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1.	Rothenberg, Elisabet, et al. (författare) Måltiden 2016 Ingår i: Geriatrisk nutrition. - Lund : Studentlitteratur. ; :2, s. 131-147 Bokkapitel (övrigt vetenskapligt/konstnärligt)
2.	Andersson, Agneta, et al. (författare) Cholesterol-lowering effects of stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet. 1999 Ingår i: European Heart Journal,Supplements 1,1999; Supplements S80 - S90. ; 1, s. 80-90 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
3.	Andersson, Agneta, et al. (författare) Oförändrad insulinkänslighet och lipidperoxidation efter ökat intag av fullkornsprodukter hos friska män och kvinnor. 2006 Ingår i: Livsmedelsforskardagarna. Konferensbidrag (populärvet., debatt m.m.)abstract Flertalet epidemilogiska studier har visat positiva hälsoeffekter av ett högt intag av fullkornsprodukter. Framförallt är en minska risk för hjärtinfarkt/sjukdom visad, och datatalar även för en minskad risk för typ 2 diabetes. Mekanismerna bakom fullkornets positiva effekter är dock fortfarande oklara. Såväl en förbättrad insulinkänslighet som en minskad förekomst av lipidperoxidation och inflammation har föreslagits, vilket vi därför önskade undersöka i denna studie.I en randomiserad cross-over design deltog 30 lätt överviktiga (BMI 282) kvinnor (n=22) och män (n=8). Under två på varandra följande 6 veckors perioder fick deltagarna antingen cerealieprodukter med fullkorn eller utan fullkorn. En standardiserad mängd (3 skivor mjukt bröd, 2 skivor hårt bröd, 1 portion musli/gryn och 1 portion pasta/ris) inkluderades dagligen i deras vanliga kost. Perifer insulinkänslighet mättes med euglykemisk hyperinsulinemisk clampteknik. Lipidperoxidationsmarkören 8-iso-PGF2 mättes i urin och inflammationsmarkörerna CRP och IL-6 mättes i plasma. Kostinterventionen monitorerades med hjälp av vägda kostregisteringar och dagboksnoteringar.Kostregistreringarna bekräftade ett högre intag av fiber och flertalet mineralämnen under fullkornsperioden jämfört med icke-fullkornsperioden. Vi fann dock ingen förbättring av insulinkänsligheten och inte heller någon förändring av lipidperoxidation eller inflammationsmarkörer.Att ersätta icke-fullkorns produkter med fullkorn under en 6 veckors period hos vuxna lätt överviktiga friska män och kvinnor gav således ingen mätbar effekt på vare sig insulinkänslighet, lipidperoxidation eller inflammationsmarkörer. Frågan om vilka mekanismerna som ligger bakom de positiva hälsoeffekterna av fullkornsprodukter kvarstår och längre koststudier på deltagare med varierande metaboltstatus behövs.
4.	Andersson, Agneta, et al. (författare) Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects 2007 Ingår i: Journal of Nutrition. - 0022-3166 .- 1541-6100. ; 137:6, s. 1401-1407 Tidskriftsartikel (refereegranskat)abstract High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 +/- 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F(2alpha) (8-iso PGF(2alpha)), an F(2)-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose . kg body wt(-1) . min(-1) per unit plasma insulin (mU/L) x 100] did not improve when subjects consumed whole-grain products (6.8 +/- 3.0 at baseline and 6.5 +/- 2.7 after 6 wk) or refined products (6.4 +/- 2.9 and 6.9 +/- 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF(2alpha) in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.
5.	Andersson, Agneta, et al. (författare) Ökat intag av fullkornsprodukter. Effekter på insulinkänslighet, lipidperoxidation och inflammationsmarkörer? 2006 Ingår i: Svenska Läkarsällskapets Riksstämma. Konferensbidrag (populärvet., debatt m.m.)abstract Bakgrund: Flertalet epidemiologiska studier har visat positiva hälsoeffekter av ett högt intag av fullkornsprodukter. Framförallt är en minskad risk för hjärtinfarkt/sjukdom visad, men data talar även för en minskad risk för typ 2 diabetes. Mekanismerna bakom fullkornets positiva effekter är dock fortfarande oklara. Såväl en förbättrad insulinkänslighet som en minskad förekomst av lipidperoxidation och inflammation har föreslagits, vilket vi önskade undersöka i denna studie.Metod: I en randomiserad cross-over design deltog 30 lätt överviktiga (BMI 282) kvinnor (n=22) och män (n=8). Under två på varandra följande 6-veckors perioder fick deltagarna antingen cerealieprodukter med fullkorn eller utan fullkorn. En standardiserad mängd (3 skivor mjukt bröd, 2 skivor hårt bröd, 1 portion musli/gryn och 1 portion pasta/ris) inkluderades dagligen i deras vanliga kost. Perifer insulinkänslighet mättes med euglykemisk hyperinsulinemisk clampteknik. Lipidperoxidationsmarkören 8-iso-PGF2 mättes i urin och inflammationsmarkörerna CRP och IL-6 mättes i plasma. Kostinterventionen monitorerades med hjälp av vägda kostregisteringar och dagboksnoteringar.Resultat: Kostregistreringarna bekräftade ett högre intag av fiber och flertalet mineralämnen under fullkornsperioden jämfört med icke-fullkornsperioden. Vi fann dock ingen förbättring av insulinkänsligheten och inte heller någon förändring av lipidperoxidation eller inflammationsmarkörer.Sammanfattning: Att ersätta icke-fullkorns produkter med fullkorn under en 6-veckors period hos vuxna lätt överviktiga friska män och kvinnor gav ingen mätbar effekt på insulinkänslighet, lipidperoxidation eller inflammationsmarkörer. Frågan om vilka mekanismerna som ligger bakom de positiva hälsoeffekterna av fullkornsprodukter kvarstår och längre koststudier på deltagare med varierande metaboltstatus behövs.
6.	Andersson, Karin, et al. (författare) A two-year clinical lifestyle intervention program for weight loss in obesity 2008 Ingår i: Food & nutrition research. - : Co-Action Publishing. - 1654-661X .- 1654-6628. ; 52, s. 1656- Tidskriftsartikel (refereegranskat)abstract BACKGROUND: In recent randomised prospective studies, lifestyle intervention induced a weight loss of approximately 5%. OBJECTIVE: To describe and evaluate a 2-year on-going group intervention program in clinical practice in terms of weight loss and changes in metabolic risk factors, i.e. sagital abdominal diameter (SAD), triglycerides, fasting blood glucose and blood pressure. DESIGN: The aim of the intervention program was to motivate lifestyle changes concerning food intake and physical activity. The emphasis was on lifestyle modification, followed up at regular visits during 2 years. Subjects evaluated were 100 women with mean BMI 37.6 kg/m(2) and 26 men with mean BMI 36.5 kg/m(2). RESULTS: One hundred of 151 enrolled women and 26 of 36 men completed the program. Mean weight decreased by 3.8 kg in women (from 103.5 to 99.7, p<0.001) and 4.4 kg in men (from 116.5 to 112.1, p<0.05), respectively. SAD decreased by 5% (p=0.001 in women, p=0.01 in men), and triglycerides by 16% in women (p=0.01) and 24% in men (p=0.001), however systolic and diastolic blood pressure increased slightly but significantly. CONCLUSION: It is possible to perform a clinical lifestyle intervention program for outpatients on an ongoing basis with weight loss, lowered SAD and triglycerides, and a similar or lower dropout rate compared to clinical trials.
7.	Arvidsson-Lenner, R, et al. (författare) Glychemic Index : Relevance for health, dietary recommendations and food labeling 2004 Ingår i: Scandinavian Journal of Nutrition. ; :48, s. 84-94 Tidskriftsartikel (populärvet., debatt m.m.)
8.	Axelsen, Mette, 1965, et al. (författare) Mat vid diabetes. En systematisk översikt 2010 Rapport (övrigt vetenskapligt/konstnärligt)
9.	Byberg, Liisa, et al. (författare) Reply to WB Grant 2017 Ingår i: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 106:2, s. 700-701 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
10.	Byberg, Liisa, et al. (författare) Reply to Y Mao and H Yu. 2017 Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 106:2, s. 698-699 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
11.	Daryani, Achraf, 1954- (författare) Diet and Metabolic Risk Factors in Immigrant Women from the Middle East and Swedish-Born Women : A Cross-Sectional Study of Women from Iran, Turkey and Sweden 2006 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The increasing number of immigrants in Sweden during the past decades has brought the health of different ethnic groups into focus. Many groups of immigrants in Sweden have a higher risk of cardiovascular disease (CVD) and coronary heart disease (CHD) than a Swedish reference group. The objective of this thesis was to study the health status and prevalence of metabolic risk factors among immigrant women from Iran and Turkey in comparison with native-Swedish women. The analyses are based on a cross-sectional study of first-generation immigrant women and women born in Sweden aged 35-64. The women underwent a clinical examination, including blood sampling and anthropometric measurements. Dietary intake was assessed by four repeated 24-hour food intake recalls. The results show important ethnic differences in risk factors for CHD and the metabolic syndrome between the immigrant and the Swedish-born women. Immigrant women from Iran and Turkey are heavier, with a higher prevalence of abdominal obesity and an unfavourable lipid profile and a high degree of physical inactivity during leisure-time, which may predispose for a higher incidence of diabetes and atherosclerotic CVD. The associations between dietary variables and metabolic risk factors were generally relatively weak. The degree of underreporting of the energy was significant, especially among immigrant women, which might have attenuated possible associations. The fatty acid profile of the diet and in serum among the immigrant women indicated both favourable and unfavourable features, despite a higher prevalence of obesity and dyslipidemia compared to the Swedish-born women. Signs of oxidative stress and inflammation are evident in the immigrant women from the Middle East. With reference to ethnical differences in metabolic risk factors, as demonstrated in this thesis, increased emphasis should be given to modifying the underlying factors such as overweight/obesity and physical inactivity associated with the metabolic syndrome in various immigrant groups.
12.	Daryani, Achraf, et al. (författare) Reported macronutrient intake and metabolic risk factors : immigrant women from Iran and Turkey compared with native Swedish women 2006 Ingår i: Scandinavian Journal of Food and Nutrition. - 1748-2976 .- 1748-2984. ; 50:4 Tidskriftsartikel (refereegranskat)abstract Background: Immigrants in general seem to be more vulnerable than the host populations to developing nutrition-related chronic conditions. This may be in part related to diverging dietary habits. Objective: The aim of the study was to examine the nutrient intake and its relationship to metabolic variables among immigrant versus native Swedish women. Design: A cross-sectional health survey of 157 randomly selected foreign-born and native Swedish women. This included 24 h dietary recall repeated four times and administered in the native language. Results: Underreporting was significant, especially among immigrant women. There were no major differences in terms of energy distribution of the macronutrients between very low energy reporters and acceptable energy reporters, indicating that the dietary data reflected the qualitative composition in spite of the underreporting of energy intake. Immigrant women consumed less alcohol and obtained a lower proportion of their energy from saturated fatty acids, but a higher proportion from polyunsaturated fatty acids, sucrose and total carbohydrates. Associations between dietary variables and metabolic risk factors were relatively weak. Conclusions: Underreporting might have attenuated possible associations between diet and risk factors. The study illustrates specific problems in the dietary assessment and the need to develop valid techniques when studying groups of people of diverging ethnic backgrounds.
13.	Delgado-Lista, J., et al. (författare) A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome 2013 Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 23:5, s. 417-423 Tidskriftsartikel (refereegranskat)abstract Background and aims: CCAAT/enhancer-binding protein alpha (CEBPA) is a transcription factor involved in adipogenesis and energy homeostasis. Caloric restriction reduces CEBPA protein expression in patients with metabolic syndrome (MetS). A previous report linked rs12691 SNP in CEBPA to altered concentration of fasting triglycerides. Our objective was to assess the effects of rs12691 in glucose metabolism in Metabolic Syndrome (MetS) patients. Methods and results: Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. Carriers of the minor A allele of rs12691 had altered disposition index (p = 0.0003), lower acute insulin response (p = 0.005) and a lower insulin sensitivity index (p = 0.025) indicating a lower insulin sensitivity and a lower insulin secretion, at baseline and at the end of the diets. Furthermore, A allele carriers displayed lower HDL concentration. Conclusion: The presence of the A allele of rs12691 influences glucose metabolism of MetS patients. Clinical Trials Registry number NCT00429195.
14.	Faxén Irving, Gerd, et al. (författare) Geriatrisk nutrition 2016. - 2 Bok (övrigt vetenskapligt/konstnärligt)abstract Geriatrisk nutrition utkom första gången 2010. Denna bok är en reviderad upplaga, som har förändrats på flera sätt både avseendeinnehåll, struktur och lay-out. Boken riktar sig både till studenter inom olika vårdutbildningar och till yrkesverksamma inomvård och omsorg av äldre. Den har ambitionen att ge en förståelse för hur åldrandet påverkar kroppens funktioner och hälsan.Fokus i boken ligger på mat, näring och nutrition och de specifika nutritionsproblem som följer med åldrandet. Boken vill ävenge en medicinsk bakgrund till olika sjukdomar som är vanliga hos äldre, vilket är förutsättningen för att förstå sjukdomsspecifiknutritionsbehandling. Boken tar också upp regelverk, organisation och kvalitet samt etiska och kulturella aspekter på nutritionsomhändertagandeav äldre. Helt nytt är ett kapitel om centrala begrepp och termer samt ett separat kapitel om kulturella aspekteroch ett utökat avsnitt som behandlar D vitamin. Boken är faktagranskad av personer med specifika kompetenser inom olikaområden som boken tar upp.
15.	Faxén Irving, Gerd, et al. (författare) Geriatrisk nutrition 2010 Bok (övrigt vetenskapligt/konstnärligt)
16.	Faxén Irving, Karlström Brita, Landin I-L, Rothenberg E, Överby E. (författare) Mat och kostråd inom äldrevården. 1998 Ingår i: Uppsala: Statens Livsmedelsverk Manuskript. Annan publikation (övrigt vetenskapligt/konstnärligt)
17.	Ferguson, Jane F, et al. (författare) Gene-nutrient interactions in the metabolic syndrome : single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance 2010 Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 91:3, s. 794-801 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Progression of the metabolic syndrome (MetS) is determined by genetic and environmental factors. Gene-environment interactions may be important in modulating the susceptibility to the development of MetS traits. OBJECTIVE: Gene-nutrient interactions were examined in MetS subjects to determine interactions between single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) and plasma fatty acid composition and their effects on MetS characteristics. DESIGN: Plasma fatty acid composition, insulin sensitivity, plasma adiponectin and lipid concentrations, and ADIPOQ, ADIPOR1, and ADIPOR2 SNP genotypes were determined in a cross-sectional analysis of 451 subjects with the MetS who participated in the LIPGENE (Diet, Genomics, and the Metabolic Syndrome: an Integrated Nutrition, Agro-food, Social, and Economic Analysis) dietary intervention study and were repeated in 1754 subjects from the LIPGENE-SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) case-control study (http://www.ucd.ie/lipgene). RESULTS: Single SNP effects were detected in the cohort. Triacylglycerols, nonesterified fatty acids, and waist circumference were significantly different between genotypes for 2 SNPs (rs266729 in ADIPOQ and rs10920533 in ADIPOR1). Minor allele homozygotes for both of these SNPs were identified as having degrees of insulin resistance, as measured by the homeostasis model assessment of insulin resistance, that were highly responsive to differences in plasma saturated fatty acids (SFAs). The SFA-dependent association between ADIPOR1 rs10920533 and insulin resistance was replicated in cases with MetS from a separate independent study, which was an association not present in controls. CONCLUSIONS: A reduction in plasma SFAs could be expected to lower insulin resistance in MetS subjects who are minor allele carriers of rs266729 in ADIPOQ and rs10920533 in ADIPOR1. Personalized dietary advice to decrease SFA consumption in these individuals may be recommended as a possible therapeutic measure to improve insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT00429195.
18.	Ferguson, Jane F., et al. (författare) NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids 2010 Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 211:2, s. 539-544 Tidskriftsartikel (refereegranskat)abstract Objective: Omega-3 polyunsaturated fatty acids (n-3 PUFA) may protect against the development of cardiovascular disease (CVD). Genotype at key genes such as nitric oxide synthase (NOS3) may determine responsiveness to fatty acids. Gene-nutrient interactions may be important in modulating the development of CVD, particularly in high-risk individuals with the metabolic syndrome (MetS). Methods: Biomarkers of CVD risk, plasma fatty acid composition, and NOS3 single nucleotide polymorphism (SNP) genotype (rs11771443, rs1800783, rs1800779, rs1799983, rs3918227, and rs743507) were determined in 450 individuals with the MetS from the LIPGENE dietary intervention cohort. The effect of dietary fat modification for 12 weeks on metabolic indices of the MetS was determined to understand potential NOS3 gene-nutrient interactions. Results: Several markers of inflammation and dyslipidaemia were significantly different between the genotype groups. A significant gene-nutrient interaction was observed between the NOS3 rs1799983 SNP and plasma n-3 PUFA status on plasma triacylglycerol (TAG) concentrations. Minor allele carriers (AC + AA) showed an inverse association with significantly higher plasma TAG concentrations in those with low plasma n-3 PUFA status and vice versa but the major allele homozygotes (CC) did not. Following n-3 PUFA supplementation, plasma TAG concentrations of minor allele carriers of rs1799983 were considerably more responsive to changes in plasma n-3 PUFA, than major allele homozygotes. Conclusions: Carriers of the minor allele at rs1799983 in NOS3 have plasma TAG concentrations which are more responsive to n-3 PUFA. This suggests that these individuals might show greater beneficial effects of n-3 PUFA consumption to reduce plasma TAG concentrations.
19.	Fugmann, Andreas, et al. (författare) Blood flow is an important determinant of forearm glucose uptake following a mixed meal 2003 Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 40:3, s. 113-117 Tidskriftsartikel (refereegranskat)abstract Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p<0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p<0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p<0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p<0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p<0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.
20.	Garcia-Rios, Antonio, et al. (författare) A Period 2 Genetic Variant Interacts with Plasma SFA to Modify Plasma Lipid Concentrations in Adults with Metabolic Syndrome 2012 Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 142:7, s. 1213-1218 Tidskriftsartikel (refereegranskat)abstract Genetic variants of Period 2 (PER2), a circadian clock gene, have been linked to metabolic syndrome (MetS). However, it is still unknown whether these genetic variants interact with the various types of plasma fatty acids. This study investigated whether common single nucleotide polymorphisms (SNPs) in the PER2 locus (rs934945 and rs2304672) interact with various classes of plasma fatty acids to modulate plasma lipid metabolism in 381 participants with MetS in the European LIPGENE study. Interestingly, the rs2304672 SNP interacted with plasma total SFA concentrations to affect fasting plasma TG, TG-rich lipoprotein (TRL-TG), total cholesterol, apoC-II, apoB, and apoB-48 concentrations (P-interaction <0.001-0.046). Carriers of the minor allele (GC+GG) with the highest SFA concentration (>median) had a higher plasma TG concentration (P = 0.001) and higher TRL-TG (P < 0.001) than the CC genotype. In addition, participants carrying the minor G allele for rs2304672 SNP and with a higher SFA concentration (>median) had higher plasma concentrations of apo C-II (P < 0.001), apo C-III (P = 0.009), and apoB-48 (P = 0.028) compared with the homozygotes for the major allele (CC). In summary, the rs2304672 polymorphism in the PER2 gene locus may influence lipid metabolism by interacting with the plasma total SEA concentration in participants with MetS. The understanding of these gene-nutrient interactions could help to provide a better knowledge of the pathogenesis in MetS.
21.	Garcia-Rios, Antonio, et al. (författare) Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism 2011 Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 218:2, s. 416-422 Tidskriftsartikel (refereegranskat)abstract Objective: To investigate whether seven common single nucleotide polymorphisms (SNPs) at the lipoprotein lipase (LPL) locus interact with total plasma fatty acids to modulate plasma lipid metabolism in metabolic syndrome (MetS) patients. Methods: Plasma fatty acid composition, plasma lipid concentrations and LPL SNPs were determined in 452 subjects with the MetS in the European LIPGENE human study and were repeated in 1754 subjects from the LIPGENE-SU.VI.MAX Study. Results: Triglycerides (TG) were lower, and HDL higher in the carriers of rs328 and rs1059611 in the SUVIMAX cohort (all P < 0.001), and these findings showed a similar, non-significant trend in LIPGENE cohort. In this last cohort, we found a gene-fatty acids interaction, as the carriers of the minor allele displayed a lower fasting TG and triglyceride rich lipoproteins-TG (TRL-TG) concentrations only when they had n-6 polyunsaturated fatty acids below the median (all P < 0.05). Moreover, subjects carrying the minor allele for rs328 SNP and with a low level of n-6 PUFA displayed higher nonesterified fatty acid (NEFA) plasma concentrations as compared with homozygous for the major allele (P = 0.034). Interestingly, the n-6 PUFA-dependent associations between those SNPs and TG metabolism were also replicated in subjects without MetS from the SU.VI.MAX cohort. Conclusion: Two genetic variations at the LPL gene (rs328 and rs1059611) influence plasma lipid concentrations and interact with plasma n-6 PUFA to modulate lipid metabolism. The knowledge of new genetic factors together with the understanding of these gene-nutrient interactions could help to a better knowledge of the pathogenesis in the MetS.
22.	Gulseth, Hanne L., et al. (författare) Dietary fat modifications and blood pressure in subjects with the metabolic syndrome in the LIPGENE dietary intervention study 2010 Ingår i: British Journal of Nutrition. - 0007-1145 .- 1475-2662. ; 104:2, s. 160-163 Tidskriftsartikel (refereegranskat)abstract Hypertension is a key feature of the metabolic syndrome. Lifestyle and dietary changes may affect blood pressure (BP), but the knowledge of the effects of dietary fat modification in subjects with the metabolic syndrome is limited. The objective of the present study was to investigate the effect of an isoenergetic change in the quantity and quality of dietary fat on BP in subjects with the metabolic syndrome. In a 12-week European multi-centre, parallel, randomised controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to one of the four diets distinct in fat quantity and quality: two high-fat diets rich in saturated fat or monounsaturated fat and two low-fat, high-complex carbohydrate diets with or without 1.2 g/d of very long-chain n-3 PUFA supplementation. There were no overall differences in systolic BP (SBP), diastolic BP or pulse pressure (PP) between the dietary groups after the intervention. The high-fat diet rich in saturated fat had minor unfavourable effects on SBP and PP in males.
23.	Husdal, Rebecka (författare) The organisation of diabetes care for persons with type 2 diabetes mellitus : A nationwide cross-sectional study in Swedish primary health care 2017 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract Aim To extend the current knowledge about changes in Swedish diabetes care from 2006 to 2013 (Paper I), and to investigate the association between personnel resources and organisational features of primary health care centres (PHCCs) and the individual level of glycated haemoglobin (HbA1c) among persons with type 2 diabetes mellitus (T2DM) (Paper II).Methods The longitudinal cross-sectional study described in Paper I included a total of 684 (74.3%) of eligible 921 PHCCs in 2006 and 880 (76.4%) of eligible 1152 PHCCs in 2013. The Swedish National Survey of the Quality and Organisation of Diabetes Care in Primary Healthcare (Swed-QOP) questionnaire was sent to PHCC managers in 2007 and 2014. In Paper II, persons with T2DM (n = 230 958) attending 846 PHCCs were included. The PHCC-level data for 2013 were obtained from the Swed-QOP questionnaire and the individual-level data for 2013 were obtained from the National Diabetes Register. These data were linked to national registers containing individual-level data on socio-economic status and comorbidities.Results From 2006 to 2013, the median list size of PHCCs decreased while the median number of persons with T2DM at the PHCC increased (all P < 0.001). The median number of whole time equivalent registered nurses (RNs) per 500 persons with T2DM increased from 0.64 in 2006 to 0.79 in 2013 (P < 0.001). Compared with 2006, 30% percentage points more PHCCs (17.0% in 2006 and 47.5% in 2013) had an RN with at least 16 European Credit Transfer and Accumulation System (ECTS) credits in diabetes-specific education in 2013 (P < 0.001). Access to an in-house psychologist increased from 25.9% in 2006 to 47.1% in 2013 (P < 0.001). No change was found regarding in-house access to dietitians, chiropodists, social workers or physiotherapists. Observed changes in the organisational features of PHCCs from 2006 to 2013 included increased frequency of medical check-ups, use of call–recall systems and use of systems for checking that persons with T2DM participated in annual visits to general practitioners (GPs) and RNs (all P < 0.05). Providing group education remained scarce in both years (Paper I). After adjusting for several important confounders, personnel resources associated with decreasing individual HbA1c levels were the number of ECTS credits in diabetes-specific education among RNs (P < 0.001) and the duration of regular visits to RNs (P < 0.001). However, the opposite effect (i.e., increased HbA1c levels) was found for the duration of visits to GPs (P < 0.001). Organisational features associated with decreased individual HbA1c levels were PHCCs having a diabetes team (P < 0.01) and providing group education (P < 0.01) (Paper II).Conclusions The findings presented in this thesis add important knowledge on evaluating changes in diabetes care in Sweden. Some findings can be interpreted as initiatives to focus on increasing the time RNs devote to caring for persons with T2DM, and in ensuring RNs undergo diabetes-specific education. Furthermore, factors such as diabetes-specific education, diabetes teams and group education were associated with lower individual HbA1c levels. These findings could stimulate decision-makers to prioritise these factors for offering high-quality, equitable care to persons with diabetes.
24.	Järvi, Anette, et al. (författare) Increased intake of fruits and vegetables in overweight subjects : effects on body weight, body composition, metabolic risk factors and dietary intake 2016 Ingår i: British Journal of Nutrition. - 0007-1145 .- 1475-2662. ; 115:10, s. 1760-1768 Tidskriftsartikel (refereegranskat)abstract A diet rich in fruits and vegetables has been associated with several health benefits. However, the effects on body weight (BW) and metabolic markers are not fully known. The present study investigated the effects of increased intake of fruits and vegetables in overweight and obese men and women on dietary habits, anthropometry and metabolic control. In a 16-week controlled intervention, thirty-four men and thirty-four women aged 35-65 years (BMI>27 kg/m(2)) were randomised to an intervention (IN) or a reference (RG) group. All participants received general dietary advice, and subjects in the IN group received fruits and vegetables for free, of which >= 500 g had to be eaten daily. BW, waist circumference (WC), sagittal abdominal diameter (SAD), plasma insulin, blood glucose, glycated Hb (HbA1c), serum lipids, blood pressure, plasminogen activator inhibitor-1 activity, urinary isoprostane (iso-8-PGF 2 alpha) and serum carotenoids were measured. Diet was assessed using 3-d weighed food records. In all, thirty subjects in the IN group and thirty-two in the RG group completed the intervention. Intake of fruits and vegetables doubled in the IN group, whereas intake of fruits increased in the RG group. Serum a-and beta-carotene concentrations and intakes of folate and vitamin C increased significantly in the IN group. Energy intake, BW, WC and SAD decreased significantly in both groups. Supine systolic blood pressure decreased significantly in the IN group, with no between-group differences. No significant changes were observed for other metabolic markers. Provision of fruits and vegetables led to substantially increased intakes, with subsequent favourable changes in anthropometry and insulin levels, which tended to be more pronounced in the IN group. The observed improvements may, in combination with improved nutritional markers, have health benefits in the long term.
25.	Järvi A, Karlström Brita, Vessby Bengt. (författare) Är glykemiskt index användbart i praktiken? 1998 Ingår i: (Rapport) Scandianvian Journal of Nutrition 1998;42:83-6. ; 42, s. 83- Annan publikation (övrigt vetenskapligt/konstnärligt)
26.	Järvi Anette, Karlström Brita , Granfeldt Yvonne , Björck Inger, Vessby (författare) The influence of food structure on postprandial metabolism in patients with noninsulin-dependent diabetes mellitus. 1995 Ingår i: Am J Clin Nutr. ; 61, s. 837-842 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
27.	Karlsson, Mikael, et al. (författare) Ability to predict resting energy expenditure with six equations compared to indirect calorimetry in octogenarian men 2017 Ingår i: Experimental Gerontology. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0531-5565 .- 1873-6815. ; 92, s. 52-55 Tidskriftsartikel (refereegranskat)abstract The accuracy of predictive equations for calculating resting energy expenditure (REE) in elderly people has been questioned. Aging is associated with progressive declines in REE, which partly is explained by loss of fat free mass (FFM). Against this background we aimed to identify the most accurate predictive equation for REE in octogenarian men, taking body composition into account and using indirect calorimetry as reference value. REE was measured in 22 men (mean age 82.6 +/- 0.3 years) and compared with six predictive equations: two based on FFM and four based on body weight, height and/or age. FFM was derived from Dual-energy X-ray absorptiometry analyses. Spearman's rank correlations showed a moderate to high positive monotonic correlation (r = 0.62 to 0.79) between measured and calculated REE (all p < 0.005).The mean calculated REE was significantly different from measured REE for all equations except Mifflin-St Jeor. A calculated REE within 10% of measured REE was considered acceptable and the equations of Mifflin-St Jeor, WHO and Harris-Benedict captured 64%, 50% and 45% of the participant, respectively. The Mifflin-St Jeor equation had the lowest root mean square error (138 kcal), followed by the equation by Harris-Benedict (189 kcal) and WHO (220 kcal). The equations from Luhrmann, Henry and Cunningham predicted REE rather poorly in our study subjects, with e.g. <40% of the individuals within 10% of measured REE. Our results indicate that the Mifflin-St Jeor equation (using FFM) is the most accurate equation estimating REE in these octogenarian men. Harris-Benedict or WHO equations are potential alternatives if information on FFM is unavailable, although their accuracy on an individual level is limited.
28.	Karlsson Pia, Apelgren Joanna, Cederholm Tommy, Karlström Brita, Lindblad Lena. (författare) Näringsintag hos äldre - En pilotstudie av boende på servicehus och hemmaboende. 1995 Ingår i: Svenska Läkaresällskapets riksstämma 30 nov- 2 dec 1994. Hygea Band 104 Häfte 2 1995:9P. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
29.	Karlström, Brita (författare) Dietary treatment of type 2 diabetes mellitus : with special reference to the importance of dietary fibre 1988 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
30.	Karlström, Brita E., et al. (författare) Fatty fish in the diet of patients with type 2 diabetes : comparison of the metabolic effects of foods rich in n-3 and n-6 fatty acids 2011 Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 94:1, s. 26-33 Tidskriftsartikel (refereegranskat)abstract Background: Dietary advice, including modification of dietary fat quality, is the basis of treatment of diabetes, but there is some uncertainty about the optimal amount of polyunsaturated fatty acids of the n-6 (omega-6) and n-3 (omega-3) series. Objective: The objective was to compare the effects of diets rich in n-3 or n-6 fatty acids on glucose and lipoprotein metabolism in type 2 diabetes. Design: In a crossover study during 2 consecutive 3.5-wk periods, the participants were provided diets with identical nutrient compositions containing either a high proportion of n-3 (n-3 diet) or n-6 (n-6 diet) fatty acids through the inclusion of fatty fish or lean fish and fat containing linoleic acid, respectively. Results: Blood glucose concentrations at fasting and during the day were lower with the n-6 than with the n-3 diet (P = 0.009 and P = 0.029, respectively), and the area under the insulin curve during the day was significantly higher (P = 0.03) with the n-6 diet. Both diets showed similar effects on insulin sensitivity and plasminogen activator inhibitor 1 concentrations. The reductions in VLDLs and serum apolipoprotein B concentrations were more pronounced after the n-3 diet. Conclusions: The risk related to the moderately higher blood glucose concentrations with the n-3-enriched diet may be counteracted by positive effects with regard to lipoprotein concentrations. An increase in long-chain n-3 fatty acids from fatty fish, and of n-6 fatty acids from linoleic acid, may be recommended for patients with type 2 diabetes.
31.	Karlström, Brita, et al. (författare) Mata och kostbehandling för äldre 1998 Bok (övrigt vetenskapligt/konstnärligt)
32.	Karlström Brita, Eliasson M, Vessby Bengt, Cedermark G, Nilsson U. (författare) A presentation of the new Swedish booklet "Good food for children - Food for children with diabetes" 1997 Ingår i: Satellite Symposium on Nutrition, Obesity and Diabetes. July 17-19, 1997, Kuopio, Finland. Kuopio University Publications D. Medical Sciences 128, Kupio 1997:65.. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
33.	Koochek, Afsaneh, et al. (författare) Dietary differences between elderly Iranians living in Sweden and Iran a cross-sectional comparative study 2011 Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 11, s. 411- Tidskriftsartikel (refereegranskat)abstract Background: During the last decades, global migration has increased and many immigrant groups have a higher prevalence than the native born population of several cardiovascular disease risk factors, including poor dietary habits. However, it is uncertain if dietary habits in immigrant populations reflect dietary habits in their country of origin or if the current diet is a consequence of the migration and possible change of dietary habits. The aim of this study was to examine possible dietary differences between elderly Iranians living in Stockholm, Sweden with elderly Iranians living in Tehran, Iran, taking into account sex, age, marital status, and education. Methods: Dietary intakes were assessed by semi - quantitative food frequency questionnaire in a cross-sectional study of 121 Iranians living in Stockholm and 52 Iranians living in Tehran, aged 60-80. Differences in dietary habits between the two groups was analysed by bootstrapped regression analyses with 1000 replications. Results: Iranians living in Sweden had significantly higher intake of protein, total fat, fiber than Iranians living in Iran, but lower consumption of carbohydrates. The observed differences in intake of macronutrients were reflected in consumed amount of all food items, which were higher among Iranians living in Iran with the exception of bread and grain consumption which was lower. Conclusions: There are general differences in dietary habits between Iranians living in Iran and Iranians living in Sweden. Parts of observed differences in dietary habits may reflect a favourable adoption process to the Swedish dietary habits after migration. Meanwhile other differences are point of concern in light of the high prevalence of overweight, among Iranians living in Sweden and can have unfavourable impact in particular in the context of cardiovascular health.
34.	Koochek, Afsaneh, et al. (författare) Is migration to Sweden associated with increased prevalence of risk factors for cardiovascular disease? 2008 Ingår i: European Journal of Cardiovascular Prevention & Rehabilitation. - : Sage Publications. - 1741-8267 .- 1741-8275. ; 15:1, s. 78-82 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: [corrected] The proportion of elderly immigrants in Sweden is increasing. This is an important issue considering that the prevalence of cardiovascular disease (CVD) is a global health problem and that CVD is one of the main causes of morbidity among the elderly. The aim of this study is to analyze whether there is an association between migration status, that is being an elderly Iranian immigrant in Sweden, as compared with being an elderly Iranian in Iran, and the prevalence of risk factors for CVD. DESIGN: Population-based cross-sectional study with face-to-face interviews. PARTICIPANTS AND SETTING: A total of 176 Iranians in Stockholm and 300 Iranians in Tehran, aged 60-84 years. METHODS: The prevalence of general obesity, abdominal obesity, hypertension, smoking, and diabetes was determined. Unconditional logistic regression analysis was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for outcomes. RESULTS: The age-adjusted risk of hypertension and smoking was higher in Iranian women and men in Sweden. OR for hypertension was 1.9 (95% CI: 1.1-3.2) for women and 3.1 (95% CI: 1.5-6.3) for men and OR for smoking was 6.9 (95% CI: 2.2-21.6) for women and 4.7 (95% CI: 2.0-11.0) for men. The higher risk for hypertension and smoking remained significant after accounting for age, socioeconomic status, and marital status. Abdominal obesity was found in nearly 80% of the women in both groups. CONCLUSION: The findings show a strong association between migration status and the prevalence of hypertension and smoking. Major recommendation for public health is increased awareness of CVD risk factors among elderly immigrants.
35.	Lundkvist, Pernilla, et al. (författare) Användning av sjudagars menybok hos 82-åriga män i ULSAM-kohorten 2004 Ingår i: Svenska Läkarsällskapets Rikstämma 24-26 nov. 2006. Konferensbidrag (populärvet., debatt m.m.)
36.	Lövestam, Elin, et al. (författare) An NCP-based audit instrument for dietitians´documentation in medical records 2012 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
37.	Lövestam, Elin, et al. (författare) Evaluating Documentation of Dietetic Care in Swedish Medical Records 2013 Ingår i: MEDINFO 2013. - 9781614992899 - 9781614992882 ; 192, s. 1078- Konferensbidrag (refereegranskat)abstract An adequate documentation in medical records is essential for patient safety and high quality care. The aim of this study was to evaluate documentation by dietitians in Swedish medical records. A retrospective audit of 147 dietetic notes in electronic medical records was performed. The audit focused at documentation of essential parts of the dietetic care, as well as other quality aspects such as lingual clarity and structure of the documentation. The nutrition intervention showed to be the most documented part of dietetic care. However, the audit showed that several important parts of nutrition care were poorly documented, for instance nearly half of the audited records had no clear nutrition problem documented, and in most of the records, the goal of nutrition intervention was missing. The study shows that Swedish dietitians need to improve documentation in medical records, as a suggestion by implementing a more structured documentation model.
38.	Lövestam, Elin, 1983-, et al. (författare) Evaluation of a Nutrition Care Process-based audit instrument, the Diet-NCP-Audit, for documentation of dietetic care in medical records 2014 Ingår i: Scandinavian Journal of Caring Sciences. - : Wiley. - 0283-9318 .- 1471-6712. ; 28:2, s. 390-397 Tidskriftsartikel (refereegranskat)abstract Adequate documentation in medical records is important for high-quality health care. Documentation quality is widely studied within nursing, but studies are lacking within dietetic care. The aim of this study was to translate, elaborate and evaluate an audit instrument, based on the four-step Nutrition Care Process model, for documentation of dietetic care in medical records. The audit instrument includes 14 items focused on essential parts of dietetic care and the documentation's clarity and structure. Each item is to be rated 0-1 or 0-2 points, with a maximum total instrument score of 26. A detailed manual was added to facilitate the interpretation and increase the reliability of the instrument. The instrument is based on a similar tool initiated 9 years ago in the United States, which in this study was translated to Swedish and further elaborated. The translated and further elaborated instrument was named Diet-NCP-Audit. Firstly, the content validity of the Diet-NCP-Audit instrument was tested by five experienced dietitians. They rated the relevance and clarity of the included items. After a first rating, minor improvements were made. After the second rating, the Content Validity Indexes were 1.0, and the Clarity Index was 0.98. Secondly, to test the reliability, four dietitians reviewed 20 systematically collected dietetic notes independently using the audit instrument. Before the review, a calibration process was performed. A comparison of the reviews was performed, which resulted in a moderate inter-rater agreement with Krippendorff's α = 0.65-0.67. Grouping the audit results in three levels: lower, medium or higher range, a Krippendorff's α of 0.74 was considered high reliability. Also, an intra-rater reliability test-retest with a 9 weeks interval, performed by one dietitian, showed strong agreement. To conclude, the evaluated audit instrument had high content validity and moderate to high reliability and can be used in auditing documentation of dietetic care.
39.	Lövestam, Elin, et al. (författare) Evaluation of Nutrition Care Process documentation in electronic patient records : Need of improvement 2015 Ingår i: Nutrition & Dietetics. - : Wiley. - 1446-6368 .- 1747-0080. ; 72:1, s. 74-80 Tidskriftsartikel (refereegranskat)abstract AimHigh-quality documentation in patient records is essential for patient safety and plays a prominent role in the delivery and evaluation of dietetic/nutrition care. We aimed to evaluate dietitians' documentation in patient records according to the four steps in the Nutrition Care Process: assessment, diagnosis, intervention and monitoring/evaluation.MethodsA retrospective audit of 147 systematically collected outpatient dietetic notes from primary care centres and hospitals in central Sweden was performed using a validated audit instrument. The instrument was used to assess the documentation of 14 items: 10 items focusing on the Nutrition Care Process steps and four items on language clarity and structure, with a maximum total score of 26 for each dietetic note. The notes were divided into three different quality levels, A (high score), B (medium score) or C (low score). Comparisons were made between notes from primary care and hospitals.ResultsThe audit showed that the majority of the notes were placed at level B, scoring 13.5–19.5. Only 3% of the notes scored higher than 19.5. The most frequently documented items were intervention (90%), evaluation (70%) and nutrition problem (56%), whereas the least documented items were nutrition prescription (15%), goal of intervention (9%) and connection of problem-etiology-symptom (5%). Flaws in lingual clarity were common (72%). Primary care notes received higher scores than those from hospitals.ConclusionsThe audit shows that Swedish dietetic documentation needs to be improved, for example, by further training and education in the Nutrition Care Process and its standardised terminology.
40.	Malmgren A, Anna, et al. (författare) Indications for percultaneous endoscopic gastrostomy and survival in old adults 2011 Ingår i: Food & Nutrition Research. - : SNF Swedish Nutrition Foundation. - 1654-6628 .- 1654-661X. ; 55, s. 6037- Tidskriftsartikel (refereegranskat)abstract BACKGROUND:Many diseases striking old adults result in eating difficulties. Indications for selecting individuals for percutaneous endoscopic gastrostomy (PEG) are unclear and everybody may not benefit from the procedure.OBJECTIVE:The aim of this study was to evaluate indications for and survival after PEG insertion in patients older than 65 years.DESIGN AND METHODS:A retrospective analysis including age, gender, diagnosis, indication, and date of death was made in 201 consecutive individuals, 94 male, mean age 79±7 years, who received a nutritional gastrostomy.RESULTS:Dysphagia was present in 86% of the patients and stroke was the most common diagnosis (49%). Overall median survival was 123 days and 30-day mortality was 22%. Patients with dementia and Mb Parkinson had the longest survival (i.e. 244 and 233 days), while those with other neurological diseases, and head and neck malignancy had the shortest (i.e. 75 and 106 days). There was no difference in mortality in patients older or younger than 80 years, except in patients with dementia.CONCLUSIONS:Old age should not be a contraindication for PEG. A high 30-day mortality indicates that there is a need of better criteria for selection and timing of PEG insertion in the elderly.
41.	Melin, Ingela, et al. (författare) Education and supervision of health care professionals to initiate, implement and improve management of obesity. 2005 Ingår i: Patient Educ and Couns. ; 58 (2):Aug, s. 127-136 Tidskriftsartikel (refereegranskat)
42.	Nordhamn, Karin, et al. (författare) Reliability of anthropometric measurements in overweight and lean subjects: : consequences for corelations between anthropometric and other variable 2000 Ingår i: International Journal of Obesity. - 0307-0565 .- 1476-5497. ; 24:5, s. 652-657 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract OBJECTIVETo estimate the reliability of anthropometric measurements in overweight and lean subjects, and to examine the influence of this reliability on correlations to other variables, since low reliability leads to underestimation of correlations.DESIGNReplicate measurements by two observers in 26 overweight and 25 lean subjects measured at two occasions.MEASUREMENTSSagittal abdominal diameter (SAD), waist circumference (waist), waist-to-hip ratio (W/H) and skinfold measurements.RESULTSIntra-class correlation coefficients (ICCs) for SAD and waist were higher than for W/H (0.98 vs 0.90, P<0.001, and 0.97 vs 0.90, P=0.001, respectively). For waist, the ICC was lower for overweight than for lean subjects (0.85 vs 0.95, P=0.030), but the ICC values were comparable for SAD and W/H (0.92 vs 0.95 and 0.78 vs 0.83, respectively). Intra-observer variations (IOV) for SAD and waist were lower than for W/H (coefficients of variation; 1.6%, 1.4% and 2.3%, respectively), as were intra-subject variations (ISV) (2.7%, 3.0% and 3.4%, respectively). ICC values ranged from 0.84 to 0.93 and were lower for overweight than for lean subjects for biceps, subscapular and umbilical skinfolds (P=0.031, P<0.001 and P=0.048, respectively). Coefficients of variations for skinfold measurements ranged between 7.3% and 16.0% for IOV and between 14.9% and 20.8% for ISV.CONCLUSIONSThe low ICC values imply that correlations can be underestimated in overweight groups. We propose that, because of their higher reliability, SAD and waist have a higher predictive capacity for cardiovascular risk than W/H. SAD is the only measurement with high reliability in both weight groups and its use is recommended.
43.	Olsson, Erika, et al. (författare) Body composition, dietary intake and estimated energy expenditure in female patients on geriatric rehabilitation wards 2003 Ingår i: Scandinavian Journal of Nutrition/Næringsforskning. - : Informa UK Limited. - 1102-6480 .- 1651-2359 .- 1748-2976. ; 47:4, s. 179-187 Tidskriftsartikel (refereegranskat)abstract BackgroundAn adequate nutritional status is a prerequisite for successful rehabilitation.Objective: To examine body composition, to investigate nutritional intake, to calculate energy expenditure inelderly females at a geriatric rehabilitation clinic, to classify whether they were considered as undernourishedor at risk of becoming undernourished, and to investigate the subjects’ opinions on diet-related issues.Design20 patients aged 829/6 (mean9/SD) years participated. Percentage body fat was calculated fromskinfold thickness measurements, bioelectrical impedance analysis (BIA) and a combination of the two in amulticompartment model. Dietary intake was assessed through a 7 day food record. Energy expenditure wascalculated with three established formulae and physical activity level (PAL) factors of 1.2 and 1.4. Questionswere asked on diet-related issues.ResultsAverage BMI was 23.79/4.5 kg m2 and four subjects had BMIB/20. Relative body fat mass asassessed by skinfold was 29.89/6.9%, by BIA 38.99/7.7% and by a multicompartment model 35.59/7.1%.Mean energy intake was 13409/170 kcal (5.69/0.7 MJ), around 79% of the recommended daily intake. In 18of 19 subjects the observed dietary energy intake was lower than estimated energy expenditure when using twoof the formulae and a PAL factor of 1.4. All subjects considered that they received a sufficient amount offood.ConclusionsOnly one of the subjects had a satisfactory energy intake relative to calculated energyexpenditure, although all believed that they received sufficient food. Four subjects were considered asundernourished (BMIB/20) and all others as at risk of undernutrition.
44.	Olsson, Erika, et al. (författare) Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men 2015 Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 43:1, s. 109-119 Tidskriftsartikel (refereegranskat)abstract Background:Adherence to dietary patterns has been associated with cognitive decline and dementia, but studies are inconsistent.Objective:Dietary patterns, i.e., WHO recommendations (Healthy Diet Indicator), a Mediterranean-like diet (modified Mediterranean Diet Score, mMDS), and a low carbohydrate high protein diet (LCHP), were related to incident cognitive dysfunction, as indicated by Alzheimer's disease (AD), all-type dementia, and all-type cognitive impairment, in a cohort of 1,138 elderly Swedish men.Methods:Dietary patterns were derived from 7-day records. Risk relations were calculated by Cox and logistic regression analyses, adjusted for potential confounders. Sensitivity analysis was performed in a subpopulation (n = 564) with energy intake according to the Goldberg cut-off. Results:During a mean follow-up of 12 years, 84, 143, and 198 men developed AD, all-type dementia, and all-type cognitive impairment, respectively. There was no association between Healthy Diet Indicator and any of the outcomes. Hazard ratios associated with 1 standard deviation (SD) increment in the LCHP score were 1.16 (95% confidence interval [CI]: 0.95, 1.43) for AD and 1.16 (95% CI: 0.99, 1.37) for all-type dementia. mMDS was not associated with dementia diagnosis. Odds ratio (OR)/1 SD increase for mMDS and all-type cognitive impairment was 0.82 (95% CI: 0.65, 1.05). In the subpopulation OR for mMDS and all-type cognitive impairment was 0.32 (95% CI: 0.11, 0.89).Conclusion:We found no strong associations with development of cognitive dysfunction for any of the dietary patterns investigated. However, there was a potentially beneficial association for a Mediterranean-like diet on the development of cognitive dysfunction in the subpopulation.
45.	Olsson, Erika, et al. (författare) Dietary Patterns And Cognitive Dysfunction In A Prospective Study Of 70-Year-Old Swedish Men 2013 Ingår i: Annals of Nutrition and Metabolism. - 0250-6807 .- 1421-9697. ; 63:Suppl. 1, s. 862-862 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
46.	Olsson, Erika, et al. (författare) Kostmönster och risk för utveckling av demenssjukdom : en 12 års uppföljning av 70 åriga män 2011 Ingår i: Svenska läkaresällskapets riksstämma. Konferensbidrag (refereegranskat)
47.	Olsson, Erika, et al. (författare) Kostmönster och risk för utveckling av demenssjukdom : en 12 års uppföljning av 70 åriga män 2011 Ingår i: Svenska läkaresällskapets riksstämma. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Samband mellan kost och demenssjukdom är inte tydligt fastställda. Studiens syfte var att prospektivt undersöka hur tre olika kostmönster relaterar till utvecklingen av demenssjukdom, inkl. Alzheimers sjukdom (AD), eller alla typer av kognitiv störning hos äldre friska män.
48.	Olsson, Erika, et al. (författare) Vitamin D is not associated with incident dementia or cognitive impairment : an 18-y follow-up study in community-living old men 2017 Ingår i: American Journal of Clinical Nutrition. - : AMER SOC NUTRITION-ASN. - 0002-9165 .- 1938-3207. ; 105:4, s. 936-943 Tidskriftsartikel (refereegranskat)abstract Background: Vitamin D has been implicated as being important for maintaining cognitive function in old age. Results from longitudinal studies examining the association of vitamin D with incident dementia and cognitive impairment have been inconsistent. Objective: We investigated the relation between vitamin D, assessed in 3 different ways, and the risk of dementia. Design: We measured plasma 25-hydroxyvitamin D [25(OH) D] with the use of high-performance liquid chromatography-mass spectrometry, assessed dietary vitamin D intake with the use of 7-d dietary records, and created a vitamin D-synthesis genetic risk score (GRS) at baseline (1991-1995) in a cohort of 1182 Swedish men (mean age: 71 y). In a maximum of 18 y (median: 12 y) of follow-up, 116 men developed Alzheimer disease, 64 men developed vascular dementia, and 250 men developed all-cause dementia. An additional 80 men declined in cognitive function as assessed with the use of the Mini-Mental State Examination. Adjusted HRs and ORs were calculated with the use of Cox and logistic regressions. Results: The mean +/- SD plasma 25(OH) D concentration was 68.7 +/- 19.1 nmol/L. Plasma 25(OH) D, dietary vitamin D intake, and vitamin D-synthesis GRS were not associated with any cognitive outcomes (crude and adjusted HRs and ORs were similar to 1.0 for all continuous exposures). The adjusted HR for all-cause dementia was 0.88 (95% CI: 0.59, 1.31) in men with plasma 25(OH) D concentrations <= 50 compared with >75 nmol/L. The adjusted HR for all-cause dementia was 0.92 (95% CI: 0.63, 1.32) for the lowest compared with highest tertiles of vitamin D intake. The adjusted HR for the continuous GRS for all-cause dementia was 1.04 (95% CI: 0.91, 1.19). Conclusion: In this cohort study, we show that there is no association between baseline vitamin D status and long-term risk of dementia or cognitive impairment over an 18-y period of time.
49.	Perez-Martinez, Pablo, et al. (författare) Calpain-10 interacts with plasma saturated fatty acid concentrations to influence insulin resistance in individuals with the metabolic syndrome 2011 Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 93:5, s. 1136-1141 Tidskriftsartikel (refereegranskat)abstract Background: Calpain-10 protein (intracellular Ca2+-dependent cysteine protease) may play a role in glucose metabolism, pancreatic beta cell function, and regulation of thermogenesis. Several CAPN10 polymorphic sites have been studied for their potential use as risk markers for type 2 diabetes and the metabolic syndrome (MetS). Fatty acids are key metabolic regulators that may interact with genetic factors and influence glucose metabolism. Objective: The objective was to examine whether the genetic variability at the CAPN10 gene locus is associated with the degree of insulin resistance and plasma fatty acid concentrations in subjects with MetS. Design: The insulin sensitivity index, glucose effectiveness, insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)], insulin secretion (disposition index, acute insulin response, and HOMA of beta cell function), plasma fatty acid composition, and 5 CAPN10 single nucleotide polymorphisms (SNPs) were determined in a cross-sectional analysis of 452 subjects with MetS participating in the LIPGENE dietary intervention cohort. Results: The rs2953171 SNP interacted with plasma total saturated fatty acid (SFA) concentrations, which were significantly associated with insulin sensitivity (P < 0.031 for fasting insulin, P < 0.028 for HOMA-IR, and P < 0.012 for glucose effectiveness). The G/G genotype was associated with lower fasting insulin concentrations, lower HOMA-IR, and higher glucose effectiveness in subjects with low SFA concentrations (below the median) than in subjects with the minor A allele (G/A and A/A). In contrast, subjects with the G/G allele with the highest SFA concentrations (above the median) had higher fasting insulin and HOMA-IR values and lower glucose effectiveness than did subjects with the A allele. Conclusion: The rs2953171 polymorphism at the CAPN10 gene locus may influence insulin sensitivity by interacting with the plasma fatty acid composition in subjects with MetS. This trial was registered at clinicaltrials. gov as NCT00429195.
50.	Perez-Martinez, Pablo, et al. (författare) Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects 2013 Ingår i: Clinical Nutrition. - : Elsevier BV. - 0261-5614 .- 1532-1983. ; 32:4, s. 630-635 Tidskriftsartikel (refereegranskat)abstract Background & aims: Genetic background may interact with habitual dietary fat composition, and affect development of the metabolic syndrome (MetS). The phosphoenolpyruvate carboxykinase gene (PCK1) plays a significant role regulating glucose metabolism, and fatty acids are key metabolic regulators, which interact with transcription factors and influence glucose metabolism. We explored genetic variability at the PCK1 gene locus in relation to degree of insulin resistance and plasma fatty acid levels in MetS subjects. Moreover, we analyzed the PCK1 gene expression in the adipose tissue of a subgroup of MetS subjects according to the PCK1 genetic variants. Methods: Insulin sensitivity, insulin secretion, glucose effectiveness, plasma concentrations of C-peptide, fatty acid composition and three PCK1 tag-single nucleotide polymorphisms (SNPs) were determined in 443 MetS participants in the UPGENE cohort. Results: The rs2179706 SNP interacted with plasma concentration of n - 3 polyunsaturated fatty acids (n - 3 PUFA), which were significantly associated with plasma concentrations of fasting insulin, peptide C, and HOMA-IR. Among subjects with n - 3 PUFA levels above the population median, carriers of the C/C genotype exhibited lower plasma concentrations of fasting insulin (P = 0.036) and HOMA-IR (P = 0.019) as compared with C/C carriers with n - 3 PUFA below the median. Moreover, homozygous C/C subjects with n - 3 PUFA levels above the median showed lower plasma concentrations of peptide C as compared to individuals with the T-allele (P = 0.006). Subjects carrying the T-allele showed a lower gene PCK1 expression as compared with carriers of the C/C genotype (P = 0.015). Conclusions: The PCK1 rs2179706 polymorphism interacts with plasma concentration of n - 3 PUFA levels modulating insulin resistance in MetS subjects.

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