| 1. |
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| 2. |
- Bedoya-Reina, O. C., et al.
(författare)
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Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of neuroblastoma with different clinical risk groups and stages, including healthy adrenal gland. We compare tumor cell populations with embryonic mouse sympatho-adrenal derivatives, and post-natal human adrenal gland. We provide evidence that low and high-risk neuroblastoma have different cell identities, representing two disease entities. Low-risk neuroblastoma presents a transcriptome that resembles sympatho- and chromaffin cells, whereas malignant cells enriched in high-risk neuroblastoma resembles a subtype of TRKB+ cholinergic progenitor population identified in human post-natal gland. Analyses of these populations reveal different gene expression programs for worst and better survival in correlation with age at diagnosis. Our findings reveal two cellular identities and a composition of human neuroblastoma tumors reflecting clinical heterogeneity and outcome. Childhood neuroblastoma can be separated into high and low risk groups, with prognosis depending on age at diagnosis. Here, the authors show that low and high risk neuroblastoma tumours are composed of different cell types with different malignancy potential.
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| 3. |
- Simancas, J.F., et al.
(författare)
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The seismic crustal structure of the Ossa-Morena Zone and its geological interpretation
- 2004
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Ingår i: Journal of Iberian Geology. - 1698-6180 .- 1886-7995. ; 30, s. 133-142
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Tidskriftsartikel (refereegranskat)abstract
- The IBERSEIS deep reflection seismic experiment has provided a crustal image of the Variscan orogen of southwest Iberia. A brief presentation of the entire seismic profile is given, and then the Ossa-Morena Zone (OMZ) and its boundaries are considered. The crust of the OMZ is shown to be divided into an upper crust, characterized by dominantly NE-dipping reflectivity, and a poorly reflective lower crust. The reflectivity of the upper crust has good correlation with the geological cross-section constructed from surface mapping. In the seismic image, the upper crustal geological structures are seen to merge in the middle crust. Nevertheless, the OMZ middle crust is not a mere detachment level, as it shows very unusual features: it appears as a band of strong reflectivity and irregular thickness (the Iberian Reflective Body, IRB) that we interpret as a great sill-like intrusion of basic rocks. The boundaries of the OMZ are considered sutures of the orogen, and their geometrical features, as deduced from geological mapping and the seismic image, are in accordance with the transpressional character of the Variscan collision recorded in SW Iberia. The present Moho is flat, obliterating the root of the orogen.
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| 4. |
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| 5. |
- Ask, Maria, et al.
(författare)
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The Innovative Exploration Drilling and Data Acquisition Research School
- 2021
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Ingår i: NSG2021 27th European Meeting of Environmental and Engineering Geophysics. - : European Association of Geoscientists and Engineers.
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Konferensbidrag (refereegranskat)abstract
- The Innovative Exploration Drilling and Data Acquisition Research School (I-EDDA-RS) is aimed at educating emerging scientists and engineers in on-site drilling and geoscientific investigation technology for mining. I-EDDA-RS consists if a consortium of scientists and specialists from six universities and research institutes in Germany and Sweden. A central component of the research school is that the courses have hands-on components at drill sites, boreholes and repositories. In addition, a course on entrepreneurial skills required in the exploration industry is also included in I-EDDA-RS. The arrival of the Covid-19 pandemic resulted in altered plans. Instead of offering ten courses with strong field work, practical, and entrepreneurial components during 2020, four courses via distant learning were offered. While this was disappointing in many aspects, two of the courses attracted a larger group of students from a wider part of the world than original envisioned. Outreach via on-line and open webinars is also a route to explore, as a complement to meetings and conferences in real life. The I-EDDA-RS courses in 2021 welcomes students at MSc & PhD level, as well as experienced professionals for lifelong learning (c.f. https://www.iedda.eu/rs). The form and type of teaching is to be determined.
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| 6. |
- Batra, Gorav, et al.
(författare)
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Data standards for atrial fibrillation/flutter and catheter ablation : The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
- 2023
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Ingår i: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 9:6, s. 609-620
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Standardized data definitions are essential for monitoring and assessment of care and outcomes in observational studies and randomized controlled trials (RCTs). The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart) project of the European Society of Cardiology aimed to develop contemporary data standards for atrial fibrillation/flutter (AF/AFL) and catheter ablation.METHODS AND RESULTS: We used the EuroHeart methodology for development of data standards and formed a Working Group comprising 23 experts in AF/AFL and catheter ablation registries, as well as representatives from the European Heart Rhythm Association and EuroHeart. We conducted a systematic literature review of AF/AFL and catheter ablation registries and data standard documents to generate candidate variables. We used a modified Delphi method to reach consensus on a final variable set. For each variable, the Working Group developed permissible values and definitions, and agreed as to whether the variable was mandatory (Level 1) or additional (Level 2). In total, 70 Level 1 and 92 Level 2 variables were selected and reviewed by a wider Reference Group of 42 experts from 24 countries. The Level 1 variables were implemented into the EuroHeart IT platform as the basis for continuous registration of individual patient data.CONCLUSION: By means of a structured process and working with international stakeholders, harmonized data standards for AF/AFL and catheter ablation for AF/AFL were developed. In context of the EuroHeart project, this will facilitate country-level quality of care improvement, international observational research, registry-based RCTs and post-marketing surveillance of devices and pharmacotherapies.
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| 7. |
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| 8. |
- Brown, D., et al.
(författare)
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Arc-continent collision in the Southern Urals
- 2006
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Ingår i: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 79:3-4, s. 261-287
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Tidskriftsartikel (refereegranskat)abstract
- The Southern Urals of Russia contain what is arguably one of the best-preserved examples of an arc–continent collision in anyPaleozoic orogen. The arc–continent collision history recorded in the rocks of the Southern Urals began in the Early Devonian withthe onset of intra-oceanic subduction and the formation of the Magnitogorsk Arc and ended with its collision with the margin ofBaltica during the Late Devonian. The Baltica margin consisted of a basement that was composed predominantly of rocks ofArchean and Proterozoic age that, by the time of arc–continent collision, was overlain by Cambrian, Ordovician, Silurian, andDevonian sediments interpreted to have been deposited in rift-related grabens on the continental slope and rise, and on the shallowmarine platform. The Magnitogorsk Arc consists of Early to Late Devonian island arc volcanic rocks and overlying volcaniclasticsediments. Arc–continent collision led to the development of an accretionary complex that includes shallowly and deeplysubducted continental margin rocks, ophiolite fragments, and sediments that were deposited in a foreland-basin setting. Thegeochemistry of the Magnitogorsk Arc volcanic rocks, the structure of the arc–continent collision accretionary complex and theforearc, the high-pressure rocks beneath and along the suture zone, the mafic and ultramafic ophiolitic material, and the syn-tectonic sediments show that the Paleozoic tectonic processes recorded in the Southern Urals can be favorably compared with thosein currently active settings such as the west Pacific.© 2006 Elsevier B.V. All rights reserved.
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| 13. |
- Malehmir, Alireza, et al.
(författare)
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3D reflection seismic investigation for mine planning and exploration in the Kevitsa Ni-Cu-PGE deposit, northern Finland
- 2011
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A 3D reflection seismic survey was conducted over an area of about 9 km2 at the Kevitsa Ni-Cu-PGE platinum group elements deposit, northern Finland. The principal objective of the survey was to image major fault and fracture zones at depth. Understanding the geometry of these zones is important for designing a steep open-pit for mining. Initial processing results suggest that the 3D seismic survey has been successful in imaging both gently dipping and steeply dipping reflections as shallow as 50 ms or about 150 m, many of which correlate with fault systems and lithological contacts observed at the surface. Several new target areas can be identified in the seismic data that require further investigations for their mineralization potential.
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| 14. |
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| 15. |
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| 16. |
- Alcalde, J., et al.
(författare)
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3-D reflection seismic imaging of the Hontomin structure in the Basque-Cantabrian Basin (Spain)
- 2013
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Ingår i: Solid Earth. - : Copernicus GmbH. - 1869-9510 .- 1869-9529. ; 4:2, s. 481-496
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Tidskriftsartikel (refereegranskat)abstract
- The Basque-Cantabrian Basin of the northern Iberia Peninsula constitutes a unique example of a major deformation system, featuring a dome structure developed by extensional tectonics followed by compressional reactivation. The occurrence of natural resources in the area and the possibility of establishing a geological storage site for carbon dioxide motivated the acquisition of a 3-D seismic reflection survey in 2010, centered on the Jurassic Hontomin dome. The objectives of this survey were to obtain a geological model of the overall structure and to establish a baseline model for a possible geological CO2 storage site. The 36 km(2) survey included approximately 5000 mixed (Vibroseis and explosives) source points recorded with a 25 m inline source and receiver spacing. The target reservoir is a saline aquifer, at approximately 1450 m depth, encased and sealed by carbonate formations. Acquisition and processing parameters were influenced by the rough topography and relatively complex geology. A strong near-surface velocity inversion is evident in the data, affecting the quality of the data. The resulting 3-D image provides constraints on the key features of the geologic model. The Hontom n structure is interpreted to consist of an approximately 10(7) m(2) large elongated dome with two major (W-E and NW-SE) striking faults bounding it. Preliminary capacity estimates indicate that about 1.2 Gt of CO2 can be stored in the target reservoir.
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| 17. |
- Alcalde, J., et al.
(författare)
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Active seismic characterization experiments of the Hontomin research facility for geological storage of CO2, Spain
- 2013
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Ingår i: International Journal of Greenhouse Gas Control. - : Elsevier BV. - 1750-5836 .- 1878-0148. ; 19:0, s. 785-795
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Tidskriftsartikel (refereegranskat)abstract
- An active source seismic experiment was carried out as part of the subsurface characterization study of the first Spanish Underground Research Facility for Geological Storage of CO2 in Hontomín (Burgos, Spain). The characterization experiment included a 36 km2 3D seismic reflection survey and two three-component seismic profiles. The target reservoir is a saline aquifer located at 1450 m depth within Lower Jurassic carbonates (Lias). The main seal is formed by interlayered marlstones and marly limestones of Early to Middle Jurassic age (Dogger and Lias). The seismic images obtained allow defining the 3D underground architecture of the reservoir site. The structure consists of an asymmetric dome crosscut by a relatively complex fault system. The detailed characterization of the fracture system is currently under study to unravel the geometric distribution of the faults and their extent within the different formations that form the structure. The constrained model has guided the design of the injection and monitoring boreholes and provided the data for the baseline study. The resultant high resolution seismic model will be used as a reference in future monitoring stages.
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| 18. |
- Ayarza, P, et al.
(författare)
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Contrasting tectonic history of the are-continent suture in the Southern and Middle Urals: implications for the evolution of the orogen
- 2000
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Ingår i: Journal of the Geological Society. - : Geological Society of London. - 0016-7649 .- 2041-479X. ; 157, s. 1065-1076
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Tidskriftsartikel (refereegranskat)abstract
- The Main Uralian Fault has been considered the original arc–continent suture for 2000 km along the Uralide orogen. The symmetry of the tectonic units across it suggested a consistent east-dipping polarity for the palaeosubduction zone, which, together with its topographic and aeromagnetic signature, supported the idea of a single suture. However, several characteristics vary at different latitudes. In the Middle Urals, it is a strike-slip fault zone with moderately deformed and metamorphosed volcanic arc fragments in its hanging wall, and low-grade metamorphic rocks of the East European Craton in its footwall. Here, it has a prominent NNW-trending magnetic signature which cross-cuts north-trending anomalies in its hanging wall, and a pronounced reflection seismic signature that can be traced to the top of the middle crust at c. 5 s. TWT. In the Southern Urals, it is a serpentinite mélange zone of ambiguous kinematics, with a weakly deformed and metamorphosed volcanic arc in its hanging wall, and moderately metamorphosed to high pressure rocks of the East European Craton in its footwall. In this part of the orogen, it has a weak reflection seismic character, and a magnetic signature that parallels that of its hanging wall. On the basis of an integrated analysis of these different data sets, we suggest that the Main Uralian Fault, as it is currently defined, is not a single entity, but rather the original arc–continent suture in the south, and the western strand of a strike-slip fault system that reworked the original suture in the Middle Urals.
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| 19. |
- Ayarza, P., et al.
(författare)
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Geophysical constraints on the structure of a limited ocean-continent subduction zone at the north Iberian margin
- 2004
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Ingår i: Tectonics. ; 23, s. 1010-
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Tidskriftsartikel (refereegranskat)abstract
- Late Cretaceous to Cenozoic convergence between Iberia and Europe led to the partial closure of the Bay of Biscay with limited southward subduction of oceanic crust below the North Iberian Margin. Inclined sub-Moho reflections and diffractions observed in deep seismic reflection profiles shot across the margin are especially well represented in two reflection profiles: ESCIN-3.2 and ESCIN-3.3. These two profiles have been chosen to test if the sub-Moho reflections correspond to true primary deep events and, provided that they are reflecting off the subduction zone, to investigate its deep structure. Spectral analysis together with travel time estimation and migration allow us to characterize a number of these sub-Moho events as deep-source, low-frequency (∼19 Hz), reflections and diffractions. Synthetic seismograms were generated by three-dimensional seismic modeling of a sub-Moho southward dipping surface, interpreted to correspond to the top of subducted oceanic crust. Comparison between the real and synthetic data show that inclined, low-frequency sub-Moho reflections in both, ESCIN-3.2 and ESCIN-3.3 profiles may correspond to reflections from southward subducted Bay of Biscay oceanic crust. Geoid, free-air gravity, and absolute topography modeling provides additional constraints on the lithospheric-scale structure of this limited ocean-continent subduction zone beneath the North Iberian Margin.
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| 20. |
- Ayarza, P, et al.
(författare)
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Integrated geological and geophysical studies in the SG4 borehole area, Tagil Volcanic Arc, Middle Urals: Location of seismic reflectors and source of the reflectivity
- 2000
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Ingår i: Journal of Geophysical Research. - : AMER GEOPHYSICAL UNION. - 0148-0227 .- 2156-2202. ; 105:B9, s. 21333-21352
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Tidskriftsartikel (refereegranskat)abstract
- Near-vertical incidence reflection seismic data acquired in the Tagil Volcanic Arc (Middle Urals) show the upper crust to be highly reflective. Two intersecting seismic lines located near the ongoing ∼5400 m deep SG4 borehole show that the main reflectivity strikes approximately N-S and dips ∼35°–55° to the east. Prominent reflections intercept the borehole at ∼1000, ∼1500, 2800–2900, ∼3400, and between ∼4000 and 5400 m, which correspond to intervals of low velocity/low density/low resistivity. The surface projections of these reflections lie parallel to the strike of magnetic anomaly trends. Multioffset vertical seismic profile (VSP) data acquired in the SG4 borehole show a seismic response dominated by P to S reflected converted waves from the moderately east dipping reflectivity and from a set of very steep east dipping reflectors not imaged by the surface data. Modeling of the VSP data constrains the depth at which reflectors intercept the borehole and suggests that the P to S conversions are best explained by low-velocity porous intervals rather than higher-velocity mafic material. The most prominent east dipping reflection on the surface seismic data is only imaged on VSP shots that sample the crust closer to the E-W seismic line. This discrepancy between the VSP and the surface seismic data is attributed to rapid lateral changes in the physical properties of the reflector. Surface and borehole data suggest that the low-velocity/low-density/low-resistivity intervals are the most important source of reflectivity in the SG4 borehole area, although lithological contrasts may also play a role. Drill cores from the these zones contain hydrothermal alteration minerals indicating interaction with fluids. Tectonic criteria suggest that they might represent imbricated fracture zones often bounding different lithologies and/or intrusions. Some of them might also represent high-porosity lava flows or pyroclastic units, common in island arc environments.
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| 21. |
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| 22. |
- Brown D., Juhlin C., Tryggvason A., Steer D., Ayarza P., Beckholmen M., Rybalka A. and Bliznetsov M.
(författare)
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The Crustal Architecture of the Southern and Middle Urals from the URSEIS, ESRU, and Alapaev Reflection Seismic Profiles, in Orogenic Processes in the Paleozoic Uralides
- 2002
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Ingår i: Geophysical Monograph Series, AGU. ; , s. 33-48
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Tidskriftsartikel (refereegranskat)
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| 23. |
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| 24. |
- Bruckman, Viktor J., et al.
(författare)
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Preface to the special issue of the Division Energy, Resources and the Environment at vEGU2021 : Gather online
- 2021
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Ingår i: Advances in Geosciences. - : Copernicus Publications. - 1680-7340 .- 1680-7359. ; 56, s. 13-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The European Geosciences Union (EGU) is one of the leading global bottom-up societies that promotes earth, planetary and space sciences. In its annual general assemblies, EGU brings together experts from all over the world to discuss cutting-edge research and implementation of findings in its respective disciplines and thus offers a unique forum for scientific exchange, science-policy interaction, and joint development of strategies for future research endeavours.This special issue in Advances in Geosciences comprises a collection of contributions from the Division Energy, Resources and the Environment (ERE) of the EGU, which were presented at the General Assembly 2021, vEGU2021: Gather online. It was held entirely online for the second time after EGU2020 from 19 to 30 April 2021.
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| 25. |
- Carbonell, R., et al.
(författare)
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Geophysical Evidence of a Mantle Plume Derived Intrusion Complex
- 2004
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 31, s. L11601-
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Deep seismic reflection data acquired as part of the SW-Iberia EUROPROBE project across the transpressional Variscan orogen sample three tectonic terranes: the South Portuguese Zone, the Ossa-Morena Zone, and the Central Iberian Zone. The seismic data reveal the existence of a mid-crustal reflective body 140 km long and of variable thickness (up to 5 km), the Iberian Reflective body. The conductivity image provided by coincident MT soundings, the amplitude characteristics of the seismics, mineralization studies related to magmatic ore deposits, and the surface geology suggest that the IRB is a mantle-derived mafic intrusion. The geophysical, geological and petrological data suggest that the IRB is most probably an Early Carboniferous (approximately at 350–340 Ma) mantle-derived intrusion possibly linked to plume activity that took place in Europe in the Carboniferous and Permian.
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| 26. |
- Cavallin, L, et al.
(författare)
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Voxel-based correlation between coregistered single-photon emission computed tomography and dynamic susceptibility contrast magnetic resonance imaging in subjects with suspected Alzheimer disease
- 2008
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 49:10, s. 1154-1161
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Tidskriftsartikel (refereegranskat)abstract
- Background: Current diagnosis of Alzheimer disease is made by clinical, neuropsychologic, and neuroimaging assessments. Neuroimaging techniques such as magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) could be valuable in the differential diagnosis of Alzheimer disease, as well as in assessing prognosis. Purpose: To compare SPECT and MRI in a cohort of patients examined for suspected dementia, including patients with no objective cognitive impairment (control group), mild cognitive impairment (MCI), and Alzheimer disease (AD). Material and Methods: 24 patients, eight with AD, 10 with MCI, and six controls, were investigated with SPECT using 99mTc-hexamethylpropyleneamine oxime (HMPAO, Ceretec; GE Healthcare Ltd., Little Chalsont UK) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a contrast-enhancing gadobutrol formula (Gadovist; Bayer Schering Pharma, Berlin, Germany). Voxel-based correlation between coregistered SPECT and DSC-MR images was calculated. Region-of-interest (ROI) analyses were then performed in 24 different brain areas using brain registration and analysis of SPECT studies (BRASS; Nuclear Diagnostics AB, Stockholm, Sweden) on both SPECT and DSC-MRI. Results: Voxel-based correlation between coregistered SPECT and DSC-MR showed a high correlation, with a mean correlation coefficient of 0.94. ROI analyses of 24 regions showed significant differences between the control group and AD patients in 10 regions using SPECT and five regions in DSC-MR. Conclusion: SPECT remains superior to DSC-MRI in differentiating normal from pathological perfusion, and DSC-MRI could not replace SPECT in the diagnosis of patients with Alzheimer disease.
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| 27. |
- Christofer Juhlin, C., et al.
(författare)
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Whole-exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene
- 2015
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Ingår i: Genes, Chromosomes and Cancer. - : Wiley: 12 months. - 1045-2257 .- 1098-2264. ; 54:9, s. 542-554
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Tidskriftsartikel (refereegranskat)abstract
- As subsets of pheochromocytomas (PCCs) lack a defined molecular etiology, we sought to characterize the mutational landscape of PCCs to identify novel gene candidates involved in disease development. A discovery cohort of 15 PCCs wild type for mutations in PCC susceptibility genes underwent whole-exome sequencing, and an additional 83 PCCs served as a verification cohort for targeted sequencing of candidate mutations. A low rate of nonsilent single nucleotide variants (SNVs) was detected (6.1/sample). Somatic HRAS and EPAS1 mutations were observed in one case each, whereas the remaining 13 cases did not exhibit variants in established PCC genes. SNVs aggregated in apoptosis-related pathways, and mutations in COSMIC genes not previously reported in PCCs included ZAN, MITF, WDTC1, and CAMTA1. Two somatic mutations and one constitutional variant in the well-established cancer gene lysine (K)-specific methyltransferase 2D (KMT2D, MLL2) were discovered in one sample each, prompting KMT2D screening using focused exome-sequencing in the verification cohort. An additional 11 PCCs displayed KMT2D variants, of which two were recurrent. In total, missense KMT2D variants were found in 14 (11 somatic, two constitutional, one undetermined) of 99 PCCs (14%). Five cases displayed somatic mutations in the functional FYR/SET domains of KMT2D, constituting 36% of all KMT2D-mutated PCCs. KMT2D expression was upregulated in PCCs compared to normal adrenals, and KMT2D overexpression positively affected cell migration in a PCC cell line. We conclude that KMT2D represents a recurrently mutated gene with potential implication for PCC development. (c) 2015 The Authors. Genes, Chromosomes and Cancer Published by Wiley Periodicals, Inc.
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| 30. |
- Dehghannejad, M., et al.
(författare)
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High-resolution reflection seismic imaging in the Kristineberg mining area, Northern Sweden
- 2010
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Ingår i: Society of Petroleum Engineers - 72nd European Association of Geoscientists and Engineers Conference and Exhibition 2010 - Incorporating SPE EUROPEC 2010. - Barcelona : Curran Associates, Inc.. - 9781617386671 ; , s. 5368-5371
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Konferensbidrag (refereegranskat)abstract
- The Kristineberg mining area is located in the western part of the Skellefte Ore District, one of the most important mining districts in Europe. As a part of a 4D geologic modeling project, two new reflection seismic profiles were acquired. Although the structural geology is complex, the processed seismic data reveal a series of steeply dipping to sub-horizontal reflections, some of which reach the surface and allow correlation with surface geology. Reflection modeling was carried out to obtain the 3D orientation of the main reflections and to provide insight into the possible contribution of out-of-the-plane reflections. The new reflection seismic profiles have improved our understanding of shallow geological structures in the area and in conjunction with recently acquired potential field data, magnetotelluric data and geological observations will help to refine previous 3D geologic modeling interpretations that were aimed at larger scale structures.
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| 31. |
- Förster, A, et al.
(författare)
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Baseline characterization of the CO2SINK geological storage site at Ketzin, Germany
- 2006
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Ingår i: Environmental Geosciences. - : American Association of Petroleum Geologists AAPG/Datapages. - 1075-9565 .- 1526-0984. ; 13:3, s. 145-161
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Tidskriftsartikel (refereegranskat)abstract
- Since April 2004, preparatory work prior to CO2injection hasbeen conducted in the CO2SINK Project, the European Union’sfirst research and development activity on the in-situ testing ofgeological storage of CO2near the town of Ketzin, Germany.Carbon dioxide will be injected into a saline aquifer of the TriassicStuttgart Formation in an anticlinal structure of the northeastGerman Basin. The drilling of one injection and two observationwells will commence at the end of 2006. The predrilling phasefocuses on the baseline geological parameters of the anticline. TheStuttgart Formation is lithologically heterogeneous; it consists ofsandy channel-(string)-facies rocks, with good reservoir propertiesalternating with muddy flood-plain-facies rocks of poor reservoirquality. Playa-type rocks form the immediate cap rock above theCO2SINK reservoir. A geostatistical approach has been applied todescribe the reservoir architecture between and beyond well con-trol. This model forms the basis for the generation of reservoir-dynamic models of CO2injection that assist in the planning ofinjection operations and in the understanding of CO2plume evo-lution. A verification of the geometry of the reservoir and thestructural situation of its overburden is expected from a three-dimensional baseline seismic survey that was conducted in theautumn of 2005. Laboratory experiments under simulated in-situconditions were performed to evaluate the geophysical signatureof rocks saturated with CO2. The chemical composition of thegroundwater and the CO2flux in the soil were analyzed across theKetzin anticline, providing the baseline for a monitoring programduring and after injection of CO2, targeted at the detection ofpotential CO2leakage from the storage reservoir.
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| 36. |
- Johnson, Linda S.B., et al.
(författare)
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Irregularity and lack of p waves in short tachycardia episodes predict atrial fibrillation and ischemic stroke
- 2018
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Ingår i: Heart Rhythm. - : Elsevier BV. - 1547-5271. ; 15:6, s. 805-811
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Tidskriftsartikel (refereegranskat)abstract
- Background: Atrial fibrillation (AF) is defined as an irregular supraventricular tachycardia (SVT) without p waves, with duration >30 seconds. Whether AF characteristics during short SVT episodes predict AF and stroke is not known. Objective: The purpose of this study was to determine whether irregularity and lack of p waves, alone or in combination, during short SVT episodes increase the risk of incident AF and ischemic stroke. Methods: The population-based Malmö Diet and Cancer study includes 24-hour ECG screening of 377 AF-free individuals (mean age 64.5 years; 43% men) who were prospectively followed for >13 years. There were 65 AF events and 25 ischemic stroke events during follow-up. Subjects with an SVT episode ≥5 beats were identified, and the longest SVT episode was assessed for irregularity and lack of p waves. The association between SVT classification and AF and stroke was assessed using multivariable adjusted Cox regression. Results: The incidence of AF increased with increasing abnormality of the SVTs. The risk-factor adjusted hazard ratio for AF was 4.95 (95% confidence interval 2.06–11.9; P <.0001) for those with short irregular SVTs (<70 beats) without p waves. The incidence of ischemic stroke was highest in the group with regular SVT episodes without p waves (hazard ratio 14.2; 95% confidence interval 3.76–57.6; P <.0001, adjusted for age and sex). Conclusion: Characteristics of short SVT episodes detected at 24-hour ECG screening are associated with incident AF and ischemic stroke. Short irregular SVTs without p waves likely represent early stages of AF or atrial myopathy. Twenty-four–hour ECG could identify subjects suitable for primary prevention efforts.
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| 39. |
- Liu, YX, et al.
(författare)
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Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer
- 2022
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Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:5
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is the most prevalent malignancy among women worldwide and hereditary breast cancer (HBC) accounts for about 5–10% of the cases. Today, the most recurrent genes known are BRCA1 and BRCA2, accounting for around 25% of familial cases. Although thousands of loss-of-function variants in more than twenty predisposing genes have been found, the majority of familial cases of HBC remain unexplained. The aim of this study was to identify new predisposing genes for HBC in three non-BRCA families with autosomal dominant inheritance pattern using whole-exome sequencing and functional prediction tools. No pathogenic variants in known hereditary cancer-related genes could explain the breast cancer susceptibility in these families. Among 2122 exonic variants with maximum minor allele frequency (MMAF) < 0.1%, between 17–35 variants with combined annotation-dependent depletion (CADD) > 20 segregated with disease in the three analyzed families. Selected candidate genes, i.e., UBASH3A, MYH13, UTP11L, and PAX7, were further evaluated using protein expression analysis but no alterations of cancer-related pathways were observed. In conclusion, identification of new high-risk cancer genes using whole-exome sequencing has been more challenging than initially anticipated, in spite of selected families with pronounced family history of breast cancer. A combination of low- and intermediate-genetic-risk variants may instead contribute the breast cancer susceptibility in these families.
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- Ozata, DM, et al.
(författare)
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Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors
- 2017
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Ingår i: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 8:5, s. e2759-
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Tidskriftsartikel (refereegranskat)abstract
- Deregulation of microRNAs (miRNAs) contributes to the development and progression of many cancer types; however, their functions in the pathogenesis of testicular germ cell tumor (TGCT) remain unclear. Here, we determined miRNA expression profiles of TGCTs and normal testes using small RNA sequencing, and identified several deregulated miRNAs in TGCTs, including the miR-506~514 cluster. In functional studies in vitro we demonstrated that miR-514a-3p induced apoptosis through direct regulation of the paternally expressed gene 3 (PEG3), and ectopically expressed PEG3 could rescue the apoptotic effect of miR-514a-3p overexpression. Silencing of PEG3 or miR-514a-3p overexpression reduced nuclear accumulation of p50 and NF-κB reporter activity. Furthermore, PEG3 was co-immunoprecipitated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in TGCT cell lysates. We propose a model of PEG3-mediated activation of NF-κB in TGCT. Loss of miR-514a-3p expression in TGCT increases PEG3 expression that recruits TRAF2 and activates the NF-kappa B pathway, which protects germ cells from apoptosis. Importantly, we observed strong expression of PEG3 and nuclear p50 in the majority of TGCTs (83% and 78%, respectively). In conclusion, our study describes a novel function for miR-514a-3p in TGCT and highlights an unrecognized mechanism of PEG3 regulation and NF-κB activation in TGCT.
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- Paulsson, JO, et al.
(författare)
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Absence of the BRAF V600E mutation in pheochromocytoma
- 2016
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Ingår i: Journal of endocrinological investigation. - : Springer Science and Business Media LLC. - 1720-8386. ; 39:6, s. 715-716
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Simancas, J. F., et al.
(författare)
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Crustal structure of the transpressional Variscan orogen of SW Iberia : SW Iberia deep seismic reflection profile (IBERSEIS)
- 2003
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Ingår i: Tectonics. - : AGU. - 0278-7407 .- 1944-9194. ; 22, s. 1062-
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Tidskriftsartikel (refereegranskat)abstract
- IBERSEIS, a 303 km long (20 s) deep seismic reflection profile, was acquired across the Variscan belt in SW Iberian Peninsula. The acquisition parameters were designed to obtain a high-resolution crustal-scale image of this orogen. The seismic profile samples three major tectonic terranes: the South Portuguese Zone, the Ossa-Morena Zone, and the Central Iberian Zone, which were accreted in Late Paleozoic times. These terranes show a distinctive seismic signature, as do the sutures separating them. Late strike-slip movements through crustal wedges are apparent in the seismic image and have strongly modified the geometry of sutures. The upper crust appears to be decoupled from the lower crust all along the seismic line, but some deformation has been accommodated at deeper levels. A sill-like structure is imaged in the middle crust as a 1–2 s thick and 175 km long high-amplitude conspicuous reflective band. It is interpreted as a great intrusion of mafic magma in a midcrustal decollement. Taking into account surface geological data and the revealed crustal architecture, a tectonic evolution is proposed for SW Iberia which includes transpressional collision interacting during Early Carboniferous with a mantle plume. The Moho can be identified along the entire transect as subhorizontal and located at 10 to 11 s, indicating a 30–35 km average crustal thickness. Its seismic signature changes laterally, being very reflective beneath the South Portuguese Zone and the Central Iberian Zone, but discontinuous and diffuse below the Ossa Morena Zone.
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