| 1. |
- Mancini, L., et al.
(författare)
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Physical properties and transmission spectrum of the WASP-74 planetary system from multiband photometry
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 485:4, s. 5168-5179
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Tidskriftsartikel (refereegranskat)abstract
- We present broad-band photometry of 11 planetary transits of the hot Jupiter WASP-74 b, using three medium-class telescopes and employing the telescope-defocusing technique. Most of the transits were monitored through I filters and one was simultaneously observed in five optical (U, g', r', i', z') and three near-infrared (J, H, K) passbands, for a total of 18 light curves. We also obtained new high-resolution spectra of the host star. We used these new data to review the orbital and physical properties of the WASP-74 planetary system. We were able to better constrain the main system characteristics, measuring smaller radius and mass for both the hot Jupiter and its host star than previously reported in the literature. Joining our optical data with those taken with the HST in the near infrared, we built up an observational transmission spectrum of the planet, which suggests the presence of strong optical absorbers, as TiO and VO gases, in its atmosphere.
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| 2. |
- Fic, A, et al.
(författare)
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Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.
- 2015
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Ingår i: Toxicology in Vitro. - : Elsevier BV. - 1879-3177 .- 0887-2333. ; 29:5, s. 1060-1069
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Tidskriftsartikel (refereegranskat)abstract
- The bisphenols AF (BPAF) and S (BPS) are structural analogs of the endocrine disruptor bisphenol A (BPA), and are used in common products as a replacement for BPA. To elucidate genome-wide gene expression responses, estrogen-dependent osteosarcoma cells were cultured with 10nM BPA, BPAF, or BPS, for 8h and 3months. Genome-wide gene expression was analyzed using the Illumina Expression BeadChip. Three months exposure had significant effects on gene expression, particularly for BPS, followed by BPAF and BPA, according to the number of differentially expressed genes (1980, 778, 60, respectively), the magnitude of changes in gene expression, and the number of enriched biological processes (800, 415, 33, respectively) and pathways (77, 52, 6, respectively). 'Embryonic skeletal system development' was the most enriched bone-related process, which was affected only by BPAF and BPS. Interestingly, all three bisphenols showed highest down-regulation of genes related to the cardiovascular system (e.g., NPPB, NPR3, TXNIP). BPA only and BPA/BPAF/BPS also affected genes related to the immune system and fetal development, respectively. For BPAF and BPS, the 'isoprenoid biosynthetic process' was enriched (up-regulated genes: HMGCS1, PDSS1, ACAT2, RCE1, DHDDS). Compared to BPA, BPAF and BPS had more effects on gene expression after long-term exposure. These findings stress the need for careful toxicological characterization of BPA analogs in the future.
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| 3. |
- Katrakazis, T., et al.
(författare)
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Enhancing Research Impact in Heritage Conservation
- 2018
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Ingår i: Studies in Conservation. - : Informa UK Limited. - 0039-3630 .- 2047-0584. ; 63:8, s. 450-465
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines how research impact is defined, measured, and generated - with a view to understanding how it can be enhanced within heritage conservation. It examines what is meant by impact' and how it can be promoted within heritage science through effective inter-disciplinary collaboration. Following a general examination of the current discourse concerning research impact, the study examined: (i) active research networks within heritage science; (ii) research planning and evaluation practices within heritage science; and (iii) the experiences of users (i.e. conservators and other heritage professionals) within research collaborations. Terminologies surrounding the notion of impact and the various phases of the research process were reviewed - from the initial identification of a knowledge gap to the eventual application of new findings in practice. Next, the reach and diversity of research collaborations (as identified through publication co-authorship) were studied to characterise the inter-disciplinary nature of heritage science and its connectedness to users. Findings showed substantial growth in international research collaborations over recent years, predominantly involving academic- and research-oriented institutions - although the engagement of heritage institutions has proportionally decreased. In addition, a worldwide survey of institutional planning and evaluation practices revealed a general reliance on processes driven by the interests of researchers - the systematic consideration of stakeholder opinion and evaluation of research outcomes being less common. Finally, a series of semi-structured interviews with senior heritage professionals explored their experience of collaborative research. The results identified key areas where strategic support is needed to promote user participation and enhance impact. These include training for research readiness, engagement, and impact for both researchers and users; better methods for needs and outcome assessment; affordable open access options and greater diversity of knowledge exchange opportunities. Finally, the need for ethical guidelines for responsible research, and greater emphasis on non-academic impact within research rating systems are discussed.
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| 4. |
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| 5. |
- Lorbek, G, et al.
(författare)
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Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury
- 2015
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5, s. 8777-
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis and inflammation, but without steatosis. The key trigger was reduced cholesterol esters that provoked cell cycle arrest, senescence-associated secretory phenotype and ultimately the oval cell response, while elevated CYP51 substrates promoted the integrated stress response. In spite of the oval cell-driven fibrosis being histologically similar in both sexes, data indicates a female-biased down-regulation of primary metabolism pathways and a stronger immune response in males. Liver injury was ameliorated by dietary fats predominantly in females, whereas dietary cholesterol rectified fibrosis in both sexes. Our data place defective cholesterol synthesis as a focus of sex-dependent liver pathologies.
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| 6. |
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| 7. |
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| 8. |
- Urlep, Z, et al.
(författare)
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Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
- 2017
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 40775-
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Tidskriftsartikel (refereegranskat)abstract
- Development of mice with hepatocyte knockout of lanosterol 14α-demethylase (HCyp51−/−) from cholesterol synthesis is characterized by the progressive onset of liver injury with ductular reaction and fibrosis. These changes begin during puberty and are generally more aggravated in the knockout females. However, a subgroup of (pre)pubertal knockout mice (runts) exhibits a pronounced male prevalent liver dysfunction characterized by downregulated amino acid metabolism and elevated Casp12. RORC transcriptional activity is diminished in livers of all runt mice, in correlation with the depletion of potential RORC ligands subsequent to CYP51 disruption. Further evidence for this comes from the global analysis that identified a crucial overlap between hepatic Cyp51−/− and Rorc−/− expression profiles. Additionally, the reduction in RORA and RORC transcriptional activity was greater in adult HCyp51−/− females than males, which correlates well with their downregulated amino and fatty acid metabolism. Overall, we identify a global and sex-dependent transcriptional de-regulation due to the block in cholesterol synthesis during development of the Cyp51 knockout mice and provide in vivo evidence that sterol intermediates downstream of lanosterol may regulate the hepatic RORC activity.
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