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Sökning: WFRF:(Käck Camilla)

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  • Elmlund, Louise, 1981-, et al. (författare)
  • Study of the Interaction of Trastuzumab and SKOV3 Epithelial Cancer Cells Using a Quartz Crystal Microbalance Sensor
  • 2015
  • Ingår i: Sensors. - : MDPI. - 1424-8220. ; 15:3, s. 5884-5894
  • Tidskriftsartikel (refereegranskat)abstract
    • Analytical methods founded upon whole cell-based assays are of importance in early stage drug development and in fundamental studies of biomolecular recognition. Here we have studied the binding of the monoclonal antibody trastuzumab to human epidermal growth factor receptor 2 (HER2) on human ovary adenocarcinoma epithelial cancer cells (SKOV3) using quartz crystal microbalance (QCM) technology. An optimized procedure for immobilizing the cells on the chip surface was established with respect to fixation procedure and seeding density. Trastuzumab binding to the cell decorated sensor surface was studied, revealing a mean dissociation constant, K-D, value of 7 +/- 1 nM (standard error of the mean). This study provides a new perspective on the affinity of the antibody-receptor complex presented a more natural context compared to purified receptors. These results demonstrate the potential for using whole cell-based QCM assay in drug development, the screening of HER2 selective antibody-based drug candidates, and for the study of biomolecular recognition. This real time, label free approach for studying interactions with target receptors present in their natural environment afforded sensitive and detailed kinetic information about the binding of the analyte to the target.
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  • Eriksson, Daniel, 1987-, et al. (författare)
  • Laboratory measurement method for the mechanical interaction between a tactile sensor and a cartonboard package – presentation and evaluation
  • 2021
  • Ingår i: Nordic Pulp & Paper Research Journal. - : Walter de Gruyter. - 0283-2631 .- 2000-0669. ; 36:1, s. 91-99
  • Tidskriftsartikel (refereegranskat)abstract
    • The importance of sensory information in product purchasing decisions has gained increasing attention in recent years. Tactile properties of packaging are usually measured with the help of trained evaluators. An objective, fast and repeatable method that describes the mechanical interaction and does not rely on a panel would have many benefits. We propose and evaluate such a method for measuring the mechanical interaction between a deformable finger-like shaped sensor and a package. Evaluation of the method shows good repeatability, the variability in the measurement result is within a few percent in most cases. The method captures indentation differences at contact between sensor and package due to measurement position and package design.
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  • Resultat 1-9 av 9

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