| 1. |
- Tiensuu, Kiira, et al.
(författare)
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RAVEN: a student rocket program at Luleå University of Technology, Sweden
- 2021
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Ingår i: IAC 2021 Congress Proceedings, 72nd International Astronautical Congress (IAC), Dubai, United Arab Emirates. - : International Astronautical Federation (IAF).
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Konferensbidrag (refereegranskat)abstract
- RAVEN, Rocketry and Aerospace Vehicle Engineering in Norrbotten, is the first rocket project at Luleå University of Technology (LTU), Sweden. The project started in early 2020, and it aims to design, build, test and launch a hybrid propulsion rocket. The initial objectives are to reach an altitude of 10 km with an accompanying payload of 10 kg. The RAVEN team is based at the Kiruna Space Campus and consists of approximately 30 graduate students. The main goal of the first RAVEN rocket is to demonstrate its technology. The team is designing the entire rocket from scratch, including the hybrid propulsion system that uses nitrous oxide as the oxidising agent and paraffin as the solid fuel component, to produce approximately 6 kN of thrust. A modular rocket structure will offer customisation, enabling simple design changes in future iterations. Thus, the layout allows individual subsystems to be re-designed without changes directly affecting others. The project is meant to create a foundation for future student and research rocket projects at LTU. The follow-up developments could further iterate on the first rocket design, increasing hands-on education and providing more collaboration opportunities between the university and the aerospace industry – and eventually provide an in-house platform for research and education at the university or even for commercial start-ups. The infrastructure and resources, such as the proximity to the Esrange Space Center launch facility and support from the university and industry, make Northern Sweden an ideal location to establish a continuous rocket program.
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| 2. |
- Holmberg, Rebecka, et al.
(författare)
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Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats
- 2009
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Ingår i: Microbiology and immunology. - : Wiley. - 0385-5600 .- 1348-0421. ; 53:10, s. 567-572
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Tidskriftsartikel (refereegranskat)abstract
- The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed to LV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
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| 3. |
- McKenna, Jessica, et al.
(författare)
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RAVEN: Test Bench and Test Plan Development
- 2022
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Ingår i: IAC 2022 Congress Proceedings, 73<sup>rd</sup> International Astronautical Congress (IAC), Paris, France. - : International Astronautical Federation, IAF.
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Konferensbidrag (refereegranskat)
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| 4. |
- Niklasson, Bo, et al.
(författare)
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Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats
- 2016
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Ingår i: Viral immunology. - : Mary Ann Liebert Inc. - 0882-8245 .- 1557-8976. ; 29:8, s. 452-458
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Tidskriftsartikel (refereegranskat)abstract
- A picornavirus (Ljungan virus) has been associated with diabetes in its wild rodent reservoir and in diabetesprone biobreeding (DP-BB) rats. We attempted to alter the development of diabetes in DP-BB rats using two anti-picornavirus compounds (pleconaril and APO-N039), singly or in combination. Antiviral therapy was initiated 2 weeks before expected onset of diabetes. Pleconaril or APO-N039 alone did not affect the debut of diabetes. However, animals receiving a combination of both compounds were protected for at least the entire period of treatment (4 weeks after expected time of diabetes onset). Immunohistochemistry demonstrated that the presence and distribution of virus antigen in the pancreatic islets coincided with the clinical status of the animal. Data indicate that a treatable picornavirus can be involved in the cellular assault resulting in diabetes and in these cases the disease mechanism appears to involve a virus present in the pancreatic beta cell mass itself.
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