| 1. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
-
Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
-
Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 2. |
- Al-Abbadi, Mousa A., et al.
(författare)
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A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology : The Sydney System
- 2020
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Ingår i: Acta Cytologica. - : S. Karger AG. - 0001-5547 .- 1938-2650. ; 64:4, s. 306-322
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC. METHODS: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. It is based on a review of the international literature and on the expertise of the members. The system integrates clinical and imaging data with cytopathological features and ancillary techniques. The project has received the endorsement and patronage of the International Academy of Cytology and the European Federation of the Cytology Societies. RESULTS: Clinical, imaging, and serological data of lymphadenopathies, indications for LN-FNAC, technical procedures, and ancillary techniques are evaluated with specific recommendations. The reporting system includes two diagnostic levels. The first should provide basic diagnostic information and includes five categories: inadequate/insufficient, benign, atypical lymphoid cells of undetermined/uncertain significance, suspicious, and malignant. For each category, specific recommendations are provided. The second diagnostic level, when achievable, should produce the identification of specific benign or malignant entities and additional information by utilizing ancillary testing. CONCLUSION: The authors believe that the introduction of this system for performing and reporting LN-FNAC may improve the quality of the procedure, the report, and the communication between cytopathologists and the clinicians. This system may lead to a greater acceptance and utilization of LN-FNAC and to a better interdisciplinary understanding of the results of this procedure.
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| 3. |
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| 4. |
- Araujo, Nathalia, et al.
(författare)
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Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity
- 2022
-
Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53. We identified complement factor c3 as a p53-regulated gene linked to fat storage in adipocytes. Par-4 re-expression in adipocytes or c3 deletion reversed the obese mouse phenotype. Moreover, obese human subjects showed lower expression of Par-4 relative to lean subjects, and in longitudinal studies, low baseline Par-4 levels denoted an increased risk of developing obesity later in life. These findings indicate that Par-4 suppresses p53 and its target c3 to regulate obesity.
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| 5. |
- Arcavi, Iair, et al.
(författare)
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Energetic eruptions leading to a peculiar hydrogen-rich explosion of a massive star
- 2017
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 551:7679, s. 210-213
-
Tidskriftsartikel (refereegranskat)abstract
- Every supernova so far observed has been considered to be the terminal explosion of a star. Moreover, all supernovae with absorption lines in their spectra show those lines decreasing in velocity over time, as the ejecta expand and thin, revealing slower-moving material that was previously hidden. In addition, every supernova that exhibits the absorption lines of hydrogen has one main light-curve peak, or a plateau in luminosity, lasting approximately 100 days before declining(1). Here we report observations of iPTF14hls, an event that has spectra identical to a hydrogen-rich core-collapse supernova, but characteristics that differ extensively from those of known supernovae. The light curve has at least five peaks and remains bright for more than 600 days; the absorption lines show little to no decrease in velocity; and the radius of the line-forming region is more than an order of magnitude bigger than the radius of the photosphere derived from the continuum emission. These characteristics are consistent with a shell of several tens of solar masses ejected by the progenitor star at supernova-level energies a few hundred days before a terminal explosion. Another possible eruption was recorded at the same position in 1954. Multiple energetic pre-supernova eruptions are expected to occur in stars of 95 to 130 solar masses, which experience the pulsational pair instability(2-5). That model, however, does not account for the continued presence of hydrogen, or the energetics observed here. Another mechanism for the violent ejection of mass in massive stars may be required.
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| 6. |
- Benatar, Michael, et al.
(författare)
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Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
- 2024
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 23:7, s. 687-699
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Tidskriftsartikel (refereegranskat)abstract
- Background: Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis.Methods: ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed.Findings: Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]).Interpretation: Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated.Funding: Orphazyme.
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| 7. |
- Blondin, Stéphane, et al.
(författare)
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StaNdaRT : a repository of standardised test models and outputs for supernova radiative transfer
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
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Tidskriftsartikel (refereegranskat)abstract
- We present the first results of a comprehensive supernova (SN) radiative-transfer (RT) code-comparison initiative (StaNdaRT), where the emission from the same set of standardised test models is simulated by currently used RT codes. We ran a total of ten codes on a set of four benchmark ejecta models of Type Ia SNe. We consider two sub-Chandrasekhar-mass (Mtot = 1.0 M⊙) toy models with analytic density and composition profiles and two Chandrasekhar-mass delayed-detonation models that are outcomes of hydrodynamical simulations. We adopt spherical symmetry for all four models. The results of the different codes, including the light curves, spectra, and the evolution of several physical properties as a function of radius and time are provided in electronic form in a standard format via a public repository. We also include the detailed test model profiles and several Python scripts for accessing and presenting the input and output files. We also provide the code used to generate the toy models studied here. In this paper, we describe the test models, radiative-transfer codes, and output formats in detail, and provide access to the repository. We present example results of several key diagnostic features.
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| 8. |
- Borrow, Julian, et al.
(författare)
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Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts
- 1992
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 82:3, s. 529-540
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Tidskriftsartikel (refereegranskat)abstract
- Acute promyelocytic leukaemia (APL; AML M3) is identified by a unique t(15;17) translocation which fuses the PML gene to the retinoic acid receptor alpha gene (RARA). Reverse transcription coupled with the polymerase chain reaction (RT-PCR) has been used to develop a diagnostic test for APL based on the PML-RARA fusion message. Separate PCR assays were designed to amplify either PML-RARA (15q+ derived) or RARA-PML (17q- derived) chimaeric transcripts. PML-RARA transcripts were detected in every case from a series of 18 APL patients with cytogenetically confirmed t(15;17) translocations, whereas RARA-PML messages were detected in only 67% (12/18) of these patients. This suggests that it is the 15q+ derivative which mediates leukaemogenesis. Furthermore the PCR approach (or Southern analysis) may be used to identify in which of the alternative PML introns the breakpoint occurs; 52% of cases (15/29 patients) utilize a 5' PML intron and 48% the 3' intron (14/29 cases). Neither the choice of PML intron nor the expression of the 17q- derivative could be correlated with the microgranular variant of APL (M3V), overall survival rate, age, sex or presence of coagulopathy. Finally, the fusion message is undetectable in five remission samples. This indicates a possible use for RT-PCR in monitoring remission patients for evidence of relapse.
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| 9. |
- Caputo, Alessandro, et al.
(författare)
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Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS). An international, multi-institutional study
- 2023
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Ingår i: Cancer Cytopathology. - 1934-662X. ; 131:11, s. 679-692
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Tidskriftsartikel (refereegranskat)abstract
- Background: After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malignancy for the categories of the Sydney system has been explored by several studies, but no studies have yet examined the interobserver reproducibility of the Sydney system. Methods: The authors assessed interobserver reproducibility of the Sydney system on 85 lymph node fine-needle aspiration cytology cases reviewed by 15 cytopathologists from 12 institutions in eight different countries, resulting in 1275 diagnoses. In total, 186 slides stained with Diff-Quik, Papanicolaou, and immunocytochemistry were scanned. A subset of the cases included clinical data and results from ultrasound examinations, flow cytometry immunophenotyping, and fluorescence in situ hybridization analysis. The study participants assessed the cases digitally using whole-slide images. Results: Overall, the authors observed an almost perfect agreement of cytopathologists with the ground truth (median weighted Cohen κ = 0.887; interquartile range, κ = 0.210) and moderate overall interobserver concordance (Fleiss κ = 0.476). There was substantial agreement for the inadequate and malignant categories (κ = 0.794 and κ = 0.729, respectively), moderate agreement for the benign category (κ = 0.490), and very slight agreement for the suspicious (κ = 0.104) and atypical (κ = 0.075) categories. Conclusions: The Sydney system for reporting lymph node cytopathology shows adequate interobserver concordance. Digital microscopy is an adequate means to assess lymph node cytopathology specimens.
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| 10. |
- Chen, Ping, et al.
(författare)
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A 12.4-day periodicity in a close binary system after a supernova
- 2024
-
Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 253-258
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Tidskriftsartikel (refereegranskat)abstract
- Neutron stars and stellar-mass black holes are the remnants of massive star explosions1. Most massive stars reside in close binary systems2, and the interplay between the companion star and the newly formed compact object has been theoretically explored3, but signatures for binarity or evidence for the formation of a compact object during a supernova explosion are still lacking. Here we report a stripped-envelope supernova, SN 2022jli, which shows 12.4-day periodic undulations during the declining light curve. Narrow Hα emission is detected in late-time spectra with concordant periodic velocity shifts, probably arising from hydrogen gas stripped from a companion and accreted onto the compact remnant. A new Fermi-LAT γ-ray source is temporally and positionally consistent with SN 2022jli. The observed properties of SN 2022jli, including periodic undulations in the optical light curve, coherent Hα emission shifting and evidence for association with a γ-ray source, point to the explosion of a massive star in a binary system leaving behind a bound compact remnant. Mass accretion from the companion star onto the compact object powers the light curve of the supernova and generates the γ-ray emission.
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| 11. |
- Gabrielsson, Jonas, et al.
(författare)
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Categorization and analysis of academic patents: Developing a framework to examine differences in technology, opportunity and commercializaton characteristics
- 2014
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Ingår i: Academic entrepreneurship: Creating an entrepreneurial ecosystem. - Bingley : Emerald Group Publishing Limited. - 1074-7540. - 9781783509843 - 9781783509836 ; 16, s. 169-196
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Bokkapitel (refereegranskat)abstract
- There has been a significant rise in the number of patents originating from academic environments. However, current conceptualizations of academic patents provide a largely homogenous approach to define this entrepreneurial form of technology transfer. In this study we develop a novel categorization framework that identifies three subsets of academic patents which are conceptually distinct from each other. By applying the categorization framework on a unique database of Swedish patents we furthermore find support for its usefulness in detecting underlying differences in technology, opportunity, and commercialization characteristics among the three subsets of academic patents.
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| 12. |
- Honig, Benson, et al.
(författare)
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The Blessing of Necessity and Advantages of Newness
- 2013
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Ingår i: Advances in Entrepreneurship, Firm Emergence and Growth - Entrepreneurial Resourcefulness: Competing with Constraints. - 1074-7540. ; 15, s. 63-94
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Bokkapitel (refereegranskat)
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| 13. |
- Katz, Andrew, et al.
(författare)
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Software, copyright and the learning environment : An analysis of the IT contracts Swedish schools impose on their students and the implications for FOSS
- 2016
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Ingår i: International Free and Open Source Software Law Review. - : International Free and Open Source Software Law Review. - 1877-6922. ; 8:1, s. 1-28
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Tidskriftsartikel (refereegranskat)abstract
- Free and open source software (FOSS) is commonly made available to students in schools, but the schools do not necessarily take a holistic approach to their provision of IT (including software) which takes into account the nature of FOSS. In particular, we have identified a number of contracts with which Swedish students who are provided with laptops by their schools are required to comply which set out conditions for the use of the laptops, and associated software and content. Many clauses in these contracts are legally incompatible with certain FOSS licences, or contain misconceptions about FOSS, licensing and culture. This paper explores the relationship between the contracts and FOSS licensing and culture, and suggests a number of resolutions to the contradictions and misconceptions, as well as considering related issues.
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| 14. |
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| 15. |
- Li, Jing, et al.
(författare)
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An obligatory role for neurotensin in high-fat-diet-induced obesity
- 2016
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 533, s. 411-415
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Tidskriftsartikel (refereegranskat)abstract
- Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually and are among the most prevalent and challenging conditions confronting the medical profession. Neurotensin (NT; also known as NTS), a 13-amino-acid peptide predominantly localized in specialized enteroendocrine cells of the small intestine and released by fat ingestion, facilitates fatty acid translocation in rat intestine, and stimulates the growth of various cancers. The effects of NT are mediated through three known NT receptors (NTR1, 2 and 3; also known as NTSR1, 2, and NTSR3, respectively). Increased fasting plasma levels of pro-NT (a stable NT precursor fragment produced in equimolar amounts relative to NT) are associated with increased risk of diabetes, cardiovascular disease and mortality; however, a role for NT as a causative factor in these diseases is unknown. Here we show that NT-deficient mice demonstrate significantly reduced intestinal fat absorption and are protected from obesity, hepatic steatosis and insulin resistance associated with high fat consumption. We further demonstrate that NT attenuates the activation of AMP-activated protein kinase (AMPK) and stimulates fatty acid absorption in mice and in cultured intestinal cells, and that this occurs through a mechanism involving NTR1 and NTR3 (also known as sortilin). Consistent with the findings in mice, expression of NT in Drosophila midgut enteroendocrine cells results in increased lipid accumulation in the midgut, fat body, and oenocytes (specialized hepatocyte-like cells) and decreased AMPK activation. Remarkably, in humans, we show that both obese and insulin-resistant subjects have elevated plasma concentrations of pro-NT, and in longitudinal studies among non-obese subjects, high levels of pro-NT denote a doubling of the risk of developing obesity later in life. Our findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment.
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| 16. |
- Lundell, Björn, et al.
(författare)
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Addressing Lock-in Effects in the Public Sector : How Can Organisations Deploy a SaaS SolutionWhile Maintaining Control of Their Digital Assets?
- 2020
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Ingår i: Proceedings of Ongoing Research, Practitioners, Posters, Workshops, and Projects at EGOV-CeDEM-ePart 2020co-located with the IFIP WG 8.5 International Conference EGOV-CeDEM-ePart 2020. - Aachen : CEUR. ; , s. 289-296
-
Konferensbidrag (refereegranskat)abstract
- As software as a service (SaaS) adoption increases in both the public and private sectors, so does dependency on specific providers and technologies and the consequent danger of lock-in. This paper reports on how public sector organisations (PSOs) can, and should, avoid lock-in throughout the lifecycle (commissioning, deployment and decommissioning) of their deployment of the Microsoft Office 365 SaaS product (O365). We investigate how 33 PSOs address different lock-in effects, focussing on the City of Gothenburg, and show that none of the PSOs determined possible lock-in effects prior to implementation or were able to provide documented evidence that they would be able to independently access, process and maintain the digital assets processed by the SaaS solution after decommissioning. We also report on jurisdictional and data processing issues, with consequent impact on digital sovereignty.
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| 17. |
- Lundell, Björn, et al.
(författare)
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Avoiding lock-in effects through obtaining all necessary licences before use of a SaaS solution in a public sector organisation
- 2023
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Ingår i: European Journal of Law and Technology. - 2042-115X. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- With increased adoption and use of cloud-based software-as-a-service (SaaS) solutions from international providers many public sector organisations expose themselves to a dependency on specific providers and a range of different lock-in effects. The article reports from a case study which investigated how a large Swedish public sector organisation addressed licensing issues and lock-in effects during adoption and use of a SaaS solution (Microsoft 365). The study identifies problematic licensing issues and presents a legal analysis related to the organisational implementation of the SaaS solution in the specific organisation. Findings show that the organisation has failed to successfully obtain all necessary licences and all necessary rights which would allow for long-term maintenance of all its digital assets independently of the SaaS solution currently in use.
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| 18. |
- Lundell, Björn, et al.
(författare)
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Data processing and maintenance in different jurisdictions when using a SaaS solution in a public sector organisation
- 2022
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Ingår i: eJournal of eDemocracy & Open Government. - Krems : Department for E-Governance and Administration, Danube University Krems. - 2075-9517. ; 14:2, s. 214-234
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Tidskriftsartikel (refereegranskat)abstract
- Many public sector organisations (PSO) use SaaS solutions from dominant global providers. Implementation of these solutions may raise issues concerning both lawful data processing, and the obligations that those PSOs have to maintain their digital assets. One example is a large Swedish PSO which addressed these issues as part of the adoption and implementation of Microsoft 365. The study identifies challenges and presents an analysis of the organisational implementation of that SaaS solution, exposing legal issues that arose in that context. Findings show an absence of a documented risk analysis related to the PSO's use of that SaaS solution, covering data processing and maintenance of its digital assets. Recommendations are presented to facilitate a PSO's procurement and implementation of such a SaaS solution to address issues around data processing and the processing of digital assets.
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| 19. |
- Lundell, Björn, et al.
(författare)
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Effective Strategies for Using Open Source Software and Open Standards in Organizational Contexts : Experiences From the Primary and Secondary Software Sectors
- 2022
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Ingår i: IEEE Software. - : IEEE. - 0740-7459 .- 1937-4194. ; 39:1, s. 84-92
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Tidskriftsartikel (refereegranskat)abstract
- Open source software (OSS) and open standards have become increasingly important for addressing challenges related to lock-in, interoperability and long-term maintenance of systems and associated digital assets. OSS projects operate under different conditions and many projects and organisations consider successful governance and strategic involvement with projects to constitute major challenges. Today, many companies seek to establish work practices which facilitate strategic engagement with OSS projects. Based on findings from collaborative research which draws from rich insights and extensive experiences from practice, the paper presents seven actionable strategies for organisations that seek to leverage long-term involvement with OSS projects.
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| 20. |
- Lundell, Björn, et al.
(författare)
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Half a step behind – bulk disclosure of confidential data in third-party GenAI solutions under the Swedish Public Access to Information and Secrecy Act
- 2024
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Ingår i: Digital Government: Research and Practice. - : ACM Digital Library. - 2691-199X .- 2639-0175.
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Tidskriftsartikel (refereegranskat)abstract
- Technological progress poses unique challenges for the public sector. New technology should be adopted, but it must always be done within the framework of good administration. It follows laws governing public administration must be continuously adapted. Sweden recently amended its secrecy legislation to facilitate the use of third-party cloud solutions by public authorities. When the amendment was enacted, most public sector organisations had already been using external cloud solutions for a long time. Today, there is as much pressure on authorities to implement AI technology as there ever was to move administration into the cloud. This paper uses traditional legal methodology to investigate if the Swedish secrecy legislation adequately enables the use of cloud-based GenAI solutions. Findings indicate that the recent amendment is likely insufficient and that there are significant practical hurdles for the application of the law, particularly with services from global cloud providers. The paper contributes to the understanding of Swedish law, and of the difficulties that can occur anywhere when policy makers and legislators do not move in tandem.
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| 21. |
- Lundell, Björn, et al.
(författare)
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Implementing IT Standards in Software : Challenges and Recommendations for Organisations Planning Software Development Covering IT Standards
- 2019
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Ingår i: European Journal of Law and Technology. - 2042-115X. ; 10:2
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Tidskriftsartikel (refereegranskat)abstract
- To develop software based on standards, developers will often require patent licences for the patents which impinge on those standards. This paper reports on an investigation into acquiring patent licences required to implement three specific formal standards in software, namely ISO 32000-1 (a standard based on PDF 1.7), ISO/IEC 29500 (Office Open XML), and ISO 20022 (a standard for international financial business communication). In particular, the licences were requested in the context of implementation of those standards in open source software. We elaborate on the challenges of seeking to obtain those rights, providing examples. Findings show evidence of significant practical difficulty of obtaining the necessary licences, and we examine the implications of that evidence. We make specific recommendations both in terms of the steps which an organisation should take into account prior to considering implementing such a standard in software, as well as recommendations to changes in policy and practice aimed at reducing friction in implementing such standards in open source software.
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| 22. |
- Lundell, Björn, et al.
(författare)
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Implementing the HEVC standard in software : Challenges and Recommendations for organisations planning development and deployment of software
- 2023
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Ingår i: Journal of Standardisation. - Delft : TU Delft OPEN. - 2772-9249. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Implementation and use of an IT standard in software involves legal, technical and societal challenges. This paper addresses how an organisation can, and should, determine the conditions for implementation and use of the HEVC standard in software. The investigation considers the availability of the standard’s complete technical specification and the extent to which an organisation can access the information necessary to assess the licence conditions for standard essential patents impinging on the standard. Through an action case study approach the investigation analyses declarations in patent databases relevant to the standard and seeks to obtain patent licences from each declarant permitting implementation of the standard in software, where that software is to be provided under one (or several) of three specific open source software licences, and alternatively to be provided as an online service. Our analysis of legal and licensing conditions for use of the standard shows significant obstacles. We find that it is impossible to obtain licences from patent holders that would allow for implementation and use of the standard in open source software. The paper illuminates significant challenges related to conditions for use of the standard under (F)RAND terms and identifies that references to the standard in public procurement projects lead to anti-competitive effects.
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| 23. |
- Lundell, Björn, et al.
(författare)
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On Challenges for Implementing ISO Standards in Software : Can Both Open and Closed Standards Be Implemented in Open Source Software?
- 2018. - 1
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Ingår i: Corporate and Global Standardization Initiatives in Contemporary Society. - Hershey : IGI Global. - 9781522553205 - 1522553207 - 9781522553212 ; , s. 219-251
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Bokkapitel (refereegranskat)abstract
- Over the years, the importance of open standards has been acknowledged in EU and national policies. Formal (e.g., ISO) standards are often referred to in software development and procurement. Use of formal (ISO) standards and to what extent ISO standards can be implemented in open source software is considered, with particular reference to patent licensing. It is shown that not all formal standards are open standards and that FRAND commitments may impose major challenges for use of such standards. Further policies and procedures set by standards setting organisations (SSOs) regarding the notification of standards-essential patents (SEPs) present challenges for organisations wishing to implement standards in software. This chapter elaborates implications and suggests ways of addressing the challenges identified. Use of formal standards may create barriers for implementation in open source software and inhibit an open and inclusive business-friendly ecosystem.
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| 24. |
- Lundell, Björn, et al.
(författare)
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On Challenges for Implementing ISO Standards in Software : Can Both Open and Closed Standards Be Implemented in Open Source Software?
- 2021
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Ingår i: Research Anthology on Usage and Development of Open Source Software. - : IGI Global. - 9781799891598 - 9781799891581 - 1799891585 ; , s. 63-95
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Bokkapitel (refereegranskat)abstract
- Over the years, the importance of open standards has been acknowledged in EU and national policies. Formal (e.g., ISO) standards are often referred to in software development and procurement. Use of formal (ISO) standards and to what extent ISO standards can be implemented in open source software is considered, with particular reference to patent licensing. It is shown that not all formal standards are open standards and that FRAND commitments may impose major challenges for use of such standards. Further policies and procedures set by standards setting organisations (SSOs) regarding the notification of standards-essential patents (SEPs) present challenges for organisations wishing to implement standards in software. This chapter elaborates implications and suggests ways of addressing the challenges identified. Use of formal standards may create barriers for implementation in open source software and inhibit an open and inclusive business-friendly ecosystem.
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| 25. |
- Lundell, Björn, et al.
(författare)
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On implementation of Open Standards in software : To what extent can ISO standards be implemented in open source software?
- 2015
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Ingår i: International Journal of Standardization Research. - : IGI Global. - 2470-8542. ; 13:1, s. 47-73
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Tidskriftsartikel (refereegranskat)abstract
- Several European countries, as well as the European Commission, have acknowledged the importance of open standards (under various definitions of that term) and have taken steps accordingly. Formal (e.g. ISO) standards are often referred to in software development and procurement, but may not necessarily also be open standards. The authors consider the application of formal standards where national policy promotes their use, and, since much contemporary software development involves open source software, they further consider the interaction between the requirement to comply with open standards, and the implementation of open and formal standards in open source software, with particular reference to patent licensing. It is shown that not all formal standards are open standards. SSO policies and procedures regarding the notification of standards-essential patents (SEPs) present challenges for organisations wishing to implement standards in software since such policies and procedures need to be compliant with procurement requirements, patent licences and open source software licences. This paper draws out some implications for those organisations (differentiating where appropriate between small companies and other organisations) and suggests a number of ways of addressing the challenges identified. Use of formal standards may create barriers for implementation in open source software and inhibit an open and inclusive business-friendly ecosystem, and to avoid such barriers is of particular importance for small companies that are essential players in an innovative and international society.
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| 26. |
- Lundell, Björn, et al.
(författare)
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Perceived and Actual Lock-in Effects Amongst Swedish Public Sector Organisations when Using a SaaS Solution
- 2021
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Ingår i: Electronic Government. - Cham : Springer. - 9783030847883 - 9783030847890 ; , s. 59-72
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Konferensbidrag (refereegranskat)abstract
- When a public sector organisation (PSO) uses a software as a service (SaaS) solution from a global provider this imposes risks for different types of lock-in effects. In turn, use of such solutions by PSOs may prevent full control of digital assets that need to be created, processed, maintained, and archived for use and reuse over long life-cycles. This paper addresses perceived and actual lock-in effects related to use of SaaS solutions in the public sector. We review perceptions of lock-in amongst government agencies and investigate how 46 PSOs have addressed challenges related to obtaining licences and an effective exit plan related to use of the Microsoft Office 365 SaaS solution. Through a review of responses to a survey conducted by the Swedish Government Offices we find significant misconceptions concerning lock-in effects. We find that every one of the 46 PSOs investigated neither obtained necessary licences nor established an effective exit strategy to allow the PSO to independently access, process and maintain digital assets processed by the SaaS solution after decommissioning. We present recommendations for any PSO considering use of a SaaS solution.
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| 27. |
- Lundell, Björn, et al.
(författare)
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Use of Commercial SaaS Solutions in Swedish Public Sector Organisations under Unknown Contract Terms
- 2022
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Ingår i: Electronic Government. - Cham : Springer Nature Switzerland AG. - 9783031150869 - 9783031150852 ; , s. 73-92
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Konferensbidrag (refereegranskat)abstract
- Lawful and appropriate use of cloud-based globally provided Software-as-a-Service (SaaS) solutions by a public sector organisation (PSO) for data processing and maintenance of digital assets presupposes an investigation of all relevant contract terms. Having obtained, analysed, and filed all relevant contract terms when using a SaaS solution is a prerequisite for good administration. Identifying and obtaining all relevant contract terms for a SaaS solution involves significant obstacles which in practice may be impossible to overcome for each PSO. This paper addresses how PSOs investigate contract terms prior to adoption, and why PSOs use a globally provided SaaS solution without having identified and obtained all relevant contract terms. Through a review of responses to questions and public documents from Swedish PSOs we analysed how each PSO had investigated contract terms and licences for the Microsoft 365 (M365) solution prior to adoption and use of the solution in each PSO. We find that no PSO had investigated all relevant contract terms prior to use of M365, which implies that each PSO uses M365 under unknown contract terms. Further, we find that all PSOs use M365 for data processing of its digital assets under unknown contract terms and that each PSO has significant dependence and trust in its supplier.
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| 28. |
- Ng, Bobby G, et al.
(författare)
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ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients.
- 2016
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Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794.
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Tidskriftsartikel (refereegranskat)abstract
- Congenital disorders of glycosylation (CDG) arise from pathogenic mutations in over one hundred genes leading to impaired protein or lipid glycosylation. ALG1 encodes a β1,4 mannosyltransferase that catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide intermediate (DLO) required for proper N-linked glycosylation. ALG1 mutations cause a rare autosomal recessive disorder termed ALG1-CDG. To date thirteen mutations in eighteen patients from fourteen families have been described with varying degrees of clinical severity. We identified and characterized thirty-nine previously unreported cases of ALG1-CDG from thirty-two families and add twenty-six new mutations. Pathogenicity of each mutation was confirmed based on its inability to rescue impaired growth or hypoglycosylation of a standard biomarker in an alg1-deficient yeast strain. Using this approach we could not establish a rank order comparison of biomarker glycosylation and patient phenotype, but we identified mutations with a lethal outcome in the first two years of life. The recently identified protein-linked xeno-tetrasaccharide biomarker, NeuAc-Gal-GlcNAc2 , was seen in all twenty-seven patients tested. Our study triples the number of known patients and expands the molecular and clinical correlates of this disorder. This article is protected by copyright. All rights reserved.
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| 29. |
- Paci, Chris, et al.
(författare)
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Northern Science and Research : Postsecondary Perspectives in the Northwest Territories
- 2008
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Ingår i: Journal of Northern Studies. - Umeå : Umeå University & The Royal Skyttean Society. - 1654-5915. ; :1, s. 23-52
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Tidskriftsartikel (refereegranskat)abstract
- The International Polar Year (IPY) provides an opportunity to reflect on Northern science and research. For all Canadians, science and research should contribute to living a good life. A good life includes successfully making sense of the world within local contexts, sharing this knowledge beyond the immediate community and reconciling it with knowledge held by outsiders. Northern science and research are inherent in Traditional Dene, Inuvialuit and Metis knowledge; and they continue to be reflected in Northern governance, economy, and cultures. Alongside Aboriginal sciences are Western sciences; these are primarily disciplinary in nature and formally structure postsecondary education globally. Postsecondary science and research education is still being introduced to the Northwest Territories (NWT). Over the last forty years the territorial government has developed the capacity for educational services, funding, institutions, and authority through the Department of Education, Culture and Employment. The delivery of Northern-based postsecondary education through Aurora College provides Northerners with the capacity to generate science and research in the North. What place do science and research have in the North? (North in this paper demarcates the socially constructed geopolitical territories north of the 60th parallel that we use cautiously as a structural term for the purposes of our narrative.) What kinds of investments need to be made and will Northerners be prepared to overcome barriers and take advantage of the opportunities?
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| 30. |
- Pattaro, Cristian, et al.
(författare)
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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| 31. |
- Peters, Ruth, et al.
(författare)
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An investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.
- 2020
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Ingår i: Neurology. - 1526-632X. ; 94:3
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Tidskriftsartikel (refereegranskat)abstract
- High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.To identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.Over 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.Our findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.The review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.
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| 32. |
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| 33. |
- Shlipak, Michael G., et al.
(författare)
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Cystatin C versus Creatinine in Determining Risk Based on Kidney Function
- 2013
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 369:10, s. 932-943
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Adding the measurement of cystatin C to that of serum creatinine to determine the estimated glomerular filtration rate (eGFR) improves accuracy, but the effect on detection, staging, and risk classification of chronic kidney disease across diverse populations has not been determined. METHODS We performed a meta-analysis of 11 general-population studies (with 90,750 participants) and 5 studies of cohorts with chronic kidney disease (2960 participants) for whom standardized measurements of serum creatinine and cystatin C were available. We compared the association of the eGFR, as calculated by the measurement of creatinine or cystatin C alone or in combination with creatinine, with the rates of death (13,202 deaths in 15 cohorts), death from cardiovascular causes (3471 in 12 cohorts), and end-stage renal disease (1654 cases in 7 cohorts) and assessed improvement in reclassification with the use of cystatin C. RESULTS In the general-population cohorts, the prevalence of an eGFR of less than 60 ml per minute per 1.73 m(2) of body-surface area was higher with the cystatin C-based eGFR than with the creatinine-based eGFR (13.7% vs. 9.7%). Across all eGFR categories, the reclassification of the eGFR to a higher value with the measurement of cystatin C, as compared with creatinine, was associated with a reduced risk of all three study outcomes, and reclassification to a lower eGFR was associated with an increased risk. The net reclassification improvement with the measurement of cystatin C, as compared with creatinine, was 0.23 (95% confidence interval [CI], 0.18 to 0.28) for death and 0.10 (95% CI, 0.00 to 0.21) for end-stage renal disease. Results were generally similar for the five cohorts with chronic kidney disease and when both creatinine and cystatin C were used to calculate the eGFR. CONCLUSIONS The use of cystatin C alone or in combination with creatinine strengthens the association between the eGFR and the risks of death and end-stage renal disease across diverse populations.
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| 34. |
- Svorc, Jiri, et al.
(författare)
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Breathe In, Breathe Out : How open hardware licensing can help save the world
- 2019
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Ingår i: The Journal of Open Law, Technology & Society. - 2666-8106. ; 11:1, s. 49-56
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Tidskriftsartikel (refereegranskat)abstract
- As with any other open source field, there are countless far-reaching advantages in open hardware licensing, as opposed to its proprietary counterpart. This paper takes the example of a low-cost portable mechanical ventilator design and considers the effect of the application of the three different variants of the newly-released CERN Open Hardware Licence Version 2. This paper considers the importance of licensing, and demonstrates how open hardware licensing can facilitate efficient further development of a project, improve its safety and reliability, and encourage collaboration. Most importantly, open hardware licensing allows anyone to freely use, study, modify and distribute improvements to project design, and make, sell or otherwise distribute products made to that design, making it a cost-effective means of developing and deploying the device throughout the world, from the most developed to the most vulnerable territories. Finally, this paper argues that open hardware licensing also encourages economic activity whilst it protects third-party intellectual property rights.
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| 35. |
- van Leeuwen, F., et al.
(författare)
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Gaia Data Release 1 : Open cluster astrometry: Performance, limitations, and future prospects
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 601
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Tidskriftsartikel (refereegranskat)abstract
- Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information. Aims. We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters. Methods. Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed. Results. Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters. Conclusions. The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs.
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| 36. |
- Wilkinson, Jack, et al.
(författare)
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Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
- 2024
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 14:3
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions.Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare.Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from all survey participants. All results will be published as open-access articles. The final tool will be made freely available.
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| 37. |
- Zeppa, Pio, et al.
(författare)
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Announcement : The International System for Reporting Lymph Node Cytopathology
- 2020
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Ingår i: Acta Cytologica. - : S. Karger AG. - 0001-5547 .- 1938-2650. ; 64:4, s. 299-305
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Forskningsöversikt (refereegranskat)abstract
- Fine needle aspiration biopsy cytopathology (FNAC) of lymph nodes is a very common, inexpensive, and rapid diagnostic procedure and can lead to the accurate and timely diagnosis of one of the wide range of pathological processes that involve lymph nodes. These diagnoses include specific reactive processes, specific infections such as tuberculosis, metastatic carcinomas and melanomas, and some lymphomas. The FNAC effectively triages the lymph node material, but the initial diagnosis often requires ancillary testing as a second diagnostic step to make a specific diagnosis, such as the particular infectious agent, the type of lymphoma or Hodgkin lymphoma, or the specific type of metastatic malignancy. An international group of cytopathologists have begun the process of developing a system for the standardized reporting of lymph node FNAC. The group is addressing the pre-analytical issues related to the FNAC, including the role of clinical information and the use of ultrasound, and developing a structure of reporting categories based on the cytopathological findings linked to management recommendations. The basis of the system is the integration of the FNAC with the clinical setting, imaging, and ancillary tests that utilize the FNAC material, to produce a final report that will enhance patient care.
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| 38. |
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