| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Evengard, B., et al.
(författare)
-
Healthy ecosystems for human and animal health : Science diplomacy for responsible development in the Arctic The Nordic Centre of Excellence, Clinf.org (Climate-change effects on the epidemiology of infectious diseases and the impacts on Northern societies)
- 2021
-
Ingår i: Polar Record. - : Cambridge University Press (CUP). - 0032-2474 .- 1475-3057. ; 57
-
Forskningsöversikt (refereegranskat)abstract
- Climate warming is occurring most rapidly in the Arctic, which is both a sentinel and a driver of further global change. Ecosystems and human societies are already affected by warming. Permafrost thaws and species are on the move, bringing pathogens and vectors to virgin areas. During a five-year project, the CLINF - a Nordic Center of Excellence, funded by the Nordic Council of Ministers, has worked with the One Health concept, integrating environmental data with human and animal disease data in predictive models and creating maps of dynamic processes affecting the spread of infectious diseases. It is shown that tularemia outbreaks can be predicted even at a regional level with a manageable level of uncertainty. To decrease uncertainty, rapid development of new and harmonised technologies and databases is needed from currently highly heterogeneous data sources. A major source of uncertainty for the future of contaminants and infectious diseases in the Arctic, however, is associated with which paths the majority of the globe chooses to follow in the future. Diplomacy is one of the most powerful tools Arctic nations have to influence these choices of other nations, supported by Arctic science and One Health approaches that recognise the interconnection between people, animals, plants and their shared environment at the local, regional, national and global levels as essential for achieving a sustainable development for both the Arctic and the globe.
|
|
| 9. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
Healthy ecosystems for human and animal health : Science diplomacy for responsible development in the Arctic
- 2021
-
Ingår i: Polar Record. - : Cambridges Institutes Press. - 0032-2474 .- 1475-3057. ; 57
-
Tidskriftsartikel (refereegranskat)abstract
- Climate warming is occurring most rapidly in the Arctic, which is both a sentinel and a driver of further global change. Ecosystems and human societies are already affected by warming. Permafrost thaws and species are on the move, bringing pathogens and vectors to virgin areas. During a five-year project, the CLINF - a Nordic Center of Excellence, funded by the Nordic Council of Ministers, has worked with the One Health concept, integrating environmental data with human and animal disease data in predictive models and creating maps of dynamic processes affecting the spread of infectious diseases. It is shown that tularemia outbreaks can be predicted even at a regional level with a manageable level of uncertainty. To decrease uncertainty, rapid development of new and harmonised technologies and databases is needed from currently highly heterogeneous data sources. A major source of uncertainty for the future of contaminants and infectious diseases in the Arctic, however, is associated with which paths the majority of the globe chooses to follow in the future. Diplomacy is one of the most powerful tools Arctic nations have to influence these choices of other nations, supported by Arctic science and One Health approaches that recognise the interconnection between people, animals, plants and their shared environment at the local, regional, national and global levels as essential for achieving a sustainable development for both the Arctic and the globe.
|
|
| 10. |
|
|
| 11. |
- Sohrabi, N., et al.
(författare)
-
A probabilistic-deterministic analysis of human health risk related to the exposure to potentially toxic elements in groundwater of Urmia coastal aquifer (NW of Iran) with a special focus on arsenic speciation and temporal variation
- 2020
-
Ingår i: Stochastic environmental research and risk assessment (Print). - : Springer Science and Business Media Deutschland GmbH. - 1436-3240 .- 1436-3259.
-
Tidskriftsartikel (refereegranskat)abstract
- The human exposure to groundwater contamination with toxic elements is a worldwide concern. In this study, multivariate statistics coupled with probabilistic and deterministic risk estimation approaches were applied to 173 groundwater samples of Urmia aquifer (UA) to evaluate human health risks in relation to the consumption of groundwater contaminated with toxic elements. The concentrations of aluminum (Al), barium (Ba), cadmium (Cd), copper (Cu), manganese (Mn), nickel (Ni), and zinc (Zn) were below their corresponding maximum permissible levels as advised by the WHO, USEPA, and Iranian guidelines. However, arsenic (As), lead (Pb), iron (Fe), and selenium (Se) were elevated at some locations. Monte Carlo simulation-based probabilistic risk estimation suggested ingestion as the dominant pathway for water-hosted element exposure. Mean values of hazard index estimated for As exposure from combined ingestion and dermal contact pathways exceeded the safe level of 1.0 for both adults and children, indicated potential non-carcinogenic health risks. The total cancer risk induced by groundwater As exceeded the acceptable limit of 1 × 10–4. Sensitivity analysis highlighted exposure duration, element concentration in water, and average time as the most significant variables causing the probable health risks. Speciation modeling using PHREEQC highlighted the occurrence of As(V) and As(III) in groundwater of the UA. Reductive dissolution of Fe(III) (oxyhydr)oxides and clay minerals was identified as the main controlling mechanism of As mobilization. This communication emphasizes the need for appropriate approaches in mitigating toxic element contamination of water resources in coastal parts of the UA to safeguard public health from carcinogenic and non-carcinogenic risks.
|
|
| 12. |
- Asgardoon, MH, et al.
(författare)
-
Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity
- 2020
-
Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 181:9, s. 706-714
-
Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and decreased immunoglobulin levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis. <b><i>Methods:</i></b> Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency Registry at Children’s Medical Center Hospital in Iran, 83 patients have been genetically examined and 27 patients with autoimmunity and confirmed genetic mutations were selected for analysis. Whole-exome sequencing and confirmatory Sanger sequencing methods were used for the study population. A questionnaire was retrospectively filled for all patients to evaluate demographic, laboratory, clinical, and genetic data. <b><i>Results:</i></b> In the 27 studied patients, 11 different genetic defects were identified, and the most common mutated gene was <i>LRBA</i>, reported in 17 (63.0%) patients. Two patients (7.7%) showed autoimmune complications as the first presentation of immunodeficiency. Eleven patients (40.7%) developed one type of autoimmunity, and 16 patients (59.3%) progressed to poly-autoimmunity. Most of the patients with mono-autoimmunity (<i>n</i> = 9, 90.0%) primarily developed infectious complications, while in patients with poly-autoimmunity, the most common first presentation was enteropathy (<i>n</i> = 6, 37.6%). In 13 patients (61.9%), the diagnosis of autoimmune disorders preceded the diagnosis of primary immunodeficiency. The most frequent autoimmune manifestations were hematologic (40.7%), gastrointestinal (48.1%), rheumatologic (25.9%), and dermatologic (22.2%) disorders. Patients with poly-autoimmunity had lower regulatory T cells than patients with mono-autoimmunity. <b><i>Conclusion:</i></b> In our cohort, the diagnosis of autoimmune disorders preceded the diagnosis of primary immunodeficiency in most patients. This association highlights the fact that patients referring with autoimmune manifestations should be evaluated for humoral immunity.
|
|
| 13. |
- Delbari, MT, et al.
(författare)
-
Clinical Manifestations, Immunological Characteristics and Genetic Analysis of Patients with Hyper-Immunoglobulin M Syndrome in Iran
- 2019
-
Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 180:1, s. 52-63
-
Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Hyper-immunoglobulin M (HIGM) syndrome is a rare heterogeneous group of primary immunodeficiency disorders characterized by low or absent serum levels of IgG and IgA along with normal or elevated serum levels of IgM. <b><i>Methods:</i></b> Clinical and immunological data were collected from the 75 patients’ medical records diagnosed in Children’s Medical Center affiliated to Tehran University Medical Sciences and other Universities of Medical Sciences in Iran. Among 75 selected patients, 48 patients (64%) were analyzed genetically using targeted and whole-exome sequencing. <b><i>Results:</i></b> The ratio of male to female was 2.9:1. The median age at the onset of the disease, time of diagnosis, and diagnostic delay were 10.5, 50, and 24 months, respectively. Pneumonia and lower respiratory tract infections (61.3%) were the most common complications. Responsible genes were identified in 35 patients (72.9%) out 48 ge<i>netically</i> analyzed patients. <i>Cluster of differentiation 40 ligand</i> gene was the most mutated gene observed in 24 patients (68.5%) followed by <i>activation-induced cytidine deaminase</i> gene in 7 patients, <i>lipopolysaccharide-responsive and beige-like anchor</i> (1 patient), <i>nuclear factor-kappa-B essential modulator</i> (1 patient), <i>phosphoinositide-3-kinase regulatory subunit 1</i> (1 patient), and <i>nuclear factor kappa B subunit 1</i> (1 patient) genes. Nineteen (25.3%) patients died during the study period, and pneumonia was the major cause of death occurred in 6 (31.6%) patients. <b><i>Conclusion:</i></b> Physicians in our country should carefully pay attention to respiratory tract infections and pneumonia, particularly in patients with a positive family history. Further investigations are required for detection of new genes and pathways resulting in HIGM phenotype.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
- Andersson, Erik, et al.
(författare)
-
Ambio fit for the 2020s
- 2022
-
Ingår i: Ambio. - : Springer Nature. - 0044-7447 .- 1654-7209. ; 51:5, s. 1091-1093
-
Tidskriftsartikel (refereegranskat)
|
|
| 20. |
- Asadian, S, et al.
(författare)
-
Rhenium Perrhenate (188ReO4) Induced Apoptosis and Reduced Cancerous Phenotype in Liver Cancer Cells
- 2022
-
Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 11:2
-
Tidskriftsartikel (refereegranskat)abstract
- Recurrence in hepatocellular carcinoma (HCC) after conventional treatments is a crucial challenge. Despite the promising progress in advanced targeted therapies, HCC is the fourth leading cause of cancer death worldwide. Radionuclide therapy can potentially be a practical targeted approach to address this concern. Rhenium-188 (188Re) is a β-emitting radionuclide used in the clinic to induce apoptosis and inhibit cell proliferation. Although adherent cell cultures are efficient and reliable, appropriate cell-cell and cell-extracellular matrix (ECM) contact is still lacking. Thus, we herein aimed to assess 188Re as a potential therapeutic component for HCC in 2D and 3D models. The death rate in treated Huh7 and HepG2 lines was significantly higher than in untreated control groups using viability assay. After treatment with 188ReO4, Annexin/PI data indicated considerable apoptosis induction in HepG2 cells after 48 h but not Huh7 cells. Quantitative RT-PCR and western blotting data also showed increased apoptosis in response to 188ReO4 treatment. In Huh7 cells, exposure to an effective dose of 188ReO4 led to cell cycle arrest in the G2 phase. Moreover, colony formation assay confirmed post-exposure growth suppression in Huh7 and HepG2 cells. Then, the immunostaining displayed proliferation inhibition in the 188ReO4-treated cells on 3D scaffolds of liver ECM. The PI3-AKT signaling pathway was activated in 3D culture but not in 2D culture. In nude mice, Huh7 cells treated with an effective dose of 188ReO4 lost their tumor formation ability compared to the control group. These findings suggest that 188ReO4 can be a potential new therapeutic agent against HCC through induction of apoptosis and cell cycle arrest and inhibition of tumor formation. This approach can be effectively combined with antibodies and peptides for more selective and personalized therapy.
|
|
| 21. |
|
|
| 22. |
- Bemmoussat, A., et al.
(författare)
-
Contribution of Satellite-Based Precipitation in Hydrological Rainfall–Runoff Modeling : Case Study of the Hammam Boughrara Region in Algeria
- 2021
-
Ingår i: Earth Systems and Environment. - : Springer Nature. - 2509-9426 .- 2509-9434. ; 5:4, s. 873-881
-
Tidskriftsartikel (refereegranskat)abstract
- Hydrological models are viewed as powerful tools that have a major importance for managing water resources and predicting flows. It should be specified that the meteorological parameter rainfall is the main input in these models. In the current study, data from only one rainfall station are available over the analysis domain, which cannot represent the entire Hammam Boughrara watershed of Algeria. The precipitation data remotely detected by the tropical rainfall measuring mission (TRMM) provide good spatial coverage in the watershed and can be used to fill in the missing data. The use of raw TRMM data gives poor results from the simulated flow rates with a Nash–Sutcliffe efficiency NSE equal to 0.34 for the validation period that ranges from year 2000 to 2005; this is mainly due to uncertainties in the TRMM data. For this reason, it was deemed necessary to carry out a performance test of the model. The results obtained give an unsatisfactory percent bias (PBIAS) of − 46.24%, which suggests the need to perform a correction to decrease the PBIAS of satellite precipitation. For this, two methods were used: the linear regression method and the multiplicative method. These two techniques can only be applied if there is at least one rainfall measurement station available in the watershed. The obtained results are very satisfactory since the PBIAS reaches − 0.62% for the linear regression method and − 11.58% for the multiplicative method. In addition, the use of corrected TRMMs gives also very good results with a Nash–Sutcliffe efficiency that ranges from 0.74 to 0.88 for both validation and calibration periods. Overall, the current study is supportive to estimate the satellite-based rainfall, one of the very sensitive to measure the meteorological parameter, in northwestern Algeria.
|
|
| 23. |
- Derouiche, Abderahmane, 1980, et al.
(författare)
-
Bacillus subtilisSalA is a phosphorylation-dependent transcription regulator that represses scoC and activates the production of the exoprotease AprE
- 2015
-
Ingår i: Molecular Microbiology. - : Wiley. - 1365-2958 .- 0950-382X. ; 97:6, s. 1195-1208
-
Tidskriftsartikel (refereegranskat)abstract
- Bacillus subtilisMrp family protein SalA has been shown to indirectly promote the production of the exoprotease AprE by inhibiting the expression of scoC, which codes for a repressor of aprE. The exact mechanism by which SalA influences scoC expression has not been clarified previously. We demonstrate that SalA possesses a DNA-binding domain (residues 1-60), which binds to the promoter region of scoC. The binding of SalA to its target DNA depends on the presence of ATP and is stimulated by phosphorylation of SalA at tyrosine 327. The B.subtilis protein-tyrosine kinase PtkA interacts specifically with the C-terminal domain of SalAin vivo and in vitro and is responsible for activating its DNA binding via phosphorylation of tyrosine 327. In vivo, a mutant mimicking phosphorylation of SalA (SalA Y327E) exhibited a strong repression of scoC and consequently overproduction of AprE. By contrast, the non-phosphorylatable SalA Y327F and the ΔptkA exhibited the opposite effect, stronger expression of scoC and lower production of the exoprotease. Interestingly, both SalA and PtkA contain the same ATP-binding Walker domain and have thus presumably arisen from the common ancestral protein. Their regulatory interplay seems to be conserved in other bacteria.
|
|
| 24. |
|
|
| 25. |
- Kreplin, Hanna N., et al.
(författare)
-
Arctic wetland system dynamics under climate warming
- 2021
-
Ingår i: WIREs Water. - : Wiley. - 2049-1948. ; 8:4
-
Tidskriftsartikel (refereegranskat)abstract
- Warming and hydrological changes have already affected and shifted environments in the Arctic. Arctic wetlands are complex systems of coupled hydrological, ecological, and permafrost-related processes, vulnerable to such environmental changes. This review uses a systems perspective approach to synthesize and elucidate the various interlinked responses and feedbacks of Arctic wetlands to hydroclimatic changes. Starting from increased air temperatures, subsequent permafrost thaw and concurrent hydrological changes are identified as key factors for both shrinkage and expansion of wetland area. Other diverse factors further interact with warming, hydrological changes, and permafrost thaw in altering the Arctic wetland systems. Surface albedo shifts driven by land cover alterations are powerful in reinforcing Arctic warming, while vegetation-related factors can balance and decelerate permafrost thaw, causing negative feedback loops. With the vast amounts of carbon stored in Arctic wetlands, their changes in turn affect the global carbon cycle. Overall, the systems perspectives outlined and highlighted in this review can be useful in structuring and elucidating the interactions of wetlands with climate, hydrological, and other environmental changes in the Arctic, including the essential permafrost-carbon feedback. This article is categorized under: Water and Life > Nature of Freshwater Ecosystems Water and Life > Stresses and Pressures on Ecosystems Science of Water > Water and Environmental Change.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
- Åhlen, Imenne, et al.
(författare)
-
Hydro-climatic changes of wetlandscapes across the world
- 2021
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Assessments of ecosystem service and function losses of wetlandscapes (i.e., wetlands and their hydrological catchments) suffer from knowledge gaps regarding impacts of ongoing hydro-climatic change. This study investigates hydro-climatic changes during 1976–2015 in 25 wetlandscapes distributed across the world’s tropical, arid, temperate and cold climate zones. Results show that the wetlandscapes were subject to precipitation (P) and temperature (T) changes consistent with mean changes over the world’s land area. However, arid and cold wetlandscapes experienced higher T increases than their respective climate zone. Also, average P decreased in arid and cold wetlandscapes, contrarily to P of arid and cold climate zones, suggesting that these wetlandscapes are located in regions of elevated climate pressures. For most wetlandscapes with available runoff (R) data, the decreases were larger in R than in P, which was attributed to aggravation of climate change impacts by enhanced evapotranspiration losses, e.g. caused by land-use changes.
|
|
