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| 4. |
- Ramilowski, JA, et al.
(författare)
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Functional annotation of human long noncoding RNAs via molecular phenotyping
- 2020
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Ingår i: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 30:7, s. 1060-1072
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Tidskriftsartikel (refereegranskat)abstract
- Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.
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| 7. |
- Janhunen, P., et al.
(författare)
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Invited Article: Electric solar wind sail : Toward test missions
- 2010
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 81:11, s. 111301-
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Tidskriftsartikel (refereegranskat)abstract
- The electric solar wind sail (E-sail) is a space propulsion concept that uses the natural solar wind dynamic pressure for producing spacecraft thrust. In its baseline form, the E-sail consists of a number of long, thin, conducting, and centrifugally stretched tethers, which are kept in a high positive potential by an onboard electron gun. The concept gains its efficiency from the fact that the effective sail area, i.e., the potential structure of the tethers, can be millions of times larger than the physical area of the thin tethers wires, which offsets the fact that the dynamic pressure of the solar wind is very weak. Indeed, according to the most recent published estimates, an E-sail of 1 N thrust and 100 kg mass could be built in the rather near future, providing a revolutionary level of propulsive performance (specific acceleration) for travel in the solar system. Here we give a review of the ongoing technical development work of the E-sail, covering tether construction, overall mechanical design alternatives, guidance and navigation strategies, and dynamical and orbital simulations.
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| 8. |
- Sardh, E, et al.
(författare)
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Overall Health, Daily Functioning, and Quality of Life in Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
- 2020
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Ingår i: DIGESTIVE AND LIVER DISEASE. - : Elsevier BV. - 1590-8658. ; 52, s. E35-E35
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 11. |
- Gorkina, Alexandra L, et al.
(författare)
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Transparent and conductive hybrid graphene/carbon nanotube films
- 2016
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Ingår i: Carbon. - : Elsevier. - 0008-6223 .- 1873-3891. ; 100, s. 501-507
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanomaterials (carbon nanotubes (CNTs) and graphene) are promising materials for optoelectronic applications, including flexible transparent and conductive films (TCFs) due to their extraordinary electrical, optical and mechanical properties. However, the performance of CNT- or graphene-only TCFs still needs to be improved. One way to enhance the optoelectrical properties of TCFs is to hybridize CNTs and graphene. This approach leads to creation of a novel material that exhibits better properties than its individual constituents. In this work, the novel hybrid CNT-graphene nanomaterial was fabricated by graphene oxide deposition on top of CNT films. The graphene oxide was then reduced by thermal annealing at ambient atmosphere or in H2 atmosphere. At the final step the CNT-graphene hybrids were chemically doped using gold(III) chloride. As a result, we show that the hybrids demonstrate excellent optoelectrical performance with the sheet resistance as low as 73 Ω/□ at 90% transmittance.
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- Mäkinen, Taija, et al.
(författare)
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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
- 2001
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal. Transgenic mice develop a lymphedema-like phenotype characterized by swelling of feet, edema and dermal fibrosis. They survive the neonatal period in spite of a virtually complete lack of lymphatic vessels in several tissues, and later show regeneration of the lymphatic vasculature, indicating that induction of lymphatic regeneration may also be possible in humans.
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| 16. |
- Nasibulina, Larisa I., et al.
(författare)
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Direct synthesis of carbon nanofibers on cement particles
- 2010
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Ingår i: Transportation Research Record. - : SAGE Publications. - 0361-1981 .- 2169-4052. ; :2142, s. 96-101
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotubes (CNTs) and nanofibers (CNFs) are promising candidates for the next generation of high-performance structural and multifunctional composite materials. One of the largest obstacles to creating strong, electrically or thermally conductive CNT-CNF composites is the difficulty of getting a good dispersion of the carbon nanomaterials in a matrix. Typically, time-consuming steps are required in purifying and functionalizing the carbon nanomaterial. A new approach under which CNTs-CNFs are grown directly on the surface of matrix and matrix precursor particles is proposed. Cement was selected as the precursor matrix, since it is the most important construction material. A novel cement hybrid material (CHM) was synthesized in which CNTs and CNFs are attached to the cement particles by two different methods: screw feeder and fluidized bed reactors. CHM has been proved to increase the compressive strength by two times and the electrical conductivity of the hardened paste by 40 times.
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| 18. |
- van Loggerenberg, W, et al.
(författare)
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Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation
- 2023
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Ingår i: bioRxiv : the preprint server for biology. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Defects in hydroxymethylbilane synthase (HMBS) can cause Acute Intermittent Porphyria (AIP), an acute neurological disease. Although sequencing-based diagnosis can be definitive, ~⅓ of clinical HMBS variants are missense variants, and most clinically-reported HMBS missense variants are designated as “variants of uncertain significance” (VUS). Using saturation mutagenesis,en masseselection, and sequencing, we applied a multiplexed validated assay to both the erythroid-specific and ubiquitous isoforms of HMBS, obtaining confident functional impact scores for >84% of all possible amino-acid substitutions. The resulting variant effect maps generally agreed with biochemical expectation. However, the maps showed variants at the dimerization interface to be unexpectedly well tolerated, and suggested residue roles in active site dynamics that were supported by molecular dynamics simulations. Most importantly, these HMBS variant effect maps can help discriminate pathogenic from benign variants, proactively providing evidence even for yet-to-be-observed clinical missense variants.
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| 19. |
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| 20. |
- Yli-Rantala, E., et al.
(författare)
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Graphitised Carbon Nanofibres as Catalyst Support for PEMFC
- 2011
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Ingår i: Fuel Cells. - : Wiley-Blackwell. - 1615-6846 .- 1615-6854. ; 11:6, s. 715-725
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Tidskriftsartikel (refereegranskat)abstract
- Graphitised carbon nanofibres (G-CNFs) show superior thermal stability and corrosion resistance in PEM fuel cell environment over traditional carbon black (CB) and carbon nanotube catalyst supports. However, G-CNFs have an inert surface with only very limited amount of surface defects for the anchorage of Pt catalyst nanoparticles. Modification of the fibre surface is therefore needed. In this study Pt nanoparticles have been deposited onto as-received and surface-modified G-CNFs. The surface modifications of the fibres comprise acid treatment and nitrogen doping by pyrolysis of a polyaniline (PANI) precursor. The modified surfaces were studied by FTIR and XPS and the electrochemical characterization, including long-term Pt stability tests, was performed using a low-temperature PEMFC single cell. The performance and stability of the G-CNF supported catalysts were compared with a CB supported catalyst and the effects of the different surface treatments were discussed. On the basis of these results, new membrane electrode assemblies (MEAs) were manufactured and tested also for carbon corrosion by in situ FTIR analysis of the cathode exhaust gases. It was observed that the G-CNFs showed 5?times lower carbon corrosion compared to CB based catalyst when potential reached 1.5?V versus RHE in simulated start/stop cycling.
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| 21. |
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| 22. |
- Anttila, A, et al.
(författare)
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Excess lung cancer among workers exposed to lead
- 1995
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Ingår i: Scandinavian journal of work, environment & health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 21:6, s. 460-469
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Tidskriftsartikel (refereegranskat)
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| 26. |
- Kauppinen, Lauri, et al.
(författare)
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Investing in Time-to-Build Projects With Uncertain Revenues and Costs : A Real Options Approach
- 2018
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Ingår i: IEEE transactions on engineering management. - 0018-9391 .- 1558-0040. ; 65:3, s. 448-459
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Tidskriftsartikel (refereegranskat)abstract
- Lagging public-sector investment in infrastructure and the deregulation of many industries mean that the private sector has to make decisions under multiple sources of uncertainty. We analyze such investment decisions by accounting for both multiple sources of uncertainty and the time-to-build aspect. The latter feature arises in the energy and transportation sectors, because investors can decide the rate at which the project is completed. Furthermore, two explicit sources of uncertainty represent the discounted cash inflows and outflows of the completed project. We use a finite-difference scheme to solve numerically the option value and the optimal investment threshold. Somewhat counterintuitively, with a relatively long time to build, a reduction in the growth rate of the discounted operating cost may actually lower the investment threshold. This is contrary to the outcome when the stepwise aspect is ignored in a model with uncertain price and cost. Hence, research and development efforts to enhance emerging technologies may be more relevant for infrastructure projects with long lead times.
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| 29. |
- Mudimela, Prasantha R., et al.
(författare)
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Synthesis of carbon nanotubes and nanofibers on silica and cement matrix materials
- 2009
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Ingår i: Journal of Nanomaterials. - : Hindawi Limited. - 1687-4110 .- 1687-4129. ; 2009
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Tidskriftsartikel (refereegranskat)abstract
- In order to create strong composite materials, a good dispersion of carbon nanotubes (CNTs) and nanofibers (CNFs) in a matrix material must be obtained. We proposed a simple method of growing the desirable carbon nanomaterial directly on the surface of matrix particles. CNTs and CNFs were synthesised on the surface of model object, silica fume particles impregnated by iron salt, and directly on pristine cement particles, naturally containing iron oxide. Acetylene was successfully utilised as a carbon source in the temperature range from 550 to 750 °C. 5-10 walled CNTs with diameters of 10-15nm at 600 °C and 12-20nm at 750 °C were synthesised on silica particles. In case of cement particles, mainly CNFs with a diameter of around 30nm were grown. It was shown that high temperatures caused chemical and physical transformation of cement particles. © 2009 Prasantha R. Mudimela et al.
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| 32. |
- Rasmus, S., et al.
(författare)
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Estimation of winter leaf area index and sky view fraction for snow modelling in boreal coniferous forests : Consequences on snow mass and energy balance
- 2013
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 27:20, s. 2876-2891
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Tidskriftsartikel (refereegranskat)abstract
- Leaf area index (LAI) and canopy coverage are important parameters when modelling snow process in coniferous forests, controlling interception and transmitting radiation. Estimates of LAI and sky view factor show large variability depending on the estimation method used, and it is not clear how this is reflected in the calculated snow processes beneath the canopy. In this study, the winter LAI and sky view fraction were estimated using different optical and biomass-based approximations in several boreal coniferous forest stands in Fennoscandia with different stand density, age and site latitude. The biomass-based estimate of LAI derived from forest inventory data was close to the values derived from the optical measurements at most sites, suggesting that forest inventory data can be used as input to snow hydrological modelling. Heterogeneity of tree species and site fertility, as well as edge effects between different forest compartments, caused differences in the LAI estimates at some sites. A snow energy and mass balance model (SNOWPACK) was applied to detect how the differences in the estimated values of the winter LAI and sky view fraction were reflected in simulated snow processes. In the simulations, an increase in LAI and a decrease in sky view fraction changed the snow surface energy balance by decreasing shortwave radiation input and increasing longwave radiation input. Changes in LAI and sky view fraction affected directly snow accumulation through altered throughfall fraction and indirectly snowmelt through the changed surface energy balance. Changes in LAI and sky view fraction had a greater impact on mean incoming radiation beneath the canopy than on other energy fluxes. Snowmelt was affected more than snow accumulation. The effect of canopy parameters on evaporation loss from intercepted snow was comparable with the effect of variation in governing meteorological variables such as precipitation intensity and air temperature.
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| 36. |
- Valter-Lithander, Mikael, et al.
(författare)
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Microkinetic Model Fitted with a Genetic Algorithm to Experimental XPS Coverages at High Pressure-CO Hydrogenation on Rh(111)
- 2024
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Ingår i: Journal of Physical Chemistry C. - 1932-7447 .- 1932-7455. ; 128:28, s. 11598-11611
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Tidskriftsartikel (refereegranskat)abstract
- Comparisons to experiments are important when developing kinetic models based on density functional theory (DFT) calculations. The comparisons are, however, often challenging due to the assumed uncertainties in the energies from which the kinetic parameters are calculated. Here, we introduce a genetic algorithm to adjust the DFT-energies to better match experimental XPS data, using CO hydrogenation on Rh(111) as an example. The adjustments are made to adsorption energies, adsorbate-adsorbate interactions, XPS energies, and peak shapes. While these parameters improve the experimental agreement considerably, the required changes to the DFT energies are relatively large, which indicates the need for refined treatments of, for example, possible surface species and reaction steps, surface inhomogeneities, or higher levels of electronic structure calculations. We propose the genetic-algorithm based method as a general tool for assessment of computational models.
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