| 1. |
|
|
| 2. |
|
|
| 3. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 5. |
|
|
| 6. |
- Thomas, HS, et al.
(författare)
-
- 2019
-
swepub:Mat__t
|
|
| 7. |
- Glasbey, JC, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 8. |
|
|
| 9. |
- Fullman, N., et al.
(författare)
-
Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016
- 2018
-
Ingår i: Lancet. - : Elsevier BV. - 0140-6736. ; 391:10136, s. 2236-2271
-
Tidskriftsartikel (refereegranskat)abstract
- Background A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016. Methods Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which death should not occur in the presence of effective care to approximate personal health-care access and quality by location and over time. To better isolate potential effects of personal health-care access and quality from underlying risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We transformed each cause to a scale of 0-100, with 0 as the first percentile (worst) observed between 1990 and 2016, and 100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values, providing an overall score of 0-100 of personal health-care access and quality by location over time. We then compared HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall development. As derived from the broader GBD study and other data sources, we examined relationships between national HAQ Index scores and potential correlates of performance, such as total health spending per capita. Findings In 2016, HAQ Index performance spanned from a high of 97.1 (95% UI 95.8-98.1) in Iceland, followed by 96.6 (94.9-97.9) in Norway and 96.1 (94.5-97.3) in the Netherlands, to values as low as 18.6 (13.1-24.4) in the Central African Republic, 19.0 (14.3-23.7) in Somalia, and 23.4 (20.2-26.8) in Guinea-Bissau. The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000. Striking subnational disparities emerged in personal health-care access and quality, with China and India having particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged from 91.5 (89.1-936) in Beijing to 48.0 (43.4-53.2) in Tibet (a 43.5-point difference), while India saw a 30.8-point disparity, from 64.8 (59.6-68.8) in Goa to 34.0 (30.3-38.1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4.8-point difference), whereas differences between subnational locations with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20.9-point to 17.0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17.2-point to 20.4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases. Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from 2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these relationships were quite heterogeneous, particularly among low-to-middle SDI countries. Interpretation GBD 2016 provides a more detailed understanding of past success and current challenges in improving personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle-SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health coverage upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view and subsequent provision of quality health care for all populations. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
|
|
| 10. |
- Lozano, Rafael, et al.
(författare)
-
Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
-
Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
|
|
| 11. |
|
|
| 12. |
- Khan, Hajra, et al.
(författare)
-
Defective Microstrip Structure Based Phase Shifter with Reduced Size for Phased Antenna Array Applications
- 2023
-
Ingår i: Proceedings of the 12th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications, IDAACS 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 297-301
-
Konferensbidrag (refereegranskat)abstract
- In this work, we propose a small-size and low-cost phase shifter based on defective microstrip structure (DMS) technique, with a modified reconfigurable unit cell (MRDMS) for WLAN applications at 5.2 GHz. The phase shifter is made up of an MRDMS unit, created by etching slots on a simple microstrip line with an outline of three bridges. To further increase the phase shift, a T-shaped slot is introduced in the central bridge and PIN diodes on the edges of the outer bridges are used. By switching the diodes on and off, the MRDMS unit cell is capable of operating in a variety of different modes to give a phase shift of 37.71° at 5.2 GHz. Additionally, MRDMS unit cells are cascaded for higher phase shift as required. Cascaded two- and four-cell phase shifters were designed and simulated in HFSS and a parametric study on various parameters was conducted to show the detailed operating properties of the proposed phase shifter. Compared to previously reported research, the present study shows that two cascaded phase shifters introduce 75.08° phase shifts and 151.75°, respectively. To the best of our knowledge, this is the maximum phase shift obtained by a phase shifter based on MRDMS.
|
|
| 13. |
- Khan, Owais, et al.
(författare)
-
Highly Directive Compact Multiband MIMO Antenna with Improved Gain for 5G Wireless Communication System
- 2023
-
Ingår i: International Conference on Electromagnetics in Advanced Applications and IEEE-APS Topical Conference on Antennas and Propagation in Wireless Communications, ICEAA-APWC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 62-67
-
Konferensbidrag (refereegranskat)abstract
- A novel wide dual-band, Multiple-Input Multiple-Output (MIMO) antenna design for the upcoming fifth generation (5G) wireless communication is presented in this work. The size of single element of the proposed MIMO configuration is 4×5 mm2having L-shaped slot at the top edge. Rogers TMM4 with thickness of 0.508 mm having relative permittivity of 4.5 is used as a substrate material. Resonating frequencies of single antenna element are 40.15, 67.80 and 91.23 GHz with a wide impedance bandwidth of 2.22 and 34.43 GHz, respectively. The return loss at resonating frequencies are - 29.25, -66.30. and -20.00 dB with a good gain of 5.51, 4.27 and 3.70 dBi, respectively. The overall size of proposed 1×2 MIMO antenna is 4×7 mm2with a separation of 3.6 mm in between two elements and 0.6 mm separation between the edges and elements. The resonating frequencies of the proposed MIMO antenna are 40.36 GHz with reasonable gain of 4.62 dBi, and 67.59 and 95.73 GHz with improved gain of 5.42 and 5.70 dBi, respectively. The simulated return loss below -10db at resonating frequencies are -21.92, -63.38 and -27.87 dB, respectively. Inter-port isolation of above 20 dB throughout the operating frequencies, is achieved without using any complex technique. Envelope Correlation Coefficient (ECC) and Diversity Gain (DG), are important MIMO antenna parameters are less than 0.001 and 10 dB respectively. The proposed design with a high radiation efficiency at resonating frequencies is a good candidate for the satellite and radar communication as the achieved operating range lies in the proposed Ka-band (26-40 GHz), V-band (40-75 GHz), E-band (60-90 GHz) and W-band (75-110 GHz).
|
|
| 14. |
- Naghavi, Mohsen, et al.
(författare)
-
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
-
Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
-
Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
|
|
| 15. |
- Sarfraz, Harris, et al.
(författare)
-
Design of a Miniaturized Dual Band Dielectric Resonator Antenna by Using Complimentary Split Ring Resonator
- 2023
-
Ingår i: Proceedings of the 12th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications, IDAACS 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 579-584
-
Konferensbidrag (refereegranskat)abstract
- We discuss a dual band Complementary Split Ring Resonator (CSRR) based Rectangular Dielectric Resonator Antenna (RDRA). The proposed design operates at 2.3 GHz and 2.6 GHz resonance frequencies respectively. The dual band operation is achieved by using CSRR unit cell in the ground of the proposed antenna along with the Dielectric Resonator (DR). The Dielectric Resonator Antenna (DRA) is excited using a simple microstrip feed line. The 2.3 GHz resonance frequency is obtained by excitation of the CSRR unit cell while the 2.6 GHz resonance frequency is achieved by the excitation of the DRA. The proposed design is simulated using Computer Simulation Technology (CST) software. The antenna has high gain of 6.86 dBi at 2.3 GHz and high gain of 6.4 dBi at 2.6 GHz respectively. Considering the overall performance, the proposed DRA has good characteristics for the WiMAX and LTE wireless applications.
|
|
| 16. |
- Sarfraz, Harris, et al.
(författare)
-
Next-Generation Multiband Wireless Systems : A Compact CSSR-Based MIMO Dielectric Resonator Antenna Approach
- 2024
-
Ingår i: IEEE Access. - : Institute of Electrical and Electronics Engineers (IEEE). - 2169-3536. ; 12, s. 4910-4924
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a compact penta-band Multiple Input Multiple Output (MIMO) Dielectric Resonator Antenna (DRA). The proposed MIMO DRA consists of two rectangular DRs incorporating complementary split ring resonators (CSRRs) and an inverted T-shaped slot. The MIMO DRA achieves low impedance matching through simple microstrip feedlines, which is further enhanced by integrating a microstrip line with the DRA itself. Remarkably, the introduction of CSRRs enables the design to resonate at five distinct frequency bands, namely 2.8-GHz, 4.4-GHz, 5.8-GHz, 6.4-GHz, and 6.9-GHz. The simulated properties of the MIMO DRA were validated through over-the-air measurements performed on a fabricated prototype. The proposed MIMO design demonstrates impedance bandwidths of 2.09 %, 2.43 %, 2.17 %, 2.55 %, and 4.91 % at the above respective resonance frequencies. The proposed design exhibits exceptional stability in radiation pattern, featuring a noteworthy peak gain of 6.08 dBi and an efficiency of 91.35 %. Notably, the incorporation of an inverted T-shaped slot effectively enhances isolation between the MIMO elements, achieving a maximum diversity gain of 10 dB and an envelope correlation coefficient of 0.005 over 20-dB isolation. A good agreement between the simulation and measured results is obtained, which underscores the suitability of the CSRR-based MIMO DRA for multiband wireless applications (blue tooth, radio astronomy, remote sensing, WIFI, satellite television and 6G), making it a very valuable contribution to the field.
|
|
| 17. |
|
|
| 18. |
- Abbafati, Cristiana, et al.
(författare)
-
- 2020
-
Tidskriftsartikel (refereegranskat)
|
|
| 19. |
- Al-Shishtawy, Ahmad, et al.
(författare)
-
Robust Fault-Tolerant Majority-Based Key-Value Store Supporting Multiple Consistency Levels
- 2011
-
Ingår i: 2011 IEEE 17TH INTERNATIONAL CONFERENCE ON PARALLEL AND DISTRIBUTED SYSTEMS (ICPADS). - 9780769545769 ; , s. 589-596
-
Konferensbidrag (refereegranskat)abstract
- The wide spread of Web 2.0 applications with rapidly growing amounts of user generated data, such as, wikis, social networks, and media sharing, have posed new challenges on the supporting infrastructure, in particular, on storage systems. In order to meet these challenges, Web 2.0 applications have to tradeoff between the high availability and the consistency of their data. Another important issue is the privacy of user generated data that might be caused by organizations that own and control datacenters where user data are stored. We propose a large-scale, robust and fault-tolerant key-value object store that is based on a peer-to-peer network owned and controlled by a community of users. To meet the demands of Web 2.0 applications, the store supports an API consisting of different read and write operations with various data consistency guarantees from which a wide range of web applications would be able to choose the operations according to their data consistency, performance and availability requirements. For evaluation, simulation has been carried out to test the system availability, scalability and fault-tolerance in a dynamic, Internet wide environment.
|
|
| 20. |
- Alegiry, Mohamed H., et al.
(författare)
-
Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants
- 2021
-
Ingår i: Frontiers in Psychiatry. - : Frontiers Media S.A.. - 1664-0640. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: This study was designed to investigate Saudis' attitudes toward mental distress and psychotropic medication, attribution of causes, expected side effects, and to analyze participants' expectations toward alternative or complementary medicine using aromatic and medicinal plants, through a survey.Method: The study included 674 participants (citizens and residents in Saudi Arabia) who were randomly contacted via email and social media and gave their consent to complete a questionnaire dealing with 39 items that can be clustered in six parts. Descriptive statistics and Chi-square for cross-tabulation were generated using SPSS.Results: Among the 664 participants, 73.4% believed that there are some positive and negative outcomes of psychotropic medication. Participants (72.0%) think that the most important reason leading to psychological disorders is mainly due to the loss of a relative or beloved person, and 73.9% considered psychic session as one of the possible treatments of psychological disorders. Surprisingly, only 18.8% of the participants agreed that medicinal and aromatic plants could be a possible treatment of the psychological disorder. Participants (82%) consider that physicians are the most trustful and preferred source of information about alternative and complementary medicine.
|
|
| 21. |
- Boetker, Johan P, et al.
(författare)
-
Anhydrate to hydrate solid-state transformations of carbamazepine and nitrofurantoin in biorelevant media studied in situ using time-resolved synchrotron X-ray diffraction.
- 2016
-
Ingår i: European Journal of Pharmaceutics and Biopharmaceutics. - : Elsevier BV. - 0939-6411. ; 100, s. 119-127
-
Tidskriftsartikel (refereegranskat)abstract
- Transformation of the solid-state form of a drug compound in the lumen of the gastrointestinal tract may alter the drug bioavailability and in extreme cases result in patient fatalities. The solution-mediated anhydrate-to-hydrate phase transformation was examined using an in vitro model with different biorelevant media, simulated fasted and fed state intestinal fluids containing bile salt and dioleoylphosphatidylcholine (DOPC) micelles, DOPC/sodium dodecyl sulfate (SDS) mixture, bile salt solution and water. Two anhydrate compounds (carbamazepine, CBZ and nitrofurantoin, NF) with different overall transformation time into hydrate form were used as model compounds. The transformations were monitored using direct structural information from time-resolved synchrotron X-ray diffraction. The kinetics of these transformations were estimated using multivariate data analysis (principal component analysis, PCA) and compared to those for nitrofurantoin (NF). The study showed that the solution-mediated phase transformation of CBZ anhydrate was remarkably faster in the DOPC/SDS medium compared to transformation in all the other aqueous dispersion media. The conversion time for CBZ anhydrate in water was shorter than for DOPC/SDS but still faster than the conversion seen in fed and fasted state micellar media. The conversion of CBZ anhydrate to hydrate was the slowest in the solution containing bile salt alone. In contrast, the solution-mediated phase transformations of NF did only show limited kinetic dependence on the dispersion media used, indicating the complexity of the nucleation process. Furthermore, when the CBZ and NF material was compacted into tablets the transformation times were remarkably slower. Results suggest that variations in the composition of the contents of the stomach/gut may affect the recrystallization kinetics, especially when investigating compounds with relatively fast overall transformation time, such as CBZ.
|
|
| 22. |
- Clulow, Andrew J., et al.
(författare)
-
Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid
- 2017
-
Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 121:48, s. 10869-10881
-
Tidskriftsartikel (refereegranskat)abstract
- The absorption of hydrophobic drugs and nutrients from the intestine is principally determined by the amount that can be dissolved by the endogenous fluids present in the gut. Human intestinal fluids (HIFs) comprise a complex mixture of bile salts, phospholipids, steroids and glycerides that vary in composition in the fed and fasted state and between subjects. A number of simulated intestinal fluid (SIF) compositions have been developed to mimic fasted and fed state intestinal conditions and allow the in vitro determination of drug solubility as a proxy for the maximum dissolved concentration it is possible to reach. In particular these solvents are used during the development of lipophilic and poorly water-soluble drugs but questions remain around the differences that may arise from the source and methods of preparation of these fluids. In this work, a range of SIFs were studied using small angle X-ray scattering (SAXS), cryogenic -transmission electron microscopy (cryo-TEM) and molecular dynamics (MD) simulations in order to analyze their structures. In-house prepared SIFs based on sodium taurodeoxycholate (NaTDC) and 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) formed oblate ellipsoidal micelles irrespective of lipid concentration and preparation conditions. In contrast, commercially available SIFs based on sodium taurocholate and lecithin formed prolate ellipsoidal micelles in the fed state and vesicles in the fasted state. These structural variations are the likely reason for the dramatic differences sometimes observed in the solubility enhancements for hydrophobic drugs, nutrients and digestion products when using different SIFs. However, the structural homogeneity of the NaTDC/DOPC micelles makes them ideal candidates for standardizing SIF formulations as the structures of the solubilizing nanoaggregates therein are not sensitive to the preparation method.
|
|
| 23. |
- Ebeed, Mohamed, et al.
(författare)
-
A Modified Artificial Hummingbird Algorithm for solving optimal power flow problem in power systems
- 2024
-
Ingår i: Energy Reports. - : ELSEVIER. - 2352-4847. ; 11, s. 982-1005
-
Tidskriftsartikel (refereegranskat)abstract
- Optimal power flow (OPF) problem solution is a crucial task for the operators and decision makers to assign the best setting of the system components to obtain the most economic, environmental, and technical suitable state. Artificial Hummingbird Algorithm is a recent optimization algorithm that has been applied to solving several optimization problems. In this paper, a Modified Artificial Hummingbird Algorithm (MAHA) is proposed for improving the performance of the orignal Artificial Hummingbird Algorithm as well as effectivelly solve the OPF problem. The proposed MAHA is based on improving the searching capability by boosting the exploitation using the bandwidth motion around the best solution, while the exploration process is improved using the Levy flight distribution motion and the fitness-distance balance selection. This modified version helps overcome issues such as stagnation, premature convergence, and a propensity for local optima when tackling complex, nonlinear, and non-convex optimization problems like OPF. In order to confirm the effectiveness of the proposed algorithm, a series of tests are conducted on 23 standard benchmark functions, including CEC2020. The resulting outcomes are then compared to those obtained using other algorithms such as fitness-distance balance selection-based stochastic fractal search (FDBSFS), antlion optimizer (ALO), whale optimization algorithm (WOA), sine-cosine algorithm (SCA), fitness-distance balance and learning based artificial bee colony (FDB-TLABC), and traditional artificial hummingbird algorithm (AHA).The proposed algorithm is evaluated by solving the OPF problem with multiple objective functions on the IEEE 30-bus system. These objectives include fuel cost, fuel cost with valve loading effects, power losses, emissions, and voltage profile. Additionally, the algorithm's effectiveness is further assessed by testing it on single objective functions using medium and large-scale IEEE 57 and 118-bus networks.The results obtained by the proposed MAHA demonstrate its power and superiority for solving the OPF problem as well as the standard benchmark functions , surpassing the performance of other reported techniques.
|
|
| 24. |
- Farooq, Muhammad, et al.
(författare)
-
Computing Expectiles Using k-Nearest Neighbours Approach
- 2021
-
Ingår i: Symmetry. - : MDPI AG. - 2073-8994. ; 13:4
-
Tidskriftsartikel (refereegranskat)abstract
- Expectiles have gained considerable attention in recent years due to wide applications in many areas. In this study, the k-nearest neighbours approach, together with the asymmetric least squares loss function, called ex-kNN, is proposed for computing expectiles. Firstly, the effect of various distance measures on ex-kNN in terms of test error and computational time is evaluated. It is found that Canberra, Lorentzian, and Soergel distance measures lead to minimum test error, whereas Euclidean, Canberra, and Average of (L1,L∞) lead to a low computational cost. Secondly, the performance of ex-kNN is compared with existing packages er-boost and ex-svm for computing expectiles that are based on nine real life examples. Depending on the nature of data, the ex-kNN showed two to 10 times better performance than er-boost and comparable performance with ex-svm regarding test error. Computationally, the ex-kNN is found two to five times faster than ex-svm and much faster than er-boost, particularly, in the case of high dimensional data.
|
|
| 25. |
- Johannesson, Jenny, et al.
(författare)
-
3D-printing of solid lipid tablets from emulsion gels
- 2021
-
Ingår i: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 597
-
Tidskriftsartikel (refereegranskat)abstract
- Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation development is continuously challenged by the large number of poorly water-soluble drugs, which require more advanced enabling formulations to improve oral bioavailability. In this work, we used semi-solid extrusion (SSE) printing of emulsion gels with three types of emulsified lipid-based formulations (LBFs) to produce solid lipid tablets incorporating the poorly water-soluble drug, fenofibrate. Tablets were successfully 3D-printed from emulsion gels using SSE at room temperature, making the methodology particularly useful for thermolabile compounds. The tablets were well-defined in mass and disintegrated rapidly (<15 min). Importantly, the oil droplet size reconstituted after dispersion of the tablets and subsequent lipid digestion was similar to traditional liquid LBFs. This work demonstrates the successful use of SSE for fabricating solid lipid tablets based on emulsion gels. The method is further promising for on demand production of personalized dosage forms, necessary for flexible dosage adjustment in e.g., pediatric patients, when poorly water-soluble compounds constitute the core of the therapy.
|
|
| 26. |
- Micah, Angela E., et al.
(författare)
-
Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
-
Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
-
Forskningsöversikt (refereegranskat)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
|
|
| 27. |
- Naeem, Samreen, et al.
(författare)
-
The Classification of Medicinal Plant Leaves Based on Multispectral and Texture Feature Using Machine Learning Approach
- 2021
-
Ingår i: Agronomy. - : MDPI AG. - 2073-4395. ; 11:2
-
Tidskriftsartikel (refereegranskat)abstract
- This study proposes the machine learning based classification of medical plant leaves. The total six varieties of medicinal plant leaves-based dataset are collected from the Department of Agriculture, The Islamia University of Bahawalpur, Pakistan. These plants are commonly named in English as (herbal) Tulsi, Peppermint, Bael, Lemon balm, Catnip, and Stevia and scientifically named in Latin as Ocimum sanctum, Mentha balsamea, Aegle marmelos, Melissa officinalis, Nepeta cataria, and Stevia rebaudiana, respectively. The multispectral and digital image dataset are collected via a computer vision laboratory setup. For the preprocessing step, we crop the region of the leaf and transform it into a gray level format. Secondly, we perform a seed intensity-based edge/line detection utilizing Sobel filter and draw five regions of observations. A total of 65 fused features dataset is extracted, being a combination of texture, run-length matrix, and multi-spectral features. For the feature optimization process, we employ a chi-square feature selection approach and select 14 optimized features. Finally, five machine learning classifiers named as a multi-layer perceptron, logit-boost, bagging, random forest, and simple logistic are deployed on an optimized medicinal plant leaves dataset, and it is observed that the multi-layer perceptron classifier shows a relatively promising accuracy of 99.01% as compared to the competition. The distinct classification accuracy by the multi-layer perceptron classifier on six medicinal plant leaves are 99.10% for Tulsi, 99.80% for Peppermint, 98.40% for Bael, 99.90% for Lemon balm, 98.40% for Catnip, and 99.20% for Stevia.
|
|
| 28. |
|
|
