| 1. |
- Lind, Lars, et al.
(författare)
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- 2021
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Ingår i: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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| 2. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 8. |
- Nowak, G., et al.
(författare)
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Boron carbide coatings for neutron detection probed by x-rays, ions, and neutrons to determine thin film quality
- 2015
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Ingår i: Applied Physics Reviews. - : AIP Publishing. - 1931-9401. ; 117:3
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Tidskriftsartikel (refereegranskat)abstract
- Due to the present shortage of He-3 and the associated tremendous increase of its price, the supply of large neutron detection systems with He-3 becomes unaffordable. Alternative neutron detection concepts, therefore, have been invented based on solid B-10 converters. These concepts require development in thin film deposition technique regarding high adhesion, thickness uniformity and chemical purity of the converter coating on large area substrates. We report on the sputter deposition of highly uniform large-area (B4C)-B-10 coatings of up to 2 mu m thickness with a thickness deviation below 4% using the Helmholtz-Zentrum Geesthacht large area sputtering system. The (B4C)-B-10 coatings are x-ray amorphous and highly adhesive to the substrate. Material analysis by means of X-ray-Photoelectron Spectroscopy, Secondary-Ion-Mass-Spectrometry, and Rutherford-Back-Scattering (RBS) revealed low impurities concentration in the coatings. The isotope composition determined by Secondary-Ion-Mass-Spectrometry, RBS, and inelastic nuclear reaction analysis of the converter coatings evidences almost identical B-10 isotope contents in the sputter target and in the deposited coating. Neutron conversion and detection test measurements with variable irradiation geometry of the converter coating demonstrate an average relative quantum efficiency ranging from 65% to 90% for cold neutrons as compared to a black He-3-monitor. Thus, these converter coatings contribute to the development of He-3-free prototype detectors based on neutron grazing incidence. Transferring the developed coating process to an industrial scale sputtering system can make alternative He-3-free converter elements available for large area neutron detection systems. (C) 2015 AIP Publishing LLC.
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| 9. |
- Andersson, Joel B.H., et al.
(författare)
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U-Pb zircon-titanite-apatite age constraints on basin development and basin inversion in the Kiruna mining district, Sweden
- 2022
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Ingår i: Precambrian Research. - : Elsevier. - 0301-9268 .- 1872-7433. ; 372
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Tidskriftsartikel (refereegranskat)abstract
- To constrain the tectonothermal evolution of the type locality for iron oxide-apatite deposits, we have obtained U-Pb zircon, titanite, and apatite age data for the Kiruna mining district in northernmost Sweden. The results indicate that the host basin initiated in an overall extensional regime as indicated by the deposition of alluvial conglomerates and greywackes. A volcanic intercalation in a conglomerate unit northwest of the Luossavaara iron oxide-apatite deposit yields a U-Pb zircon age of 1887 ± 3 Ma representing the timing of the earliest Orosirian volcanism in the central Kiruna mining district coinciding with the onset of basin development. In-situ analysis of titanite on hydrothermally altered fracture planes within a cataclastic fault damage zone (c. 270 m from the fault core system associated to the Luossavaara iron oxide-apatite deposit) yields complex U-Pb data. Applying a strict discordance filter yields a 207Pb/206Pb age of 1889 ± 26 Ma. The age implies that the fault probably has a syn-volcanic origin and that syn-volcanic faults may have played an important role during iron ore emplacement. The mineralized basin was subsequently buried and metamorphosed under upper greenschist-facies conditions and later tectonically exhumed and cooled below the apatite closure temperature at 1805 ± 26 Ma indicated by apatite from the Nukutus iron oxide-apatite deposit. Basin inversion is temporally constrained by syn-tectonic titanite as part of sodic-calcic + Fe + Cl hydrothermal alteration along a brittle-ductile reverse shear zone to the east of the study area. Titanite grains that show sector and oscillatory zoning yield an age of 1812 ± 3 Ma, which we interpret as the onset of basin inversion. Homogeneous (relatively unzoned) titanite in the same sample yields an age of 1802 ± 8 Ma, tentatively indicating that the tectonothermal activity lasted up to c. 20 m.y.
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| 13. |
- Jansson, Nils F., et al.
(författare)
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Age constraints on c. 1.9 Ga volcanism, basin evolution and mineralization at the world-class Zinkgruvan Zn-Pb-Ag(-Cu) deposit, Bergslagen, Sweden
- 2023
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Ingår i: Precambrian Research. - : Elsevier. - 0301-9268 .- 1872-7433. ; 395
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Tidskriftsartikel (refereegranskat)abstract
- We present improved age constraints for the world-class Zinkgruvan Zn-Pb-Ag and Cu deposit: one of the largest Zn deposits of the Fennoscandian shield, and one of the earliest large, basin-hosted Zn deposits that formed from oxidized saline brines. Secondary Ion Mass Spectrometry (SIMS) U-Pb dating on zircon is used to constrain at least two phases of c. 1.9 Ga volcanism in the Zinkgruvan area, separated by a period of fluvial sedimentation, all of which predated formation of the stratiform Zn-Pb-Ag mineralization. A 1908 ± 4 Ma age for a rhyolitic rock of the first volcanic phase is the oldest recorded U-Pb zircon age of a volcanic rock in the Bergslagen lithotectonic unit (BLU) where Zinkgruvan is located. Similarly, two identical ages of 1898 ± 5 Ma for volcanic rocks belonging to the second volcanic phase indicate that the local volcanic activity, which formed the stratigraphic footwall, ended earlier in the Zinkgruvan area than in other parts of the BLU, where intense explosive felsic volcanic and intrusive activity until c. 1891 Ma has been demonstrated. This, along with a hybrid siliciclastic-volcaniclastic (tuffitic) character of the Zinkgruvan ore host, confirms earlier interpretations that the Zinkgruvan deposit formed in an actively subsiding basin, distal to active volcanic centers in the BLU in the time range 1.90–1.89 Ga. Our results support models suggesting that basinal brine-driven hydrothermal systems in sedimentary basins distal to volcanic centers could form world-class Zn deposits as early as c. 1.90 Ga.
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| 14. |
- Kamal, H., et al.
(författare)
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Long-Term Study of Hepatitis Delta Virus Infection at Secondary Care Centers: The Impact of Viremia on Liver-Related Outcomes
- 2020
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Ingår i: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 72:4, s. 1177-1190
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims Hepatitis delta virus (HDV) infection is associated with fast progression to liver cirrhosis and liver complications. Previous studies have, however, been mainly from tertiary care centers, with risk for referral bias toward patients with worse outcomes. Furthermore, the impact of HDV viremiaper seon liver-related outcomes is not really known outside the human immunodeficiency virus co-infection setting. We have therefore evaluated the long-term impact of HDV viremia on liver-related outcomes in a nationwide cohort of patients with hepatitis B and D co-infection, cared for at secondary care centers in Sweden. Approach and Results In total, 337 patients with anti-HDV positivity, including 233 patients with HDV RNA viremia and 91 without HDV viremia at baseline, were retrospectively studied, with a mean follow-up of 6.5 years (range, 0.5-33.1). The long-term risks for liver-related events (i.e., hepatocellular carcinoma [HCC], hepatic decompensation, or liver-related death/transplantation) were assessed, using Cox regression analysis. The risk for liver-related events and HCC was 3.8-fold and 2.6-fold higher, respectively, in patients with HDV viremia compared with those without viremia, although the latter was not statistically significant. Among patients with HDV viremia with no baseline cirrhosis, the cumulative risk of being free of liver cirrhosis or liver-related events was 81.9% and 64.0% after 5 and 10 years of follow-up, respectively. This corresponds to an incidence rate of 0.04 cases per person-year. Conclusions HDV RNA viremia is associated with a 3.8-fold higher risk for liver-related outcomes. The prognosis was rather poor for patients with HDV viremia without cirrhosis at baseline, but it was nevertheless more benign than previous estimates from tertiary centers. Our findings may be of importance when making decisions about treatment and evaluating potential outcomes of upcoming antivirals against HDV.
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| 15. |
- Kampmann, C., et al.
(författare)
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Composition of human faecal microbiota in resistance to Campylobacter infection
- 2016
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Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 22:1, s. 1-61
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Tidskriftsartikel (refereegranskat)abstract
- In mice, specific species composition of gut microbiota enhances susceptibility to Campylobacter jejuni but little is known about the specific composition of the human gut microbiota in providing protection from infections caused by enteropathogens. Healthy adult individuals, who travelled in groups from Sweden to destinations with an estimated high risk for acquisition of Campylobacter infection, were enrolled. Faecal samples, collected before travelling and after returning home, were cultured for bacterial enteropathogens, and analysed for Campylobacter by PCR and for the species composition of the microbiota by 16S amplicon massive parallel sequencing. The microbiota compositions were compared between persons who became infected during their travel and those who did not. A total of 63 participants completed the study; 14 became infected with Campylobacter, two with Salmonella and 47 remained negative for the enteropathogens tested. After exclusion of samples taken after antimicrobial treatment, 49 individuals were included in the final analyses. Intra-individual stability of the microbiota was demonstrated for samples taken before travelling. The original diversity of the faecal microbiota was significantly lower among individuals who later became infected compared with those who remained uninfected. The relative abundances of bacteria belonging to the family Lachnospiraceae, and more specifically its two genera Dorea and Coprococcus, were significantly higher among those who remained uninfected. The travel-related infection did not significantly modify the faecal microbiota composition. Species composition of human gut microbiota is important for colonization resistance to Campylobacter infection. Especially individuals with a lower diversity are more susceptible to Campylobacter infection.
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| 17. |
- Lange, C, et al.
(författare)
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Preventive chemotherapy for contacts of MDR-TB: is the proof in the pudding?
- 2014
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Ingår i: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. - : International Union Against Tuberculosis and Lung Disease. - 1815-7920. ; 18:11, s. 1262-1263
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 19. |
- van Oers, Lauran, et al.
(författare)
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Top-down characterization of resource use in LCA : from problem definition of resource use to operational characterization factors for dissipation of elements to the environment
- 2020
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Ingår i: The International Journal of Life Cycle Assessment. - Cham, Switzerland : Springer Nature. - 0948-3349 .- 1614-7502. ; 25:11, s. 2255-2273
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Tidskriftsartikel (refereegranskat)abstract
- PurposeThe methods for assessing the impact of using abiotic resources in life cycle assessment (LCA) have always been heavily debated. One of the main reasons for this is the lack of a common understanding of the problem related to resource use. This article reports the results of an effort to reach such common understanding between different stakeholder groups and the LCA community. For this, a top-down approach was applied.MethodsTo guide the process, a four-level top-down framework was used to (1) demarcate the problem that needs to be assessed, (2) translate this into a modeling concept, (3) derive mathematical equations and fill these with data necessary to calculate the characterization factors, and (4) align the system boundaries and assumptions that are made in the life cycle impact assessment (LCIA) model and the life cycle inventory (LCI) model.ResultsWe started from the following definition of the problem of using resources: the decrease of accessibility on a global level of primary and/or secondary elements over the very long term or short term due to the net result of compromising actions. The system model distinguishes accessible and inaccessible stocks in both the environment and the technosphere. Human actions can compromise the accessible stock through environmental dissipation, technosphere hibernation, and occupation in use or through exploration. As a basis for impact assessment, we propose two parameters: the global change in accessible stock as a net result of the compromising actions and the global amount of the accessible stock. We propose three impact categories for the use of elements: environmental dissipation, technosphere hibernation, and occupation in use, with associated characterization equations for two different time horizons. Finally, preliminary characterization factors are derived and applied in a simple illustrative case study for environmental dissipation.ConclusionsDue to data constraints, at this moment, only characterization factors for “dissipation to the environment” over a very-long-term time horizon could be elaborated. The case study shows that the calculation of impact scores might be hampered by insufficient LCI data. Most presently available LCI databases are far from complete in registering the flows necessary to assess the impacts on the accessibility of elements. While applying the framework, various choices are made that could plausibly be made differently. We invite our peers to also use this top-down framework when challenging our choices and elaborate that into a consistent set of choices and assumptions when developing LCIA methods.
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| 22. |
- Westin, Johan, 1965, et al.
(författare)
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Dismal prognosis for cirrhotic patients with hepatitis C after initial failure of direct acting anti-virals, but salvage therapy may be life-saving
- 2023
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Ingår i: Infectious Diseases. - 2374-4235. ; 55:11, s. 786-793
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundEffective direct-acting antiviral treatment against hepatitis C virus infection is available in many countries worldwide. Despite good treatment results, a proportion of patients does not respond to treatment. The aim of this study was to investigate the long-term prognosis and the outcome of salvage therapy, after an initial treatment failure, in a nation-wide real-life setting.MethodData from all adult patients registered in the national Swedish hepatitis C treatment register who did not achieve sustained virological response after initial antiviral treatment, was retrieved from 2014 through 2018.ResultsIn total, 288 patients with primary treatment failure were included, of whom 236 underwent a second treatment course as salvage therapy after a median delay of 353 (IQR: 215-650) days. Fifteen patients received a third treatment course as second salvage treatment after a further median delay of 193 (IQR: 160-378) days. One-hundred-eleven out of 124 (90%) non-cirrhotic and 62/79 (78%) cirrhotic patients achieved sustained virological response following the first salvage treatment. Sustained virological response was achieved by 108/112 (96%) patients who received a triple antiviral regimen. In total 69 patients were lost to follow-up or died waiting for salvage treatment. Baseline cirrhosis was associated with poor long-term survival.ConclusionOur study indicates that salvage therapy was effective in most patients with primary treatment failure, in particular when a triple direct acting antiviral regimen was given. To avoid the risk of death or complications, patients with primary treatment failure should be offered salvage therapy with a triple regimen, as soon as possible.
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