| 1. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 2. |
- Abreu, P, et al.
(författare)
-
b-tagging in DELPHI at LEP
- 2004
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 32:2, s. 185-208
-
Tidskriftsartikel (refereegranskat)abstract
- The standard method used for tagging b-hadrons in the DELPHI experiment at the CERN LEP Collider is discussed in detail. The main ingredient of b-tagging is the impact parameters of tracks, which relies mostly on the vertex detector. Additional information, such as the mass of particles associated to a secondary vertex, significantly improves the selection efficiency and the background suppression. The paper describes various discriminating variables used for the tagging and the procedure of their combination. In addition, applications of b-tagging to some physics analyses, which depend crucially on the performance and reliability of b-tagging, are described briefly.
|
|
| 3. |
- Edvinsson, Magnus, 1988-, et al.
(författare)
-
Male pelvic pain : the role of psychological factors and sexual dysfunction in a young sample
- 2022
-
Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter. - 1877-8860 .- 1877-8879. ; 23:1, s. 104-109
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: Male pelvic pain is a common yet poorly understood condition, strongly influencing quality of life of those affected. Research on psychological and sexual factors is lacking, specifically on younger men in family-forming ages. This study aims to explore psychological and sexual factors related to pelvic pain in younger men (<40 years) through a cross-sectional design.Methods: Participants were recruited via social media, and completed a digital survey regarding sexual health and psychological distress (n=2,647). Men with varying levels of pelvic pain were compared on levels of psychological distress and self-reported sexual health.Results: Men with pelvic pain (n=369) reported significantly higher levels of catastrophizing, anxiety and premature ejaculation compared to men without pelvic pain. Furthermore, men with higher pain intensity reported significantly higher levels of catastrophizing, anxiety and depressive symptoms compared to men experiencing lower pain intensity. Hierarchical regression analysis revealed catastrophizing and depressive symptoms as significantly predictors of pain intensity.Conclusions: These findings underscore the role of psychological factors in male pelvic pain, and points to the need for integrating a psychological understanding for further treatment development.
|
|
| 4. |
- Egelberg, Moa, et al.
(författare)
-
Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer : a long-term follow-up of the SweBCG91RT randomized trial
- 2023
-
Ingår i: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 17:10, s. 2029-2040
-
Tidskriftsartikel (refereegranskat)abstract
- Downregulation of the DNA repair protein WD40-encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels as prognostic and predictive markers in the SweBCG91RT trial, in which breast cancer patients were randomized for postoperative radiotherapy. Using tissue microarray and microarray-based gene expression, 965 and 759 tumors were assessed for WRAP53 protein and RNA levels, respectively. Correlation with local recurrence and breast cancer-related death was assessed for prognosis, and the interaction between WRAP53 and radiotherapy in relation to local recurrence was assessed for radioresistance prediction. Tumors with low WRAP53 protein levels had a higher subhazard ratio (SHR) for local recurrence [1.76 (95% CI 1.10–2.79)] and breast cancer-related death [1.55 (1.02–2.38)]. Low WRAP53 RNA levels were associated with almost a three-fold decreased effect of radiotherapy in relation to ipsilateral breast tumor recurrence [IBTR; SHR 0.87 (95% CI 0.44–1.72)] compared with high RNA levels [0.33 (0.19–0.55)], with a significant interaction (P = 0.024). In conclusion, low WRAP53 protein is prognostic for local recurrence and breast cancer-related death. Low WRAP53 RNA is a potential marker for radioresistance.
|
|
| 5. |
- Hjort, Mattias, 1972-, et al.
(författare)
-
Smarta gator : VR-simulering av framtida stadsmiljöer
- 2022
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport beskriver arbetet av arbetspaket 6 och 8 i det Vinnova-finansierade projektet Smarta gator. Utifrån arkitektoniska beskrivningar har tre olika VR-miljöer skapats – så kallade ”digitala tvillingar” av en idag existerande gatumiljö i Stockholm, samt två olika tänkbara framtida versioner av gatumiljön. Den simulerade miljön kan upplevas av fotgängare i VTI:s fotgängarsimulator, och alternativt också av bilist genom co-simulering med annan körsimulator. De två tänkbara framtidsvisionerna utvärderades från ett fotgängarperspektiv genom en workshop med 30 försökspersoner i VTI:s fotgängarsimulator i Linköping. Deltagarnas svar visar tydligt att upplevelsen av trygghet, prioritet samt trevlighet/trivsel ökade i de smarta miljöerna jämfört med den ursprungliga miljön. Läsbarheten av gaturummet upplevdes i de smarta miljöerna dock något sämre än i ursprungsmiljön. En förklaring kan vara att många känner igen ursprungsmiljön eftersom det är en relativt vanlig gatutyp – breda körfält för bil, kantstensparkering och trottoarer, medan de smarta miljöerna är uppbyggda på ett annorlunda sätt vilket kan innebära en omställning för att förstå en ”ny typ” av gata. Sammantaget visar studien på hur man kan skapa gaturum som upplevs trevligare och tryggare genom att prioritera gång- och cykeltrafik genom en större yta tillägnat gång, cykel och vistelse än för motortrafik. Även skapandet av vistelseytor och sociala funktioner längs gatan hade en positiv effekt på upplevelsen av gaturummet. Att placera träd och grönska längs gatan är utöver de ekologiska fördelarna också viktigt för trivseln och upplevelsen av gaturummet. Vi konstaterar att VR-simulering kan vara ett användbart verktyg för att på ett tidigt stadium bedöma olika designlösningar. VTI:s fotgängarsimulator har ett state-of-the-art bildsystem, men dess fria yta om 3x6 meter är för liten för att på ett smidigt sätt kunna promenera runt i stadsmiljön. Autonoma fotgängare, styrda av spelmotorn Unreal Engine, upplevdes av de flesta försökspersoner som väldigt verklighetstrogna, och de bidrog till illusionen om att vara på plats i miljön.
|
|
| 6. |
- Jergéus, Erik, et al.
(författare)
-
Towards Learning Abstractions via Reinforcement Learning
- 2022
-
Ingår i: CEUR Workshop Proceedings. - 1613-0073. ; 3400, s. 120-126
-
Konferensbidrag (refereegranskat)abstract
- In this paper we take the first steps in studying a new approach to synthesis of efficient communication schemes in multi-agent systems, trained via reinforcement learning. We combine symbolic methods with machine learning, in what is referred to as a neuro-symbolic system. The agents are not restricted to only use initial primitives: reinforcement learning is interleaved with steps to extend the current language with novel higher-level concepts, allowing generalisation and more informative communication via shorter messages. We demonstrate that this approach allow agents to converge more quickly on a small collaborative construction task.
|
|
| 7. |
- Karlsson, Christer, Professor, 1965-, et al.
(författare)
-
Dimensions of disagreement in EU affairs : is parliamentary opposition driven by left-right or European integration contestation?
- 2024
-
Ingår i: West European Politics. - 0140-2382 .- 1743-9655.
-
Tidskriftsartikel (refereegranskat)abstract
- This study provides new insights regarding how the EU dimension relates to the left-right dimension in national politics. It does so by examining to what extent parties’ oppositional behaviour in EU affairs in parliament is a function of their distance to the government, other parties, the voters and party supporters on the EU dimension and the left-right dimension, respectively. The results suggest that oppositional behaviour is determined by two parallel dynamics: When expressing opposition, political parties are receptive both to the positions of the government and other parties on the EU dimension, and to the positions of voters and supporters on the left-right dimension. Our results thus indicate that the politicization of EU affairs in national parliaments primarily is an elite phenomenon. In their relation to the voters and supporters, parties still primarily navigate along the traditional left-right dimension.
|
|
| 8. |
- Karlsson, Christer, Professor, 1965-, et al.
(författare)
-
Do Members of Parliament Express More Opposition in the Plenary than in the Committee? : Comparing Frontstage and Backstage Behaviour in Five National Parliaments
- 2024
-
Ingår i: Parliamentary Affairs. - : Oxford University Press. - 0031-2290 .- 1460-2482. ; 77:1, s. 173-195
-
Tidskriftsartikel (refereegranskat)abstract
- This study attempts to break new ground by systematically comparing oppositional behaviour of Members of Parliament (MPs) in the two key arenas found in parliament: the plenary and the committee. Do MPs express more opposition frontstage in the plenary than backstage in the committee when discussing European affairs? The article sheds new light on political opposition in parliament by using a dataset of hand-coded statements made by MPs during plenary debates and European Affairs committee deliberations in five national parliaments. The results lend strong support to the main hypothesis that MPs express more opposition during plenary debates than committee deliberations.
|
|
| 9. |
|
|
| 10. |
- Karlsson, Christer, Professor, 1965-, et al.
(författare)
-
Hur mycket opposition finns det i svensk EU-politik?
- 2019
-
Ingår i: EU i riksdagen. - Stockholm : Svenska institutet för europapolitiska studier (Sieps). - 9789186107826 ; , s. 37-60
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 11. |
- Karlsson, Christer, Professor, 1965-, et al.
(författare)
-
Is Oppositional Behaviour in European Union Affairs Gendered? Evidence from Plenary Debates and Committee Deliberations in Four Legislatures
- 2024
-
Ingår i: Journal of Common Market Studies. - : John Wiley & Sons. - 0021-9886 .- 1468-5965. ; 62:2, s. 412-429
-
Tidskriftsartikel (refereegranskat)abstract
- Is oppositional behaviour in legislatures gendered? Despite a growing literature on gender and legislative behaviour, there is a conspicuous absence of research on differences between female and male members of parliament (MPs) when it comes to one of the key aspects of parliamentary debates: the voicing of opposition. This article connects the literature on gender and legislative behaviour with opposition scholarship. We examine the role of gender for oppositional behaviour in four legislatures with a focus on debates concerning European Union affairs. Our results show that female MPs generally are equally likely to express opposition as their male colleagues. This result, however, is conditioned by government status. Whilst there is no significant difference between the proportion of opposition expressed by female and male MPs from opposition parties, we find that male MPs representing government parties express more than twice as much opposition as their female colleagues.
|
|
| 12. |
|
|
| 13. |
- Karlsson, Edvin, et al.
(författare)
-
Airborne microbial biodiversity and seasonality in Northern and Southern Sweden
- 2020
-
Ingår i: PeerJ. - : PeerJ. - 2167-8359. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- Microorganisms are essential constituents of ecosystems. To improve our understanding of how various factors shape microbial diversity and composition in nature it is important to study how microorganisms vary in space and time. Factors shaping microbial communities in ground level air have been surveyed in a limited number of studies, indicating that geographic location, season and local climate influence the microbial communities. However, few have surveyed more than one location, at high latitude or continuously over more than a year. We surveyed the airborne microbial communities over two full consecutive years in Kiruna, in the Arctic boreal zone, and Ljungbyhed, in the Southern nemoral zone of Sweden, by using a unique collection of archived air filters. We mapped both geographic and seasonal differences in bacterial and fungal communities and evaluated environmental factors that may contribute to these differences and found that location, season and weather influence the airborne communities. Location had stronger influence on the bacterial community composition compared to season, while location and season had equal influence on the fungal community composition. However, the airborne bacterial and fungal diversity showed overall the same trend over the seasons, regardless of location, with a peak during the warmer parts of the year, except for the fungal seasonal trend in Ljungbyhed, which fluctuated more within season. Interestingly, the diversity and evenness of the airborne communities were generally lower in Ljungbyhed. In addition, both bacterial and fungal communities varied significantly within and between locations, where orders like Rhizobiales, Rhodospirillales and Agaricales dominated in Kiruna, whereas Bacillales, Clostridiales and Sordariales dominated in Ljungbyhed. These differences are a likely reflection of the landscape surrounding the sampling sites where the landscape in Ljungbyhed is more homogenous and predominantly characterized by artificial and agricultural surroundings. Our results further indicate that local landscape, as well as seasonal variation, shapes microbial communities in air.
|
|
| 14. |
- Karlsson, Lovisa, et al.
(författare)
-
A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection
- 2021
-
Ingår i: Scientific Reports. - : Nature Portfolio. - 2045-2322. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the pulmonary-resident immune cells. The role of epigenetic regulations in the immune cells is emerging and we have previously shown that macrophages capacity to kill M. tuberculosis is reflected in the DNA methylome. The aim of this study was to investigate epigenetic modifications in alveolar macrophages and T cells in a cohort of medical students with an increased risk of TB exposure, longitudinally. DNA methylome analysis revealed that a unique DNA methylation profile was present in healthy subjects who later developed latent TB during the study. The profile was reflected in a different overall DNA methylation distribution as well as a distinct set of differentially methylated genes (DMGs). The DMGs were over-represented in pathways related to metabolic reprogramming of macrophages and T cell migration and IFN-gamma production, pathways previously reported important in TB control. In conclusion, we identified a unique DNA methylation signature in individuals, with no peripheral immune response to M. tuberculosis antigen who later developed latent TB. Together the study suggests that the DNA methylation status of pulmonary immune cells can reveal who will develop latent TB infection.
|
|
| 15. |
- Karlsson, S. C. Hannah, et al.
(författare)
-
Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy
- 2013
-
Ingår i: Cancer Gene Therapy. - : Springer Science and Business Media LLC. - 0929-1903 .- 1476-5500. ; 20:7, s. 386-393
-
Tidskriftsartikel (refereegranskat)abstract
- B-cell malignancies upregulate the B-cell lymphoma 2 (Bcl-2) family inhibitors of the intrinsic apoptosis pathway, making them therapy resistant. However, small-molecule inhibitors of Bcl-2 family members such as ABT-737 restore a functional apoptosis pathway in cancer cells, and its oral analog ABT-263 (Navitoclax) has entered clinical trials. Gene engineered chimeric antigen receptor (CAR) T cells also show promise in B-cell malignancy, and as they induce apoptosis via the extrinsic pathway, we hypothesized that small-molecule inhibitors of the Bcl-2 family may potentiate the efficacy of CAR T cells by engaging both apoptosis pathways. CAR T cells targeting CD19 were generated from healthy donors as well as from pre-B-ALL (precursor-B acute lymphoblastic leukemia) patients and tested together with ABT-737 to evaluate apoptosis induction in five B-cell tumor cell lines. The CAR T cells were effective even if the cell lines exhibited different apoptosis resistance profiles, as shown by analyzing the expression of apoptosis inhibitors by PCR and western blot. When combining T-cell and ABT-737 therapy simultaneously, or with ABT-737 as a presensitizer, tumor cell apoptosis was significantly increased. In conclusion, the apoptosis inducer ABT-737 enhanced the efficacy of CAR T cells and could be an interesting drug candidate to potentiate T-cell therapy.
|
|
| 16. |
- Mårtensson, Moa, 1975-
(författare)
-
Political Representation in the European Union : A Multi-Channel Approach
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The European Union (EU) is the most far-reaching attempt yet undertaken to institutionalize democratic policy-making beyond the nation-state. To what extent, and in what ways, do various channels of representation contribute towards the realization of this aim? This dissertation takes stock of current research on the EU’s system of representation, and seeks to expand its agenda so that this central question can be properly addressed. In contrast to prior empirical work in the field, the dissertation employs research designs that incorporate several forms of representation into a unified evaluative framework. This multi-channel approach to political representation paves the way for a systematic comparison of how different forms of representation (electoral, territorial and corporate) perform in the EU context. It also makes possible an empirical assessment of a key proposition in current representation theory: that elections, in large and heterogeneous political systems, are outperformed by other forms of representation.The three articles in the dissertation draw on existing cross-country data, interviews with policy-makers and a new dataset collected by the author. They scrutinize representation in three principal channels: electoral representation in the European Parliament, government representation in the preparatory bodies of the Council of Ministers, and representation through organized interests that seek to influence EU policy. The first article examines the balance of power that has emerged between these three channels of representation in the EU’s legislative process, and how the current balance is likely to affect the Union’s legitimacy. The second article investigates how different channels of representation perform in terms of providing linkage between Brussels-based representatives and their domestic principals. The third article examines the extent to which different channels of representation contribute to the coordination of EU policy-making domestically, at the European level, and across the two levels of government.Finally, this dissertation makes a methodological contribution by applying social network analysis (SNA) to classic problems of representation within and across different channels of representation. This approach is novel to the field. Researchers should be able to exploit SNA and relational data fruitfully in the future, in the study of representational relationships in the EU and numerous other contexts.
|
|
| 17. |
- Persson, Mats, et al.
(författare)
-
Energy-resolved CT imaging with a photon-counting silicon-strip detector
- 2014
-
Ingår i: Medical Imaging 2014. - : SPIE - International Society for Optical Engineering. - 9780819498267 ; , s. 90333L-
-
Konferensbidrag (refereegranskat)abstract
- Photon-counting detectors are promising candidates for use in the next generation of x-ray CT scanners. Among the foreseen benefits are higher spatial resolution, better trade-off between noise and dose, and energy discriminating capabilities. Silicon is an attractive detector material because of its low cost, mature manufacturing process and high hole mobility. However, it is sometimes claimed to be unsuitable for use in computed tomography because of its low absorption efficiency and high fraction of Compton scatter. The purpose of this work is to demonstrate that high-quality energy-resolved CT images can nonetheless be acquired with clinically realistic exposure parameters using a photon-counting silicon-strip detector with eight energy thresholds developed in our group. We use a single detector module, consisting of a linear array of 50 0.5 × 0.4 mm detector elements, to image a phantom in a table-top lab setup. The phantom consists of a plastic cylinder with circular inserts containing water, fat and aqueous solutions of calcium, iodine and gadolinium, in different concentrations. We use basis material decomposition to obtain water, calcium, iodine and gadolinium basis images and demonstrate that these basis images can be used to separate the different materials in the inserts. We also show results showing that the detector has potential for quantitative measurements of substance concentrations.
|
|
| 18. |
- Persson, Mats, et al.
(författare)
-
Energy-resolved CT imaging with a photon-counting silicon-strip detector
- 2014
-
Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 59:22, s. 6709-6727
-
Tidskriftsartikel (refereegranskat)abstract
- Photon-counting detectors are promising candidates for use in the next generation of x-ray computed tomography (CT) scanners. Among the foreseen benefits are higher spatial resolution, better trade-off between noise and dose and energy discriminating capabilities. Silicon is an attractive detector material because of its low cost, mature manufacturing process and high hole mobility. However, it is sometimes overlooked for CT applications because of its low absorption efficiency and high fraction of Compton scatter. The purpose of this work is to demonstrate that silicon is a feasible material for CT detectors by showing energy-resolved CT images acquired with an 80 kVp x-ray tube spectrum using a photon-counting silicon-strip detector with eight energy thresholds developed in our group. We use a single detector module, consisting of a linear array of 50 0.5 x 0.4 mm detector elements, to image a phantom in a table-top lab setup. The phantom consists of a plastic cylinder with circular inserts containing water, fat and aqueous solutions of calcium, iodine and gadolinium, in different concentrations. By using basis material decomposition we obtain water, calcium, iodine and gadolinium basis images and demonstrate that these basis images can be used to separate the different materials in the inserts. We also show results showing that the detector has potential for quantitative measurements of substance concentrations.
|
|
| 19. |
- Persson, Thomas, 1969-, et al.
(författare)
-
Drivers of parliamentary opposition in European Union politics: institutional factors or party characteristics?
- 2024
-
Ingår i: Journal of European Public Policy. - : Informa UK Limited. - 1350-1763 .- 1466-4429. ; 31:3
-
Tidskriftsartikel (refereegranskat)abstract
- A vital political opposition is one of the cornerstones of democracy, yet we know surprisingly little about the conditions that shape it. In this paper, we offer a comprehensive assessment of the drivers of parliamentary opposition in European Union (EU) politics in five countries: Denmark; Germany; Ireland; Sweden; and the United Kingdom. Based on an extensive hand-coded data set of 7,520 statements made by members of parliament (MPs) during both plenary sessions and deliberations during European Affairs Committee (EAC) meetings, we examine how institutions and party characteristics shape two types of oppositional behaviour: the expression of critique and the presentation of alternatives. We find that both factors are important for understanding to what extent, and how, opposition is voiced in national parliaments. Oversight institutions’ strength and a party’s degree of Euroscepticism jointly function as significant determinants of the likelihood that MPs will express opposition in the form of critique. However, when it comes to the likelihood of offering alternatives, oversight institutions’ strength fails to explain variations in the share of alternatives, while degree of Euroscepticism remains a significant predictor.
|
|
| 20. |
- Persson, Thomas, 1969-, et al.
(författare)
-
Eurosceptic Challenger Parties and Political Opposition in European Union Politics : Part of the Problem or Part of the Solution?
- 2019
-
Ingår i: Scandinavian Political Studies. - : John Wiley & Sons. - 0080-6757 .- 1467-9477. ; 42:3-4, s. 245-269
-
Tidskriftsartikel (refereegranskat)abstract
- Despite extensive research on Eurosceptic challenger parties, our knowledge of their influence on political opposition has so far been sparse. In this article we make an in-depth assessment of parliamentary EU opposition, based on 4,264 statements made by national parliamentarians in the European Affairs Committees (EACs) of Denmark and Sweden. Our analysis shows that the presence of Eurosceptic challenger parties in the national parliamentary arena impacts patterns and practices of EU opposition significantly. A greater presence of ‘hard’ Eurosceptic parties in parliament is associated with more opposition in EU politics. These parties deliver a vast majority of the polity-oriented opposition towards the EU and present more policy alter- natives than mainstream parties. The findings presented have implications for our understand- ing of national parliamentary EU opposition as well as for the assessment of the impact of Eurosceptic challenger parties on the process of European integration.
|
|
| 21. |
- Persson, Thomas, 1969-, et al.
(författare)
-
The influence of Eurosceptic challenger parties on mainstream party behaviour : Is oppositional behaviour contagious?
- 2023
-
Ingår i: Party Politics. - : Sage Publications. - 1354-0688 .- 1460-3683. ; 29:1, s. 100-111
-
Tidskriftsartikel (refereegranskat)abstract
- Previous research has looked at how Eurosceptic challenger parties can cause mainstream parties to change their policy positions and bring about adjustments to their programmes. We explore whether this contagion effect extends to the parliamentary behaviour of mainstream parties in European Union (EU) affairs. The empirical analysis is based on a large-scale study of 6215 statements made by national parliamentarians in the European Affairs Committee of Sweden between 1995 and 2016. A dynamic panel analysis of the data shows that the oppositional behaviour of Eurosceptic challenger parties has a significant impact on the opposition statements made in EU affairs by mainstream parties. These findings have important implications for the general understanding of factors that drive national EU opposition.
|
|
| 22. |
- Piussi, Ramana, et al.
(författare)
-
When context creates uncertainty : experiences of patients who choose rehabilitation as a treatment after an ACL injury
- 2023
-
Ingår i: BMJ Open Sport and Exercise Medicine. - London : BMJ Publishing Group Ltd. - 2055-7647. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Up to 50% of patients who suffer an anterior cruciate ligament (ACL) injury receive or opt for rehabilitation alone as initial treatment in Scandinavia. Knowledge of whether patients treated with rehabilitation alone after ACL injury are satisfied is lacking. This study aimed to explore the experiences of patients treated with rehabilitation alone after an ACL injury. Fourteen patients (35.9 (19-56) years old) who suffered an ACL injury treated with rehabilitation alone, a mean of 32 months before inclusion, were interviewed. The interview transcripts were analysed using qualitative content analysis with an inductive approach. The experiences of patients treated with rehabilitation after an ACL injury were summarised in one theme: Is the grass greener on the other side? Context characterised by uncertainty', supported by three main categories and nine subcategories. Uncertainty permeated the context of all levels of knee-related life following ACL injury: (1) in the past, patients felt uncertainty regarding treatment choices, (2) in the present, patients felt uncertainty regarding their physical capacity and knee self-efficacy, and (3) for the future, patients felt uncertainty regarding what might happen. With few exceptions, patients' experiences after an ACL injury treated with rehabilitation alone are characterised by uncertainty regarding their physical function, psychological impairments and possible future limitation of knee function. Uncertainty is experienced by patients in the past, the present and the future. Patients experience the knee as a symptomatic obstacle and need to adapt the physical activity to the presence of symptoms. © 2023 BMJ Publishing Group. All rights reserved.
|
|
| 23. |
- Ståhle, Alexander, et al.
(författare)
-
Designguide för Smarta gator
- 2022
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
|
|
| 24. |
- Venetsanos, Dimitrios, et al.
(författare)
-
Uninterrupted Oral Anticoagulant Therapy in Patients Undergoing Unplanned Percutaneous Coronary Intervention
- 2021
-
Ingår i: JACC. - : ELSEVIER SCIENCE INC. - 1936-8798 .- 1876-7605. ; 14:7, s. 754-763
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES This study sought to compare interrupted and uninterrupted oral anticoagulant therapy (I-OAC vs. U-OAC) in patients on OAC undergoing percutaneous coronary intervention. BACKGROUND There is a paucity of data regarding the optimal peri-procedural management of OAC-treated patients. METHODS In the SWEDEHEART registry, all patients on OAC who were admitted acutely and underwent percutaneous coronary intervention or coronary angiography with a diagnostic procedure, from 2005 to 2017, were included. Outcomes were major adverse cardiac and cerebrovascular events (MACCE; death, myocardial infarction, or stroke) and bleeds at 120 days. Propensity score was used to adjust for the nonrandomized treatment selection. RESULTS The study included 6,485 patients: 3,322 in the I-OAC group and 3,163 in the U-OAC group. The cumulative incidence of MACCE was 8.2% (269 events) versus 8.2% (254 events) in the I-OAC and the U-OAC groups, respectively. The adjusted risk for MACCE did not differ between the groups (I-OAC vs. U-OAC hazard ratio: 0.89; 95% confidence interval: 0.71 to 1.12). Similarly, no difference was found in the risk for MACCE or bleeds (12.6% vs. 12.9%, adjusted hazard ratio: 0.87; 95% confidence interval: 0.70 to 1.07). The risk for major or minor in-hospital bleeds did not differ between the groups. However, U-OAC was associated with a significantly shorter duration of hospitalization: 4 (3 to 7) days versus 5 (3 to 8) days; p < 0.01. CONCLUSIONS I-OAC and U-OAC were associated with equivalent risk for MACCE and bleeding complications. An U-OAC strategy was associated with shorter length of hospitalization. These data support U-OAC as the preferable strategy in patients on OAC undergoing coronary intervention. (c) 2021 by the American College of Cardiology Foundation.
|
|
| 25. |
- Xu, Cheng, et al.
(författare)
-
Evaluation of an ultra-fast photon-counting energy-resolved ASIC for spectral CT
- 2012
-
Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE - International Society for Optical Engineering. - 9780819489623 ; , s. 83130Y-
-
Konferensbidrag (refereegranskat)abstract
- We have developed an ultra-fast photon-counting energy-resolved application specific integrated circuit (ASIC) for spectral computed tomography (CT). A comprehensive characterization has been carried out to investigate the performance of the ASIC in terms of energy resolution under different photon flux rates and the count rate linearity in photon-counting mode. An energy resolution of 4.7 % has been achieved for 59.5 keV low flux photons. The count rate performance of the ASIC was measured with 120 kVp polychromatic x-rays. The results indicate that the count rate linearity can be kept for a flux rate up to 150 Mphotons s -1 mm -2 with retained energy information, and this value is increased to be 250 Mphotons s -1 mm -2 in photon-counting mode.
|
|
