| 1. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Benze, Susanne, et al.
(författare)
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Making limb and nadir measurements comparable : A common volume study of PMC brightness observed by Odin OSIRIS and AIM CIPS
- 2018
-
Ingår i: Journal of Atmospheric and Solar-Terrestrial Physics. - : Elsevier BV. - 1364-6826 .- 1879-1824. ; 167, s. 66-73
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Tidskriftsartikel (refereegranskat)abstract
- Combining limb and nadir satellite observations of Polar Mesospheric Clouds (PMCs) has long been recognized as problematic due to differences in observation geometry, scattering conditions, and retrieval approaches. This study offers a method of comparing PMC brightness observations from the nadir-viewing Aeronomy of Ice in the Mesosphere (AIM) Cloud Imaging and Particle Size (CIPS) instrument and the limb-viewing Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS). OSIRIS and CIPS measurements are made comparable by defining a common volume for overlapping OSIRIS and CIPS observations for two northern hemisphere (NH) PMC seasons: NH08 and NH09. We define a scattering intensity quantity that is suitable for either nadir or limb observations and for different scattering conditions. A known CIPS bias is applied, differences in instrument sensitivity are analyzed and taken into account, and effects of cloud inhomogeneity and common volume definition on the comparison are discussed. Not accounting for instrument sensitivity differences or inhomogeneities in the PMC field, the mean relative difference in cloud brightness (CIPS - OSIRIS) is -102 +/- 55%. The differences are largest for coincidences with very inhomogeneous clouds that are dominated by pixels that CIPS reports as non-cloud points. Removing these coincidences, the mean relative difference in cloud brightness reduces to -6 +/- 14%. The correlation coefficient between the CIPS and OSIRIS measurements of PMC brightness variations in space and time is remarkably high, at 0.94. Overall, the comparison shows excellent agreement despite different retrieval approaches and observation geometries.
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| 3. |
- Braekeveldt, Noémie, et al.
(författare)
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Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma
- 2018
-
Ingår i: Cancer Research. - 0008-5472. ; 78:20, s. 5958-5969
-
Tidskriftsartikel (refereegranskat)abstract
- Patient-derived xenografts (PDX) and the Avatar, a single PDX mirroring an individual patient, are emerging tools in preclinical cancer research. However, the consequences of intratumor heterogeneity for PDX modeling of biomarkers, target identification, and treatment decisions remain underexplored. In this study, we undertook serial passaging and comprehensive molecular analysis of neuroblastoma orthotopic PDXs, which revealed strong intrinsic genetic, transcriptional, and phenotypic stability for more than 2 years. The PDXs showed preserved neuroblastoma-associated gene signatures that correlated with poor clinical outcome in a large cohort of patients with neuroblastoma. Furthermore, we captured spatial intratumor heterogeneity using ten PDXs from a single high-risk patient tumor. We observed diverse growth rates, transcriptional, proteomic, and phosphoproteomic profiles. PDX-derived transcriptional profiles were associated with diverse clinical characteristics in patients with high-risk neuroblastoma. These data suggest that high-risk neuroblastoma contains elements of both temporal stability and spatial intratumor heterogeneity, the latter of which complicates clinical translation of personalized PDX-Avatar studies into preclinical cancer research.
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| 4. |
- Bylund, Johan, 1975, et al.
(författare)
-
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
- 2004
-
Ingår i: BMC cell biology. - 1471-2121. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by uncoupling GCPR from the cytoskeleton. The receptor uncoupling results in respiratory burst activity when signals generated by reactivated formyl peptide receptors trigger the NADPH-oxidase to produce superoxide anions. RESULTS: Tumor necrosis factor alpha (TNF-alpha) primes neutrophils for subsequent activation by cytochalasin B. Pretreatment with TNF-alpha induced mobilization of receptor-storing neutrophil organelles, suggesting that receptor up-regulation significantly contributes to the response, but the receptor mobilization was not sufficient for induction of the cytochalasin B sensitive state. The TNF-alpha primed state resembled that of the desensitized non-signaling state of agonist-occupied neutrophil formyl peptide receptors. The fact that the TNF-alpha primed, cytochalasin B-triggered activation process was pertussis toxin sensitive suggests that the activation process involves a GPCR. Based on desensitization experiments the unidentified receptor was found to be distinct from the C5a receptor as well as the formyl peptide receptor family members FPR and FPRL1. Based on the fact the occupied and desensitized receptors for interleukin-8 and platelet activating factor could not be reactivated by cytochalasin B, also these could be excluded as receptor candidates involved in the TNF-alpha primed state. CONCLUSIONS: The TNF-alpha-induced priming signals could possibly trigger a release of an endogenous GPCR-agonist, amplifying the response to the receptor-uncoupling effect of cytochalasin B. However, no such substance could be found, suggesting that TNF-alpha can transfer G-protein coupled receptors to a signaling state independently of agonist binding.
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| 5. |
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| 6. |
- Carmont, Michael R, 1972, et al.
(författare)
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The reliability, reproducibility and utilization of the radiographic Achilles Tendon Loading Angle in the management of Achilles Tendon rupture.
- 2021
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Ingår i: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons. - : Elsevier BV. - 1460-9584. ; 27:7, s. 760-766
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Tidskriftsartikel (refereegranskat)abstract
- During management of Achilles tendon rupture, determination of tendon-end approximation, either clinically or by ultrasound is difficult, following brace application of during loading. The Radiographic Achilles Tendon Loading Angle (RadATLA) is proposed as a method of measuring ankle position whilst loading in a brace during the management of Achilles tendon rupture. This study aims to determine the reliability and reproducibility of the RadATLA.A loaded true lateral ankle radiograph including the fifth metatarsal head was taken when wearing a brace at the 6-week time point in 18 patients (19 ankles). following Achilles tendon repair or reconstruction. The RadATLA was compared with the Tibio-talar angle, other radiographic and clinical measures used to quantify foot and ankle position during the first 6 weeks of early rehabilitation in a resting position and during loading.The intra-rater reliability of both angles was found to be good (>0.8). The RadATLA was found to have an excellent intra-rater reliability with Intra-class correlation of (ICC) 0.992-0.996 (95%CI 0.889-0.999), standard error of the measurement (SEM) 1.03-3.65 and Minimal Detectable Change (MDC) 2.86-10.12. The inter-rater reliability was good with ICC of 0.798-0.969 (95%CI-0.03 to 0.964), SEM 2.9-7.6, and MDC 8.1-20.9. The RadATLA loaded at 6 weeks in all patients was at mean (SD) (range) 41.9˚ (16.5), (18.5-75.9). There was a significant difference between the patients in the Repair group compared with patients in the Reconstruction group both in RadATLA loaded at 6 weeks: 35.6˚ (11.2), (18.5-56.5) versus 55.5˚ (19), (20-75.9), (p = 0.01). The amount loaded in all patients was at mean (SD) (range) 29.2Kg (17.7), (2-56) and the percentage Body Weight was 30.7% (19), (2.1-63.2). There were no differences between the groups neither in amount loaded nor in percentage Body weight (p = 0.614-0.651).The RadATLA is a reliable and reproducible angle and can be used to determine the position of the ankle, when loaded in a brace during rehabilitation following Achilles tendon rupture.
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| 7. |
- Delsing, Jerker, et al.
(författare)
-
Low-pressure gap discharge ultrasonic gas flowmeter
- 2010
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Ingår i: The 15th International Flow Measurement Conference. ; , s. 259-266
-
Konferensbidrag (refereegranskat)abstract
- Low-pressure gas measurements are of increasing interest in the process industry for both control purposes and emission measurements. Industrial measurement environments include some very challenging components, such as:- Dust, particles, vapor, water droplets, etc.- Temperatures up to 1200°C- Pipe diameters of 1 to 10 mUltrasound flow measurement techniques have many advantages for such industrial measurement problems. Currently, a major problem is the lack of transducer technology that is sufficiently robust to operate in the presence of the above given industrial components. For the purpose of producing more robust technology, a gap discharge sound transmitter has been developed [1, 2]. Theoretical and experimental studies of the gap discharge transmitter indicate that flow measurement performances in the range of 1-2% of the actual flow is achievable [3]. Based on this gap discharge transmitter, an experimental ultrasound gas flowmeter was designed. The design features a gap discharge transmitter and piezo-based receivers. The design was tested in a real industrial environment. The test environment included heavy dust and water vapor in an exhaust pipe at a pelletization plant at LKAB, Kiruna, Sweden. The pipe diameter is 3 m, the pressure is ambient, and the gas flow speed is in the range of 5-20 m/s. The flow conditions were highly turbulent, using a straight pipe length ten times the pipe diameter in front of the experimental flowmeter. This paper presents the experimental gap discharge ultrasonic flowmeter design, the experimental setup and some measurement data. These data indicate that the gap discharge transmitter is feasible for operation in an industrial environment. Further preliminary flow measurement data demonstrate the feasibility of using a gap discharge transmitter as the sound-emitting source in an ultrasonic gas flowmeter.
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| 8. |
- Edvardsson, Sverker, et al.
(författare)
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corr3p_tr : A particle approach for the general three-body problem
- 2016
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Ingår i: Computer Physics Communications. - : Elsevier BV. - 0010-4655 .- 1879-2944. ; 200, s. 259-273
-
Tidskriftsartikel (refereegranskat)abstract
- This work presents a convenient way to solve the non-relativistic Schrodinger equation numerically for a general three-particle system including full correlation and mass polarization. Both Coulombic and non-Coulombic interactions can be studied. The eigensolver is based on a second order dynamical system treatment (particle method). The Hamiltonian matrix never needs to be realized. The wavefunction evolves towards the steady state solution for which the Schrodinger equation is fulfilled. Subsequent Richardson extrapolations for several meshes are then made symbolically in matlab to obtain the continuum solution. The computer C code is tested under Linux 64 bit and both double and extended precision versions are provided. Test runs are exemplified and, when possible, compared with corresponding values in the literature. The computer code is small and self contained making it unusually simple to compile and run on any system. Both serial and parallel computer runs are straight forward. Program summary Program title: corr3p_tr Catalogue identifier: AEYR_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEYR_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.ukilicence/licence.html No. of lines in distributed program, including test data, etc.: 15025 No. of bytes in distributed program, including test data, etc.: 156430 Distribution format: tar.gz Programming language: ANSI C. Computer: Linux 64bit PC. Operating system: Linux 64bit. RAM: 300 M bytes Classification: 2.7, 2.8, 2.9. Nature of problem: The Schrodinger equation for an arbitrary three -particle system is solved using finite differences and a fast particle method for the eigenvalue problem [20, 21, 23]. Solution method: A fast eigensolver is applied (see Appendix). This solver works for both symmetrical and nonsymmetrical matrices (which opens up for more accurate nonsymmetrical finite difference expressions to be applied at the boundaries). The three-particle Schrodinger equation is transformed in two major steps. First step is to introduce the function Q(r(1), (r)2, mu) = r(1)r(2)(1 - mu(2))phi(r(1), r(2), mu), where mu = cos (0(12)). The cusps (r(1) = r(2), mu = 1) are then transformed into boundary conditions. The derivatives of Qare then continuous in the whole computational space and thus the finite difference expressions are well defined. Three-particle coalescence (r(1) = r(2) = 0, mu) is treated in the same way. The second step is to replace Q(r(1), r(2), mu) with (2,root x(1)x(2))(-1)Q(x(1) x(2), mu). The space (x(1), x(2), mu) is much more appropriate for a finite difference approach since the square roots x(1) = root r(1), x(2) = root r(2) allow the boundaries to be much further out. The non-linearity of the x-grid also leads to a finer description near the nucleus and a coarser one further out thus resulting in a saving of grid points. Also, in contrast to the usual variable r(12), we have instead used mu which is an independent variable. This simplifies the mathematics and numerical treatments. Several different grids can naturally run completely independent of each other thus making parallel computations trivial. From several grid results the physical property of interest is extrapolated to continuum space. The extrapolations are made in a matlab m-script where all computations can be made symbolically so the loss of decimal figures are minimized during this process. The computer code, including correlation effects and mass polarization, is highly optimized and deals with either triangular or quadratic domains in (x(1), x(2)). Restrictions: The amount of CPU time may become unreasonable for states needing boundary conditions very far beyond the origin. Also if the condition number of the corresponding Hamiltonian matrix is very high, the number of iterations will grow. The use of double precision computations also puts a limit on the accuracy of extrapolated results to about 6-7 decimal figures. Unusual features: The numerical solver is based on a particle method presented in [20, 21, 23]. In the Appendix we provide specific details of dealing with eigenvalue problems. The program uses a 64 bit environment (Linux 64bit). Parallel runs can be made conveniently through a simple bash script. Additional comments: The discretized wavefunction is complete on every given grid. New interactions can therefore conveniently be added to the Hamiltonian without the need to seek for an appropriate basis set. Running time: Given a modern CPU such as Intel core i5 and that the outer boundary conditions of r(1) and r(2) is limited to, say 16 atomic units, the total CPU time of totally 10 grids of a serial run is typically limited to a few minutes. One can then expect about 6-7 correct figures in the extrapolated eigenvalue. A single grid of say h(1) = h(2) = h(3) = 1/16 converges in less than 1 s (with an error in the eigenvalue of about 1 percent). Parallel runs are possible and can further minimize CPU times for more demanding tasks. References: [20] S. Edvardsson, M. Gulliksson, and J. Persson.). Appl. Mech. ASME, 79 (2012) 021012. [21] S. Edvardsson, M. Neuman, P Edstrom, and H. Olin. Comp. Phys. Commun. 197 (2015) 169. [23] M. Neuman, S. Edvardsson, P. Edstrom, Opt. Lett. 40 (2015) 4325.
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| 9. |
- Hagvall, Kristoffer, 1985-
(författare)
-
Characterization of aluminum in environmental systems using X-ray absorption and vibrational spectroscopy : The importance of organic matter
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The fate and behavior of many metals in the environment are highly dependent on interactions with natural organic matter (NOM), which is abundant in most soils and surface waters. The complexation with NOM can influence the speciation of the metals by affecting their hydrolysis and solubility. This in turn will also have an effect on the mobility and potential toxicity of the metals. For aluminum (Al) these interactions are of high environmental importance since Al have been shown to have negative effects on plant growth, water living organisms, and fish.This thesis will focus on the interactions between Al(III) and NOM in different environments and under varying geochemical conditions. To study this, infrared (IR) spectroscopy and X-ray absorption spectroscopy (XAS) have primarily been used. Due to the difficulties in analyzing Al using XAS, gallium(III), shown to be a suitable analogue for Al(III), was used as a probe to get complementary information from the Ga(III)-NOM system. The combined results from these studies showed that Ga(III) and Al(III) formed strong chelate complexes with carboxylic groups in NOM and that these complexes were strong enough to suppress the hydrolysis and polymerization of the metals. Furthermore, Al in organic soil and stream water samples was also studied using XAS and the results showed a variation in the speciation from a predominance of organically complexed Al(III) in the stream waters to a mixture of Al(III)-NOM complexes and precipitated Al phases (Al-hydroxides and/or Al-silicates) in the organic soils. To further study mineral-NOM interactions the effects of NOM on the dissolution of gibbsite (g-Al(OH)3(s); a common mineral in the environment) were investigated. The results showed that NOM can promote mineral dissolution and presence of inner-sphere Al(III)-NOM species on the gibbsite surface, detected by IR spectroscopy, could indicate a ligand induced dissolution. To further investigate the structure of the complex formed at the surface of the mineral, an EXAFS study was conducted on the ternary Ga(III)-NOM-gibbsite system. The results indicated either formation of inner-sphere complexes with Ga(III) acting like a bridge between NOM and the gibbsite surface, or the presence of two separate species; Ga(III)-NOM complexes in solution and a precipitated Ga(OH)3(s) phase.As a sidetrack to the Al(III)-NOM studies, a new way of characterizing NOM was developed using simultaneous infrared and potentiometric titrations, multivariate data analysis, and chemical equilibrium modeling. An acid/base model for a fulvic acid was constructed, based on spectroscopic information about functional groups and their pKa values, and indicated that the fulvic acid is to be regarded as a tetra carboxylic acid consisting of at least four fractions of carboxylic acids. This demonstrates new possibilities to study the acid/base and metal complexing properties of NOM, in which the presence of carboxylic acid groups predominate, and to design equilibrium models more reliable than presented before.
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| 10. |
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| 11. |
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| 12. |
- Hagvall, Kristoffer, et al.
(författare)
-
Speciation of aluminum in soils and stream waters: The importance of organic matter
- 2015
-
Ingår i: Chemical Geology. - : Elsevier BV. - 0009-2541 .- 1872-6836. ; 417, s. 32-43
-
Tidskriftsartikel (refereegranskat)abstract
- Aluminum (Al) is the most common metal in the Earth's crust, and exists mainly in the form of silicates, oxides and hydroxides, or in complexes with natural organic matter (NOM) or inorganic ligands. Since speciation is a key factor for understanding the environmental impact of Al, it is important to determine the chemical forms of Al that predominate in different natural media and under varying geochemical conditions. This study investigated how complexation with NOM influenced the speciation of Al(III) in different environmental samples (isolated aquatic NOM, organic soils and stream waters) using X-ray absorption spectroscopy (XAS) and Infrared (IR) spectroscopy. The combined spectroscopic results showed that Al(III) formed mononuclear complexes with carboxylic functional groups in NOM that were sufficiently stable to suppress the hydrolysis and polymerization of Al(III). These organic Al complexes were favored at slightly acidic pH values between pH 3 and 6 and at decreasing Al concentrations. The XAS results of the organic soils and the stream water samples indicated a variation in the speciation from a predominance of organically complexed Al in the stream waters to a mixture of Al-NOM complexes and precipitated Al phases (Al hydroxides and/or Al silicates) in the organic soils. Although the presented XAS results were limited by relatively low signal-to-noise caused by the low K-edge energy of Al, the combined spectroscopic results provided new and useful information about Al in different environmental samples and showed that NOM and pH are important parameters controlling the speciation of Al. (C) 2015 Elsevier B.V. All rights reserved.
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| 13. |
- Hagvall, Kristoffer, et al.
(författare)
-
Spectroscopic characterization of the coordination chemistry and hydrolysis of gallium(III) in the presence of aquatic organic matter
- 2014
-
Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier BV. - 0016-7037 .- 1872-9533. ; 146, s. 76-89
-
Tidskriftsartikel (refereegranskat)abstract
- Interactions between metals and natural organic matter (NOM) are of great environmental importance and one of the key factors influencing hydrolysis, solubility, and speciation of the metals. However, studying geochemically relevant metals like Al, Fe, and Cu is sometimes associated with analytical problems; for example Fe and Cu are both redox active. Gallium (Ga) is a non-redox active metal that usually occurs at very low concentrations in environmental samples and therefore a wide concentration range of metal(III)-NOM species can be explored by adding Ga(III) to such samples. This makes Ga(III) a good probe and analogue for other metal ions, in particular Al. In addition, due to the increased usage of Ga in society, a better understanding of how Ga interacts with NOM is of importance but such studies are scarce. In this work, Ga(III) interactions with two different organic materials (Suwannee River natural organic matter and Suwannee River fulvic acid) were studied using infrared (IR) and extended X-ray absorption fine structure (EXAFS) spectroscopy in a large experimental range (101-84,076 mu g Ga g(-1) dry weight; pH 3-8). Our IR spectroscopic results showed that Ga(III) is bonded mainly to carboxylic functional groups and suggested that only a fraction of the total number of carboxylic sites in the samples was actively involved in the bonding. Modeling of the EXAFS data revealed that Ga(III) formed mononuclear chelate complexes with NOM that strongly suppressed the hydrolysis and polymerization of Ga(III). At low Ga(III) concentrations (1675-16,649 mu g g(-1)) organic complexes, consisting of 1-3 chelate ring structures, were the dominating species in the entire pH range while at higher concentrations (67,673-84,076 mu g g(-1), pH 3.0-7.0) we detected mixtures of mononuclear organic Ga(III) complexes, Ga(III) (hydr) oxide, and free Ga(III) (here defined as the hydrated Ga(III) ion and its soluble hydrolysis products). Moreover, the EXAFS results showed significantly higher contribution from second-shell C atoms (9-11) for the Ga(III)-organic complexes at the lowest concentration (101-125 mu g g(-1), pH 4.9-5.1), indicating formation of cage-like structures similar to Ga(III)-EDTA. Our combined results showed that Ga(III)-NOM interactions can be of importance for the solubility and speciation of Ga in environmental systems. Furthermore, the similarities between Ga(III) and previous Fe(III) results demonstrate that Ga(III) can be utilized as a probe for metal(III)-NOM interactions over an extended experimental range (e. g., pH and metal concentration) and thereby improve our knowledge about these interactions in general. (C) 2014 Elsevier Ltd. All rights reserved.
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| 14. |
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| 15. |
- Holt, Kristoffer, 1976-, et al.
(författare)
-
Edited participation : A comparative study of editorial influence on three online news media in Sweden
- 2010
-
Konferensbidrag (refereegranskat)abstract
- Although participatory journalism often involves the publishing of content created by users, editorial influence is an important aspect of the emerging participatory online mediascape. The choices that editors make shape the conditions under which user generated content is produced, the immediate context of publication and the perceived prominence of the published content. The question is how this influence manifests itself, and how this can be related to the discussion about participatory media’s potential for revitalizing democracy. In this paper, three online news media in Sweden are analysed comparatively: Sourze – one of the first Swedish sites that invited citizens as primary contributors; Newsmill – a social media focusing on news and debate; and DN – the online version of the largest Swedish morning paper Dagens Nyheter. The question is how participation is affected by editorial influence.The findings suggest that participatory arenas to some extent are constrained by the logic of their context of production. Participation is not the same for everyone, and people from different categories in society participate on different terms. Furthermore, editors influence the agenda by suggesting topics, and by rewarding articles that follow their suggestions. These findings do not challenge assumptions about participatory newspapers as more accessible channels for citizens to publish content, and therefore interesting as possible means of allowing a more democratically involved citizenry, but it challenges assumptions about freedom from constraints related to traditional mass media, such as agenda setting, gate-keeping and media logic.
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| 16. |
- Holt, Kristoffer, 1976-, et al.
(författare)
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Edited participation comparing editorial influence on traditional and participatory online newspapers in Sweden
- 2011
-
Ingår i: Javnost - The Public. - 1318-3222. ; 18:2, s. 19-36
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Tidskriftsartikel (refereegranskat)abstract
- Although participatory journalism involves publishing content created by users, editorial influence is an important aspect of participatory online media. Editors shape the conditions under which user generated content is produced, the context of publication and the perceived prominence of the content. It is still unclear how this influence manifests itself, and how it can be related to the discussion about participatory media’s potential for revitalising democracy. In this paper, three online news media in Sweden are analysed comparatively: Sourze – the first Swedish participatory newspaper; Newsmill – a social media focusing on news and debate; and DN – the online version of the largest Swedish morning paper Dagens Nyheter. The question is how participation is affected by editorial influence. The findings suggest that participatory arenas are constrained by the logic of their context of production. People from different categories in society participate on different terms. Furthermore, editors influence the agenda by suggesting topics, and by rewarding articles that follow their suggestions. These fi ndings do not challenge assumptions about participatory newspapers as more accessible channels for citizens and therefore interesting as possible means of allowing a more democratically involved citizenry, but it challenges assumptions about freedom from constraints related to traditional mass media, such as agenda setting, gate-keeping and media logic.
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| 17. |
- Holt, Kristoffer, et al.
(författare)
-
How are citizen journalists telling news? The Swedish case
- 2013
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Konferensbidrag (refereegranskat)abstract
- Previous research on citizen journalism has an Anglo-Saxon bias and frequently studies specific cases that focus on conflict, crisis events or war creating a selection bias of existing and, at least modestly, successful examples. In this study, situated in Sweden, we reverse the process and examine how actual communities are served by digital citizen community journalism in an everyday context. The study has a particular focus on how events are portrayed in terms of news topics dimensions, framing, presentation style, geographical focus and the authorship of news items. Preliminary findings indicate that the citizen journalists’ only present one perspective, rarely refers to policy plans or talks to the actors involved and provide individual and episodic news frames. Their focus is mostly on the local level and they have embraced the impersonal and unemotional presentation style from mainstream news. Half of the news items are being written by citizens while representatives from organisations or politicians author a quarter of them. All in all, citizen journalism in general falls short from both traditional journalistic standards and many scholarly claims of being alternative.
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| 18. |
- Holt, Kristoffer, 1976-, et al.
(författare)
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How are citizen journalists telling the news? : An inventory of Swedish online citizen journalism sites
- 2013
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Ingår i: Nordmedia 2013.
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Konferensbidrag (refereegranskat)abstract
- In this study, situated in Sweden, we examine what actual communities that are served by digital citizen community journalism in an everyday context. The results show that there are very few cases of citizen journalism and that they are situated in the same legacy media logic that they allegedly should be an alternative to. Moreover, the study shows that the citizen journalists focus on business news, entertainment and sports and do not cover local authorities. When sources are used they are few and originate from social institutions such as business, media, authorities and politics rather than citizens. All in all, this empirical study suggests that the reality of citizen journalism fall very short from the expectations expressed in much of the scholarly debate.
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| 19. |
- Holt, Kristoffer, 1976-, et al.
(författare)
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Om journalistikens existentiella kris : behövs verkligen journalister när vem som helst kan bli publicist?
- 2014
-
Ingår i: IKAROS tidskrift om människan och vetenskapen. - Åbo : Fbf. Folkets Bildningsförbund, Finland. - 1796-1998. ; 11:3-4, s. 5-7
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Aldrig förr har journalister tagit så mycket så mycket plats i offentligheten som i våra dagar. Exempel: Valrörelserna 2014 i Sverige prägla(de)s i högre utsträckning än någonsin tidigare av en ohejdad journalistisk kommentarlusta. Ett typiskt nyhetsinslag innehåller ofta ett kort uttalande av någon politiker, följt av en lång diskussion med kanalens politiska kommentatorer. Klyftan mellan de politiska partierna och den intet ont anande allmänheten fylls till bredden av journalistisk analys, tyckande, reflekterande och debatt med andra journalister. Många har frågat sig om vi medborgare verkligen får en chans att fundera själva över vad politikerna egentligen menar, innan en journalistisk expert har hunnit förklara det oss. Samtidigt pågår en annan utveckling journalistiken befinner sig 1 sedan cirka ett decennium tillbaka i en existentiell kris.2 Just nu pågår en fas som präglas av ett stort behov av att definiera vad en journalist egentligen är, varför de finns och vilken uppgift de förvänts fylla i samhället. Anledningen är att den teknologiska utveckingen, parallellt med stora ekonomiska svårigheter för många mediehus, skapat helt nya förutsättningar för en verksamhet som under decennier präglats av rutin och förutsägbarhet.3 Mitt i detta skeende dyker de sociala medierna upp, där bloggare och twittrare utan journalistisk skolning tävlar med de professionella journalisterna om att tycka och tänka – och inte minst att leverera nyheter.
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| 20. |
- Holt, Kristoffer, et al.
(författare)
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Participatory Journalism and Editorial Influence
- 2011
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Ingår i: Communication @ the Center. - : International Communication Association.
-
Konferensbidrag (refereegranskat)abstract
- Although participatory journalism involves publishing content created by users, editors shape the conditions under which user generated content is produced; the context of publication and the perceived prominence of the content. In this paper, three online news media in Sweden are analysed comparatively: Sourze – the first Swedish participatory newspaper; Newsmill – a social media focusing on news and debate; and DN – the online version of the Dagens Nyheter. The question is how participation is affected by editorial influence.Findings suggest that participatory arenas are constrained by the logic of their context of production. People from different categories in society participate on different terms. Furthermore, editors influence the agenda by suggesting topics, and by rewarding articles that follow their suggestions. This challenges assumptions about freedom from constraints related to traditional mass media, such as agenda setting, gate-keeping and media logic.
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| 21. |
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| 22. |
- Holt, Kristoffer, 1976-, et al.
(författare)
-
Random acts of journalism? : How citizen journalists tell the news in Sweden
- 2015
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Ingår i: New Media and Society. - : SAGE Publications. - 1461-4448 .- 1461-7315. ; 17:11, s. 1795-1810
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Tidskriftsartikel (refereegranskat)abstract
- In this study, the results from a content analysis of four Swedish online citizen journalism outlets are presented and discussed. The analysis focuses on new digital venues for news-making in theory and the question of the political relevance of citizen journalism in reality. This broad question is operationalized by asking more specifically how citizen journalists tell the news, according to established distinctions between variations in topic dimensions, focus, and presentational style. Our results show that citizen journalists tend to tell soft news. They rarely report on policy issues, local authorities, or people affected by decisions being made by them. Furthermore, the news focuses on individual relevance and is mostly episodic in nature. The style of writing is predominantly impersonal and unemotional. In sum, our results suggest that citizen journalism in Sweden is not yet at a stage where it can be considered a plausible alternative to traditional journalism.
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| 23. |
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| 24. |
- Karlsson, Jennie, 1979, et al.
(författare)
-
Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors
- 2005
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Ingår i: Journal of leukocyte biology. - : Oxford University Press (OUP). - 0741-5400 .- 1938-3673. ; 78:3, s. 762-71
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Tidskriftsartikel (refereegranskat)abstract
- Truncation of the N-terminal part of the calcium-regulated and phospholipid-binding protein annexin AI has been shown to change the functional properties of the protein and to generate immunoregulatory peptides. Proinflammatory as well as anti-inflammatory signals are triggered by these peptides, and the two formyl peptide receptor (FPR) family members expressed in neutrophils, FPR and FPR-like 1 (FPRL1), have been suggested to transduce these signals. We now report that an annexin AI peptide (Ac9-25) activates, as well as inhibits, the neutrophil release of superoxide anions. Results obtained from experiments with receptor antagonists/inhibitors, desensitized cells, and transfected cells reveal that the Ac9-25 peptide activates the neutrophil reduced nicotinamide adenine dinucleotide phosphate oxidase through FPR but not through FPRL1. The Ac9-25 peptide also inhibits the oxidase activity in neutrophils triggered, not only by the FPR-specific agonist N-formyl-Met-Leu-Phe but also by several other agonists operating through different G protein-coupled receptors. Our data show that the two signals generated by the Ac9-25 peptide are transmitted through different receptors, the inhibitory signal being transduced by a not-yet identified receptor distinct from FPR and FPRL1.
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| 25. |
- Karlsson, Kristoffer
(författare)
-
Gap discharge transducers applied to ultrasonic flow measurement
- 2012
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, the potential of the gap discharge transducer is investigated as both a sound pulse emitter and a sound pulse receiver in a gas flow measurement setup. The main objective is to use the gap discharge transducer as an integral part in a gas flow measurement system developed for harsh environments. The idea for the method considered in this study to determine the flow was taken from the time-of-flight technique used in ultrasonic flow measurements. The gap discharge transducer should then be used as both an emitter and a receiver in a setup that somewhat mimics those in ultrasonics. Earlier studies with the gap discharge transducer has shown that it is both very durable and a potent sound pulse emitter. This thesis continues these studies by incorporating the transducer into a measurement system as an emitter and also investigates its capabilities to be used as a sound pulse receiver. As an emitter in a flow measurement system the transducer was placed in a pipe with a variable flow in a laboratory environment. The transducer was set to generate sparks to create the sound pulse and standard piezoelectric receivers were used to capture the signal.To determine the possibilities to use the transducer as a receiver the transducer was placed in a vacuum chamber to test the dependence between breakdown voltage and pressure. Since a sound pulse is a change in pressure the pulse might cause breakdown in the gap between the electrodes of the transducer if an initial voltage between the electrodes is set close enough to breakdown. The investigation shows that the gap discharge transducer is a potential sound pulse emitter in a flow measurement system and, with some small calibration and more precise alignment, is capable to determine the flow quite accurately. On the other hand, to use the transducer as a receiver is concluded to be very difficult. The breakdown voltage is too unstable to allow an initial voltage close to breakdown to be set without risking spontaneous breakdown due to random events.
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| 26. |
- Karlsson, Kristoffer
(författare)
-
Gap Discharge Transducers in a Transit Time Flow Measurement System Designed for Harsh Environments
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, the potential of the gap discharge transducer is investigated as transducers in a time-of-flight gas flow measurement setup designed for harsh environments.In this thesis the gap discharge transducer is operated in two different modes, named spark discharge transducer and glow discharge transducer. The spark discharge transducer generates a spark over a gap while the glow discharge transducer generates a continuous glow discharge.Earlier studies show that the spark discharge transducer is very durable and a potent sound pulse emitter. This thesis continues these studies by incorporating the spark discharge transducer into a flow measurement system as a sound pulse emitter. Further more, the gap discharge transducer is investigated as a potential sound pulse receiver.As an emitter in a flow measurement system the spark discharge transducer was placed in a pipe with a variable flow in a laboratory environment. The transducer was set to generate sparks to create the sound pulse and standard piezoelectric receivers were used to capture the signal.As a receiver, the gap discharge transducer was tested in two experiments. In the first experiment the spark discharge transducer was placed in a vacuum chamber to test the dependence between breakdown voltage and pressure. The pressure change from a sound pulse might cause breakdown in the gap of the transducer if an initial voltage between the electrodes is set close enough to breakdown. The breakdown leads to a spark which can be used to determine when a sound pulse arrives. In the second experiment the transducer was set to generate a glow discharge. The glow discharge was then subjected to a sound source. The voltage and current of the glow discharge depends on the environmental conditions in the gap. Pressure changes from a sound pulse will then affect the air in the gap which in turn changes the voltage and current characteristics of the discharge. The change in voltage and/or current can then be used to determine when a sound pulse has arrived.The investigation shows that the spark discharge transducer is a potential sound pulse emitter in a flow measurement system and could be capable of determining a flow quite accurately. As a receiver, the spark discharge transducer show limited potential. The pressure change of a spark generated sound pulse requires the receiver to be set very close to the breakdown voltage. But that close to the determined breakdown voltage will very often cause the gap to breakdown spontaneously. The glow discharge transducer, on the other hand, show promising potential. The transducer is proven to be able to receive sound waves and has a sensitivity that is deemed compatible with the spark discharge transducer as a sound pulse emitter.
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| 27. |
- Karlsson, Kristoffer, et al.
(författare)
-
The gap discharge transducer as a sound pulse emitter in an ultrasonic gas flow meter
- 2013
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Ingår i: 16th International Flow Measurement Conference 2013 (FLOMEKO 2013). - Red Hook, NY : Curran Associates, Inc.. - 9781629938189 ; , s. 472-478
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Konferensbidrag (refereegranskat)abstract
- In this paper the gap discharge transducer is used as a sound pulse emitter in an ultrasonic flow measurement setup to determine its capabilities to measure a gas flow. An industrial fan and a 3 m long pipe with diameter 62 cm was used to create a flow scenario. The gap discharge transducer was placed between two standard piezoelectric receivers to mimic an ultrasonic flow meter setup. A hot-wire anemometer was used as reference. The gap discharge transducer shows good potential as a sound pulse emitter in a flow measurement setup if more care is taken in aligning the system
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| 28. |
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| 29. |
- Karlsson, Michaela Elisabeth, et al.
(författare)
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“Knowing That This Is My Place Is Very Positive” : The Case of a Swedish Table Tennis Club
- 2021
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Ingår i: Case Studies in Sport and Exercise Psychology. - Champaign, IL : Human Kinetics. - 2470-4849 .- 2470-4857. ; 5:1, s. 154-163
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Tidskriftsartikel (refereegranskat)abstract
- This case study is guided by the holistic ecological approach and aimed at (a) providing a holistic description of an athletic talent development environment using a table tennis club in Sweden as a case study and (b) examining the factors perceived as influential to the effectiveness of the club’s talent development. The holistic ecological approach’s two working models informed the data collection (through interviews, observation, and analysis of documents) and were subsequently transformed into empirical models, acting as a summary of the case. Findings revealed that the environment’s success in talent development can be seen as an outcome of the following key features: (a) flexible and supportive training groups, (b) opportunities to learn from senior elite athletes, (c) support through the club and sport-friendly schools, (d) support of the development of psychosocial skills, (e) regular and intensive training, (f) focus on long-term development and athletes as whole persons, (g) strong and coherent organizational culture centered around the basic assumption, “we are a community of committed members,” and (h) integrated efforts among the club and sport-friendly schools to support athletes’ development. This case study can inform other athletic talent development environments on how to optimize talent development processes.
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| 30. |
- Karlsson, Michael, 1970-, et al.
(författare)
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Is Anyone out There? : Assessing Swedish citizen-generated community journalism
- 2014
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Ingår i: Journalism Practice. - : Informa UK Limited. - 1751-2786 .- 1751-2794. ; 8:2, s. 164-180
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Tidskriftsartikel (refereegranskat)abstract
- In this study, situated in Sweden, citizen community journalism in 290 municipalities is evaluated. The results reveal that there are very few cases of citizen journalism at a community level, and that the existing citizen journalists focus on business news, entertainment and sports. When sources are used, they are few and originate from social institutions such as business, media, authorities and politics rather than citizens. Furthermore, there are only a few occasions when local authorities are included at all, even less so scrutinised, in the news stories. All in all, the study indicates that Swedish citizen community journalism has trouble either providing information that maintains the community or being the watchdog of that community.
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| 31. |
- Karlsson, Michael, et al.
(författare)
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Is anyone out there? : Assessing Swedish citizen-generated community journalism
- 2015
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Ingår i: Community journalism midst media revolution. - : Routledge. - 9781138811065 ; , s. 52-68
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Bokkapitel (refereegranskat)abstract
- In this study, situated in Sweden, citizen community journalism in 290 municipalities is evaluated. The results reveal that there are very few cases of citizen journalism at a community level, and that the existing citizen journalists focus on business news, entertainment and sports. When sources are used, they are few and originate from social institutions such as business, media, authorities and politics rather than citizens. Furthermore, there are only a few occasions when local authorities are included at all, even less so scrutinised, in the news stories. All in all, the study indicates that Swedish citizen community journalism has trouble either providing information that maintains the community or being the watchdog of that community.
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| 32. |
- Karlsson, Michael, et al.
(författare)
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Journalism on the web
- 2016
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Ingår i: Oxford Research Encyclopedia of Communication. - : Oxford University Press. - 9780190228613
-
Bokkapitel (refereegranskat)abstract
- In the early 21st century, almost everyone takes journalism on the web for granted. However, it was not many years ago that journalism moved online and a distinct form of journalism began to develop. Ranging from online doubles of the paper editions to publications exclusively produced for the web, the evolvement of web journalism has entailed both dramatic and not-so-dramatic changes in the way that journalistic products are produced, disseminated, and received. Online journalism has usually been demarcated from traditional journalism by four traits: interactivity, immediacy, hypertextuality, and multimodality. These characteristics are generally identified by scholars as points where journalism on the web brings added value in comparison to the old print newspapers. Interactivity involves various aspects of user activity and participation in the processes of consuming, contributing to, and disseminating news afforded by the web. Immediacy refers to the nature and consequences of the faster pace of publication in web news. Hypertextuality has to do with the possibilities of linking journalistic texts to other texts, which makes the text more transparent and open.Multimodality denotes the telling of news with the use of many different modes at the same time. When studying research about these aspects of web journalism, three general observations can be made. First, researchers have approached these characteristics unevenly in terms of scope and interest. The interactive aspects of web journalism are by far the most investigated. Second, the four characteristics have been studied through the lenses of different theoretical frameworks. Third, empirical research shows that change in journalism is slow and not always as radical as many predicted when journalism on the web was in its infancy.
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| 33. |
- Karlsson, Olof Magnus, 1972-
(författare)
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Predicting Ecosystem Response from Pollution in Baltic Archipelago areas using Mass-balance Modelling
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Baltic archipelago areas have high nature values despite being polluted from various antrophogenic activities within the Baltic Sea catchment area and from long-range transport of airborne substances. The discovery of environmental problems in the Baltic Sea in the 1960s led to countermeasures that gradually gave results in reducing the toxic pollution, e.g. from PCBs. Today, much of the environmental management is focused on reducing the effects of eutrophication. There is a demand from society on science to develop strategies that can direct remedial actions so that the cost-effectiveness is maximised. This work focuses on how mass-balance models can be used to understand how coastal ecosystems are controlled by abiotic processes and to predict the response to changes in loading of different substances. Advection, sedimentation and burial are examples of general transport processes that are regulated by morphometrical characteristics, e.g. size, form, effective fetch and topographical openness. This is why different coastal areas have different sensitivity to loading of pollutants. A comparison of six phosphorus and chlorophyll models of different complexity showed that the model performance was not improved with more state variables of total phosphorus (TP) than two water and two sediment compartments. Modelling chlorophyll as a separate state variable did not improve the results for individual values compared to a simple regression against total phosphorus in surface water. Field investigations of the phosphorus content in accumulation sediments along the coast of Svealand showed a distribution pattern that probably is related to differences in the redox status. The average content of mobile phosphorus was much higher than previously found in offshore Baltic sediments indicating that sediments may play an important role for the phosphorus turnover in Baltic archipelago areas. A one-year field study to measure the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in water, sediments and fish during different seasons was carried out in Kallrigafjärden Bay. The collected data set was used to test a mass-balance model for PCCD/F-turnover. It was possible to reproduce the concentrations of different PCDD/F-congeners with high accuracy using a general model approach, including one water compartment and two sediment compartments, indicating that the applied model has the necessary qualifications for successful predictions of PCDD/F-turnover in Baltic coastal areas.
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| 34. |
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| 35. |
- Karlsson Valik, John, et al.
(författare)
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Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score With Implications for the Sepsis-3 Criteria
- 2022
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Ingår i: Critical Care Medicine. - 0090-3493 .- 1530-0293. ; 50:3, s. e272-e283
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Sequential Organ Failure Assessment score is the basis of the Sepsis-3 criteria and requires arterial blood gas analysis to assess respiratory function. Peripheral oxygen saturation is a noninvasive alternative but is not included in neither Sequential Organ Failure Assessment score nor Sepsis-3. We aimed to assess the association between worst peripheral oxygen saturation during onset of suspected infection and mortality.DESIGN: Cohort study of hospital admissions from a main cohort and emergency department visits from four external validation cohorts between year 2011 and 2018. Data were collected from electronic health records and prospectively by study investigators.SETTING: Eight academic and community hospitals in Sweden and Canada.PATIENTS: Adult patients with suspected infection episodes.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: The main cohort included 19,396 episodes (median age, 67.0 [53.0–77.0]; 9,007 [46.4%] women; 1,044 [5.4%] died). The validation cohorts included 10,586 episodes (range of median age, 61.0–76.0; women 42.1–50.2%; mortality 2.3–13.3%). Peripheral oxygen saturation levels 96–95% were not significantly associated with increased mortality in the main or pooled validation cohorts. At peripheral oxygen saturation 94%, the adjusted odds ratio of death was 1.56 (95% CI, 1.10–2.23) in the main cohort and 1.36 (95% CI, 1.00–1.85) in the pooled validation cohorts and increased gradually below this level. Respiratory assessment using peripheral oxygen saturation 94–91% and less than 91% to generate 1 and 2 Sequential Organ Failure Assessment points, respectively, improved the discrimination of the Sequential Organ Failure Assessment score from area under the receiver operating characteristics 0.75 (95% CI, 0.74–0.77) to 0.78 (95% CI, 0.77–0.80; p < 0.001). Peripheral oxygen saturation/Fio2 ratio had slightly better predictive performance compared with peripheral oxygen saturation alone, but the clinical impact was minor.CONCLUSIONS: These findings provide evidence for assessing respiratory function with peripheral oxygen saturation in the Sequential Organ Failure Assessment score and the Sepsis-3 criteria. Our data support using peripheral oxygen saturation thresholds 94% and 90% to get 1 and 2 Sequential Organ Failure Assessment respiratory points, respectively. This has important implications primarily for emergency practice, rapid response teams, surveillance, research, and resource-limited settings.
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| 36. |
- Olsson, Ella, et al.
(författare)
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Urdarbrunnen: Towards an AI-enabled mission system for Combat Search and Rescue operations
- 2023
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Ingår i: Proceedings of the 35th Annual Workshop of the Swedish Artificial Intelligence Society (SAIS 2023). - : Linköping University Electronic Press. - 9789180752749 ; , s. 38-45
-
Konferensbidrag (refereegranskat)abstract
- The Urdarbrunnen project is a Saab-led exploratory initiative that aims to develop an operator-assisted AI-enabled mission system for basic autonomous functions. In its first iteration, presented in this project paper, the system is designed to be capable of performing the search task of a combat search and rescue mission in a complex and dynamic environment, while providing basic human machine interaction support for remote operators. The system enables a team of agents to cooperatively plan and execute a search mission while also interfacing with the WARA-PS core system that allows human operators and other agents to monitor activities and interact with each other. The aim of the project is to develop the system iteratively, with each iteration incorporating feedback from simulations and real-world experiments. In future work, the capability of the system will be extended to incorporate additional tasks for other scenarios, making it a promising starting point for the integration of autonomous capabilities in a future air force.
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| 37. |
- Richter, Kai-Florian, et al.
(författare)
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Icon-based Navigation
- 2018
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Ingår i: Geospatial Technologies for All. - Lund : Lund University. - 9783319782089
-
Konferensbidrag (refereegranskat)abstract
- Icon-based navigation uses a minimalist approach to mobile navigation assistance by offering navigators only icon displays representing landmark objects at waypoints along a route in an indoor environment. In this paper, we motivate this new concept and its usefulness, present a first prototype implementation exploring the concept, and results of an initial empirical evaluation. While results are not fully conclusive, they point to the potential of this kind of navigation assistance.
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| 38. |
- Sjöholm, Kristoffer, et al.
(författare)
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A comprehensive analysis of the Streptococcus pyogenes and human plasma protein interaction network.
- 2014
-
Ingår i: Molecular BioSystems. - : Royal Society of Chemistry (RSC). - 1742-2051. ; 10:7, s. 1698-1708
-
Tidskriftsartikel (refereegranskat)abstract
- Streptococcus pyogenes is a major human bacterial pathogen responsible for severe and invasive disease associated with high mortality rates. The bacterium interacts with several human blood plasma proteins and clarifying these interactions and their biological consequences will help to explain the progression from mild to severe infections. In this study, we used a combination of mass spectrometry (MS) based techniques to comprehensively quantify the components of the S. pyogenes-plasma protein interaction network. From an initial list of 181 interacting human plasma proteins defined using liquid chromatography (LC)-MS/MS analysis we further subdivided the interacting protein list using selected reaction monitoring (SRM) depending on the level of enrichment and protein concentration on the bacterial surface. The combination of MS methods revealed several previously characterized interactions between the S. pyogenes surface and human plasma along with many more, so far uncharacterised, possible plasma protein interactions with S. pyogenes. In follow-up experiments, the combination of MS techniques was applied to study differences in protein binding to a S. pyogenes wild type strain and an isogenic mutant lacking several important virulence factors, and a unique pair of invasive and non-invasive S. pyogenes isolates from the same patient. Comparing the plasma protein-binding properties of the wild type and the mutant and the invasive and non-invasive S. pyogenes bacteria revealed considerable differences, underlining the significance of these protein interactions. The results also demonstrate the power of the developed mass spectrometry method to investigate host-microbial relationships with a large proteomics depth and high quantitative accuracy.
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| 39. |
- Solis, Jorge, 1976-, et al.
(författare)
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Development of an Off-board Vision-Based Control for a Micro Aerial Vehicle
- 2020
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Ingår i: ROMANSY 23 - Robot Design, Dynamics and Control. - Cham : Springer International Publishing. ; , s. 387-395
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Konferensbidrag (refereegranskat)abstract
- Our research aims to develop an intelligent robot vehicle with multimodal locomotion capabilities for the forest monitoring purpose. Due to the complexity of the proposed research, in this paper, we proposed a visual-based control system; capable to detect fiducial markers and pose estimation even with limited capabilities and transmission losses, in order to hover, navigate and fly to the desired target location while remaining stable without adversely affecting the effective flight time due to additional sensors and computation. Based on the experimental results, the MAV was able to detect the fiducial markers with a success ratio of about 92.8% as well as to land on the desired location within a radius of about 10 cm from the center-point of the landing pad, with a reduction of the effective flight time of about 28%.
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| 40. |
- Solis, Jorge, 1976-, et al.
(författare)
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Towards the Development of an Automatic UAV-Based Indoor Environmental Monitoring System : Distributed Off-Board Control System for a Micro Aerial Vehicle
- 2021
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Ingår i: Applied Sciences. - : MDPI. - 1454-5101 .- 2076-3417. ; 11:5
-
Tidskriftsartikel (refereegranskat)abstract
- This research aims to develop an automatic unmanned aerial vehicle (UAV)-based indoor environmental monitoring system for the acquisition of data at a very fine scale to detect rapid changes in environmental features of plants growing in greenhouses. Due to the complexity of the proposed research, in this paper we proposed an off-board distributed control system based on visual input for a micro aerial vehicle (MAV) able to hover, navigate, and fly to a desired target location without considerably affecting the effective flight time. Based on the experimental results, the MAV was able to land on the desired location within a radius of about 10 cm from the center point of the landing pad, with a reduction in the effective flight time of about 28%.
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| 41. |
- Strandén, Lars, et al.
(författare)
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AstaZero - kommunikationsbehov V2X
- 2013
-
Rapport (refereegranskat)abstract
- This report shows the current need for wireless V2X communication equipment (vehicle to vehicle and vehicle to infrastructure) for the evaluation of cooperative systems at the AstaZero proving ground. The work has been conducted within the project EQUIPP which is a collaboration between SP Technical Research institute of Sweden and Viktoria Swedish ICT and funded by RISE (Research institutes of Sweden).
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| 42. |
- Trøen, Erik, et al.
(författare)
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Pole Length’s Influence on Performance During Classic-Style Snow Skiing in Well-Trained Cross-Country Skiers
- 2020
-
Ingår i: International Journal of Sports Physiology and Performance. - : Human Kinetics. - 1555-0265 .- 1555-0273. ; 15:6, s. 884-891
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: To investigate how self-selected pole length (PL) of ∼84% (PL84%) compared with ∼90% (PL90%) of body height influenced performance during a 700-m time trial with undulating terrain on snow. Methods: Twenty-one cross-country skiers, 7 of whom were women, performed 4 trials at a maximal effort in a counterbalanced fashion with PL84% and PL90% separated by 20-minute breaks between trials. In trials I and II, only double poling was allowed, while in trials III and IV, skiers used self-selected classical subtechniques. Continuous speed, cyclic parameters, and heart rate were collected using microsensors in addition to a post-time-trial rating of perceived exertion (RPE). Results: The 700-m times with only double poling were significantly shorter with PL90% than PL84% (mean ± 95% confidence limits –1.6% ± 1.0%). Segment analyses showed higher speed with PL90% in uphill sections than with PL84% (3.7% ± 2.1%), with the greatest difference found for the female skiers (5.6% ± 2.9%). In contrast, on flat terrain at high skiing speeds, speed was reduced with PL90% compared with PL84% (–1.5% ± 1.4%); this was only significant for the male skiers. During free choice of classical subtechniques, PL did not influence performance in any segments, choice of subtechnique, or cycle rate during the trials. No differences in rating of perceived exertion or heart rate between PLs were found. Conclusions: PL90% improved performance in uphills at low speeds when using double poling but hindered performance on flat terrain and at higher speeds compared with self-selected PLs. Choice of PL should, therefore, be based on racecourse topography, preferred subtechniques, and the skier’s physiological and technical abilities.
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| 43. |
- Vinner, Lasse, et al.
(författare)
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Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.
- 2011
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Ingår i: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - : Wiley. - 1600-0463. ; 119:8, s. 487-497
-
Tidskriftsartikel (refereegranskat)abstract
- For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.
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| 44. |
- Wallgren, Marcus, 1978-, et al.
(författare)
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Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein
- 2013
-
Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
-
Tidskriftsartikel (refereegranskat)abstract
- The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial outer membrane (MOM) and there determine whether the cell will live or be sentenced to death remains unknown. Competing models have been presented that describe how Bcl-2 inhibits the cell-killing activity of Bax, which is common in treatment-resistant tumors where Bcl-2 is overexpressed. Some studies suggest that Bcl-2 binds directly to and sequesters Bax, while others suggest an indirect process whereby Bcl-2 blocks BH3-only proteins and prevents them from activating Bax. Here we present the results of a biophysical study in which we investigated the putative interaction of solubilized full-length human Bcl-2 with Bax and the scope for incorporating the former into a native-like lipid environment. Far-UV circular dichroism (CD) spectroscopy was used to detect direct Bcl-2-Bax-interactions in the presence of polyoxyethylene-(23)-lauryl-ether (Brij-35) detergent at a level below its critical micelle concentration (CMC). Additional surface plasmon resonance (SPR) measurements confirmed this observation and revealed a high affinity between the Bax and Bcl-2 proteins. Upon formation of this protein-protein complex, Bax also prevented the binding of antimycin A(2) (a known inhibitory ligand of Bcl-2) to the Bcl-2 protein, as fluorescence spectroscopy experiments showed. In addition, Bcl-2 was able to form mixed micelles with Triton X-100 solubilized neutral phospholipids in the presence of high concentrations of Brij-35 (above its CMC). Following detergent removal, the integral membrane protein was found to have been fully reconstituted into a native-like membrane environment, as confirmed by ultracentrifugation and subsequent SDS-PAGE experiments.
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| 45. |
- Zelan, Martin, 1981-, et al.
(författare)
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Fluctuation-induced drift in a gravitationally tilted optical lattice
- 2010
-
Ingår i: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics. - 1063-651X .- 1095-3787. ; 82:3
-
Tidskriftsartikel (refereegranskat)abstract
- Experimental and theoretical studies are made of Brownian particles trapped in a periodic potential, which is very slightly tilted due to gravity. In the presence of fluctuations, these will trigger a measurable average drift along the direction of the tilt. The magnitude of the drift varies with the ratio between the bias force and the trapping potential. This can be closely compared to a theoretical model system, based on a Fokker-Planck equation formalism. We show that the level of control and measurement precision we have in our system, which is based on cold atoms trapped in a three-dimensional dissipative optical lattice, makes the experimental setup suitable as a testbed for fundamental statistical physics. We simulate the system with a very simplified and general classical model, as well as with an elaborate semiclassical Monte Carlo simulation. In both cases, we achieve good qualitative agreement with experimental data.
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| 46. |
- Zhang, Renyun, et al.
(författare)
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Soap-film coating : High-speed deposition of multilayer nanofilms
- 2013
-
Ingår i: Scientific Reports. - Nature Publishing Group : Springer Science and Business Media LLC. - 2045-2322. ; 3, s. Art. no. 1477-
-
Tidskriftsartikel (refereegranskat)abstract
- The coating of thin films is applied in numerous fields and many methods are employed for the deposition of these films. Some coating techniques may deposit films at high speed; for example, ordinary printing paper is coated with micrometre-thick layers of clay at a speed of tens of meters per second. However, to coat nanometre thin films at high speed, vacuum techniques are typically required, which increases the complexity of the process. Here, we report a simple wet chemical method for the high-speed coating of films with thicknesses at the nanometre level. This soap-film coating technique is based on forcing a substrate through a soap film that contains nanomaterials. Molecules and nanomaterials can be deposited at a thickness ranging from less than a monolayer to several layers at speeds up to meters per second. We believe that the soap-film coating method is potentially important for industrial-scale nanotechnology.
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