| 1. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 2. |
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| 3. |
- Burlakovs, Juris, 1977-, et al.
(författare)
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Platinum Group Elements in Geosphere and Anthroposphere : Interplay among the Global Reserves, Urban Ores, Markets and Circular Economy
- 2020
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Ingår i: Minerals. - : MDPI. - 2075-163X. ; 10:6, s. 1-19
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Forskningsöversikt (refereegranskat)abstract
- Industrial and strategic significance of platinum group elements (PGEs)-Os, Ir, Ru, Rh, Pd, Pt-makes them irreplaceable; furthermore, some PGEs are used by investors as "safe heaven" assets traded in the commodity markets. This review analyzes PGEs from various aspects: their place in the geosphere, destiny in the anthroposphere, and opportunity in the economy considering interactions among the exploration, recycling of urban ores, trade markets, speculative rhetoric, and changes required for successful technological progress towards the implementation of sustainability. The global market of PGEs is driven by several concerns: costs for extraction/recycling; logistics; the demand of industries; policies of waste management. Diversity of application and specific chemical properties, as well as improper waste management, make the recycling of PGEs complicated. The processing approach depends on composition and the amount of available waste material, and so therefore urban ores are a significant source of PGEs, especially when the supply of elements is limited by geopolitical or market tensions. Recycling potential of urban ores is particularly important in a long-term view disregarding short-term economic fluctuations, and it should influence investment flows in the advancement of innovation.
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| 4. |
- Chubarenko, B., et al.
(författare)
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Converting beach wrack into a resource as a challenge for the Baltic Sea (an overview)
- 2021
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Ingår i: Ocean and Coastal Management. - : Elsevier. - 0964-5691 .- 1873-524X. ; 200, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- The paper distinguishes beach wrack, the marine generated organic part of beach cast, as a separate management object and discusses research questions related to its management and economically viable use. Based on experiences from the Baltic Sea and existing practices from countries with different management systems clear distinction between the management of natural and anthropogenic components of cast material is seen as an essential prerequisite for developing sustainable product chains that allow beach wrack to be used as a resource of commercial value. Presenting and discussing examples from Denmark (Koge Municipality), Germany (Kuhlungsborn, Rugen and Poel Island), Poland (Gulf of Gdansk), Russia (Curonian and Vistula spits) and Sweden (Kalmar municipality and Oland), social, ecological, and economic consequences of beach wrack removal are analysed to improve the attractiveness of beaches for recreational purposes. It also includes potential contribution to Baltic Sea water restoration processes through the removal of the organic part of beach cast, where indeed more studies about the chemical (nutrients, metals) composition of beach wrack are required for reliable calculation of a depuration rate. For local economies within the Baltic Sea region, the organic part of beach cast (beach wrack and terrestrial debris) has reasonable economic prospects as a renewable natural resource, e.g. for soil improvement products, in fertilisers and bio-coal production, for landfill covers (contributing to climate change mitigation), biogas generation, and even for coastal protection by providing humus-like material for accelerated dune vegetation succession. For all these recycling options the development of cost-efficient technologies for collecting beach cast on sandy as well as stony beaches and also for separating the organic part from sand and anthropogenic litter (mainly plastic), is urgently required. Amendments of legal regulations, that better reflect the dualism of beach cast are also required. In essence, dualism results from the fact that beach wrack is a part of nature (or a natural resource) when it remains on a beach. However, beach wrack immediately becomes legally categorised as waste once humans collect it irrespective of its litter content. Another legal aspect being dealt with originates from the migration of the beach wrack between water and beach, whilst it is an object of epleagl cleaning operations only at the beach it onto the beach, but not whilst in the water.
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| 5. |
- Engel, Philipp, et al.
(författare)
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The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions
- 2016
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Ingår i: mBio. - : American Society for Microbiology. - 2161-2129 .- 2150-7511. ; 7:2
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Forskningsöversikt (refereegranskat)abstract
- As pollinators, bees are cornerstones for terrestrial ecosystem stability and key components in agricultural productivity. All animals, including bees, are associated with a diverse community of microbes, commonly referred to as the micro biome. The bee micro biome is likely to be a crucial factor affecting host health. However, with the exception of a few pathogens, the impacts of most members of the bee microbiome on host health are poorly understood. Further, the evolutionary and ecological forces that shape and change the microbiome are unclear. Here, we discuss recent progress in our understanding of the bee microbiome, and we present challenges associated with its investigation. We conclude that global coordination of research efforts is needed to fully understand the complex and highly dynamic nature of the interplay between the bee micro biome, its host, and the environment. High-throughput sequencing technologies are ideal for exploring complex biological systems, including host-microbe interactions. To maximize their value and to improve assessment of the factors affecting bee health, sequence data should be archived, curated, and analyzed in ways that promote the synthesis of different studies. To this end, the BeeBiome consortium aims to develop an online database which would provide reference sequences, archive metadata, and host analytical resources. The goal would be to support applied and fundamental research on bees and their associated microbes and to provide a collaborative framework for sharing primary data from different research programs, thus furthering our understanding of the bee microbiome and its impact on pollinator health.
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| 6. |
- Nicholson, George, et al.
(författare)
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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection
- 2011
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:9, s. e1002270-
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Tidskriftsartikel (refereegranskat)abstract
- We have performed a metabolite quantitative trait locus (mQTL) study of the 1H nuclear magnetic resonance spectroscopy (1H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by 1H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10−11<p<2.8×10−23). Three of these—trimethylamine, 3-amino-isobutyrate, and an N-acetylated compound—were measured in urine. The other—dimethylamine—was measured in plasma. Trimethylamine and dimethylamine mapped to a single genetic region (hence we report a total of three implicated genomic regions). Two of the three hit regions lie within haplotype blocks (at 2p13.1 and 10q24.2) that carry the genetic signature of strong, recent, positive selection in European populations. Genes NAT8 and PYROXD2, both with relatively uncharacterized functional roles, are good candidates for mediating the corresponding mQTL associations. The study's longitudinal twin design allowed detailed variance-components analysis of the sources of population variation in metabolite levels. The mQTLs explained 40%–64% of biological population variation in the corresponding metabolites' concentrations. These effect sizes are stronger than those reported in a recent, targeted mQTL study of metabolites in serum using the targeted-metabolomics Biocrates platform. By re-analysing our plasma samples using the Biocrates platform, we replicated the mQTL findings of the previous study and discovered a previously uncharacterized yet substantial familial component of variation in metabolite levels in addition to the heritability contribution from the corresponding mQTL effects.
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| 7. |
- Valujeva, K., et al.
(författare)
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Environmental management of Remediative and revitalization initiatives in Baltic sea region
- 2019
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Ingår i: 19th International Multidisciplinary Scientific GeoConference SGEM 2019. - : International Multidisciplinary Scientific Geoconference. - 9786197408843 ; , s. 253-259
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Konferensbidrag (refereegranskat)abstract
- Population growth in coastal areas worldwide call for new challenges to be solved. Blue growth initiatives are elaborated and developed in order to prevent sea resources depletion unsustainably by fishing, mining, transportation, tourism, and waste. The EU Water Framework Directive (2000/60/EC), EU Groundwater Directive (2002/118/EC) as well as EU Waste Framework Directive (2006/12/EC) are the legislative tools that base the pillars for more detailed action plans that prevents contamination spread, promote clean-up and drives us to sustainable solutions. In EC there are Joint Research Centre (JRC) for Land Management and Natural Hazards Unit to encourage the development and broader use of environmental technologies, including environmental remediation technologies. This paper aims to give different best practices to solve individual cases similarly as in The Network for Industrially Contaminated Lands in Europe (NICOLE), The European Coordination Action for Demonstration of Efficient Soil and Groundwater Remediation (EURODEMO) projects decades ago which also promoted cost-effective soil and groundwater remediation technologies, unifying efforts for joint European Sustainable Development Strategies. Baseline studies and pilot scale test-fields were developed in Baltic Sea Region with Triple helix approach that implements collaboration among stakeholders (firms, authorities and scientists). Interregional collaboration projects on Blue Economy and Sustainable Growth such as “Reviving Baltic Resilience” (RBR), “Enhancement of Green Infrastructure in the Landscape of Lowland Rivers” (ENGRAVE), “Baltic Beach Wrack - Conversion of a Nuisance To a Resource and Asset” (CONTRA) as well as Swedish Institute knowledge exchange project LASUWAMA are just a few examples how to disseminate good practices and implement in local and regional levels. Sustainability and circular economy are steps forward to green innovation revolution.
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| 8. |
- Vencels, Juris, et al.
(författare)
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Spectral solver for multi-scale plasma physics simulations with dynamically adaptive number of moments
- 2015
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Ingår i: Procedia Computer Science. - : Elsevier. - 1877-0509. ; , s. 1148-1157
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Konferensbidrag (refereegranskat)abstract
- A spectral method for kinetic plasma simulations based on the expansion of the velocity distribution function in a variable number of Hermite polynomials is presented. The method is based on a set of non-linear equations that is solved to determine the coefficients of the Hermite expansion satisfying the Vlasov and Poisson equations. In this paper, we first show that this technique combines the fluid and kinetic approaches into one framework. Second, we present an adaptive strategy to increase and decrease the number of Hermite functions dynamically during the simulation. The technique is applied to the Landau damping and two-stream instability test problems. Performance results show 21% and 47% saving of total simulation time in the Landau and two-stream instability test cases, respectively.
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