| 1. |
- Mushtaq, Iram, et al.
(författare)
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N-acetyl cysteine, selenium, and ascorbic acid rescue diabetic cardiac hypertrophy via mitochondrial-associated redox regulators
- 2021
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Ingår i: Molecules. - : MDPI AG. - 1420-3049. ; 26:23
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Tidskriftsartikel (refereegranskat)abstract
- Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy. However, the underlying mechanisms involved in diabetes-induced cardiac hypertrophy are poorly understood. In the current study, we initially established a diabetic rat model by alloxan-administration, which was validated by peripheral glucose measurement. Diabetic rats displayed myocardial stiffness and fibrosis, changes in heart weight/body weight, heart weight/tibia length ratios, and enhanced size of myocytes, which altogether demonstrated the establishment of diabetic cardiac hypertrophy (DCH). Furthermore, we examined the expression of genes associated with mitochondrial signaling impairment. Our data show that the expression of PGC-1α, cytochrome c, MFN-2, and Drp-1 was deregulated. Mitochondrial-signaling impairment was further validated by redox-system dysregulation, which showed a significant increase in ROS and thiobarbituric acid reactive substances, both in serum and heart tissue, whereas the superoxide dismutase, catalase, and glutathione levels were decreased. Additionally, the expression levels of pro-apoptotic gene PUMA and stress marker GATA-4 genes were elevated, whereas ARC, PPARα, and Bcl-2 expression levels were decreased in the heart tissues of diabetic rats. Importantly, these alloxan-induced impairments were rescued by N-acetyl cysteine, ascorbic acid, and selenium treatment. This was demonstrated by the amelioration of myocardial stiffness, fibrosis, mitochondrial gene expression, lipid profile, restoration of myocyte size, reduced oxidative stress, and the activation of enzymes associated with antioxidant activities. Altogether, these data indicate that the improvement of mitochondrial dysfunction by protective agents such as N-acetyl cysteine, selenium, and ascorbic acid could rescue diabetes-associated cardiac complications, including DCH.
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| 2. |
- Ablikim, M., et al.
(författare)
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Study of eta(1475) and X(1835) in radiative J/psi decays to gamma phi
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:5
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Tidskriftsartikel (refereegranskat)abstract
- The decay J/psi -> gamma gamma phi is studied using a sample of 1.31 x 10(9) J/psi events collected with the BESIII detector. Two structures around 1475 MeV/c(2) and 1835 MeV/c(2) are observed in the gamma phi invariant mass spectrum for the first time. With a fit on the gamma phi invariant mass, which takes into account the interference between the two structures, and a simple analysis of the angular distribution, the structure around 1475 MeV/c(2) is found to favor an assignment as the eta(1475) and the mass and width for the structure around 1835 MeV/c(2) are consistent with the X(1835). The statistical significances of the two structures are 13.5 sigma and 6.3 sigma, respectively. The results indicate that both eta(1475) and X(1835) contain a sizeable s (s) over bar component.
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| 3. |
- Ahmad, Bashir, et al.
(författare)
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Effect of Salicylic Acid and Amino Acid on Pea Plant (Pisum sativum) Late Season, Growth and Production
- 2023
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Ingår i: Polish Journal of Environmental Studies. - : HARD Publishing Company. - 1230-1485 .- 2083-5906. ; 32:3, s. 1987-1994
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Tidskriftsartikel (refereegranskat)abstract
- Salicylic acid and amino acid are plant growth promoters. Therefore, the study entitled "Effect of salicylic acid and amino acid on late season peas growth and production" was conducted. The study has two factors: amino acid (Glycine) and salicylic acid each having four levels that were sprayed on peas. Analysis of data showed that maximum germination percentage (92.50 %), plant height (63.16 cm), primary branches plant-1 (2.80), leaves plant-1 (264.27), leaf chlorophyll content (57.25 SPAD), pods plant-1 (49.25), seeds pod-1 (10.41), pod length (11.74 cm) and yield ha-1 (1922.5 kg) having least days to flowering and pod formation (50.13 and 5.12 days) were noted in 225 mg L-1 amino acid. Salicylic acid levels showed that maximum germination percentage (95.83 %) height of plants (71.85 cm), leaves plant-1 (257.13), primary branches plant-1 (3.25), leaf chlorophyll content (55.81 SPAD), pods plant-1 (52.16), seeds pod-1 (10.91), pod length(11.05 cm) and yield ha-1 (1895.0 kg) having least days to pod formation and flowering (5.26 and 48.30 days) were noted in salicylic acid level of 300 mg L-1. The combined effect of 225 mg L-1 amino acid and 300 mg L-1salicylic acid levels positively improved primary branches plant-1 (3.93), pod plant-1 (66.33), pod length (13.77 cm), seeds pod-1 (12.44), leaf chlorophyll content (64.49 SPAD) and maximum yield ha-1 (1942.66 kg). It is concluded that for higher growth and yield pea cultivar Climax when cultivated late could be applied with 225 mg L-1 amino acid and 300 mg L-1 salicylic under Peshawar climatic conditions.
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| 4. |
- Frith, Amy L, et al.
(författare)
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Breast-feeding counselling mitigates the negative association of domestic violence on exclusive breast-feeding duration in rural Bangladesh. The MINIMat randomized trial.
- 2017
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Ingår i: Public Health Nutrition. - : Cambridge University Press. - 1368-9800 .- 1475-2727. ; 20:15, s. 2810-2818
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To determine if exclusive breast-feeding counselling modifies the association of experience of any lifetime or specific forms of domestic violence (DV) on duration of exclusive breast-feeding (EBF).DESIGN: In the MINIMat trial pregnant women were randomized to receive either usual health messages (UHM) or usual health messages with breast-feeding counselling (BFC) in eight visits. During pregnancy (30 weeks), lifetime experience of any or specific forms of DV was measured. Infant feeding practice information was collected from 0 to 6 months at 15 d intervals.SETTING: Matlab, Bangladesh.SUBJECTS: Pregnant and postpartum women (n 3186) and their infants.RESULTS: Among women in the UHM group, those who had experienced any lifetime DV exclusively breast-fed for a shorter duration than women who did not experience any lifetime DV (P=0·02). There was no difference, however, in duration of EBF among women in the BFC group based on their experience of any lifetime DV exposure (P=0·48). Using Cox regression analysis, there was an interaction of exposure to any lifetime DV, sexual violence and controlling behaviour, and counselling group with duration of breast-feeding at or before 6 months (P-interaction≤0·08). Among the UHM group, experience of any lifetime DV, sexual violence or controlling behaviour was associated with fewer days of EBF (P<0·05). In contrast, among the BFC group, experience of DV was not associated with duration of EBF.CONCLUSIONS: The experience of DV compromises EBF and the support of breast-feeding counselling programmes could assist this vulnerable group towards better infant feeding practices.
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| 5. |
- Hasan, M. J., et al.
(författare)
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Health-care-seeking behaviour in patients with hypertension : experience from a dedicated hypertension centre in Bangladesh
- 2024
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Ingår i: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 33:1
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The study aimed to assess health-seeking behaviour (HSB) and associated factors among hypertensive patients in Bangladesh.Methods: This cross-sectional study was conducted in the Hypertension & Research Centre, Rangpur, Bangladesh, between January 2022 and June 2022. A total of 497 hypertensive adults were recruited consecutively. A pre-tested structured questionnaire was deployed by the research team for data collection. Multivariable logistic regression analysis was used to explore the predictors of HSB.Results: The mean age of the hypertensive patients was 52 ± 11 (SD) years. Most of them were aged between 51 and 60 years (33%), female (55%), came from rural areas (57%), and belonged to middle socioeconomic class (68%). One-fourth of the patients (27%) had chosen informal healthcare providers for their first consultation. Fear of stroke (244, 45%), headache (170, 36%), and neck pain (81, 17%) were the three most common compelling causes of their visit to the hypertension centre. Age (aOR 0.78, 95% CI 0.68 − 0.89), male sex (aOR: 1.79, 95% CI 1.05 − 3.10), living in semi-urban (aOR 4.68, 95% CI 1.45 − 15.10) and rural area (aOR 1.68, 95% CI 1.01 − 2.80), farmers as occupation (aOR: 3.24, 95%CI: 1.31 − 8.06) and belonging to lower social economic class (aOR 4.24, 95% CI 1.68 − 10.69) were predictors of visiting informal providers of hypertensive patient. One-fourth of the hypertensive patients received consultation from informal healthcare providers.Conclusions: Raising awareness among patients and proper referral to specialised hypertension centres could promulgate the patients towards appropriate behaviour.
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| 6. |
- Khan, Fazlurrahman, et al.
(författare)
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Multiple potential strategies for the application of nisin and derivatives
- 2023
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Ingår i: Critical Reviews in Microbiology. - 1040-841X .- 1549-7828. ; 49:5, s. 628-657
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Forskningsöversikt (refereegranskat)abstract
- Nisin is a naturally occurring bioactive small peptide produced by Lactococcus lactis subsp. lactis and belongs to the Type A (I) lantibiotics. Due to its potent antimicrobial activity, it has been broadly employed to preserve various food materials as well as to combat a variety of microbial pathogens. The present review discusses the antimicrobial properties of nisin and different types of their derivatives employed to treat microbial pathogens with a detailed underlying mechanism of action. Several alternative strategies such as combination, conjugation, and nanoformulations have been discussed in order to address several issues such as rapid degradation, instability, and reduced activity due to the various environmental factors that arise in the applications of nisin. Furthermore, the evolutionary relationship of many nisin genes from different nisin-producing bacterial species has been investigated. A detailed description of the natural and bioengineered nisin variants, as well as the underlying action mechanisms, has also been provided. The chemistry used to apply nisin in conjugation with natural or synthetic compounds as a synergetic mode of antimicrobial action has also been thoroughly discussed. The current review will be useful in learning about recent and past research that has been performed on nisin and its derivatives as antimicrobial agents.
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| 7. |
- Khan, Fazlurrahman, et al.
(författare)
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Retrospective analysis of the key molecules involved in the green synthesis of nanoparticles
- 2022
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3372 .- 2040-3364. ; 14, s. 14824-14857
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Forskningsöversikt (refereegranskat)abstract
- Emerging nanotechnology leads to success in synthesizing and applying nanoparticles (NPs) using the green-chemistry approach. NPs synthesized using naturally derived materials are a potential alternative to chemical and physical methods because they are simple, cost-effective, eco-friendly, and lower the possibility of hazardous residues being released into the environment. Furthermore, NPs synthesized using the green synthesis approach are stable and biocompatible. However, because natural extracts contain a diverse spectrum of bioactive components, it is difficult to pinpoint the specific component involved in NP formation. Furthermore, the bioactive component contained in the extract changes based on a number of environmental factors; therefore, several studies began with the synthesis of NPs using a pure compound isolated from diverse natural sources. Hence, the present review paper makes an effort to retrospectively analyze the key compounds of the extracts which are responsible for the synthesis of the NPs. The analysis was carried out based on the physicochemical characteristics and biological activities of NPs synthesized from either the extract or the pure compounds. These pure-compound-based NPs were studied for their antimicrobial, antibiofilm, anti-inflammatory, anticancer, and antioxidant properties. In addition, the present review also describes progress in the study of pure compound-based numerous biological activities and the underlying mechanisms of action.
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| 8. |
- Nair, Srijith K., et al.
(författare)
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Towards secure cloud bursting, brokerage and aggregation
- 2010
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Ingår i: 2010 Eighth IEEE European Conference on Web Services. - : IEEE. - 9780769543109 ; , s. 189-196
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Konferensbidrag (refereegranskat)abstract
- The cloud based delivery model for IT resources is revolutionizing the IT industry. Despite the marketing hype around “the cloud”, the paradigm itself is in a critical transition state from the laboratories to mass market. Many technical and business aspects of cloud computing need to mature before it is widely adopted for corporate use. For example, the inability to seamlessly burst between internal cloud and external cloud platforms, termed cloud bursting, is a significant shortcoming of current cloud solutions. Furthermore, the absence of a capability that would allow to broker between multiple cloud providers or to aggregate them into a composite service inhibits the free and open competition that would help the market mature. This paper describes the concepts of cloud bursting and cloud brokerage and discusses the open management and security issues associated with the two models. It also presents a possible architectural framework capable of powering the brokerage based cloud services that is currently being developed in the scope of OPTIMIS, an EU FP7 project.
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