| 1. |
|
|
| 2. |
|
|
| 3. |
- Marttila, H., et al.
(författare)
-
Nordic hydrological frontier in the 21st century
- 2022
-
Ingår i: Hydrology Research. - : IWA Publishing. - 1998-9563 .- 2224-7955 .- 0029-1277. ; 53:5, s. 700-715
-
Tidskriftsartikel (refereegranskat)abstract
- The 21st century has brought new challenges and opportunities and has also increased demands on the Nordic hydrological community. Our hydrological science focus and approaches need rethinking and adaptation to the changing requirements of society in response to climate change and human interventions, in search of more comprehensive and cross-disciplinary solutions. This commentary highlights new possibilities and suggests vital steps forward for the scientific discipline within Nordic hydrological research. By providing a common direction, we hope to increase awareness, accelerate progress in the hydrological community, and emphasize the importance of hydrological knowledge for serving other fields of science and society at large. We hope that our vision and the opportunities we identify will raise awareness of the scientific discipline and assist in the long-term development of the Nordic hydrological frontier in the 21st century.
|
|
| 4. |
|
|
| 5. |
- Gilby, L, et al.
(författare)
-
Global health without sexual and reproductive health and rights? Analysis of United Nations documents and country statements, 2014-2019
- 2021
-
Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 6:3
-
Tidskriftsartikel (refereegranskat)abstract
- The initial International Conference on Population and Development in 1994 contains the first reference to sexual and reproductive health and reproductive rights (SRHR). It has been considered agreed language on SRHR in future United Nations (UN) documents. However, opposition to SRHR in global forums has increased, including in conjunction with an increase in religious, far-right populist politics. This study provides an empirical analysis of UN documents to discover whether opposition to SRHR has resulted in changes in the language on SRHR between and what these changes are.MethodsThis is a qualitative policy analysis in which 14 UN resolutions, 6 outcome documents from the Commission on the Status of Women (CSW) and 522 country and group statements and 5 outcome reports from the Commission on Population and Development were collected from the organisations websites from 2014 to 2019. Framework analysis was used. The text from documents was charted and indexed and themes developed from these.ResultsThe results demonstrated a disappearance of the language on abortion in the CSW outcome documents from 2017 and a change in the language on comprehensive sexuality education in the CSW as well as the UN General Assembly resolutions from 2018. This change included a removal of ‘sexuality’ to an increased emphasis on the role of families. Furthermore, documents showed an inability of some states to accept any mention of sexual and reproductive health at all, expanding from the usual contestations over abortion.ConclusionOur findings suggest that the global shift in politics and anti-SRHR actors at UN negotiations and conferences have removed previously agreed on language on SRHR from future UN resolutions and outcome documents. This is a concern for the global realisation of SRHR.
|
|
| 6. |
- Hakkarainen, Teemu, et al.
(författare)
-
Te incorporation and activation as n-type dopant in self-catalyzed GaAs nanowires
- 2019
-
Ingår i: Physical Review Materials. - 2475-9953. ; 3:8
-
Tidskriftsartikel (refereegranskat)abstract
- Dopant atoms can be incorporated into nanowires either via the vapor-liquid-solid mechanism through the catalyst droplet or by the vapor-solid growth on the sidewalls. Si is a typical n-type dopant for GaAs, but in nanowires it often suffers from a strongly amphoteric nature in the vapor-liquid-solid process. This issue can be avoided by using Te, which is a promising but less common alternative for n-type doping of GaAs nanowires. Here, we present a detailed investigation of Te-doped self-catalyzed GaAs nanowires. We use several complementary experimental techniques, such as atom probe tomography, off-axis electron holography, micro-Raman spectroscopy, and single-nanowire transport characterization, to assess the Te concentration, the free-electron concentration, and the built-in potential in Te-doped GaAs nanowires. By combing the experimental results with a theoretical model, we show that Te atoms are mainly incorporated by the vapor-liquid-solid process through the Ga droplet, which leads to both axial and radial dopant gradients due to Te diffusion inside the nanowires and competition between axial elongation and radial growth of nanowires. Furthermore, by comparing the free-electron concentration from Raman spectroscopy and the Te-atom concentrations from atom probe tomography, we show that the activation of Te donor atoms is 100% at a doping level of 4×1018cm-3, which is a significant result in terms of future device applications.
|
|
| 7. |
- Huvinen, Emilia, et al.
(författare)
-
Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes
- 2022
-
Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 65:8, s. 1291-1301
-
Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods: The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes through lifestyle intervention. Participants with a BMI ≥30 kg/m2 and/or prior GDM were allocated to intervention and control groups before pregnancy or in early pregnancy. The study visits took place every 3 months before pregnancy, once in each trimester, and at 6 weeks and 6 and 12 months postpartum. We calculated a polygenic risk score (PRS) based on 50 risk variants for type 2 diabetes. Results: Altogether, 516 participants provided genetic and GDM data. The PRS was associated with higher glycaemic levels (fasting glucose and/or HbA1c) and a lower insulin secretion index in the second and third trimesters and at 12 months postpartum, as well as with a higher occurrence of GDM and glycaemic abnormalities at 12 months postpartum (n = 356). There was an interaction between the PRS and lifestyle intervention (p=0.016 during pregnancy and p=0.024 postpartum) when analysing participants who did not have GDM at the first study visit during pregnancy (n = 386). When analysing women in tertiles according to the PRS, the intervention was effective in reducing the age-adjusted occurrence of GDM only among those with the highest genetic risk (OR 0.37; 95% CI 0.17, 0.82). The risk of glycaemic abnormalities at 12 months postpartum was reduced in the same group after adjusting additionally for BMI, parity, smoking and education (OR 0.35; 95% CI 0.13, 0.97). Conclusions/interpretation: Genetic predisposition to diabetes modifies the response to a lifestyle intervention aimed at prevention of GDM and postpartum diabetes. This suggests that lifestyle intervention may benefit from being tailored according to genetic risk. Clinical trial registration: ClinicalTrials.gov identifier: NCT01698385 Graphical abstract: [Figure not available: see fulltext.]
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Rasmus, S., et al.
(författare)
-
Estimation of winter leaf area index and sky view fraction for snow modelling in boreal coniferous forests : Consequences on snow mass and energy balance
- 2013
-
Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 27:20, s. 2876-2891
-
Tidskriftsartikel (refereegranskat)abstract
- Leaf area index (LAI) and canopy coverage are important parameters when modelling snow process in coniferous forests, controlling interception and transmitting radiation. Estimates of LAI and sky view factor show large variability depending on the estimation method used, and it is not clear how this is reflected in the calculated snow processes beneath the canopy. In this study, the winter LAI and sky view fraction were estimated using different optical and biomass-based approximations in several boreal coniferous forest stands in Fennoscandia with different stand density, age and site latitude. The biomass-based estimate of LAI derived from forest inventory data was close to the values derived from the optical measurements at most sites, suggesting that forest inventory data can be used as input to snow hydrological modelling. Heterogeneity of tree species and site fertility, as well as edge effects between different forest compartments, caused differences in the LAI estimates at some sites. A snow energy and mass balance model (SNOWPACK) was applied to detect how the differences in the estimated values of the winter LAI and sky view fraction were reflected in simulated snow processes. In the simulations, an increase in LAI and a decrease in sky view fraction changed the snow surface energy balance by decreasing shortwave radiation input and increasing longwave radiation input. Changes in LAI and sky view fraction affected directly snow accumulation through altered throughfall fraction and indirectly snowmelt through the changed surface energy balance. Changes in LAI and sky view fraction had a greater impact on mean incoming radiation beneath the canopy than on other energy fluxes. Snowmelt was affected more than snow accumulation. The effect of canopy parameters on evaporation loss from intercepted snow was comparable with the effect of variation in governing meteorological variables such as precipitation intensity and air temperature.
|
|
| 11. |
- Simpson, Fiona C., et al.
(författare)
-
Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
- 2021
-
Ingår i: Communications Biology. - : Nature Research. - 2399-3642. ; 4:1
-
Tidskriftsartikel (refereegranskat)abstract
- The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The resulting CLP-PEG-MPC implants led to reduced corneal swelling, haze, and neovascularization in comparison to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. Implants incorporating MPC allowed for faster nerve regeneration and recovery of corneal sensation. CLP-PEG-MPC implants appear to be at a more advanced stage of regeneration than the CLP-PEG only implants, as evidenced by the presence of higher amounts of cornea-specific type V collagen, and a corresponding decrease in the presence of extracellular vesicles and exosomes in the corneal stroma, in keeping with the amounts present in healthy, unoperated corneas. Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.
|
|
| 12. |
|
|
| 13. |
|
|
