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Träfflista för sökning "WFRF:(Kaya Zeynep 1983) "

Sökning: WFRF:(Kaya Zeynep 1983)

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1.
  • Emilsson, Gustav, 1989, et al. (författare)
  • Gating Protein Transport in Solid State Nanopores by Single Molecule Recognition
  • 2018
  • Ingår i: ACS Central Science. - : American Chemical Society (ACS). - 2374-7951 .- 2374-7943. ; 4:8, s. 1007-1014
  • Tidskriftsartikel (refereegranskat)abstract
    • Control of molecular translocation through nanoscale apertures is of great interest for DNA sequencing, biomolecular filters, and new platforms for single molecule analysis. However, methods for controlling the permeability of nanopores are very limited. Here, we show how nanopores functionalized with poly(ethylene glycol) brushes, which fully prevent protein translocation, can be reversibly gated to an "open" state by binding of single IgG antibodies that disrupt the macromolecular barrier. On the basis of surface plasmon resonance data we propose a two-state model describing the antibody-polymer interaction kinetics. Reversibly (weakly) bound antibodies decrease the protein exclusion height while irreversibly (strongly) bound antibodies do not. Our results are further supported by fluorescence readout from pore arrays and high-speed atomic force microscopy on single pores. This type of dynamic barrier control on the nanoscale provides new possibilities for biomolecular separation and analysis.
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2.
  • Ferrand-Drake Del Castillo, Gustav, 1990, et al. (författare)
  • Generic high-capacity protein capture and release by pH control
  • 2020
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; 56:44, s. 5889-5892
  • Tidskriftsartikel (refereegranskat)abstract
    • Techniques for immobilization and release of proteins are of general interest but challenging to develop. Here we show a new method for high-capacity (several µg cm-2) immobilization of proteins in polyelectrolyte brushes by multivalent hydrogen bonds. Upon increasing pH, the proteins are fully released with preserved structure and activity.
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  • Resultat 1-2 av 2

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