| 1. |
- Ehsan, Muhsan, et al.
(författare)
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Groundwater delineation for sustainable improvement and development aided by GIS, AHP, and MIF techniques
- 2024
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Ingår i: Applied water science. - : Springer Science and Business Media Deutschland GmbH. - 2190-5487 .- 2190-5495. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Exploration of groundwater is an integral part of viable resource growth for society, economy, and irrigation. However, uncontrolled utilization is mainly reported in urban and industries due to the increasing demand for water in semi-arid and arid regions of the world. In the background, groundwater demarcation for potential areas is vital in meeting necessary demand. The current study applied an integrated method comprising the analytical hierarchy process (AHP), multiple influence factors (MIF), combined with a linear regression curve and observatory well data for groundwater prospects mapping. Thematic maps such as flow direction, flow accumulation, elevation map, land use land cover, slope, soil texture, hill shade, geomorphology, normalized vegetation index, and groundwater depth map were generated utilizing remote sensing techniques. The relative weight of each parameter was estimated and then assigned to major and minor parameters. Potential zones for groundwater were classified into five classes, namely very good, good, moderate, poor, and very poor, based on AHP and MIF methods. A spatially explicit sensitivity and uncertainty analysis method to a GIS-based multi-criteria groundwater potential zone model is presented in this research. The study addressed a flaw in the way groundwater potential mapping results are typically presented in GIS-based multi-criteria decision analysis studies, where discrete class outputs are used without any assessment of their certainty with respect to variations in criteria weighting, which is one of the main contributors to output uncertainty. The study region is categorized based on inferred results as very poor, poor, marginal, and very good in potential ground quality 3.04 km2 is considered extremely poor, 3.33 km2 is considered poor, 64.42 km2 is considered very good, and 85.84 km2 is considered marginal zones, which shows reliable and potential implementation. The outcomes of AHP and MIF were validated by linear regression curve and actual water table in a study area. The study results help to formulate the potential demarcation of groundwater zones for future sustainable planning and development of groundwater sources. This study may be helpful to provide a cost-effective solution to water resources crises. The current study finding may be helpful for decision-makers and administrative professionals for sustainable management of groundwater resources for present and future demands.
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| 2. |
- Ferreiro-Iglesias, Aida, et al.
(författare)
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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
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| 3. |
- Ji, Xuemei, et al.
(författare)
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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
- 2018
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
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| 4. |
- McKay, James D., et al.
(författare)
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
- 2017
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 49:7, s. 1126-1132
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Tidskriftsartikel (refereegranskat)abstract
- Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
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