| 1. |
- Glasbey, JC, et al.
(author)
-
- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
- Echelmeier, A., et al.
(author)
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Segmented flow generator for serial crystallography at the European X-ray free electron laser
- 2020
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In: Nature Communications. - : Nature Research. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal suspension into the path of the XFEL, wasting a vast amount of sample due to the pulsed nature of all current XFEL sources. The European XFEL (EuXFEL) delivers femtosecond (fs) X-ray pulses in trains spaced 100 ms apart whereas pulses within trains are currently separated by 889 ns. Therefore, continuous sample delivery via fast jets wastes >99% of sample. Here, we introduce a microfluidic device delivering crystal laden droplets segmented with an immiscible oil reducing sample waste and demonstrate droplet injection at the EuXFEL compatible with high pressure liquid delivery of an SFX experiment. While achieving ~60% reduction in sample waste, we determine the structure of the enzyme 3-deoxy-D-manno-octulosonate-8-phosphate synthase from microcrystals delivered in droplets revealing distinct structural features not previously reported.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Duke, T, et al.
(author)
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World Health Organization and knowledge translation in maternal, newborn, child and adolescent health and nutrition
- 2022
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In: Archives of disease in childhood. - : BMJ. - 1468-2044 .- 0003-9888. ; 107:7, s. 644-649
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Journal article (peer-reviewed)abstract
- The World Health Organization (WHO) has a mandate to promote maternal and child health and welfare through support to governments in the form of technical assistance, standards, epidemiological and statistical services, promoting teaching and training of healthcare professionals and providing direct aid in emergencies. The Strategic and Technical Advisory Group of Experts (STAGE) for maternal, newborn, child and adolescent health and nutrition (MNCAHN) was established in 2020 to advise the Director-General of WHO on issues relating to MNCAHN. STAGE comprises individuals from multiple low-income and middle-income and high-income countries, has representatives from many professional disciplines and with diverse experience and interests.Progress in MNCAHN requires improvements in quality of services, equity of access and the evolution of services as technical guidance, community needs and epidemiology changes. Knowledge translation of WHO guidance and other guidelines is an important part of this. Countries need effective and responsive structures for adaptation and implementation of evidence-based interventions, strategies to improve guideline uptake, education and training and mechanisms to monitor quality and safety. This paper summarises STAGE’s recommendations on how to improve knowledge translation in MNCAHN. They include support for national and regional technical advisory groups and subnational committees that coordinate maternal and child health; support for national plans for MNCAHN and their implementation and monitoring; the production of a small number of consolidated MNCAHN guidelines to promote integrated and holistic care; education and quality improvement strategies to support guidelines uptake; monitoring of gaps in knowledge translation and operational research in MNCAHN.
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| 8. |
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| 9. |
- Tiegs, Scott D., et al.
(author)
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Global patterns and drivers of ecosystem functioning in rivers and riparian zones
- 2019
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In: Science Advances. - Washington : American Association of Advancement in Science. - 2375-2548. ; 5:1
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Journal article (peer-reviewed)abstract
- River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented "next-generation biomonitoring" by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
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| 10. |
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| 11. |
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| 12. |
- Cesano, A, et al.
(author)
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Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges
- 2020
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In: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:2
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Journal article (peer-reviewed)abstract
- The development of strongly predictive validated biomarkers is essential for the field of immuno-oncology (IO) to advance. The highly complex, multifactorial data sets required to develop these biomarkers necessitate effective, responsible data-sharing efforts in order to maximize the scientific knowledge and utility gained from their collection. While the sharing of clinical- and safety-related trial data has already been streamlined to a large extent, the sharing of biomarker-aimed clinical trial derived data and data sets has been met with a number of hurdles that have impaired the progression of biomarkers from hypothesis to clinical use. These hurdles include technical challenges associated with the infrastructure, technology, workforce, and sustainability required for clinical biomarker data sharing. To provide guidance and assist in the navigation of these challenges, the Society for Immunotherapy of Cancer (SITC) Biomarkers Committee convened to outline the challenges that researchers currently face, both at the conceptual level (Volume I) and at the technical level (Volume II). The committee also suggests possible solutions to these problems in the form of professional standards and harmonized requirements for data sharing, assisting in continued progress toward effective, clinically relevant biomarkers in the IO setting.
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| 13. |
- Costello, David M., et al.
(author)
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Global patterns and controls of nutrient immobilization on decomposing cellulose in riverine ecosystems
- 2022
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In: Global Biogeochemical Cycles. - : John Wiley & Sons. - 0886-6236 .- 1944-9224. ; 36:3
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Journal article (peer-reviewed)abstract
- Microbes play a critical role in plant litter decomposition and influence the fate of carbon in rivers and riparian zones. When decomposing low-nutrient plant litter, microbes acquire nitrogen (N) and phosphorus (P) from the environment (i.e., nutrient immobilization), and this process is potentially sensitive to nutrient loading and changing climate. Nonetheless, environmental controls on immobilization are poorly understood because rates are also influenced by plant litter chemistry, which is coupled to the same environmental factors. Here we used a standardized, low-nutrient organic matter substrate (cotton strips) to quantify nutrient immobilization at 100 paired stream and riparian sites representing 11 biomes worldwide. Immobilization rates varied by three orders of magnitude, were greater in rivers than riparian zones, and were strongly correlated to decomposition rates. In rivers, P immobilization rates were controlled by surface water phosphate concentrations, but N immobilization rates were not related to inorganic N. The N:P of immobilized nutrients was tightly constrained to a molar ratio of 10:1 despite wide variation in surface water N:P. Immobilization rates were temperature-dependent in riparian zones but not related to temperature in rivers. However, in rivers nutrient supply ultimately controlled whether microbes could achieve the maximum expected decomposition rate at a given temperature. Collectively, we demonstrated that exogenous nutrient supply and immobilization are critical control points for decomposition of organic matter.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Maisel, Alan, et al.
(author)
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State of the art : Using natriuretic peptide levels in clinical practice
- 2008
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In: European Journal of Heart Failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 10:9, s. 824-839
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Journal article (peer-reviewed)abstract
- Natriuretic peptide (NP) levels (B-type natriuretic peptide (BNP) and N-terminal proBNP) are now widely used in clinical practice and cardiovascular research throughout the world and have been incorporated into most national and international cardiovascular guidelines for heart failure. The role of NP levels in state-of-the-art clinical practice is evolving rapidly. This paper reviews and highlights ten key messages to clinicians:•NP levels are quantitative plasma biomarkers of heart failure (HF).•NP levels are accurate in the diagnosis of HF.•NP levels may help risk stratify emergency department (ED) patients with regard to the need for hospital admission or direct ED discharge.•NP levels help improve patient management and reduce total treatment costs in patients with acute dyspnoea.•NP levels at the time of admission are powerful predictors of outcome in predicting death and re-hospitalisation in HF patients.•NP levels at discharge aid in risk stratification of the HF patient.•NP-guided therapy may improve morbidity and/or mortality in chronic HF.•The combination of NP levels together with symptoms, signs and weight gain assists in the assessment of clinical decompensation in HF.•NP levels can accelerate accurate diagnosis of heart failure presenting in primary care.•NP levels may be helpful to screen for asymptomatic left ventricular dysfunction in high-risk patients.
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| 18. |
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| 19. |
- Rutella, S, et al.
(author)
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Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges
- 2020
-
In: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:2
-
Journal article (peer-reviewed)abstract
- The sharing of clinical trial data and biomarker data sets among the scientific community, whether the data originates from pharmaceutical companies or academic institutions, is of critical importance to enable the development of new and improved cancer immunotherapy modalities. Through data sharing, a better understanding of current therapies in terms of their efficacy, safety and biomarker data profiles can be achieved. However, the sharing of these data sets involves a number of stakeholder groups including patients, researchers, private industry, scientific journals and professional societies. Each of these stakeholder groups has differing interests in the use and sharing of clinical trial and biomarker data, and the conflicts caused by these differing interests represent significant obstacles to effective, widespread sharing of data. Thus, the Society for Immunotherapy of Cancer (SITC) Biomarkers Committee convened to identify the current barriers to biomarker data sharing in immuno-oncology (IO) and to help in establishing professional standards for the responsible sharing of clinical trial data. The conclusions of the committee are described in two position papers: Volume I—conceptual challenges and Volume II—practical challenges, the first of which is presented in this manuscript. Additionally, the committee suggests actions by key stakeholders in the field (including organizations and professional societies) as the best path forward, encouraging the cultural shift needed to ensure responsible data sharing in the IO research setting.
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| 20. |
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| 21. |
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Arnott, Shelley E., et al.
(author)
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Widespread variation in salt tolerance within freshwater zooplankton species reduces the predictability of community-level salt tolerance
- 2023
-
In: Limnology and Oceanography Letters. - : John Wiley & Sons. - 2378-2242. ; 8:1, s. 8-18
-
Journal article (peer-reviewed)abstract
- The salinization of freshwaters is a global threat to aquatic biodiversity. We quantified variation in chloride (Cl-) tolerance of 19 freshwater zooplankton species in four countries to answer three questions: (1) How much variation in Cl- tolerance is present among populations? (2) What factors predict intraspecific variation in Cl- tolerance? (3) Must we account for intraspecific variation to accurately predict community Cl- tolerance? We conducted field mesocosm experiments at 16 sites and compiled acute LC(50)s from published laboratory studies. We found high variation in LC(50)s for Cl- tolerance in multiple species, which, in the experiment, was only explained by zooplankton community composition. Variation in species-LC50 was high enough that at 45% of lakes, community response was not predictable based on species tolerances measured at other sites. This suggests that water quality guidelines should be based on multiple populations and communities to account for large intraspecific variation in Cl- tolerance.
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| 26. |
- Ayyer, Kartik, et al.
(author)
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3D diffractive imaging of nanoparticle ensembles using an x-ray laser
- 2021
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In: Optica. - : Optical Society of America. - 2334-2536. ; 8:1, s. 15-23
-
Journal article (peer-reviewed)abstract
- Single particle imaging at x-ray free electron lasers (XFELs) has the potential to determine the structure and dynamics of single biomolecules at room temperature. Two major hurdles have prevented this potential from being reached, namely, the collection of sufficient high-quality diffraction patterns and robust computational purification to overcome structural heterogeneity. We report the breaking of both of these barriers using gold nanoparticle test samples, recording around 10 million diffraction patterns at the European XFEL and structurally and orientationally sorting the patterns to obtain better than 3-nm-resolution 3D reconstructions for each of four samples. With these new developments, integrating advancements in x-ray sources, fast-framing detectors, efficient sample delivery, and data analysis algorithms, we illuminate the path towards sub-nano meter biomolecular imaging. The methods developed here can also be extended to characterize ensembles that are inherently diverse to obtain their full structural landscape. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.
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| 27. |
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| 28. |
- Barabash, Victoria, et al.
(author)
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Electron density profiles in the quiet lower ionosphere based on the results of modeling and experimental data
- 2012
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In: Annales Geophysicae. - : European Geosciences Union (EGU). - 0992-7689 .- 1432-0576. ; 30:9, s. 1345-1360
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Journal article (peer-reviewed)abstract
- The theoretical PGI (Polar Geophysical Institute) model for the quiet lower ionosphere has been applied for computing the ionization rate and electron density profiles in the summer and winter D-region at solar zenith angles less than 80° and larger than 99° under steady state conditions. In order to minimize possible errors in estimation of ionization rates provided by solar electromagnetic radiation and to obtain the most exact values of electron density, each wavelength range of the solar spectrum has been divided into several intervals and the relations between the solar radiation intensity at these wavelengths and the solar activity index F10.7 have been incorporated into the model. Influence of minor neutral species (NO, H2O, O, O3) concentrations on the electron number density at different altitudes of the sunlit quiet D-region has been examined. The results demonstrate that at altitudes above 70 km, the modeled electron density is most sensitive to variations of nitric oxide concentration. Changes of water vapor concentration in the whole altitude range of the mesosphere influence the electron density only in the narrow height interval 73–85 km. The effect of the change of atomic oxygen and ozone concentration is the least significant and takes place only below 70 km. Model responses to changes of the solar zenith angle, solar activity (low–high) and season (summer–winter) have been considered. Modeled electron density profiles have been evaluated by comparison with experimental profiles available from the rocket measurements for the same conditions. It is demonstrated that the theoretical model for the quiet lower ionosphere is quite effective in describing variations in ionization rate, electron number density and effective recombination coefficient as functions of solar zenith angle, solar activity and season. The model may be used for solving inverse tasks, in particular, for estimations of nitric oxide concentration in the mesosphere.
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| 29. |
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| 30. |
- Barabash, Victoria, et al.
(author)
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Polar mesosphere summer echoes during the July 2000 solar proton event
- 2004
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In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 22:3, s. 759-771
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Journal article (peer-reviewed)abstract
- The influence of the solar proton event (SPE) 14-16 July 2000 on Polar Mesosphere Summer Echoes (PMSE) is examined. PMSE were observed by the Esrange VHF MST Radar (ESRAD) at 67°53'N, 21°06'E. The 30MHz Imaging Riometer for Ionospheric Studies IRIS in Kilpisjärvi (69°30'N, 20°47'E) registered cosmic radio noise absorption caused by ionisation changes in response to the energetic particle precipitation. An energy deposition/ion-chemical model was used to estimate the density of free electrons and ions in the upper atmosphere. Particle collision frequencies were calculated from the MSISE-90 model. Electric fields were calculated using conductivities from the model and measured magnetic disturbances. The electric field reached a maximum of 91mV/m during the most intensive period of the geomagnetic storm accompanying the SPE. The temperature increase due to Joule and particle heating was calculated, taking into account radiative cooling. The temperature increase at PMSE heights was found to be very small. The observed PMSE were rather intensive and extended over the 80-90km height interval. PMSE almost disappeared above 86km at the time of greatest Joule heating on 15 July 2000. Neither ionisation changes, nor Joule/particle heating can explain the PMSE reduction. Transport effects due to the strong electric field are a more likely explanation.
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| 31. |
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| 32. |
- Belova, A., et al.
(author)
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Five-day planetary waves in the middle atmosphere from Odin satellite data and ground-based instruments in Northern Hemisphere summer 2003, 2004, 2005 and 2007
- 2008
-
In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 26:11, s. 3557-3570
-
Journal article (peer-reviewed)abstract
- A number of studies have shown that 5-day planetary waves modulate noctilucent clouds and the closely related Polar Mesosphere Summer Echoes (PMSE) at the summer mesopause. Summer stratospheric winds should inhibit wave propagation through the stratosphere and, although some numerical models (Geisler and Dickinson, 1976) do show a possibility for upward wave propagation, it has also been suggested that the upward propagation may in practice be confined to the winter hemisphere with horizontal propagation of the wave from the winter to the summer hemisphere at mesosphere heights causing the effects observed at the summer mesopause. It has further been proposed (Garcia et al., 2005) that 5-day planetary waves observed in the summer mesosphere could be excited in-situ by baroclinic instability in the upper mesosphere. In this study, we first extract and analyze 5-day planetary wave characteristics on a global scale in the middle atmosphere (up to 54 km in temperature, and up to 68 km in ozone concentration) using measurements by the Odin satellite for selected days during northern hemisphere summer from 2003, 2004, 2005 and 2007. Second, we show that 5-day temperature fluctuations consistent with westward-traveling 5-day waves are present at the summer mesopause, using local ground-based meteor-radar observations. Finally we examine whether any of three possible sources of the detected temperature fluctuations at the summer mesopause can be excluded: upward propagation from the stratosphere in the summer-hemisphere, horizontal propagation from the winter-hemisphere or in-situ excitation as a result of the baroclinic instability. We find that in one case, far from solstice, the baroclinic instability is unlikely to be involved. In one further case, close to solstice, upward propagation in the same hemisphere seems to be ruled out. In all other cases, all or any of the three proposed mechanisms are consistent with the observations.
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| 33. |
- Belova, A., et al.
(author)
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Planetary waves in ozone and temperature in the Northern Hemisphere winters of 2002/2003 and early 2005
- 2009
-
In: Annales Geophysicae. - 0992-7689 .- 1432-0576. ; 27:3, s. 1189-1206
-
Journal article (peer-reviewed)abstract
- Temperature and ozone data from the submillimetre radiometer (SMR) installed aboard the Odin satellite have been examined to study the relationship between temperature and ozone concentration in the lower and upper stratosphere in winter time. The retrieved ozone and temperature profiles have been considered between the range of 24-46 km during the Northern Hemisphere (NH) winter of December 2002 to March 2003 and January to March 2005. A comparison between the ozone mixing ratio and temperature fields has been made for the zonal means, wavenumber one variations and 5-day planetary waves. The amplitude values in temperature variations are similar to 5 K in the wavenumber one and 0.5-1 K in the 5-day wave. In ozone mixing ratio, the amplitudes reach similar to 0.5 ppmv in the wavenumber one and 0.05-0.1 ppmv in the 5-day wave. Several stratospheric warming events were observed during the NH winters of 2002/2003 and early 2005. Along with these warming events, amplification of the amplitude has been detected in wavenumber one (up to 30 K in temperature and 1.25 ppmv in ozone) and partly in the 5-day perturbation ( up to 2 K in temperature and 0.2 ppmv in ozone). In general, the results show the expected in-phase behavior between the temperature and ozone fields in the lower stratosphere due to dynamic effects, and an out-of-phase pattern in the upper stratosphere, which is expected as a result of photochemical effects. However, these relationships are not valid for zonal means and wavenumber one components when the wave amplitudes are changing dramatically during the strongest stratospheric warming event (at the end of December 2002/beginning of January 2003). Also, for several shorter intervals, the 5-day perturbations in ozone and temperature are not well-correlated at lower heights, particularly when conditions change rapidly. Odin's basic observation schedule provides stratosphere mode data every third day and to validate the reliability of the 5-day waves extracted from the Odin measurements, additional independent data have been analysed in this study: temperature assimilation data by the European Centre for Medium-range Weather Forecasts (ECMWF) for the NH winter of 2002/2003, and satellite measurements of temperature and ozone by the Microwave Limb Sounder (MLS) on board the Aura satellite for the NH winter in early 2005. Good agreement between the temperature fields from Odin and ECMWF data is found at middle latitude where, in general, the 5-day perturbations from the two data sets coincide in both phase and amplitude throughout the examined interval. Analysis of the wavenumber one and the 5-day wave perturbations in temperature and ozone fields from Odin and from Aura demonstrates that, for the largest part of the examined period, quite similar characteristics are found in the spatial and temporal domain, with slightly larger amplitude values seen by Aura. Hence, the comparison between the Odin data, sampled each third day, and daily data from Aura and the ECMWF shows that the Odin data are sufficiently reliable to estimate the properties of the 5-day oscillations, at least for the locations and time intervals with strong wave activity.
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| 34. |
- Belova, E., et al.
(author)
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Multi-radar observations of polar mesosphere summer echoes during the PHOCUS campaign on 20-22 July 2011
- 2014
-
In: Journal of Atmospheric and Solar-Terrestrial Physics. - : Elsevier BV. - 1364-6826 .- 1879-1824. ; 118, s. 199-205
-
Journal article (peer-reviewed)abstract
- During the PHOCUS rocket campaign, on 20-22 July 2011, the observations of polar mesosphere summer echoes (PMSE) were made by three mesosphere-stratosphere-troposphere radars, operating at about 50 MHz. One radar, ESRAD is located at Esrange in Sweden, where the rocket was launched, two other radars, MAARSY and MORRO, are located 250 km north-west and 200 km north of the ESRAD, respectively, on the other side of the Scandinavian mountain ridge. We compared PMSE as measured by these three radars in terms of their strength, spectral width and wave modulation. Time-altitude maps of PMSE strength look very similar for all three radars. Cross-correlations with maximum values 0.5-0.6 were found between the signal powers over the three days of observations for each pair of radars. By using cross-spectrum analysis of PMSE signals, we show that some waves with periods of a few hours were observed by all three radars. Unlike the strengths, simultaneous values of PMSE spectral width, which is related to turbulence, sometimes differ significantly between the radars. For interpretation of the results we suggested that large-scale fields of neutral temperature, ice particles and electron density, which are more or less uniform over 150-250 km horizontal extent were 'modulated' by waves and smaller patches of turbulence.
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| 35. |
- Belova, E., et al.
(author)
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The dynamical background of polar mesosphere winter echoes from simultaneous EISCAT and ESRAD observations
- 2005
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In: Annales Geophysicae. - : European Geosciences Union. - 0992-7689 .- 1432-0576. ; 23:4, s. 1239-1247
-
Journal article (peer-reviewed)abstract
- On 30 October 2004 during a strong solar proton event, layers of enhanced backscatter from altitudes between 55 and 75km have been observed by both ESRAD (52MHz) and the EISCAT VHF (224MHz) radars. These echoes have earlier been termed Polar Mesosphere Winter Echoes, PMWE. After considering the morphology of the layers and their relation to observed atmospheric waves, we conclude that the radars have likely seen the same phenomenon even though the radars' scattering volumes are located about 220km apart and that the most long-lasting layer is likely associated with wind-shear in an inertio-gravity wave. An ion-chemistry model is used to determine parameters necessary to relate wind-shear induced turbulent energy dissipation rates to radar backscatter. The model is verified by comparison with electron density profiles measured by the EISCAT VHF radar. Observed radar signal strengths are found to be 2-3 orders of magnitude stronger than the maximum which can be expected from neutral turbulence alone, assuming that previously published results relating radar signal scatter to turbulence parameters, and turbulence parameters to wind shear, are correct. The possibility remains that some additional or alternative mechanism may be involved in producing PMWE, such as layers of charged dust/smoke particles or large cluster ions.
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| 36. |
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| 37. |
- Hebert, Marie-Pier, et al.
(author)
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Lake salinization drives consistent losses of zooplankton abundance and diversity across coordinated mesocosm experiments
- 2023
-
In: Limnology and Oceanography Letters. - : John Wiley & Sons. - 2378-2242. ; 8:1, s. 19-29
-
Journal article (peer-reviewed)abstract
- Human-induced salinization increasingly threatens inland waters; yet we know little about the multifaceted response of lake communities to salt contamination. By conducting a coordinated mesocosm experiment of lake salinization across 16 sites in North America and Europe, we quantified the response of zooplankton abundance and (taxonomic and functional) community structure to a broad gradient of environmentally relevant chloride concentrations, ranging from 4 to ca. 1400 mg Cl- L-1. We found that crustaceans were distinctly more sensitive to elevated chloride than rotifers; yet, rotifers did not show compensatory abundance increases in response to crustacean declines. For crustaceans, our among-site comparisons indicate: (1) highly consistent decreases in abundance and taxon richness with salinity; (2) widespread chloride sensitivity across major taxonomic groups (Cladocera, Cyclopoida, and Calanoida); and (3) weaker loss of functional than taxonomic diversity. Overall, our study demonstrates that aggregate properties of zooplankton communities can be adversely affected at chloride concentrations relevant to anthropogenic salinization in lakes.
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| 38. |
- Hintz, William D., et al.
(author)
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Current water quality guidelines across North America and Europe do not protect lakes from salinization
- 2022
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:9
-
Journal article (peer-reviewed)abstract
- Human-induced salinization caused by the use of road deicing salts, agricultural practices, mining operations, and climate change is a major threat to the biodiversity and functioning of freshwater ecosystems. Yet, it is unclear if freshwater ecosystems are protected from salinization by current water quality guidelines. Leveraging an experimental network of land-based and in-lake mesocosms across North America and Europe, we tested how salinization—indicated as elevated chloride (Cl−) concentration—will affect lake food webs and if two of the lowest Cl− thresholds found globally are sufficient to protect these food webs. Our results indicated that salinization will cause substantial zooplankton mortality at the lowest Cl− thresholds established in Canada (120 mg Cl−/L) and the United States (230 mg Cl−/L) and throughout Europe where Cl− thresholds are generally higher. For instance, at 73% of our study sites, Cl− concentrations that caused a ≥50% reduction in cladoceran abundance were at or below Cl− thresholds in Canada, in the United States, and throughout Europe. Similar trends occurred for copepod and rotifer zooplankton. The loss of zooplankton triggered a cascading effect causing an increase in phytoplankton biomass at 47% of study sites. Such changes in lake food webs could alter nutrient cycling and water clarity and trigger declines in fish production. Current Cl− thresholds across North America and Europe clearly do not adequately protect lake food webs. Water quality guidelines should be developed where they do not exist, and there is an urgent need to reassess existing guidelines to protect lake ecosystems from human-induced salinization.
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| 39. |
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| 40. |
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| 41. |
- Kirkwood, S., et al.
(author)
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Polar mesosphere winter echoes by ESRAD, EISCAT and lidar
- 2002
-
Book (other academic/artistic)abstract
- The ESRAD 52 MHz MST radar (67° 53 ‘ N, 21 ° 06 ‘ E) has observed thin layers of enhanced radar echoes in the winter mesosphere during several recent solar proton events. The detection of these polar mesosphere winter echoes (PMWE) is generally found to correlates well with low values of λ (the ratio of negative ion density to electron density). However PMWE are found to persist for values of λ up to ~100. Present knowledge of the nature of neutral turbulence in the winter mesosphere suggests that such turbulence cannot generate electron density fluctuations with scale-sizes as short as the 3 m needed to produce radar echoes at 52 MHz. This is particularly true as λ increases to ~100. Joint observations from ESRAD and the EISCAT 224 MHz radar suggest that PMWE is also detectable at 67 cm scale-sizes, further increasing the difficulty in explaining the echoes by neutral turbulence. Joint observations from ESRAD and lidar are also inconsistent with the expected behaviour of turbulence. Together with results concerning the thickness, echo aspect-sensitivity and echo spectral-width of the PMWE, these observation leads to the conclusion that the layers cannot be explained by turbulence alone. A role for charged aerosols in creating PMWE is proposed. The presence of aerosols is supported by the lidar observations.
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| 42. |
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| 43. |
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| 44. |
- Lossow, Stefan, et al.
(author)
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Middle atmospheric water vapour and dynamics in the vicinity of the polar vortex during the Hygrosonde-2 campaign
- 2009
-
In: Atmospheric Chemistry And Physics. - 1680-7316 .- 1680-7324. ; 9, s. 4407-4417
-
Journal article (peer-reviewed)abstract
- The Hygrosonde-2 campaign took place on 16 December 2001 at Esrange/Sweden (68° N, 21° E) with the aim to investigate the small scale distribution of water vapour in the middle atmosphere in the vicinity of the Arctic polar vortex. In situ balloon and rocket-borne measurements of water vapour were performed by means of OH fluorescence hygrometry. The combined measurements yielded a high resolution water vapour profile up to an altitude of 75 km. Using the characteristic of water vapour being a dynamical tracer it was possible to directly relate the water vapour data to the location of the polar vortex edge, which separates air masses of different character inside and outside the polar vortex. The measurements probed extra-vortex air in the altitude range between 45 km and 60 km and vortex air elsewhere. Transitions between vortex and extra-vortex usually coincided with wind shears caused by gravity waves which advect air masses with different water vapour volume mixing ratios. From the combination of the results from the Hygrosonde-2 campaign and the first flight of the optical hygrometer in 1994 (Hygrosonde-1) a clear picture of the characteristic water vapour distribution inside and outside the polar vortex can be drawn. Systematic differences in the water vapour concentration between the inside and outside of the polar vortex can be observed all the way up into the mesosphere. It is also evident that in situ measurements with high spatial resolution are needed to fully account for the small-scale exchange processes in the polar winter middle atmosphere.
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| 45. |
- Metra, Marco, et al.
(author)
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y Effects of Serelaxin in Patients with Acute Heart Failure
- 2019
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In: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 381:8, s. 716-726
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Journal article (peer-reviewed)abstract
- BackgroundSerelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure. MethodsIn this multicenter, double-blind, placebo-controlled, event-driven trial, we enrolled patients who were hospitalized for acute heart failure and had dyspnea, vascular congestion on chest radiography, increased plasma concentrations of natriuretic peptides, mild-to-moderate renal insufficiency, and a systolic blood pressure of at least 125 mm Hg, and we randomly assigned them within 16 hours after presentation to receive either a 48-hour intravenous infusion of serelaxin (30 mu g per kilogram of body weight per day) or placebo, in addition to standard care. The two primary end points were death from cardiovascular causes at 180 days and worsening heart failure at 5 days.ResultsA total of 6545 patients were included in the intention-to-treat analysis. At day 180, death from cardiovascular causes had occurred in 285 of the 3274 patients (8.7%) in the serelaxin group and in 290 of the 3271 patients (8.9%) in the placebo group (hazard ratio, 0.98; 95% confidence interval [CI], 0.83 to 1.15; P=0.77). At day 5, worsening heart failure had occurred in 227 patients (6.9%) in the serelaxin group and in 252 (7.7%) in the placebo group (hazard ratio, 0.89; 95% CI, 0.75 to 1.07; P=0.19). There were no significant differences between the groups in the incidence of death from any cause at 180 days, the incidence of death from cardiovascular causes or rehospitalization for heart failure or renal failure at 180 days, or the length of the index hospital stay. The incidence of adverse events was similar in the two groups.ConclusionsIn this trial involving patients who were hospitalized for acute heart failure, an infusion of serelaxin did not result in a lower incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days than placebo. (Funded by Novartis Pharma; RELAX-AHF-2 ClinicalTrials.gov number, NCT01870778.) In a randomized trial, 6545 patients with acute heart failure were assigned to either serelaxin or placebo in addition to standard care. There were no significant differences between the two groups in the incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days.
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| 46. |
- Olsson, A, et al.
(author)
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Particle precipitation in auroral breakups and westward traveling surges
- 1996
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In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. - 0148-0227. ; 101:A11, s. 24661-24673
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Journal article (other academic/artistic)abstract
- We have used data from the European Incoherent Scatter (EISCAT) facility to determine the characteristics of particle precipitation before and within auroral breakups and westward traveling surges. The EISCAT data of electron density versus altitude were
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| 47. |
- Schmauck-Medina, Tomas, et al.
(author)
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New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary
- 2022
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In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 14:16, s. 6829-6839
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Journal article (peer-reviewed)abstract
- Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
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| 48. |
- Sobolev, Egor, et al.
(author)
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Megahertz single-particle imaging at the European XFEL
- 2020
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In: Communications Physics. - : Springer Science and Business Media LLC. - 2399-3650. ; 3:1
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Journal article (peer-reviewed)abstract
- The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.
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