion” within the field, and nontechnical community aspects already being in place.
29.	Falkman, Göran, 1968-, et al. (författare) SOMWeb - Towards an Infrastructure for Knowledge Sharing in Oral Medicine 2005 Ingår i: Connecting Medical Informatics and Bio-Informatics: Proceedings of MIE2005 - The XIXth International Congress of the European Federation for Medical Informatics. - Amsterdam : IOS Press. - 1586035495 ; 116, s. 527-32, s. 527-532 Konferensbidrag (refereegranskat)abstract In a net-based society, clinicians can come together for cooperative work and distance learning around a common medical material. This requires suitable techniques for cooperative knowledge management and user interfaces that are adapted to both the group as a whole and to individuals. To support distributed management and sharing of clinical knowledge, we propose the development of an intelligent web community for clinicians within oral medicine. This virtual meeting place will support the ongoing work on developing a digital knowledge base, providing a foundation for a more evidence-based oral medicine. The presented system is founded on the use and development of web services and standards for knowledge modelling and knowledge-based systems. The work is conducted within the frame of a well-established cooperation between oral medicine and computer science.
30.	Falkman, Göran, 1968-, et al. (författare) The Origin, Representation, and Use of Collaboration Patterns in a Medical Community of Practice 2008 Ingår i: Emerging Technologies and Information Systems for the Knowledge Society. - Berlin, Heidelberg : Springer. - 9783540877806 - 9783540877813 ; 5288, s. 403-412 Konferensbidrag (refereegranskat)abstract Founded on the Semantic Web technologies OWL and RDF, SOMWeb is an online community of practice that is used for knowledge sharing and dissemination within an oral medicine community in Sweden. It is shown how patterns for communication and collaboration within SOMWeb can be identified and represented in OWL, in terms of knowledge components, such as ontologies describing domain knowledge, user models, and organization models. It is described how patterns could be put into use and inform the design of future versions of SOMWeb.
31.	Falkman, Göran, 1968, et al. (författare) Towards Pragmatic Patterns for Clinical Knowledge Management 2007 Ingår i: Proceedings of the 2nd International Conference on the Pragmatic Web (ICPW2007). - New York : Association for Computing Machinery (ACM). ; , s. 65-74, s. 65-74 Konferensbidrag (refereegranskat)abstract We present a research program for identifying, modeling, and making use of generic pragmatic patterns for clinical knowledge management that support evidence-based medicine (EBM). Part of this program is SOMWeb, a system based on Semantic Web technologies, which is used for knowledge sharing and dissemination within an oral medicine community. A study of the use of SOMWeb has been conducted as the first step in the elicitation of important contextual factors and communicative activities involved in knowledge sharing processes in oral medicine. One such activity, community discussion activation, is described using consultation patterns together with the collaboration patterns of de Moor. The general need for context-aware health information systems and the prospective use of approaches within Pragmatic Web in the pursuit of EBM are also discussed.
32.	Gale, Elliot N, et al. (författare) Effects of dentists' behavior on patients' attitudes. 1984 Ingår i: Journal of the American Dental Association (1939). - 0002-8177. ; 109:3, s. 444-6 Tidskriftsartikel (refereegranskat)abstract A group of 16 patients received Class II restorations at two different sessions. During one session a dentist interacted positively with the patient. During another session, the dentist had little interaction with the patients. Patients' ratings indicated that both dentists were perceived as equally competent but that the dentist who interacted with the patients was rated significantly better. It is possible that dentists will gain more satisfaction from their patients as they increase their interaction.
33.	Gale, Git, et al. (författare) Characterisation of a Swedish cohort with orofacial granulomatosis with or without Crohn's disease. 2015 Ingår i: Oral diseases. - : Wiley. - 1601-0825 .- 1354-523X. ; 21:1 Tidskriftsartikel (refereegranskat)abstract To compare oral manifestations in a Swedish cohort of patients with orofacial granulomatosis with or without Crohn's disease and to assess NOD2 polymorphisms in the two groups.
34.	Gale, Gita, et al. (författare) Does Crohn's Disease with Concomitant Orofacial Granulomatosis Represent a Distinctive Disease Subtype? 2016 Ingår i: Inflammatory Bowel Diseases. - : Oxford University Press (OUP). - 1078-0998. ; 22:5, s. 1071-1077 Tidskriftsartikel (refereegranskat)abstract Background: Although orofacial granulomatosis (OFG) may present as a separate clinical entity, it often seems in conjunction with various systemic diseases, of which Crohn's disease (CD) is one of the most common. The aim of this study was to investigate whether CD with concomitant OFG represents a distinctive disease subtype. Methods: Twenty-one patients with CD and concomitant OFG (CD+OFG group) were included in the study. As the reference group, a cohort of 39 patients with CD but without OFG (CD-R group) was used. Demographic data and clinical characteristics were recorded at the time of diagnosis. The 2 groups were compared using multivariate analyses. Results: The percentage of patients with intestinal inflammation in the upper gastrointestinal tract was significantly higher in the CD+OFG group, as compared with the CD-R group (81% versus 33%; P < 0.001). Furthermore, ileocolonic inflammation was significantly more common in the CD+OFG patients (81% versus 46%; P = 0.013). In addition, perianal disease was more frequently observed in the CD+OFG group (48% versus 18%; P = 0.033). Significantly more patients showed evidence of granulomas in the primary endoscopy in the CD+OFG group than in the CD-R group (81% versus 38%; P = 0.003). Conclusion: The data from this study suggest that the presence of CD in conjunction with OFG represents a distinctive subphenotype of CD that is characterized by extensive inflammation, perianal disease, and pronounced granuloma formation in the intestine.
35.	Gale, Gita, et al. (författare) Immunophenotype in orofacial granulomatosis with and without Crohn's disease. 2014 Ingår i: Medicina oral, patología oral y cirugía bucal. - : Medicina Oral, S.L.. - 1698-6946. ; 19:6 Tidskriftsartikel (refereegranskat)abstract The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn's disease (OFG+CD).
36.	Gale, Gita, et al. (författare) Reply. 2016 Ingår i: Inflammatory bowel diseases. - 1536-4844. ; 22:7 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
37.	Garsjo, V., et al. (författare) Increased levels of calprotectin in the saliva of patients with geographic tongue 2020 Ingår i: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 26:3, s. 558-565 Tidskriftsartikel (refereegranskat)abstract Objective We investigated whether patients with geographic tongue have increased salivary levels of calprotectin and whether there is a correlation between the salivary levels of calprotectin and interleukin 8 (IL-8), which is another marker of inflammation. Methods Twenty-three patients diagnosed with geographic tongue and 32 control subjects without oral mucosal lesions were included in the study. The patients with geographic tongue were classified based on clinical appearance and number of oral lesions. ELISAs were used to determine the levels of calprotectin and IL-8 in whole saliva samples. Results There was a statistically significant increase in the salivary output of calprotectin in patients with geographic tongue compared with the healthy controls (62 +/- 9,1 vs. 37,5 +/- 4,7 mu g/min; p = .0134). Furthermore, the levels of calprotectin correlated positively with the number of oral lesions in patients with geographic tongue. There was also a significant and positive correlation between the salivary levels of calprotectin and IL-8, both for the patients with geographic tongue and the controls. Conclusion This study supports the notion that GT is an inflammatory disease, in which the activation of neutrophils and production of calprotectin in the saliva may play roles in its pathogenesis.
38.	Hasséus, Bengt, 1955, et al. (författare) Langerhans cells from human oral epithelium are more effective at stimulating allogeneic T cells in vitro than Langerhans cells from skin. 2004 Ingår i: Clinical and experimental immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 136:3, s. 483-9 Tidskriftsartikel (refereegranskat)abstract This report is focused on the functional capacity of Langerhans cells (LC) in the epithelium of skin and oral mucosa, which both meet different antigenic challenges. The capacity of LC from human oral and skin epithelium to provide co-stimulatory signals to T cells in vitro was compared. LC in a crude suspension of oral epithelial cells had a significantly enhanced T cell co-stimulatory capacity compared to skin epithelial cells. This applied both to cultures with concanavalin A (con-A)-stimulated syngeneic T cells and to a mixed epithelial cell lymphocyte reaction involving allogeneic T cells. The co-stimulatory capacity of oral and skin epithelial cells was reduced by >70% if monoclonal antibodies against HLA-DR, -DP and -DQ were added to the cultures with allogeneic T cells, indicating the involvement of HLA class II expressing LC. Immunohistochemistry revealed that 6% of the epithelial cells were CD1a + LC in sections from both oral and skin epithelium. Interleukin (IL)-8 production was higher in cultures of oral epithelial cells and con-A stimulated T cells than in corresponding cultures with skin epithelial cells as accessory cells. The results suggest that LC in human oral epithelium are more efficient at stimulating T cells than those of skin.
39.	Hasséus, Bengt, 1955, et al. (författare) T-cell costimulatory capacity of oral and skin epithelial cells in vitro: presence of suppressive activity in supernatants from skin epithelial cell cultures. 2004 Ingår i: European journal of oral sciences. - 0909-8836. ; 112:1, s. 48-54 Tidskriftsartikel (refereegranskat)abstract Oral Langerhans cells (LC) have better T-cell costimulatory capacity than skin LC. In this study factors affecting this capacity have been assessed in a mixed epithelial cell lymphocyte reaction (MELR) assay. Flow cytometry analysis of freshly recovered cells revealed major histocompatibility complex (MHC) class II molecule expression on 7.5% of the oral epithelial cells and 9.7% of the skin epithelial cells. Monoclonal anti class II antibodies significantly reduced the T-cell proliferation in the MELR. Pretreatment of skin epithelial cells with interleukin-1beta, tumour necrosis factor-alpha or interferon (IFN)-gamma did not affect the MELR proliferation, but incubation with IFNgamma significantly suppressed the T-cell response. Transfer of supernatants from cultures of skin epithelial cells and allogeneic T cells to cultures of oral epithelial cells and T cells resulted in a reduced T-cell proliferation while supernatants from oral epithelial cells and T cells did not reduce proliferation. The higher proliferation in cultures of T cells and oral epithelial cells than in cultures containing skin epithelial cells may be due to the presence of a suppressive factor in the skin epithelial cell suspensions.
40.	Ibrahim, Aram, et al. (författare) Cryopreventive temperatures prior to chemotherapy 2023 Ingår i: Medical Oncology. - 1357-0560. ; 40:5 Tidskriftsartikel (refereegranskat)abstract The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best condition for OM prevention. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 min each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8 and 15 degrees C, respectively. At baseline and following 5, 10, 15, 20 and 30 min of cooling, intraoral temperatures were registered using a thermographic camera. The greatest drop in intraoral temperature was seen after 5 min of cooling with IC, ICD8 degrees C and ICD15 degrees C, respectively. A statistically significant difference, corresponding to 1.4 degrees C, was seen between IC and the ICD15 degrees C (p < 0.05). The intraoral temperature further declined throughout the 30 min of cooling, showing an additional temperature reduction of 3.1, 2.2, and 1.7 degrees C for IC, ICD8 degrees C and ICD15 degrees C, respectively.
41.	Jontell, Mats, 1951, et al. (författare) Allergiska reaktioner och andra biverkningar 2005 Ingår i: Norske tannlegeforenings tidende. - 0029-2303. ; 115:2, s. 106-112 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
42.	Jontell, Mats, 1951, et al. (författare) Elektroniskt verktyg för klinik, utbildning och forskning 2008 Ingår i: Tandläkartidningen. - 0039-6982. ; 100:12, s. 78-81 Forskningsöversikt (refereegranskat)
43.	Jontell, Mats, 1951, et al. (författare) MedView: an instrument for clinical research and education in oral medicine. 2005 Ingår i: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier BV. - 1079-2104. ; 99:1, s. 55-63 Tidskriftsartikel (refereegranskat)abstract The etiology for many of the mucosal lesions we encounter in clinical practice is frequently uncertain or unknown and there is reason to believe that multicausality plays an important role. To detect multicausal relationships, the analysis must include multiple variables and large amounts of data. A traditional retrospective analysis is often based on a limited number of variables and frequently entails methodological errors where vital information may be missing. Prospective studies may be hampered by the fact that the prevalences of many conditions are relatively low. The search for new knowledge in oral medicine should therefore be facilitated by prospective use of formalized information gathered in multicenter studies. MedView is a computer program that is based on formalized input and registration of all clinical information. The output applications are focused on visualization and statistical analysis. MedView is aimed at clinical research and is well suited for multicenter studies. It also contains applications for education and distant consultations.
44.	Jontell, Mats, 1951, et al. (författare) Munhålan 2011 Ingår i: ÖNH-handboken. - Lund : Studentlitteratur. - 9789144048833 ; , s. 174-198 Bokkapitel (övrigt vetenskapligt/konstnärligt)
45.	Jontell, Mats, 1951 (författare) Munhålans sjukdomar 2005 Ingår i: Läkemedelsboken. 2005/2006. - Stockholm : Apoteket AB. - 918557452X Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract Detta kapitel beskriver diagnostik och behandling av vanliga orala sjukdomar och viktiga problem som kan uppstå i tänder och munslemhinna. Syftet är att underlätta handläggning för läkare och tandläkare samt annan sjukvårds- och tandvårdspersonal. För närmare information och behandlingsstrategier, se Terapirekommendationerna, s 619.
46.	Jontell, Mats, 1951, et al. (författare) Munhålans sjukdomar 2006 Ingår i: Läkemedelsboken. Bokkapitel (övrigt vetenskapligt/konstnärligt)
47.	Jontell, Mats, 1951, et al. (författare) Munhålans sjukdomar 2008 Ingår i: Läkemedelsboken 2009-2010. - 9185574597 Bokkapitel (övrigt vetenskapligt/konstnärligt)
48.	Jontell, Mats, 1951, et al. (författare) Munhålans sjukdomar 2011 Ingår i: Läkemedelsboken. - Uppsala : Läkemedelsverket. - 9789197960502 ; , s. 768-784 Bokkapitel (övrigt vetenskapligt/konstnärligt)
49.	Jontell, Mats, 1951, et al. (författare) Oral health care professionals' identification of cardiovascular disease risk among patients in private dental offices in Sweden. 2009 Ingår i: Journal of the American Dental Association (1939). - 1943-4723. ; 140:11, s. 1385-91 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: The authors conducted a study to investigate whether general private dental practitioners in Sweden could identify patients at risk of experiencing a fatal outcome of cardiovascular disease (CVD) within a set time frame and to what extent those practitioners' findings would result in medical interventions. METHODS: The authors enrolled 200 patients who met the following inclusion criteria: age of 45 years or older; no history of or use of medications for hypertension, hypercholesterolemia or diabetes; and having had no visits to a health care professional during the preceding 12 months during which glucose levels, total cholesterol levels or blood pressure had been assessed. The participating dentists and their staff members used a computerized system, HeartScore (European Society of Cardiology, Sophia Antipolis, France), to calculate the risk, in percentages, of a patient's dying as a result of a CVD event within the next 10 years. Dentists advised patients with HeartScores of 10 percent or higher to seek medical advice. After six to 12 months, one of the authors conducted structured telephone interviews to ascertain the results of the medical referrals. RESULTS: Six percent of the participants, all men (n = 12), had HeartScores of 10 percent or higher. No woman had a HeartScore higher than 5 percent. Fifty percent of the identified patients (n = 6) with a HeartScore of 10 percent or higher received prescriptions for antihypertensive medications after undergoing an evaluation by a medical care provider. For three patients, the physician was not able to confirm the dentists' assessment and took no further action. CONCLUSIONS: Oral health care professionals can identify patients who are unaware of their risk of developing serious complications as a result of CVD and who are in need of medical intervention. The authors' findings suggest the need for more studies with larger sample populations.
50.	Jontell, Mats, 1951, et al. (författare) Red and White Lesions of the Oral Mucosa 2007 Ingår i: Burket's Oral Medicine. Bokkapitel (övrigt vetenskapligt/konstnärligt)

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