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Sökning: WFRF:(Juster Robert Paul)

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1.
  • Adedeji, Dickson O., et al. (författare)
  • Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients
  • 2023
  • Ingår i: Brain, Behavior, and Immunity - Health. - : Elsevier. - 2666-3546. ; 28
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases the susceptibility to stress-related health problems. Several dementia and Alzheimer's disease (AD) risk factors have been identified, yet little is known about the role of AL and its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) and cognitive function among memory clinic patients. Hence, this study aims to assess the association between AL and AD biomarkers, cognitive performance, and cognitive decline after 3-years of follow-up.Methods: Data from 188 memory clinic patients were derived from the Cortisol and Stress in AD (Co-STAR) study in Sweden. Participants underwent baseline assessments including blood tests for AL measures (including cortisol, thyroid stimulating hormone, cobalamin, homocysteine, leukocytes, glycated hemoglobin, albumin, high-density and low-density lipoprotein cholesterol, triglycerides, and creatinine), cerebrospinal fluid (CSF) sampling for AD biomarkers and neuropsychological tests including five cognitive domains. Linear regressions were conducted, adjusting for age, sex, and education.Results: Higher AL was associated with lower CSF Aβ1-42 levels (β = −0.175, p = 0.025), reflecting higher brain levels of Aβ1-42. Stratified analyses suggested a significant association among women but not men, although the AL-sex interaction was not statistically significant. AL was not significantly associated with T-tau level (β = −0.030, p = 0.682) and P-tau level (β = 0.091, p = 0.980). There were no significant associations between AL and cognition or cognitive decline after 3 years.Conclusion: This study showed that higher AL was associated with increased brain amyloid accumulation. This suggests that AL may play a role in AD/dementia pathophysiology. Potential sex-related differences should be assessed in further larger studies.
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2.
  • Adedeji, Dickson O., et al. (författare)
  • Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients
  • 2023
  • Ingår i: Brain, Behavior, and Immunity - Health. - : Elsevier BV. - 2666-3546. ; 28
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases the susceptibility to stress-related health problems. Several dementia and Alzheimer's disease (AD) risk factors have been identified, yet little is known about the role of AL and its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) and cognitive function among memory clinic patients. Hence, this study aims to assess the association between AL and AD biomarkers, cognitive performance, and cognitive decline after 3-years of follow-up.Methods: Data from 188 memory clinic patients were derived from the Cortisol and Stress in AD (Co-STAR) study in Sweden. Participants underwent baseline assessments including blood tests for AL measures (including cortisol, thyroid stimulating hormone, cobalamin, homocysteine, leukocytes, glycated hemoglobin, albumin, high-density and low-density lipoprotein cholesterol, triglycerides, and creatinine), cerebrospinal fluid (CSF) sampling for AD biomarkers and neuropsychological tests including five cognitive domains. Linear regressions were conducted, adjusting for age, sex, and education.Results: Higher AL was associated with lower CSF Aβ1-42 levels (β = −0.175, p = 0.025), reflecting higher brain levels of Aβ1-42. Stratified analyses suggested a significant association among women but not men, although the AL-sex interaction was not statistically significant. AL was not significantly associated with T-tau level (β = −0.030, p = 0.682) and P-tau level (β = 0.091, p = 0.980). There were no significant associations between AL and cognition or cognitive decline after 3 years.Conclusion: This study showed that higher AL was associated with increased brain amyloid accumulation. This suggests that AL may play a role in AD/dementia pathophysiology. Potential sex-related differences should be assessed in further larger studies.
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3.
  • Plusquellec, Pierrich, et al. (författare)
  • Pilot study on the effects of the DeStresse et Progresse program for 6th grade children integrated in a secondary school
  • 2015
  • Ingår i: Éducation et Francophonie. - : Consortium Erudit. - 0849-1089 .- 1916-8659. ; 43:2, s. 6-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Selon des études précédentes, l’événement que représente la transition du primaire au secondaire suscite une augmentation significative de cortisol (hormone de stress) chez les adolescents. Le programme DéStresse et Progresse est un programme de prévention du stress et de ses troubles associés, issu des travaux réalisés ces dernières années dans le domaine de la biologie du stress. Ce programme, testé et validé auprès d’adolescents en première année de l’école secondaire, a montré des effets significatifs sur le niveau de cortisol et sur le niveau de symptômes dépressifs des jeunes les plus à risque. La présente étude a pour objectif d’évaluer les effets du programme sur un groupe restreint de sujets vivant leur dernière année du primaire, mais dans une structure particulière, puisque ce groupe est déjà intégré à une école secondaire. Quarante-neuf sujets, répartis dans deux classes, ont donc participé à une étude selon un devis prétest / post-test à mesures répétées. Contrairement à ce qui était attendu, les résultats montrent une augmentation moyenne significative de cortisol salivaire au cours de notre étude, augmentation qui pourrait être attribuée à la transition précoce résultant de l’intégration de notre échantillon à l’école secondaire. Par contre, une amélioration des performances cognitives et de l’estime de soi ainsi qu’une diminution des symptômes dépressifs pour l’ensemble des élèves peuvent être suggérés à la suite du programme.
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