| 1. |
- Hagberg, Stig, et al.
(författare)
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Exposure to volatile methacrylates in dental personnel.
- 2005
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Ingår i: Journal of occupational and environmental hygiene. - : Informa UK Limited. - 1545-9624 .- 1545-9632. ; 2:6, s. 302-6
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Tidskriftsartikel (refereegranskat)abstract
- Dental personnel are exposed to acrylates due to the acrylic resin-based composites and bonding agents used in fillings. It is well known that these compounds can cause contact allergy in dental personnel. However, in the 1990s, reports emerged on asthma also caused by methacrylates. The main volatile acrylates in dentistry are 2-hydroxyethyl methacrylate and methyl methacrylate. The aim of this study was to quantify the exposure to these acrylates in Swedish dental personnel. We studied the exposure to 2-hydroxyethyl methacrylate and methyl methacrylate in five randomly selected public dental clinics and at the Faculty of Odontology at G?teborg University. In total, 21 whole-day and 46 task-specific short-term (1-18 min) measurements were performed. The median 8-hour time-weighted averages were 2.5 microg/m3 (dentists) and 2.9 microg/m3 (dental nurses) for 2-hydroxyethyl methacrylate, and 0.8 microg/m3 (dentists) and 0.3 microg/m3 (dental nurses) for methyl methacrylate. The maximum short-term exposure levels were 79 microg/m3 for 2-hydroxyethyl methacrylate and 15 microg/m3 for methyl methacrylate, similar in dentists and dental nurses. The observed levels are much lower than in complete denture fabrication. We found only one previous study in dentistry and it showed similar results (though it reported short-term measurements only). Irritant effects would not be expected in healthy people at these levels. Nevertheless, occupational respiratory diseases due to methacrylates may occur in dental personnel, and improvements in the handling of these chemicals in dentistry are warranted. This includes better vials for the bonding agents and avoiding evaporation from discarded materials.
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| 2. |
- Akselsson, Roland, et al.
(författare)
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Fysikaliska faktorer
- 1994
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Ingår i: Arbete Människa Teknik. - 9175224143 ; , s. 45-113
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Akselsson, Roland, et al.
(författare)
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Fysikaliska faktorer
- 2005
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Ingår i: Arbete Människa Teknik. - 9175228955 ; , s. 45-113
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Akselsson, Roland, et al.
(författare)
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Safety and Risk
- 2009
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Ingår i: Work and technology on human terms. - 9789173650588 ; , s. 425-461
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Akselsson, Roland, et al.
(författare)
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Säkerhet och risk
- 2008
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Ingår i: Arbete och teknik på människans villkor. - 9789173650373 ; , s. 425-461
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
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| 7. |
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| 8. |
- Aléx, Jonas, 1975-
(författare)
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Cold exposure and thermal comfort among patients in prehospital emergency care : innovation research in nursing
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundPatients’ cold exposure is a neglected problem in prehospital emergency care. Cold stress increases pain and anxiety and contributes to fear and an overall sense of dissatisfaction. When left untreated, cold stress disturbs vital body functions until ultimately reaches hypothermia.AimThe overall aim was to investigate patients’ experiences of thermal comfort and reactions to cold exposure in prehospital emergency care and to evaluate the effects of an intervention using active warming from underneath.MethodStudy I:Persons (n=20) injured in a cold environment in the north of Sweden were interviewed. Active heat was given to 13 of them.Study II:In wintertime, 62 patients were observed during prehospital emergency care. The field study was based on observations, questions about thermal discomfort, vital signs, and temperature measurements.Study III:Healthy young persons (n=23) participated in two trials each. Data were collected inside and outside a cold chamber. In one trial, the participants were lying on a regular ambulance stretcher and in a second trial on a stretcher supplied with a heated mattress. Outcomes were the Cold Discomfort Scale (CDS), back, finger, and core body temperature, four statements from the State-TraitAnxiety-Inventory (STAI), vital signs, and short notes about their experiences of the two stretchers.Study IV:A quantitative intervention study was conducted in prehospital emergency care in the north of Sweden. The patients (n=30) in the intervention group were transported in an ambulance supplemented with a heated mattress on the stretcher, whereas only a regular stretcher was used in the ambulance for the patients (n=30) in the control group. Outcomes were the CDS, finger, core body, and air temperature, and questions about cold experiences.ResultsStudy I:Patients suffered more because of the cold than from the pain of their injuries. The patients were in a desperate need of heat.Study II:Patients are exposed to cold stress due to cold environments. There was a significant decrease from the first measurement in finger temperature of patients who were indoors when the ambulance arrived, compared to the measurement taken in the ambulance. In the patient compartment of the ambulance, 85% of the patients had a finger temperature below the comfort zone and almost half of them experienced the patient compartment in the ambulance to be cold. The regular mattress surface temperature at the ambulance ranged from -22.3 to 8.4 ºC.Study III:A statistical increase of the participants’ back temperature was found between those lying on the heated mattress compared to those lying on the regular mattress. The heated mattress was experienced as warm, comfortable, providing security, and easy to relax on.Study IV:Thermal comfort increased for the patients in the intervention group and decreased in the control group. A significant higher proportion of the participants rated the stretcher as cold to lie on in the control group compared to the intervention group.ConclusionThe ambulance milieu is too cold to provide thermal comfort. Heat supply from underneath increased comfort and might prevent cold stress and hypothermia
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| 9. |
- Alex, Jonas, et al.
(författare)
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Effect evaluation of a heated ambulance mattress-prototype on body temperatures and thermal comfort - an experimental study
- 2014
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Ingår i: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. - : Springer Science and Business Media LLC. - 1757-7241. ; 22, s. 43-
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Tidskriftsartikel (refereegranskat)abstract
- Background:Exposure to cold temperatures is, often, a neglected problem in prehospital care. One of the leading influences of the overall sensation of cold discomfort is the cooling of the back. The aim of this study was to evaluate the effect of a heated ambulance mattress-prototype on body temperatures and thermal comfort in an experimental study.Method: Data were collected during four days in November, 2011 inside and outside of a cold chamber. All participants (n = 23) participated in two trials each. In one trial, they were lying on a stretcher with a supplied heated mattress and in the other trial without a heated mattress. Outcomes were back temperature, finger temperature, core body temperature, Cold Discomfort Scale (CDS), four statements from the state-trait anxiety - inventory (STAI), and short notes of their experiences of the two mattresses. Data were analysed both quantitatively and qualitatively. A repeated measure design was used to evaluate the effect of the two mattresses.Results:A statistical difference between the regular mattress and the heated mattress was found in the back temperature. In the heated mattress trial, the statement "I am tense" was fewer whereas the statements "I feel comfortable", "I am relaxed" and "I feel content" were higher in the heated mattress trial. The qualitative analyses of the short notes showed that the heated mattress, when compared to the unheated mattress, was experienced as warm, comfortable, providing security and was easier to relax on.Conclusions:Heat supply from underneath the body results in increased comfort and may prevent hypothermia which is important for injured and sick patients in ambulance care.
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| 10. |
- Aléx, Jonas, et al.
(författare)
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Effect evaluation of a heated ambulance mattress-prototype on thermal comfort and patients' temperatures in prehospital emergency care - an intervention study
- 2015
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Ingår i: International Journal of Circumpolar Health. - : Informa UK Limited. - 1239-9736 .- 2242-3982. ; 74
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The ambulance milieu does not offer good thermal comfort to patients during the cold Swedish winters. Patients' exposure to cold temperatures combined with a cold ambulance mattress seems to be the major factor leading to an overall sensation of discomfort. There is little research on the effect of active heat delivered from underneath in ambulance care. Therefore, the aim of this study was to evaluate the effect of an electrically heated ambulance mattress-prototype on thermal comfort and patients' temperatures in the prehospital emergency care.METHODS: A quantitative intervention study on ambulance care was conducted in the north of Sweden. The ambulance used for the intervention group (n=30) was equipped with an electrically heated mattress on the regular ambulance stretcher whereas for the control group (n=30) no active heat was provided on the stretcher. Outcome variables were measured as thermal comfort on the Cold Discomfort Scale (CDS), subjective comments on cold experiences, and finger, ear and air temperatures.RESULTS: Thermal comfort, measured by CDS, improved during the ambulance transport to the emergency department in the intervention group (p=0.001) but decreased in the control group (p=0.014). A significant higher proportion (57%) of the control group rated the stretcher as cold to lie down compared to the intervention group (3%, p<0.001). At arrival, finger, ear and compartment air temperature showed no statistical significant difference between groups. Mean transport time was approximately 15 minutes.CONCLUSIONS: The use of active heat from underneath increases the patients' thermal comfort and may prevent the negative consequences of cold stress.
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| 11. |
- Aléx, Jonas, et al.
(författare)
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Patients' experiences of cold exposure during ambulance care
- 2013
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Ingår i: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. - London : BioMed Central. - 1757-7241. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Exposure to cold temperatures is often a neglected problem in prehospital care. Cold exposure increase thermal discomfort and, if untreated causes disturbances of vital body functions until ultimately reaching hypothermia. It may also impair cognitive function, increase pain and contribute to fear and an overall sense of dissatisfaction. The aim of this study was to investigate injured and ill patients' experiences of cold exposure and to identify related factors.METHOD: During January to March 2011, 62 consecutively selected patients were observed when they were cared for by ambulance nursing staff in prehospital care in the north of Sweden. The field study was based on observations, questions about thermal discomfort and temperature measurements (mattress air and patients' finger temperature). Based on the observation protocol the participants were divided into two groups, one group that stated it was cold in the patient compartment in the ambulance and another group that did not. Continuous variables were analyzed with independent sample t-test, paired sample t-test and dichotomous variables with cross tabulation.RESULTS: In the ambulance 85% of the patients had a finger temperature below comfort zone and 44% experienced the ambient temperature in the patient compartment in the ambulance to be cold. There was a significant decrease in finger temperature from the first measurement indoor compared to measurement in the ambulance. The mattress temperature at the ambulance ranged from -22.3°C to 8.4°C.CONCLUSION: Cold exposure in winter time is common in prehospital care. Sick and injured patients immediately react to cold exposure with decreasing finger temperature and experience of discomfort from cold. Keeping the patient in the comfort zone is of great importance. Further studies are needed to increase knowledge which can be a base for implications in prehospital care for patients who probably already suffer for other reasons.
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| 12. |
- Andersson, Eva, 1955, et al.
(författare)
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Incidence of asthma among workers exposed to sulfur dioxide and other irritant gases
- 2006
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 27:4, s. 720-5.
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO2) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire. The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age. The incidence rate for asthma among sulphite mill workers reporting gassings of SO2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO2, the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males. In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.
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| 13. |
- Andersson, Håkan, 1944, et al.
(författare)
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Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model
- 2003
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Ingår i: Clin Cancer Res. - 1078-0432. ; 9:10 Pt 2
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The aim of the study was to establish and refine a preclinical model to alpha-immunoradiotherapy of ovarian cancer. EXPERIMENTAL DESIGN: At-211 was produced by cyclotron irradiation of a bismuth-209 target and isolated using a novel dry distillation procedure. Monoclonal antibodies were radiohalogenated with the intermediate reagent N-succinimidyl 3-(trimethylstannyl)benzoate and characterized in terms of radiochemical yield and in vitro binding properties. In vitro OVCAR-3 cells were irradiated using an external Cobalt-60 beam, as reference, or At-211-albumin and labeled antibody. Growth assays were used to establish cell survival. A Monte Carlo program was developed to simulate the energy imparted and the track length distribution. Nude mice were used for studies of WBC depression, with various activities of Tc-99m antibodies, as reference, and At-211 antibodies. In efficacy studies, OVCAR-3 cells were inoculated i.p., and animals were treated 2 weeks later. The animals were either dissected 6 weeks later or followed-up for long-term survival. RESULTS: A rapid distillation procedure, as well as a rapid and high-yield, single-pot labeling procedure, was achieved. From growth inhibition data, the relative biological effectiveness of the alpha-emission for OVCAR-3 cells was estimated to be approximately 5, which is in the same range as found in vivo for hematological toxicity. At-211 MOv18 was found to effectively inhibit the development of tumors and ascites, also resulting in long-term survival without significant toxic effect. CONCLUSIONS: Use of the short-range, high-linear energy transfer alpha-emitter At-211 conjugated to a surface epitope-recognizing monoclonal antibody appears to be highly efficient without significant toxicity in a mouse peritoneal tumor model, urging a Phase I clinical trial.
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| 14. |
- Andreasson, Harriet, et al.
(författare)
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On permeability of methyl methacrylate, 2-hydroxyethyl methacrylate and triethyleneglycol dimethacrylate through protective gloves in dentistry.
- 2003
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Ingår i: European journal of oral sciences. - : Wiley. - 0909-8836 .- 1600-0722. ; 111:6, s. 529-35
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Tidskriftsartikel (refereegranskat)abstract
- Continuous glove use is more common in dentistry than in most other occupations, and the glove should offer protection against blood-borne infections, skin irritants and contact allergens. Methacrylate monomers are potent contact allergens, and it is known that these substances may penetrate the glove materials commonly used. The aim of this study was to assess the permeability of various types of gloves to methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA) and triethyleneglycol dimethacrylate (TEGDMA) with special reference to combinations with ethanol or acetone. The permeation rate and time lag breakthrough (lag-BT) for MMA (neat, or diluted to 30% in ethanol or acetone), HEMA (30% in water, ethanol, or acetone) and TEGDMA (30% in ethanol or acetone) were investigated for different protective gloves. Nine different types of gloves were tested for one or several of these methacrylates. The lag-BT for neat MMA was
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| 15. |
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| 16. |
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| 17. |
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Arbete och teknik på människans villkor
- 2015. - 3
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- För att förstå samspelet mellan människor och mellan människor och teknik, krävs kunskaper inom flera olika områden. Boken inkluderar därför begrepp, kunskaper och metoder från bland annat psykologi, medicin, sociologi, fysik, kemi, ekonomi och juridik.Boken vänder sig främst till studerande inom arbetsvetenskap, ergonomi och liknande ämnesbenämningar på tekniska universitets- och högskoleutbildningar. Den passar också yrkesverksamma arbetsmiljöingenjörer, ergonomer och sjukgymnaster med flera.
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| 18. |
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| 19. |
- Axelsson, C, et al.
(författare)
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Passive leg raising during cardiopulmonary resuscitation in out-of-hospital cardiac arrest--does it improve circulation and outcome?
- 2010
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Ingår i: Resuscitation. - : Elsevier BV. - 1873-1570 .- 0300-9572. ; 81:12, s. 1615-20
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Tidskriftsartikel (refereegranskat)abstract
- Passive leg raising (PLR), to augment the artificial circulation, was deleted from cardiopulmonary resuscitation (CPR) guidelines in 1992. Increases in end-tidal carbon dioxide (P(ET)CO(2)) during CPR have been associated with increased pulmonary blood flow reflecting cardiac output. Measurements of P(ET)CO(2) after PLR might therefore increase our understanding of its potential value in CPR. We also observed the alteration in P(ET)CO(2) in relation to the return of spontaneous circulation (ROSC) and no ROSC.
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| 20. |
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| 21. |
- Bergh Alvergren, Victor, 1991, et al.
(författare)
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D17.3. Eco-Driving Assistance. Guidelines for Ergonomic Design of Eco-Driving Assistance HMIs
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Based on an extensive literature survey and an analysis of the results from EBSF_2 demonstrations of different Green Driving Assistance Systems in Barcelona, Lyon, Madrid, and San Sebastian, this deliverable proposes guidelines for the design of an eco-driving assistance system HMI. In addition to general HMI guidelines, to be applied to the design of all in-vehicle HMIs, the deliverable suggests design guidelines in relation to pre-drive, on-drive, ride-break, and post-ride HMIs, i.e. information presented in the HMI of a driver assistance system at different timeframes. The guidelines concern information content as well as the choice of information modality.
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| 22. |
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| 23. |
- Bohgard, Mats, et al.
(författare)
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Chemical Health Risks
- 2009
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Ingår i: Work and Technology on Human Terms. - 9789173650588 ; , s. 307-337
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 24. |
- Bohgard, Mats, et al.
(författare)
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Designing work and technology on human terms
- 2009. - 1:1
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Ingår i: Work and technology on human terms. - Stockholm : Prevent. - 9789173650588 ; , s. 9-18
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Bokkapitel (populärvet., debatt m.m.)
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| 25. |
- Bohgard, Mats, et al.
(författare)
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Fysikaliska faktorer
- 2008
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Ingår i: Arbete och teknik på människans villkor. - 9789173650373 ; , s. 191-307
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 26. |
- Bohgard, Mats, et al.
(författare)
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Kemiska hälsorisker
- 2008
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Ingår i: Arbete och teknik på människans villkor. - 9789173650373 ; , s. 309-337
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Bokkapitel (populärvet., debatt m.m.)
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| 27. |
- Bohgard, Mats, et al.
(författare)
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Physical Factors
- 2009
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Ingår i: Work and Technology on Human Terms. - 9789173650588 ; , s. 191-306
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 28. |
- Book, K, et al.
(författare)
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Functional adaptation to full-arch fixed prosthesis supported by osseointegrated implants in the edentulous mandible.
- 1992
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Ingår i: Clinical oral implants research. - 0905-7161. ; 3:1, s. 17-21
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Tidskriftsartikel (refereegranskat)abstract
- The objective of the present study was to assess possible adaptive functional changes in the masticatory system after insertion of fixed prostheses supported by osseointegrated implants in the edentulous mandible. Registrations of mandibular movement characteristics and maximal biteforce were performed at insertion and after 1 week, 3 months and 1 year after connection. The duration of the opening and closing phase decreased and maximal biteforce increased significantly (p < or = 0.05-0.001) from connection of the prostheses to the annual check-up. However, the process of functional adaptation implied 2 identified stages. An immediate phase that occurred within the 1st week, probably due to altered impact from mechano-sensitive receptors and a later more time-dependent phase, based on learning and new cortical engrams. Accordingly, the process of adaptation will continue over a long period of time.
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| 29. |
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| 30. |
- Brandt, Lennart, et al.
(författare)
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Myelography in the late postoperative period in patients subjected to anterior cervical decompression and fusion
- 1993
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Ingår i: Acta Neurochirurgica. - 0001-6268. ; 122:1-2, s. 97-101
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Tidskriftsartikel (refereegranskat)abstract
- During a 13 year period, 286 patients with cervical disc herniation and/or spondylotic spurs, were subjected to anterior decompression and vertebral interbody fusion with autologous bone. Twenty patients were re-admitted in the late postoperative period due to recurrent radicular symptoms and/or signs of myelopathy. In these patients myelography was performed again. In 14 patients spinal cord compression and/or nerve root involvement at a new level was visualized. At the operated level, however, the myelograms demonstrated a smooth anterior wall in the spinal canal. The series confirms the safety, effectiveness and reliability of the Cloward procedure in achieving long term spinal cord and nerve root decompression, and a solid vertebral interbody fusion.
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| 31. |
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| 32. |
- Carr, Amelia, et al.
(författare)
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Nutritional intake in elite cross-country skiers during a simulated sprint race
- 2017
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Konferensbidrag (refereegranskat)abstract
- Introduction: Habitual nutritional intakes in cross-country skiers have previously been reported (Fogelholm et al., 1992), however in elite cross-country skiers there is limited knowledge about race-specific nutritional practices, or the prevalence of dehydration and persistent low energy availability (EA). This study aimed to investigate, in the context of a simulated sprint race, energy intake, macronutrient intake, hydration status and the risk of persistent low EA in elite cross-country skiers. Methods: Thirty-two male (n = 18) and female (n = 14) elite Swedish cross-country skiers completed weighed food records the day prior to (day 1) and the day of a simulated sprint race (day 2); the food records were analysed for energy (kcal/kg), macronutrient (g/kg) and fluid intake (L). Urine specific gravity (USG) was also measured on day 1 and day 2. The risk for persistent low EA was assessed in the female skiers using the Low Energy Availability in Females Questionnaire (LEAF-Q; Melin et al., 2014). Results were analysed using a three-way mixed ANOVA. Statistical significance was set to a level of p ≤ 0.05. Results: Males had a higher energy intake (65±9 kcal/kg) on day 1, (pre-race) compared with day 2 (simulated sprint race; 58±9kcal/kg; p = 0.002). Females consumed 57±10 kcal/kg on day 1, which was similar to their day 2 energy intake (54±6 kcal on day 2; p > 0.05). Males consumed less carbohydrate (8.2±2.3g/kg) on day 1 compared with day 2 (8.9±2.3g/kg) (p = 0.026), as did females, consuming 7.0±1.5g/kg on day 1, and 8.4±1.7g/kg on day 2 (p = 0.003). There were similar fluid intakes across the two days for males (p > 0.05) and females (p > 0.05). Nine of the 18 males and 6 of the 14 females were dehydrated (USG > 1.020) on day 1, and 9 males and 5 females were dehydrated on day 2. Five of the 14 females were classified as being at risk of persistent low EA. Discussion: This study provides an initial insight into nutritional competition habits in elite cross-country skiers. The findings indicate that elite skiers’ nutritional intakes are consistent with guidelines, particularly those for endurance athletes’ carbohydrate intake for competitive events (Burke et al., 2001). There was however some evidence of persistent low EA and dehydration, suggesting additional considerations that may be relevant to cross-country skiers’ nutritional intakes for sprint races.
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| 33. |
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| 34. |
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| 35. |
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| 36. |
- Dencker, Magnus, et al.
(författare)
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Body fat related to daily physical activity and insulin concentrations in non-diabetic children.
- 2008
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Ingår i: Clinical Physiology and Functional Imaging. - 1475-0961. ; 28, s. 211-215
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Tidskriftsartikel (refereegranskat)abstract
- This study explored the associations between body fat versus daily physical activity and insulin concentrations in non-diabetic young children in a cross-sectional study of 172 children (93 boys and 79 girls) aged 8-11 years. Blood samples were analysed for serum insulin and daily physical activity was measured by accelerometers. Time spent performing vigorous activity was estimated from accelerometer data by using established cut-off points. Dual-energy x-ray absorptiometry (DXA) was used to quantify abdominal fat mass (AFM) and total body fat (TBF), also calculated as percentage of body weight (BF%). Body fat distribution was calculated as AFM/TBF. Body fat distribution was independently linked to both insulin concentrations and physical activity. In contrast, TBF, AFM, and BF% were linked to physical activity only and not to insulin concentrations. In conclusion in this population of non-diabetic children, body fat distribution was independently associated with increased concentrations of insulin and deceased amount of vigorous activity per day. Also, AFM, TBF, and BF% were independently related to minutes of vigorous activity per day.
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| 37. |
- Dencker, Magnus, et al.
(författare)
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Gender differences and determinants of aerobic fitness in children aged 8-11 years.
- 2007
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Ingår i: European Journal of Applied Physiology. - : Springer Science and Business Media LLC. - 1439-6327 .- 1439-6319. ; 99, s. 19-26
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies of gender differences in maximum oxygen uptake have come to different conclusions. Limited data exists where the determinants of maximum oxygen uptake have been evaluated in a comprehensive manner. Thus, we examined 248 children (140 boys and 108 girls), aged 7.9-11.1 years. Body composition was determined by dual-energy X-ray absorptiometry, measured variables were total body fat (TBF) and lean body mass (LBM). Maximal oxygen uptake (VO2peak) was measured by indirect calorimetry during a maximal cycle exercise test. Daily physical activity was assessed by accelerometers and duration of vigorous activity per day (VPA) was calculated. Left ventricular inner diastolic diameter (LVDD) was measured by echocardiography. Lung function was evaluated with spirometric testing and whole body plethysmography. Boys had between 8 and 18% higher values than girls for VO2peak, dependent upon whether VO2peak was expressed in absolute values or scaled to body mass, LBM or if allometric scaling was used. In multiple regression analysis absolute values of aerobic fitness were independently related to LBM, maximal heart rate (Max HR), gender, LVDD, and VPA. Furthermore, when VO2peak was scaled to body mass it was independently related to In TBF, Max HR, gender, VPA, and LVDD. Lung function had no relation to VO2peak. Our study concludes that body composition is the main predictor for VO2peak, in children aged 8-11 years, whereas VPA or LVDD has only a modest impact. Existing gender differences in VO2peak cannot be explained only by differences in body composition, physical activity, or heart size.
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| 38. |
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| 39. |
- Edlund, Agneta, et al.
(författare)
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Delirium in older patients admitted to general internal medicine.
- 2006
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Ingår i: Journal of Geriatric Psychiatry and Neurology. - : SAGE Publications. - 0891-9887 .- 1552-5708. ; 19:2, s. 83-90
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Tidskriftsartikel (refereegranskat)abstract
- Delirium on the day of admission to general internal medicine wards was studied in 400 consecutive patients aged 70 years and above regarding occurrence, associated factors, clinical profile, length of hospital stay, and mortality. The patients were assessed using the Organic Brain Syndrome Scale and the Mini-Mental State Examination, and delirium was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (4th ed) criteria. Delirium on the day of admission occurred in 31.3% of the patients and was independently associated with old age, fever on the day of admission (≥ 38°C), treatment with neuroleptics, impaired vision, male sex, and previous stroke. Delirious patients had longer hospital stay (15.4 vs 9.5 days, P < .001), a higher mortality rate during hospitalization (11/125 vs 5/275, P < .001), and a higher 1-year mortality rate (45/125 vs 55/275, P = .001). Delirium is a common complication with often easily identified causes, and it has a serious impact on outcome for older medical patients.
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| 40. |
- Edvardsson, David, et al.
(författare)
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Associations between the working characteristics of nursing staff and the prevalence of behavioral symptoms in people with dementia in residential care
- 2008
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Ingår i: International psychogeriatrics. - New York : Cambridge University Press. - 1041-6102 .- 1741-203X. ; 20:4, s. 764-776
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Clinical experience suggests that the work characteristics of staff in residential care may influence the well-being of residents with dementia. However, few studies have explored those anecdotal experiences. The aim of this study was to investigate associations between work characteristics of nursing staff and prevalence of behavioral symptoms among people with dementia in residential care settings.METHODS: The self-report job strain assessment scale was used to measure staff perceptions of their working environment, and the Multi Dimensional Dementia Assessment Scale to measure the occurrence of behavioral symptoms among residents in 40 residential care units for people with dementia.RESULTS: The findings show that in settings where staff reported high job strain, the prevalence of behavioral symptoms was significantly higher compared to settings where staff reported low job strain. Furthermore, settings characterized by staff having a more positive caring climate had significantly less prevalence of escape, restless and wandering behaviors compared to settings having a less positive caring climate. There was no statistically significant association between staff members' self-reported knowledge in caring for people with dementia and prevalence of behavioral symptoms.CONCLUSIONS: This study provides evidence for the oft-cited clinical experience that the well-being of nursing staff is associated with the well-being of people with dementia in residential care settings.
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| 41. |
- Edvardsson, David, et al.
(författare)
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Predictors of job strain in residential dementia care nursing staff
- 2009
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Ingår i: Journal of Nursing Management. - : Hindawi Limited. - 0966-0429 .- 1365-2834. ; 17:1, s. 59-65
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To identify predictors of job strain in residential nursing care staff working with people with dementia. BACKGROUND: It is well known that nursing staff experience high levels of stress, but less is known about how to predict job strain. METHODS: The job strain of nursing care staff (n = 344) within residential dementia care settings was assessed. Standard linear regression analysis was used to explore predictors of job strain. RESULT: Data from the study shows that nursing staff in residential dementia care have a demanding job and experience high levels of strain. The linear regression model with four predictor variables explained 19% of the variability in job strain scores. Perceived caring climate of the unit, staff education level, possibilities to have discussions of difficulties and ethics at work and staff age, had a statistically significant association with job strain. CONCLUSIONS: The caring climate, staff education, reflective practice and staff age can be used as screening variables when predicting job strain. IMPLICATIONS FOR NURSING MANAGEMENT: These predictors can assist managers and directors to identify targeted strategies for supervision and support of nursing staff to secure their well-being, and by that securing the quality of care provided to residents.
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| 42. |
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| 43. |
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| 44. |
- Elgqvist, Jörgen, 1963, et al.
(författare)
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Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody MX35
- 2005
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Ingår i: J Nucl Med. - 0161-5505. ; 46:11, s. 1907-15
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate the therapeutic efficacy of-and to estimate the absorbed dose to-tumor cells from radioimmunotherapy (RIT) in an ovarian cancer model using the alpha-particle-emitting nuclide (211)At labeled to monoclonal antibody (mAb) MX35. Previous studies on mAb MOv18 did not allow for dosimetry because of antigen shedding in vitro. METHODS: Five-week-old female nude BALB/c nu/nu mice were inoculated intraperitoneally with 1 x 10(7) cells of the human tumor cell line OVCAR-3. Three weeks later, the animals were given approximately 400, 800, or 1,200 kBq of (211)At-labeled mAb MX35 intraperitoneally. As controls, one group of animals was injected with unlabeled mAb and another group was injected with phosphate-buffered saline (PBS). Another group was given approximately 400 kBq of (211)At labeled to the previously investigated mAb MOv18 for efficacy comparison. Two months after treatment, the animals were sacrificed and the presence of macroscopic and microscopic tumors, as well as ascites, was determined. The absorbed dose to tumor cells on the peritoneal surface was estimated in terms of the sum of a specific and a nonspecific contribution. The specific contribution, arising from mAbs binding to the antigenic sites on the cell membrane, was calculated using a dynamic compartment model developed in-house and Monte Carlo software. The model used as input values the number of mAbs injected into the abdominal cavity, N(mAb), the specific activity, A(sp), the association rate constant, k(on), and the maximal number of mAbs bound per cell, B(max)-all determined by in vitro experiments. This specific component of the absorbed dose was calculated for assumed cell cluster sizes with radii of 25, 50, and 100 microm. The nonspecific contribution to the absorbed dose was derived from unbound mAbs freely circulating in the abdominal cavity, also using the Monte Carlo software. RESULTS: In the control groups given unlabeled MX35 or PBS, all 18 animals had ascites, 6 of 9 animals in each group had macroscopic tumors, and all animals had microscopic growth. In the 3 groups given different amounts of (211)At-MX35, only 3 of 25 animals developed ascites. None of these animals had any sign of macroscopic tumors, but 8 had microscopic growth. In the group given (211)At-MOv18, no animals had ascites or macroscopic tumors, but 3 of 10 animals had microscopic tumors. After injecting 400 kBq of (211)At-MX35, the absorbed dose due to specific binding, for a cell cluster with a radius of 50 microm, ranged from 413 to 223 Gy between 0- and 45-microm distance from the cluster center, assuming a homogeneous distribution of (211)At-MX35 in the cluster. The contribution from unbound (211)At-MX35 and (211)At-MX35 only distributed on the cluster surface, for this cluster size, ranged from 7 to 14 Gy and from 29 to 94 Gy, between 0- and 45-microm distance from the cluster center, respectively. The calculated total absorbed doses are in a clinically relevant range and were effective as verified in the nude mice with subclinical intraperitoneal growth of OVCAR-3 cells. CONCLUSION: (211)At-MX35 injected intraperitoneally exhibits a high efficacy when treating micrometastatic growth of the ovarian cancer cell line OVCAR-3 on the peritoneum of nude mice.
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| 45. |
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| 46. |
- Erneklint, Christian, 1973, et al.
(författare)
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An in vitro load evaluation of a conical implant system with 2 abutment designs and 3 different retaining-screw alloys.
- 2007
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Ingår i: The International journal of oral & maxillofacial implants. - 0882-2786. ; 21:5, s. 733-7
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The aim of this in vitro study was to evaluate the load resistance in a conical implant system by comparing combinations of 2 different abutment head angles and 3 different retaining screw materials. MATERIALS AND METHODS: The retaining screw materials (titanium alloy, gold alloy, and commercially pure titanium) were tested with abutment-head angles of 20 degrees and 45 degrees. Six groups of 10 specimens each were prepared. An oblique (30-degree) compression test was performed in a Lloyd LRX universal testing machine with the abutment attached to a superstructure with a retaining screw. All specimens were loaded until fracture or permanent deformation occurred. The results were evaluated statistically with Wilcoxon signed rank test for variance distribution (P < .05 considered significant). RESULTS: There were statistically significant differences in load resistance between 20-degree and 45-degree abutments. The titanium screws (titanium alloy and commercially pure) in the 45-degree abutment group had almost equal mean values, while the gold alloy had a significantly lower value. In the 20-degree abutment group, significantly higher values were found with commercially pure titanium compared to titanium alloy and gold alloy, but the difference between the values for the gold and titanium alloys was not significant. DISCUSSION: The angulation of the abutment head played the most significant role in determining the amount of load withstood, but the material used for the screw was also relevant. CONCLUSION: A 45-degree abutment can be combined with a retaining screw of any of these materials to create a functional implant system. The test also substantiated that, irrespective of the retaining-screw material, a 20-degree abutment could resist loading forces of at least 900 N.
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| 47. |
- Fallbjörk, Ulrika, 1967-, et al.
(författare)
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Aspects of body image after mastectomy due to breast cancer : a two-year follow up study
- 2013
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Ingår i: European Journal of Oncology Nursing. - : Elsevier. - 1462-3889 .- 1532-2122. ; 17:3, s. 340-345
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This 2-year follow-up study explores aspects of body image after mastectomy due to breast cancer.Materials and Methods: This population-based study included 76 women living in northern Sweden who, during November 2006 to October 2007, underwent mastectomy due to breast cancer. The women completed a questionnaire entitled “Life After Mastectomy (LAM)” 10 months after the mastectomy and again 2 years later. We used SPSS version 18.0 for data processing and analysis.Results:The findings indicate that few significant changes in body image had taken place during the 2-year interval between the first and second completion of the questionnaire. An exception was a significant decrease in feelings of sexual attractiveness and comfort during sexual intimacy. At follow-up, 21% of the women had undergone breast reconstruction (BR). They were significantly younger than the women who had not had BR (53 v. 63 years). Besides being younger, no other significant differences could be found between those women who had undergone BR and those who had not. The fact that the decrease in sexual attractiveness and feelings of comfort during sexual intimacy also applied to the subgroup of women who had had BR may therefore be surprising. A better understanding of issues related to breast cancer treatment and sexual function is vital.Conclusion: It is important for health care professionals to be aware of problems related to sexual intimacy and to be prepared not just to provide information about these, but also to reflect on expectations v. reality together with the women.
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| 48. |
- Fallbjörk, Ulrika, 1967-, et al.
(författare)
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Differences between women who have and have not undergone breast reconstruction after mastectomy due to breast cancer
- 2010
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 49:2, s. 174-179
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This study compares potential differences between women with breast cancer who after mastectomy had undergone breast reconstruction with those who had not. Material and methods: All women (N=149) in the northern medical region of Sweden who had undergone mastectomy in 2003 received a self-reported questionnaire entitled “Life After Mastectomy (LAM)” that included standardized measures of sociodemographic, decision-making process, breast reconstruction (BR) yes or no, sexuality, and body image. SPSS was used for data processing. Results: In total 85% of the women returned the questionnaire and of these 25% had undergone BR. In accordance with previous studies, we found that the mean age of the women in the BR group was significantly lower (52 vs. 64 years), they had a higher education, and a higher proportion were employed, influenced by the physician's opinion regarding BR, sexually active, and rated a negative impact concerning the factors attractiveness and body disclosure. A multiple regression analysis, however, showed that the choice to undergo breast reconstruction or not was only independently associated with age, feeling of attractiveness and sexual interest. Discussion: Age explained most differences found between the two groups. When researchers try to identify what differentiates the groups of women who undergo reconstruction between those who do not undergo reconstruction after mastectomy, it is thus necessary to take into consideration that the meanings of mastectomy, body image, attractiveness and similar variables may vary due to the phase of a woman's life. In conclusion, considering the impact of age is of paramount importance in future studies for our understanding of women's experiences.
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| 49. |
- Fernandes, Oswaldo J. C. B., et al.
(författare)
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Prognostic factors for the survival of surgically treated patients for non-small cell lung cancer
- 2003
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Ingår i: Acta Oncologica. - Oslo, Norway : Taylor & Francis. - 0284-186X .- 1651-226X. ; 42:4, s. 338-341
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Tidskriftsartikel (refereegranskat)abstract
- The survival and outcome rates of 284 patients who underwent surgical treatment for non-small cell lung cancer were assessed retrospectively. Resectability rate was 94.1%, hospital mortality 3.9% (n = 11) and the mortality rates in patients who underwent pneumonectomy or lobectomy were 8.9% and 0.6%, respectively. The overall 5-year survival was 43.6%. Female gender, earlier stages of disease and a complete resection were strongly predictive for a long-term survival. Women in stage IA disease had a 5-year survival rate of 92.7%. The 5-year survival rate for patients in stages IIIA and N2 disease who underwent a complete resection was 21.9%, and 9% for those who did not undergo a complete resection. It is concluded that the best surgical results were observed in women who were operated on at an early stage of disease. A complete resection also contributed to a better outcome, even for patients in stage IIIA and N2 disease.
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| 50. |
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