| 1. |
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| 2. |
- Accomando, E., et al.
(author)
-
Physics with e + e - linear colliders
- 1998
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In: Physics Reports. - 0370-1573. ; 299:1, s. 1-78
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Journal article (peer-reviewed)abstract
- The physics potential of e + e - linear colliders is summarized in this report. These machines are planned to operate in the first phase at a center-of-mass energy of 500 GeV, before being scaled up to about 1 TeV. In the second phase of the operation, a final energy of about 2 TeV is expected. The machines will allow us to perform precision tests of the heavy particles in the Standard Model, the top quark and the electroweak bosons. They are ideal facilities for exploring the properties of Higgs particles, in particular in the intermediate mass range. New vector bosons and novel matter particles in extended gauge theories can be searched for and studied thoroughly. The machines provide unique opportunities for the discovery of particles in supersymmetric extensions of the Standard Model, the spectrum of Higgs particles, the supersymmetric partners of the electroweak gauge and Higgs bosons, and of the matter particles. High precision analyses of their properties and interactions will allow for extrapolations to energy scales close to the Planck scale where gravity becomes significant. In alternative scenarios, i.e. compositeness models, novel matter particles and interactions can be discovered and investigated in the energy range above the existing colliders up to the TeV scale. Whatever scenario is realized in Nature, the discovery potential of e + e - linear colliders and the high precision with which the properties of particles and their interactions can be analyzed, define an exciting physics program complementary to hadron machines.
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| 3. |
- Adolph, C, et al.
(author)
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Measurement of the eta -> 3 pi(0) Dalitz plot distribution with the WASA detector at COSY
- 2009
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 677:1-2, s. 24-29
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Journal article (peer-reviewed)abstract
- In the first production run of the WASA experiment at COSY, the eta decay into three neutral pions was measured in proton-proton interactions at a proton beam kinetic energy of 1.4 GeV. The Dalitz plot of the three pious was Studied using 1.2 x 10(5) fully reconstructed events. and the quadratic slope parameter alpha was determined to be -0.027 +/- 0.008(stat) +/- 0.005(syst). The result is consistent with previous measurements and further corroborates the importance of pion-pion final state interactions. (C) 2009 Elsevier B.V. All rights reserved.
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| 4. |
- Akimov, D., et al.
(author)
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Physics with WASA and PROMICE
- 1994
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In: Physics with GeV-particle beams, Juelich 1994. ; , s. 519-530
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Conference paper (peer-reviewed)
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| 5. |
- Alfs, D., et al.
(author)
-
Drift chamber calibration and particle identification in the P-349 experiment
- 2019
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In: MESON 2018 - 15th International Workshop on Meson Physics. - : EDP Sciences.
-
Conference paper (peer-reviewed)abstract
- The goal of the P-349 experiment is to test whether 3.5 GeV/c antiprotons produced in high-energy proton-proton collisions are polarized in view of the preparation of a polarized antiproton beam. In this article, we present the details of the ongoing analysis focused on the drift chambers calibration and particle identification with DIRC.
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| 6. |
- Alfs, D., et al.
(author)
-
Drift Chamber Calibration And Track Reconstruction In The P349 Antiproton Polarization Experiment
- 2017
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In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 48:10, s. 1983-1988
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Journal article (peer-reviewed)abstract
- The goal of the P349 experiment is to test whether the antiproton production process can be itself a source of antiproton polarization. In this article, we present the motivation and details of the performed measurement. We report on the status of the analysis focusing mainly on calibration of the drift chambers and 3d track reconstruction.
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| 7. |
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| 8. |
- Grzonka, D., et al.
(author)
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Polarization analysis of <(p)over bar> produced in pA collisions
- 2019
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In: MESON 2018 - 15th International Workshop on Meson Physics. - : EDP Sciences.
-
Conference paper (peer-reviewed)abstract
- A quite simple procedure for the generation of a polarized antiproton beam could be worked out if antiprotons are produced with some polarization. In order to investigate this possibility measurements of the polarization of produced antiprotons have been started at a CERN/PS test beam. The polarization will be determined from the asymmetry of the elastic antiproton scattering at a liquid hydrogen target in the CNI region for which the analyzing power is well known. The data are under analysis and an additional measurement is done in 2018. Details on the experiment and the ongoing data analysis will be given.
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| 9. |
- Grzonka, D., et al.
(author)
-
Search for polarized antiproton production
- 2019
-
In: Hyperfine Interactions. - : Springer Nature. - 0304-3843 .- 1572-9540. ; 240
-
Journal article (peer-reviewed)abstract
- The production of antiprotons is studied in view of possible polarization effects as basis for a polarized antiproton beam. If antiprotons are produced with some polarization, a quite simple procedure for the generation of a polarized antiproton beam could be worked out. The experiments are performed at the CERN PS test beam T11 where secondary particles with momenta around 3.5 GeV/c are selected. The polarization analysis is performed by measuring the asymmetry of the elastic (p) over barp-scattering in the Coulomb-nuclear interference region. The detection system includes Cherenkov and tracking detectors for the particle identification and the 3d track reconstruction. Details on the detection system and the status of the analysis are given.
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| 10. |
- Moskal, P., et al.
(author)
-
Near-threshold production of the eta meson via the quasifree pn -> pn eta reaction
- 2009
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 79:1, s. 015208-
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Journal article (peer-reviewed)abstract
- Total cross sections for the quasifree pn -> pn eta reaction in the range from the kinematical threshold up to 20 MeV excess energy have been determined. At threshold they exceed corresponding cross sections for the pn -> pn eta reaction by a factor of about 3 in contrast to the factor of 6 established for higher excess energies. To large extent, the observed decrease of the ratio s(pn -> pn eta)/s=sigma(pn -> pn eta) toward threshold may be assigned to the different energy dependence of the proton-proton and proton-neutron final-state interactions. The experiment was conducted using a proton beam of the cooler synchrotron COSY and a cluster jet deuteron target. The proton- neutron reactions were tagged by the spectator proton whose momentum was measured for each event. Protons and neutron outgoing from the pn -> pn eta reaction have been registered by means of the COSY-11 facility, an apparatus dedicated for threshold meson production.
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| 11. |
- Paschke, K. D., et al.
(author)
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Experimental determination of the complete spin structure for (p)over-barp ->(Lambda)over-bar Lambda at p((p)over-bar)=1.637 GeV/c
- 2006
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 74:1, s. 015206-
-
Journal article (peer-reviewed)abstract
- The reaction (p) over barp -> (Lambda) over bar Lambda -> (p) over bar pi(+)p pi(-) has been measured with high statistics at a beam momentum of p((p) over bar)=1.637GeV/c. The use of a transversely polarized frozen-spin target combined with the self-analyzing property of Lambda/(Lambda) over bar decay allows access to unprecedented information on the spin structure of the interaction. The most general spin-scattering matrix can be written in terms of 11 real parameters for each bin of scattering angle; each of these parameters is determined with reasonable precision. From these results, all conceivable spin correlations are determined with inherent self-consistency. Good agreement is found with the few previously existing measurements of spin observables in (p) over barp ->(Lambda) over bar Lambda near this energy. Existing theoretical models do not give good predictions for those spin observables that had not been previously measured.
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| 12. |
- Alfs, D., et al.
(author)
-
Status of the analysis for the search of polarization in the antiproton production process
- 2016
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In: MESON 2016 - 14th International Workshop On Meson Production, Properties And Interaction. - : EDP Sciences.
-
Conference paper (peer-reviewed)abstract
- The P-349 experiment aims to test whether for antiprotons the production process itself can be a source of polarization in view of the preparation of a polarized antiproton beam. In this article we present the details of performed measurements and report on the status of the ongoing analysis.
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| 13. |
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| 14. |
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| 15. |
- Calén, H., et al.
(author)
-
Detector setup for a storage ring with an internal target
- 1996
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 379:1, s. 57-75
-
Journal article (peer-reviewed)abstract
- A detector setup for the cooler storage ring CELSIUS is described. The setup detects particles produced in interactions between the internal beam and a cluster-jet target. Particles emitted in the forward direction are measured by means of arrays of plastic scintillators and proportional counters. Particles, particularly photons, emitted more isotropically are measured by means of two calorimeters containing CsI(Na) crystals. The performance of the setup is given for neutral meson production in proton-proton and proton-deuteron interactions in the energy range 290-1360 MeV.
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| 16. |
- Clement, H., et al.
(author)
-
Search for narrow NN-decoupled resonances in the πNN-system : An overview
- 1996
-
In: Progress in Particle and Nuclear Physics. - : Elsevier BV. - 0146-6410 .- 1873-2224. ; 36, s. 369-378
-
Journal article (peer-reviewed)abstract
- The status of the search for NN-decoupled resonances in the πNN-system is reviewed. After a short survey on the history of dibaryon searches reactions suitable for detecting such resonances are discussed. Special emphasis is put on the pionic double charge exchange, where recently evidence for the signature of a narrow πNN resonance, called d′, with I(J P) = even (0 -) and m = 2.06 GeV has been quoted. Further reactions discussed in this context are the pion photoproduction on the deuteron and the two-pion production in nucleon-nucleon collisions.
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| 17. |
- Tinker, N. A., et al.
(author)
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New DArT markers for oat provide enhanced map coverage and global germplasm characterization
- 2009
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In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 10:39
-
Journal article (peer-reviewed)abstract
- Background: Genomic discovery in oat and its application to oat improvement have been hindered by a lack of genetic markers common to different genetic maps, and by the difficulty of conducting whole-genome analysis using high-throughput markers. This study was intended to develop, characterize, and apply a large set of oat genetic markers based on Diversity Array Technology (DArT). Results: Approximately 19,000 genomic clones were isolated from complexity-reduced genomic representations of pooled DNA samples from 60 oat varieties of global origin. These were screened on three discovery arrays, with more than 2000 polymorphic markers being identified for use in this study, and approximately 2700 potentially polymorphic markers being identified for use in future studies. DNA sequence was obtained for 2573 clones and assembled into a non-redundant set of 1770 contigs and singletons. Of these, 705 showed highly significant (Expectation < 10E-10) BLAST similarity to gene sequences in public databases. Based on marker scores in 80 recombinant inbred lines, 1010 new DArT markers were used to saturate and improve the 'Kanota' x 'Ogle' genetic map. DArT markers provided map coverage approximately equivalent to existing markers. After binning markers from similar clones, as well as those with 99% scoring similarity, a set of 1295 non-redundant markers was used to analyze genetic diversity in 182 accessions of cultivated oat of worldwide origin. Results of this analysis confirmed that major clusters of oat diversity are related to spring vs. winter type, and to the presence of major breeding programs within geographical regions. Secondary clusters revealed groups that were often related to known pedigree structure. Conclusion: These markers will provide a solid basis for future efforts in genomic discovery, comparative mapping, and the generation of an oat consensus map. They will also provide new opportunities for directed breeding of superior oat varieties, and guidance in the maintenance of oat genetic diversity.
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| 18. |
- Albers, Roland, et al.
(author)
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Magnetospheric Venus Space Explorers (MVSE) mission : a proposal for understanding the dynamics of induced magnetospheres
- 2024
-
In: Acta Astronautica. - : Elsevier. - 0094-5765 .- 1879-2030. ; 221, s. 194-205
-
Journal article (peer-reviewed)abstract
- Induced magnetospheres form around planetary bodies with atmospheres through the interaction of the solar wind with their ionosphere. Induced magnetospheres are highly dependent on the solar wind conditions and have only been studied with single spacecraft missions in the past. Without simultaneous measurements of solar wind variations and phenomena in the magnetosphere, establishing a link between both can only be done indirectly, using statistics over a large set of measurements. This gap in knowledge could be addressed by a multi-spacecraft plasma mission, optimized for studying global spatial and temporal variations in the magnetospheric system around Venus, which hosts the most prominent example of an induced magnetosphere in our solar system. The MVSE mission comprises four satellites, of which three are identical scientific spacecraft, carrying the same suite of instruments probing different regions of the induced magnetosphere and the solar wind simultaneously. The fourth spacecraft is the transfer vehicle which acts as a relay satellite for communications at Venus. In this way, changes in the solar wind conditions and extreme solar events can be observed, and their effects can be quantified as they propagate through the Venusian induced magnetosphere. Additionally, energy transfer in the Venusian induced magnetosphere can be investigated. The scientific payload includes instrumentation to measure the magnetic field, electric field, and ion–electron velocity distributions. This study presents the scientific motivation for the mission as well as requirements and the resulting mission design. Concretely, a mission timeline along with a complete spacecraft design, including mass, power, communication, propulsion and thermal budgets are given. This mission was initially conceived at the Alpbach Summer School 2022 and refined during a week-long study at ESA's Concurrent Design Facility in Redu, Belgium.
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| 19. |
- Bargholtz, Chr., et al.
(author)
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The WASA detector facility at CELSIUS
- 2008
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 594:3, s. 339-350
-
Journal article (peer-reviewed)abstract
- The WASA 4 pi multidetector system, aimed at investigating light meson production in light ion collisions and eta meson rare decays at the CELSIUS storage ring in Uppsala is presented. A unique feature of the system is the use of hydrogen pellets as internal targets for the first time. A detailed description of the design, together with the anticipated and achieved performance parameters are given. (C) 2008 Elsevier B.V. All rights reserved.
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| 20. |
- Barnes, PD, et al.
(author)
-
Antihyperon-hyperon production in the threshold region at LEAR
- 1996
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In: PHYSICS OF ATOMIC NUCLEI. - : AMER INST PHYSICS. ; , s. 1460-1466
-
Conference paper (peer-reviewed)abstract
- The experiment PSI185 studies the antihyperon-hyperon production in antiproton-proton annihilation at LEAR/CERN up to 2 GeV/c. This is achieved by investigation of the channels (p) over bar p --> <(Lambda)over bar>Lambda, <(Lambda)over bar>Sigma(0) + c.c.
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| 21. |
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| 22. |
- Bertolotto, L, et al.
(author)
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phi phi associated production in (p)over-bar-p annihilation from JETSET
- 1996
-
In: PHYSICS OF ATOMIC NUCLEI. - : AMER INST PHYSICS. ; , s. 1444-1449
-
Conference paper (peer-reviewed)abstract
- The JETSET (PS202) experiment at CERN has studied the reaction (p) over bar p --> 4K(+/-) in the invariant-mass range from 2.15 to 2.43 GeV/c(2). The phi phi, phi K+K-, and 4K(+/-) cross sections have been measured, and a spin-parity analysis of the phi p
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| 23. |
- BERTOLOTTO, L, et al.
(author)
-
RESULTS FROM (P)OVER-BAR-P-]PHI-PHI
- 1994
-
In: NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA A-NUCLEI PARTICLES AND FIELDS. - : EDITRICE COMPOSITORI BOLOGNA. ; , s. 2329-2337
-
Conference paper (peer-reviewed)abstract
- The reaction ($) over bar pp --> phi phi is investigated in the JETSET (PS202) experiment using an internal target in LEAR. Data have been analysed at a variety of beam momenta from 1.2 GeV/c to 2.0 GeV/c, corresponding to centre-of-mass energies between
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| 24. |
- Bilger, R, et al.
(author)
-
Search for a narrow pi NN-resonance in pp->pp pi(+)pi(-)
- 1996
-
In: PROGRESS IN PARTICLE AND NUCLEAR PHYSICS. - : PERGAMON PRESS LTD. ; , s. 379-381
-
Conference paper (peer-reviewed)abstract
- We report on the current status of the search for the pi NN-resonance d' with I(J(P)) = 0(0(-)) and M = 2.06 GeV in the 2 pi production in pp collisions.
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| 25. |
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| 26. |
- Bondar, A., et al.
(author)
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The pp → ppπ0 reaction near the kinematical threshold
- 1995
-
In: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 356:1, s. 8-12
-
Journal article (peer-reviewed)abstract
- The reaction pp → ppπ0 has been measured using electron-cooled protons incident on an internal gas-jet target at seven different incident beam energies, from 280.7 MeV (1 MeV above the reaction threshold) up to 310.2 MeV. The pions were measured by their decay photons. In the overlapping energy region, the measured total cross sections agree with those measured in a recent Indiana experiment. The angular distributions are consistent with a 3P0 → 1S0S0 transition in the full energy range studied. The kinematical distributions are well described when taking into account the final state and the Coulomb interactions.
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| 27. |
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| 28. |
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| 29. |
- Calén, H, et al.
(author)
-
Detector setup for a storage ring with an internal target
- 1996
-
In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 379:1, s. 57-75
-
Journal article (peer-reviewed)abstract
- A detector setup for the cooler storage ring CELSIUS is described. The setup detects particles produced in interactions between the internal beam and a cluster-jet target. Particles emitted in the forward direction are measured by means of arrays of plast
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| 30. |
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| 31. |
- Colas, Kilian, et al.
(author)
-
i-Pr2-NMgCl·LiCl Enables the Synthesis of Ketones by Direct Addition of Grignard Reagents to Carboxylate Anions
- 2019
-
In: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 21:19, s. 7908-7913
-
Journal article (peer-reviewed)abstract
- The direct preparation of ketones from carboxylate anions is greatly limited by the required use of organolithium reagents or activated acyl sources that need to be independently prepared. Herein, a specific magnesium amide additive is used to activate and control the addition of more tolerant Grignard reagents to carboxylate anions. This strategy enables the modular synthesis of ketones from CO2 and the preparation of isotopically labeled pharmaceutical building blocks in a single operation.
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| 32. |
- Comadran, J., et al.
(author)
-
Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and environmental adaptation in cultivated barley
- 2012
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:12, s. 1388-1392
-
Journal article (peer-reviewed)abstract
- As early farming spread from the Fertile Crescent in the Near East around 10,000 years before the present(1), domesticated crops encountered considerable ecological and environmental change. Spring-sown crops that flowered without the need for an extended period of cold to promote flowering and day length insensitive crops able to exploit the longer, cooler days of higher latitudes emerged and became established. To investigate the genetic consequences of adaptation to these new environments, we identified signatures of divergent selection in the highly differentiated modern-day spring and winter barleys. In one genetically divergent region, we identify a natural variant of the barley homolog of Antirrhinum CENTRORADIALIS(2) (HvCEN) as a contributor to successful environmental adaptation. The distribution of HvCEN alleles in a large collection of wild and landrace accessions indicates that this involved selection and enrichment of preexisting genetic variants rather than the acquisition of mutations after domestication.
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| 33. |
- Fafara, A, et al.
(author)
-
Dielectric spectroscopy and electrooptic studies of new MHPOBC analogues
- 1998
-
In: FERROELECTRICS. - : GORDON BREACH SCI PUBL LTD. - 0015-0193. ; 212:1-4, s. 79-
-
Journal article (other academic/artistic)abstract
- Two new MHPOBC analogues, exhibiting ferroelectric and antiferroelectric phases, have been studied by means of frequency domain dielectric spectroscopy, time domain spectroscopy and electrooptic methods. Temperature dependencies of the tilt angle and spon
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| 34. |
- Grzonka, D., et al.
(author)
-
Search for Polarization Effects in the Antiproton Production Process
- 2015
-
In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 46:1, s. 191-201
-
Journal article (peer-reviewed)abstract
- For the production of a polarized antiproton beam, various methods have been suggested including the possibility that antiprotons may be produced polarized which will be checked experimentally. The polarization of antiprotons produced under typical conditions for antiproton beam preparation will be measured at the CERN/PS. If the production process creates some polarization, a polarized antiproton beam could be prepared by a rather simple modification of the antiproton beam facility. The detection setup and the expected experimental conditions are described.
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| 35. |
- Keilwagen, J., et al.
(author)
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Separating the wheat from the chaff - a strategy to utilize plant genetic resources from ex situ genebanks
- 2014
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 4
-
Journal article (peer-reviewed)abstract
- The need for higher yielding and better-adapted crop plants for feeding the world's rapidly growing population has raised the question of how to systematically utilize large genebank collections with their wide range of largely untouched genetic diversity. Phenotypic data that has been recorded for decades during various rounds of seed multiplication provides a rich source of information. Their usefulness has remained limited though, due to various biases induced by conservation management over time or changing environmental conditions. Here, we present a powerful procedure that permits an unbiased trait-based selection of plant samples based on such phenotypic data. Applying this technique to the wheat collection of one of the largest genebanks worldwide, we identified groups of plant samples displaying contrasting phenotypes for selected traits. As a proof of concept for our discovery pipeline, we resequenced the entire major but conserved flowering time locus Ppd-D1 in just a few such selected wheat samples - and nearly doubled the number of hitherto known alleles.
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| 36. |
- Kraupner, Nadine, et al.
(author)
-
Evidence for selection of multi-resistant E. coli by hospital effluent.
- 2021
-
In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 150, s. 106436-
-
Journal article (peer-reviewed)abstract
- There is a risk that residues of antibiotics and other antimicrobials in hospital and municipal wastewaters could select for resistant bacteria. Still, direct experimental evidence for selection is lacking. Here, we investigated if effluent from a large Swedish hospital, as well as influent and effluent from the connected municipal wastewater treatment plant (WWTP) select for antibiotic resistant Escherichia coli in three controlled experimental setups. Exposure of sterile-filtered hospital effluent to a planktonic mix of 149 different E. coli wastewater isolates showed a strong selection of multi-resistant strains. Accordingly, exposure to a complex wastewater community selected for strains resistant to several antibiotic classes. Exposing individual strains with variable resistance patterns revealed a rapid bactericidal effect of hospital effluent on susceptible, but not multi-resistant E. coli. No selection was observed after exposure to WWTP effluent, while exposure to WWTP influent indicated a small selective effect for ceftazidime and cefadroxil resistant strains, and only in the E. coli mix assay. An analysis of commonly used antibiotics and non-antibiotic pharmaceuticals in combination with growth and resistance pattern of individual E. coli isolates suggested a possible contribution of ciprofloxacin and β-lactams to the selection by hospital effluent. However, more research is needed to clarify the contribution from different selective agents. While this study does not indicate selection by the studied WWTP effluent, there is some indications of selective effects by municipal influent on β-lactam-resistant strains. Such effects may be more pronounced in countries with higher antibiotic use than Sweden. Despite the limited antibiotic use in Sweden, the hospital effluent strongly and consistently selected for multi-resistance, indicating widespread risks. Hence, there is an urgent need for further evaluation of risks for resistance selection in hospital sewers, as well as for strategies to remove selective agents and resistant bacteria.
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| 37. |
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| 38. |
- Priebe, S, et al.
(author)
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Reinstitutionalisation in mental-health care: comparison of data on service provision from six European countries
- 2005
-
In: BMJ: British Medical Journal. - 1756-1833. ; 330:7483, s. 123-126
-
Journal article (peer-reviewed)abstract
- Objective To establish whether reinstitutionalisation is occurring in mental health care mid, if so, with What variations between Western European countries. Design Comparison of data on changes in service provision. Setting Six European countries with different traditions of mental health care that have all experienced deinstitutionalisation since the 1970s - England, Germany, Italy, the Netherlands, Spain, mid Sweden. Outcome measures Changes in die number of forensic hospital beds, involuntary hospital admissions, places in supported housing, general psychiatric hospital beds, and general prison population between 1990-1 mid 2002-3. Results Forensic beds and places in supported housing have increased in all countries, whereas changes in it involuntary hospital admissions have been inconsistent. The number of psychiatric hospital beds h is been reduced in five countries, but only in two countries does this reduction outweigh the number of additional places in forensic institutions and supported housing The general prison population has substantially increased in all countries. Conclusions Reinstitutionalisation is taking place in European countries with different, traditions of health care, although with significant variation between the six countries studied. The precise reasons for the phenomenon remain unclear. General attitudes to risk containment in a society, as indicated by the size of the prison population, may be more Important than changing morbidity and new methods of mental healthcare delivery.
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| 39. |
- Tricoci, Pierluigi, et al.
(author)
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Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
- 2012
-
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 366:1, s. 20-33
-
Journal article (peer-reviewed)abstract
- BACKGROUND:Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation.METHODS:In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularization.RESULTS:Follow-up in the trial was terminated early after a safety review. After a median follow-up of 502 days (interquartile range, 349 to 667), the primary end point occurred in 1031 of 6473 patients receiving vorapaxar versus 1102 of 6471 patients receiving placebo (Kaplan-Meier 2-year rate, 18.5% vs. 19.9%; hazard ratio, 0.92; 95% confidence interval [CI], 0.85 to 1.01; P=0.07). A composite of death from cardiovascular causes, myocardial infarction, or stroke occurred in 822 patients in the vorapaxar group versus 910 in the placebo group (14.7% and 16.4%, respectively; hazard ratio, 0.89; 95% CI, 0.81 to 0.98; P=0.02). Rates of moderate and severe bleeding were 7.2% in the vorapaxar group and 5.2% in the placebo group (hazard ratio, 1.35; 95% CI, 1.16 to 1.58; P<0.001). Intracranial hemorrhage rates were 1.1% and 0.2%, respectively (hazard ratio, 3.39; 95% CI, 1.78 to 6.45; P<0.001). Rates of nonhemorrhagic adverse events were similar in the two groups.CONCLUSIONS:In patients with acute coronary syndromes, the addition of vorapaxar to standard therapy did not significantly reduce the primary composite end point but significantly increased the risk of major bleeding, including intracranial hemorrhage. (Funded by Merck; TRACER ClinicalTrials.gov number, NCT00527943.).
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