| 1. |
- Andersson, Per, Professor, 1964-, et al.
(författare)
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Den vuxne studiedeltagaren
- 2020. - 1
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Ingår i: Om vuxenutbildning och vuxnas studier. - Lund : Studentlitteratur AB. - 9789144133294 ; , s. 187-207
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Att delta i studier som vuxen är mycket vanligt i Sverige. Här kommer vi att beskriva deltagandet i utbildningar, kurser och cirklar inom kommunal vuxenutbildning (komvux) inklusive svenska för invandrare (sfi) samt yrkeshögskola, folkhögskola och studieförbund. Till detta kommer alla som deltar i utbildning av olika slag, som fortbildning inom arbetsliv eller föreningsliv, och inte minst det omfattande deltagandet i högre utbildning på universitet och högskolor, områden som inte står i fokus i den här boken.Sammantaget är det en mycket stor del av den vuxna befolkningen som deltar i studier. Men en viktig skillnad jämfört med barn och ungdomar, där i princip alla går i skolan, är att många vuxna kombinerar deltids- och fritidsstudier med arbete, och ibland studerar den vuxne också på arbetstid. En viktig förutsättning är dessutom de villkor som gör det möjligt för vuxna att studera: att utbildningarna till stor del är finansierade av skattemedel, att det finns en lagstadgad rätt till tjänstledighet för studier, och att det finns ett utbyggt system för studiebidrag och studielån som gör det möjligt att försörja sig under studietiden utan att nödvändigtvis behöva kombinera studier och arbete.
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| 2. |
- Björck, Hanna M., et al.
(författare)
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Characterization of Shear-Sensitive Genes in the NormalRat Aorta Identifies Hand2 as a Major Flow-ResponsiveTranscription Factor
- 2012
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:12
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Shear forces play a key role in the maintenance of vessel wall integrity. Current understanding regarding shear-dependent gene expression is mainly based on in vitro or in vivo observations with experimentally deranged shear, hence reflecting acute molecular events in relation to flow. Our objective was to determine wall shear stress (WSS) in the rat aorta and study flow-dependent vessel wall biology under physiological conditions.Methods and Results: Animal-specific aortic WSS magnitude and vector direction were estimated using computational fluid dynamic simulation based on aortic geometry and flow information acquired by MRI. Two distinct flow pattern regions were identified in the normal rat aorta; the distal part of the inner curvature being exposed to low WSS and a non-uniform vector direction, and a region along the outer curvature being subjected to markedly higher levels of WSS and a uniform vector direction. Microarray analysis revealed a strong differential expression between the flow regions, particularly associated with transcriptional regulation. In particular, several genes related to Ca2+-signalling, inflammation, proliferation and oxidative stress were among the most highly differentially expressed.Conclusions: Microarray analysis validated the CFD-defined WSS regions in the rat aorta, and several novel flow-dependent genes were identified. The importance of these genes in relation to atherosusceptibility needs further investigation.
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| 3. |
- Eckhardt, Jenni, et al.
(författare)
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Deliverable 2: European MaaS Roadmap 2025. MAASiFiE project funded by CEDR.
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Executive summaryMobility as a Service for Linking Europe (MAASiFiE) is a two-year project funded by the trans-national research programme “Call 2014: Mobility and ITS” launched by the Conference of European Directors of Roads (CEDR). The project investigates the prerequisites for organizing user-oriented and ecological mobility services in order to provide consumers with flexible, efficient and user-friendly services covering multiple modes of transport on a one-stop-shop principle. In addition, opportunities to combine passenger and freight transport operations are included.The main expected result of the project is the European MaaS Roadmap 2025 to be defined in Work Package 2, which this deliverable, Nr 2, presents. WP2 can be considered as an umbrella interacting with WPs 3, 4 and 5. WP3 analysed MaaS state-of-the-art and value networks, and develops business and operator models. Results are presented in Deliverable Nr 3 – Business and operator models for MaaS. WP4 performed socio-economic and environmental impact assessments of MaaS, and proposes a set of key performance indicators of MaaS. These results are presented in Deliverable Nr 4 – Impact Assessment. WP5 analysed technological requirements and interoperability issues of MaaS, including usability aspects, presented in Deliverable Nr 5 – Technology for MaaS. The work in WP 2 was performed through a series of four workshops: Workshop 1 created national MaaS visions. Workshop 2 evaluated potential impacts of Maas based on national MaaS cases. Workshop 3 created national versions of Roadmap 2025 defining short- and medium-term actions and requirements to reach the visions created in the first workshop. Workshop 4 was an international workshop creating European Roadmap 2025, consolidating results and defining next steps in implementing MaaS. Workshop 4 was international, while the other workshops were organised similarly in Finland, Sweden and Austria.The European MaaS Roadmap 2025 defines short- (1-3 years) and medium-term (4-9 years) actions and transitions needed to reach the vision formed in the first workshop. The Roadmap is divided into four functional perspectives: drivers, markets, MaaS services and enablers. Each perspective presents the results using the following classification: Academia and R&D, Business, Infrastructure & built environment, Policy & regulation, Technology & data, and Society & culture. The Roadmap also indicates the most important components identified in the workshop for the future development of MaaS. Academia and R&D is mainly seen as an enabler for identifying best practices, conducting impact assessments, and developing living lab test environments. The business sector affects primarily market and MaaS services perspectives and acts as an enabler. Business is seen as responsible for e.g. creating new pilots and services, collaboration and new business models, and developing the one-stop-shop principle.Infrastructure & built environment is mainly seen as a driver for land use and the change of urban structures and space solutions resulting e.g. in fewer parking lots. Guidelines e.g. for city planning and infrastructure are considered as enablers for MaaS. Policy & regulation touches all functional perspectives by creating an environment enabling and promoting interoperability, collaboration, the MaaS ecosystem and achievement of policy targets. Regarding technology, key enabling technologies for MaaS exist, but challenges are related to e.g. interoperability and open interfaces, privacy and standardization.Society & culture aspects are mainly related to market and MaaS services perspectives. MaaS is expected to solve the life puzzle from the mobility perspective. Consumers can influence MaaS development depending on increased user acceptance and attitude change, as well as being a prosumer (producer/ consumer) by integrating e.g. private cars to the MaaS ecosystem.The continuity needed to regularly update the MaaS roadmap was seen as important, as the path of MaaS development is currently uncertain. Also impact assessments and validated results are needed to see the real quantitative impacts of MaaS.
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| 4. |
- Eckhardt, Jenni, et al.
(författare)
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The European Roadmap 2025 for Mobility as a Service
- 2018
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Ingår i: 7th Transport Research Arena TRA 2018, Vienna, April 16-19, 2018.
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Konferensbidrag (refereegranskat)abstract
- This paper is based on a Mobility as a Service (MaaS) project, Mobility as a Service for Linking Europe (MAASiFiE), conducted for the Conference of European Directors of Roads (CEDR). MaaS is an emerging concept aiming to offer user-oriented, multimodal transport services on a one-stop-shop principle utilizing digitalization and mobile applications. This paper presents the main result of the project: the European MaaS Roadmap 2025 defining short- (1-3 years) and medium-term (4-9 years) actions and transitions needed to reach the vision formed in the project. The Roadmap is divided into four functional perspectives: drivers, markets, MaaS services and enablers. Furthermore, each perspective presents the results using the following classification: Academy and R&D, Business, Infrastructure & built environment, Policy & regulation, Technology & data, and Social & culture. This paper concentrates on Policy & regulation aspects, as well as on the role of National Road Administrations (NRAs) in MaaS development.
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| 5. |
- Folkesson, Maggie, et al.
(författare)
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Differences in cardiovascular toxicities associated with cigarette smoking and snuff use revealed using novel zebrafish models
- 2016
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Ingår i: Biology Open. - : Company of Biologists. - 2046-6390. ; 5:7, s. 970-978
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Tidskriftsartikel (refereegranskat)abstract
- Tobacco use is strongly associated with cardiovascular disease and the only avoidable risk factor associated with development of aortic aneurysm. While smoking is the most common form of tobacco use, snuff and other oral tobacco products are gaining popularity, but research on potentially toxic effects of oral tobacco use has not kept pace with the increase in its use. Here, we demonstrate that cigarette smoke and snuff extracts are highly toxic to developing zebrafish embryos. Exposure to such extracts led to a palette of toxic effects including early embryonic mortality, developmental delay, cerebral hemorrhages, defects in lymphatics development and ventricular function, and aneurysm development. Both cigarette smoke and snuff were more toxic than pure nicotine, indicating that other compounds in these products are also associated with toxicity. While some toxicities were found following exposure to both types of tobacco product, other toxicities, including developmental delay and aneurysm development, were specifically observed in the snuff extract group, whereas cerebral hemorrhages were only found in the group exposed to cigarette smoke extract. These findings deepen our understanding of the pathogenic effects of cigarette smoking and snuff use on the cardiovascular system and illustrate the benefits of using zebrafish to study mechanisms involved in aneurysm development.
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| 6. |
- Jonsson, E Niclas, et al.
(författare)
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Population pharmacokinetics of levosimendan in patients with congestive heart failure
- 2003
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Ingår i: British Journal of Clinical Pharmacology. - : Wiley. - 0306-5251 .- 1365-2125. ; 55:6, s. 544-551
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: The aim of this study was to characterize the population pharmacokinetics of levosimendan in patients with heart failure (NYHA grades III and IV) and its relationship to demographic factors, disease severity and concomitant use of digoxin and beta-blocking agents. METHODS: Data from two efficacy studies with levosimendan administered by intravenous infusion were combined (190 patients in total). The data were analysed using a nonlinear mixed-effects modelling approach as implemented in the NONMEM program. The model development was done in three sequential steps. First the best structural model was determined (e.g. a one-, two- or three-compartment pharmacokinetic model). This was followed by the identification and incorporation of important covariates into the model. Lastly the stochastic part of the model was refined. RESULTS: A two-compartment model best described levosimendan pharmacokinetics. Clearance and the central volume of distribution were found to increase linearly with bodyweight. No other covariates, including concomitant use of digoxin and beta-blocking agents, influenced the pharmacokinetics. In the final model, a 76-kg patient was estimated to have a clearance +/- s.e. of 13.3 +/- 0.4 l h-1 and a central volume of distribution of 16.8 +/- 0.79 l. The interindividual variability was estimated to be 39% and 60% for clearance and central volume of distribution, respectively. Weight changed clearance by 1.5% [95% confidence interval (CI) 0.9%, 2.1%] and the central volume of distribution by 0.9% (95% CI 0.5%, 1.3%) per kg. CONCLUSIONS: The population pharmacokinetics parameters of levosimendan in this patient group were comparable to those obtained by traditional methods in healthy volunteers and patients with mild heart failure. Bodyweight influenced the clearance and the central volume of distribution, which in practice is accounted for by weight adjusting doses. None of the other covariates, including digoxin and beta-blocking agents, significantly influenced the pharmacokinetics of levosimendan.
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| 7. |
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| 8. |
- Karlsson, Christofer M. G., et al.
(författare)
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Metatranscriptomic analysis uncovers divergent responses of Baltic Sea bacteria to forest and agriculture river loadings
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Climate change is predicted to induce substantial changes in precipitation patterns across the globe. In Northern Europe, precipitation is expected to increase more than the global average (particularly in northern Scandinavia), causing increased river runoff. The Baltic Sea is one of the largest brackish environments on earth with a catchment area that spans 14 countries, encompassing primarily forested areas and agricultural landscapes. Despite the acknowledged role of marine bacteria in nutrient cycling, there is a lack of knowledge in their metabolic responses to inorganic and organic nutrient loading from riverine runoff. We investigated the bacterial growth and gene expression responses in a mesocosm experiment in which river water from boreal forest- (enriched in humic substances) or agriculture- influenced catchment areas were added to Baltic Sea Proper water. The riverine nutrient input triggered extensive phytoplankton blooms and bacterial growth, most notably in the agriculture river treatment. Interestingly, bacterial gene expression analysis (metatranscriptomics) showed similar responses to agriculture and humic river inputs at the start of the experiment (before the phytoplankton bloom), but expression patterns diverged significantly upon bloom senescence.Notably, transcripts associated with phosphate metabolism were significantly enriched , whereas transcripts related to nitrogen metabolism were significantly lower in the agriculture river treatment compared to the boreal forest river treatment. The opposite pattern was observed in the boreal forest river water treatment. Overall, our results showed that interactions between river nutrient loading and phytoplankton organic matter are important in regulating bacterial activities and responses at the molecular level. This suggests that bacterial transformations of organic matter and nutrient cycling in coastal waters and estuarine environments are sensitive to changes in precipitation patterns in a catchment area-dependent manner.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
- Karlsson, Stefan, et al.
(författare)
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Miljöeffekter av Dennispaketet
- 1993
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Ingår i: VTI:s och TFB:s forskardagar. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 151-162
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 13. |
- Karlsson, Tobias Lasse, 1987-
(författare)
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Adults between school and working life
- 2023
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Ingår i: Studies in the Education of Adults. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 0266-0830 .- 1478-9833.
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to examine what it means to be a student in a vocational education and training programme in the municipal adult education system in Sweden and how the interplay between school and working life affects students identity formation. To achieve this, 12 students from two different programmes have been interviewed at the end of their education: one group of assistant nurses and one group of floor layers. The results show that learning a vocation and developing a vocational identity is a journey through different practices with whom students both identify and dis-identify themselves. In these processes of identification, students can also undergo personal development in a broader sense or develop an identity as an adult. Understanding adult student identities, in particular how they see themselves as learners, can be beneficial for those working with and in adult learning. Furthermore, what the school teaches may conflict with the expectations and daily demands of working life, creating a divide between practices. Understanding the divide between school and working life, and how students are affected by this divide, can also facilitate the understanding of their vocational identity development process.
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| 14. |
- Karlsson, Tobias Lasse, 1987-
(författare)
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Being someone or doing something : How students in municipal adult education view their future vocation
- 2022
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Ingår i: Nordic Journal of Vocational Education and Training. ; 12:3, s. 71-94
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Tidskriftsartikel (refereegranskat)abstract
- Being an adult, deciding what to do with your life, and trying to understand the consequences of educational choices can be difficult. Vocational education and training (VET) programmes within the Swedish municipal adult education (MAE) offer an opportunity to learn a vocation, and last 6–18 months. This study aims to explore how adult VET students perceive desirable vocational habitus and is based on 18 interviews comparing students from two vocational MAE programmes in assistant nursing and floor laying. Semi-structured interviews were conducted at the beginning of the students’ training and data were analysed using inductive thematic analysis. The results show that choosing a VET programme is a process of choosing what you want to do for work but also who you want to be. However, whether or not students see themselves as suitable is contrasted between how they perceive their future vocation and what the vocational community expects from them, which in turn affects their learning process and development of a vocational identity. Noticing the discrepancies between students’ perceptions and vocational expectations can both reduce the risk of losing students during training and reduces the risk of reproducing unequal ideals.
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| 15. |
- Karlsson, Tobias Lasse, 1987-
(författare)
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Something to Do Something to Be : A study of students' vocational identity formation in adult education
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis is to understand how vocations are learned in adult education by exploring the vocational identity formation of students in Municipal Adult Education (MAE) in Sweden. By analysing interviews of adult students during different stages in their Vocational Education and Training (VET) through working life, this study contributes to the fields of adult education and VET. The theoretical framework centres on the concept of identity, utilising communities of practice, and is nuanced with the concepts of sense of self and vocational habitus, in order to analyse both social practices and individual aspects of the students’ vocational identity formation.The most standout finding is that VET in adult education can provide something beyond forming a vocational identity. In essence, the process of successfully completing an education can improve how students perceive themselves as adults, learners, and active members in society. The findings also show how the intersection between students’ perceptions of themselves, their education, and their vocation create barriers that they must overcome in order to progress in their identity formation. Overcoming barriers is an important part of the learning process that is towards a vocational identity, however, while some barriers are surpassed, some persist, and some are substituted by new ones.These processes in turn affect how students identify and dis-identify with educational and vocational practices, which in turn influence how they participate in these practices. To the extent that students progress in their vocational identity depends on a variety of factors, related to their ability to participate in the social practices offered by education, primarily time in school and access to workplace-based training. Furthermore, the process of learning a vocation is a complex social venture and the findings argue that there is a risk in attributing students’ struggles solely to issues pertaining to vocational learning as this may overlook underlying structural challenges faced by students.
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| 16. |
- Nykänen, Lasse, et al.
(författare)
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The European Roadmap 2025 for MaaS
- 2017
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Ingår i: 1st International Conference on Mobility as a Service (ICoMaaS), Tampere, Finland, November 28-29, 2017. ; , s. 266-279
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Konferensbidrag (refereegranskat)abstract
- The paper presents a European MaaS roadmap 2025, by describing drivers, enablers, market and MaaS services related to MaaS development in Europe. The main focus is on drivers and enablers, which are at the core of MaaS development and are pushing development towards the great vision of MaaS: offer user-oriented multimodal transport services on a one-stop-shop principle utilizing digitalization and mobile applications. However, there are still several open issues such as regulations, markets, business actors, and stakeholder collaboration affecting the future development of MaaS.The roadmap points out that in addition to the critical role of policy & regulation, stakeholders such as academy and R&D sector have an important role in MaaS development, since those should work as an enabler for identifying best practices, conducting an impact assessment, and developing living lab test environments. Also the business sector is seen as one of the key enablers, because the business sector is responsible for creating new pilots and services, collaboration and new business models and developing a one-stop-shop principle for mobility sector.
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| 17. |
- Vinner, Lasse, et al.
(författare)
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Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.
- 2011
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Ingår i: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - : Wiley. - 1600-0463. ; 119:8, s. 487-497
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Tidskriftsartikel (refereegranskat)abstract
- For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure 10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.
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