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1.
  • Law, Philip J., et al. (författare)
  • Association analyses identify 31 new risk loci for colorectal cancer susceptibility
  • 2019
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
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2.
  • Tossavainen, Timo, et al. (författare)
  • University mathematics students' study habits and use of learning materials
  • 2020
  • Ingår i: LUMAT International Journal of Math, Science and Technology Education. - : University of Helsinki, Finland and LUMA Centre Finland. - 2323-7104. ; 8:1, s. 252-270
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, we study a group (N=98) of students from two campuses of one Finnish university and their responses to a questionnaire that surveyed the respondents' study habits and how they use different kinds of learning materials in university mathematics courses. Our results show that the grades in the national matriculation exams in mathematics and mother tongue do not play a significant role in one's study habits or use of learning materials. The older students are more communicative with their teachers, whereas the younger students ask for help more often from fellow students. The sociomathematical norms that constitute the local study culture have a larger impact on the study habits and on the use of learning materials. For example, the use of videos and studying lecture materials before the lectures were clearly more usual at one campus than at the other. We also found some significant differences between the groups that are based on the study programmes. The students of mathematics without an intention to become a teacher were most traditional in their study habits, whereas the students of applied physics were most active to participate in teaching. The student teachers most often lie in the middle in the issues where the other groups differ from one another.
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