| 1. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Denault, V., et al.
(författare)
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L’analyse de la communication non verbale: Les dangers de la pseudoscience en contextes de sécurité et de justice
- 2020
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Ingår i: Revue Internationale de Criminologie et de Police Technique et Scientifique. - 1424-4683. ; 73:1, s. 15-44
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Tidskriftsartikel (refereegranskat)abstract
- For security and justice professionals, the thousands of peer-reviewed articles on nonverbal communication represent important sources of knowledge. However, despite the scope of the scientific work carried out on this subject, professionals can turn to programs, methods and approaches that fail to reflect the state of science. The objective of this article is to examine (i) concepts of nonverbal communication conveyed by these programs, methods and approaches, but also (ii) the consequences of their use. To achieve this objective, we describe the scope of scientific research on nonverbal communication. A program (SPOT; “Screening of Passengers by Observation Techniques”), a method (the BAI; “Behavior Analysis Interview”) and an approach (synergology) that each run counter to the state of science are examined. Finally, we outline five hypotheses to explain why some organizations in the fields of security and justice are turning to pseudoscience and pseudoscientific techniques. © 2020, Polymedia Meichtry SA. All rights reserved.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Sermeus, W, et al.
(författare)
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A workplace organisational intervention to improve hospital nurses' and physicians' mental health: study protocol for the Magnet4Europe wait list cluster randomised controlled trial
- 2022
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:7, s. e059159-
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Tidskriftsartikel (refereegranskat)abstract
- The increasing burden of mental distress reported by healthcare professionals is a matter of serious concern and there is a growing recognition of the role of the workplace in creating this problem. Magnet hospitals, a model shown to attract and retain staff in US research, creates positive work environments that aim to support the well-being of healthcare professionals.Methods and analysisMagnet4Europe is a cluster randomised controlled trial, with wait list controls, designed to evaluate the effects of organisational redesign, based on the Magnet model, on nurses’ and physicians’ well-being in general acute care hospitals, using a multicomponent implementation strategy. The study will be conducted in more than 60 general acute care hospitals in Belgium, England, Germany, Ireland, Norway and Sweden. The primary outcome is burnout among nurses and physicians, assessed in longitudinal surveys of nurses and physicians at participating hospitals. Additional data will be collected from them on perceived work environments, patient safety and patient quality of care and will be triangulated with data from medical records, including case mix-adjusted in-hospital mortality. The process of implementation will be evaluated using qualitative data from focus group and key informant interviews.Ethics and disseminationThis study was approved by the Ethics Committee Research UZ/KU Leuven, Belgium; additionally, ethics approval is obtained in all other participating countries either through a central or decentral authority. Findings will be disseminated at conferences, through peer-reviewed manuscripts and via social media.Trial registration numberISRCTN10196901.
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| 8. |
- Barregård, Lars, 1948, et al.
(författare)
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Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine
- 2013
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Ingår i: Antioxidants and Redox Signaling. - : Mary Ann Liebert Inc. - 1523-0864 .- 1557-7716. ; 18:18, s. 2377-2391
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA methods hampers interpretation of data, and this variability may increase should urine composition differ between individuals, leading to assay interference. Furthermore, optimal urine sampling conditions are not well defined. We performed inter-laboratory comparisons of 8-oxodG measurement between mass spectrometric-, electrochemical- and ELISA-based methods, using common within-technique calibrants to analyze 8-oxodG-spiked phosphate-buffered saline and urine samples. We also investigated human subject- and sample collection-related variables, as potential sources of variability. Results: Chromatographic assays showed high agreement across urines from different subjects, whereas ELISAs showed far more inter-laboratory variation and generally overestimated levels, compared to the chromatographic assays. Excretion rates in timed 'spot' samples showed strong correlations with 24 h excretion (the 'gold' standard) of urinary 8-oxodG (r(p) 0.67-0.90), although the associations were weaker for 8-oxodG adjusted for creatinine or specific gravity (SG). The within-individual excretion of 8-oxodG varied only moderately between days (CV 17% for 24 h excretion and 20% for first void, creatinine-corrected samples). Innovation: This is the first comprehensive study of both human and methodological factors influencing 8-oxodG measurement, providing key information for future studies with this important biomarker. Conclusion: ELISA variability is greater than chromatographic assay variability, and cannot determine absolute levels of 8-oxodG. Use of standardized calibrants greatly improves intra-technique agreement and, for the chromatographic assays, importantly allows integration of results for pooled analyses. If 24 h samples are not feasible, creatinine- or SG-adjusted first morning samples are recommended.
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| 9. |
- Bhowmick, A.K., et al.
(författare)
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Photomechanical degradation of thermoplastic elastomers
- 2006
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Ingår i: Journal of Applied Polymer Science. - : Wiley. - 0021-8995 .- 1097-4628. ; 99:1, s. 150-161
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Tidskriftsartikel (refereegranskat)abstract
- The photodegradation of thermoplastic elastomers designed for outdoor applications was studied with laboratory ultraviolet (UV) exposure in the unstrained state and under tensile strain (25 and 50%). Strained exposure caused a reduction of the strain to failure in subsequent tensile tests. For some combinations of material and exposure conditions, some recovery of extensibility occurred between 2 and 4 weeks. Microscopic examination revealed that this was probably due to embrittlement of the surface region that was sufficiently severe that surface cracks did not prop agate into the interior and that the observed recovery did not correspond to repair or improvement of the material. Shielding the sample surface from UV irradiation reduced the formation of surface cracking very significantly, and it was deduced that the principal cause of degradation was photooxidation rather than ozone attack. © 2005 Wiley Periodicals, Inc.
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| 10. |
- Buekers, J, et al.
(författare)
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Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population
- 2018
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Ingår i: International journal of environmental research and public health. - : MDPI AG. - 1660-4601. ; 15:10
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Tidskriftsartikel (refereegranskat)abstract
- The European Union’s 7th Environmental Action Programme (EAP) aims to assess and minimize environmental health risks from the use of hazardous chemicals by 2020. From this angle, policy questions like whether an implemented policy to reduce chemical exposure has had an effect over time, whether the health of people in specific regions or subpopulations is at risk, or whether the body burden of chemical substances (the internal exposure) varies with, for example, time, country, sex, age, or socio-economic status, need to be answered. Indicators can help to synthesize complex scientific information into a few key descriptors with the purpose of providing an answer to a non-expert audience. Human biomonitoring (HBM) indicators at the European Union (EU) level are unfortunately lacking. Within the Horizon2020 European Human Biomonitoring project HBM4EU, an approach to develop European HBM indicators was worked out. To learn from and ensure interoperability with other European indicators, 15 experts from the HBM4EU project (German Umweltbundesamt (UBA), Flemish research institute VITO, University of Antwerp, European Environment Agency (EEA)), and the World Health Organization (WHO), European Core Health Indicator initiative (ECHI), Eurostat, Swiss ETH Zurich and the Czech environmental institute CENIA, and contributed to a workshop, held in June 2017 at the EEA in Copenhagen. First, selection criteria were defined to evaluate when and if results of internal chemical exposure measured by HBM, need to be translated into a European HBM-based indicator. Two main aspects are the HBM indicator’s relevance for policy, society, health, and the quality of the biomarker data (availability, comparability, ease of interpretation). Secondly, an approach for the calculation of the indicators was designed. Two types of indicators were proposed: ‘sum indicators of internal exposure’ derived directly from HBM biomarker concentrations and ‘indicators for health risk’, comparing HBM concentrations to HBM health-based guidance values (HBM HBGVs). In the latter case, both the percentage of the studied population exceeding the HBM HBGVs (PE) and the extent of exceedance (EE), calculated as the population’s exposure level divided by the HBM HBGV, can be calculated. These indicators were applied to two examples of hazardous chemicals: bisphenol A (BPA) and per- and polyfluoroalkyl substances (PFASs), which both have high policy and societal relevance and for which high quality published data were available (DEMOCOPHES, Swedish monitoring campaign). European HBM indicators help to summarize internal exposure to chemical substances among the European population and communicate to what degree environmental policies are successful in keeping internal exposures sufficiently low. The main aim of HBM indicators is to allow follow-up of chemical safety in Europe.
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| 11. |
- Denault, Vincent, et al.
(författare)
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The Analysis of Nonverbal Communication: The Dangers of Pseudoscience in Security and Justice Contexts : Análisis de la comunicación no verbal: los peligros de la pseudociencia en entornos de seguridad y justicia
- 2020
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Ingår i: Anuario de Psicología Jurídica. - : Colegio Oficial de la Psicologia de Madrid. - 1133-0740 .- 2174-0542. ; 30:1, s. 1-12
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Forskningsöversikt (refereegranskat)abstract
- For security and justice professionals (e.g., police officers, lawyers, judges), the thousands of peer-reviewed articles on nonverbal communication represent important sources of knowledge. However, despite the scope of the scientific work carried out on this subject, professionals can turn to programs, methods, and approaches that fail to reflect the state of science. The objective of this article is to examine (i) concepts of nonverbal communication conveyed by these programs, methods, and approaches, but also (ii) the consequences of their use (e.g., on the life or liberty of individuals). To achieve this objective, we describe the scope of scientific research on nonverbal communication. A program (SPOT; Screening of Passengers by Observation Techniques), a method (the BAI; Behavior Analysis Interview) and an approach (synergology) that each run counter to the state of science are examined. Finally, we outline five hypotheses to explain why some organizations in the fields of security and justice are turning to pseudoscience and pseudoscientific techniques. We conclude the article by inviting these organizations to work with the international community of scholars who have scientific expertise in nonverbal communication and lie (and truth) detection to implement evidence-based practices.
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| 12. |
- van Meel, Evelien R., et al.
(författare)
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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
- 2022
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Ingår i: European Respiratory Journal. - : EUROPEAN RESPIRATORY SOC JOURNALS LTD. - 0903-1936 .- 1399-3003. ; 60:4
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Tidskriftsartikel (refereegranskat)abstract
- Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4-15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: -0.09 (95% CI -0.14- -0.04) to -0.30 (95% CI -0.36- -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98-2.22) to 6.30 (95% CI 5.64-7.04) and 1.25 (95% CI 1.18-1.32) to 1.55 (95% CI 1.47-1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
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| 13. |
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| 14. |
- De La Fuente Vilar, Alejandra, 1988, et al.
(författare)
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Memory of Uncooperative Witnesses
- 2017
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Ingår i: Pitch presentation during the 2017 conference of the European Association of Psychology and Law in Mechelen, Belgium.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction Despite the importance of their testimony, witnesses rarely provide sufficient information (Kebbell & Milne, 1998). However, witnesses’ reports are not necessarily a representation of memory. In fact, lack of reporting does not equal to lack of memory. But, there is no empirical evidence on whether memory is protected if it is not reported. This will be the first study to examine whether level of cooperation during an investigative interview affects memory for the target event. Specifically, we aim to learn whether memory traces are conserved when witnesses are uncooperative. Method During an in-person session, all participants will watch a mock-crime video clip and serve as eyewitnesses. They will be randomly assigned to only one of four interviewing conditions: control, enhanced cooperative style and two uncooperative style groups. Participants in the uncooperative groups will be told that the police believe they also participated in the crime. It is expected that participants to avoid self-incrimination will be less cooperative than those who are independent witnesses. Further, those in the enhanced cooperative condition will receive an extra incentive to facilitate disclosure. After a week, only one of the uncooperative groups will be debriefed. All groups will be interviewed again. Memory performance will be measured in both interviews. Results A literature review regarding memory for the unsaid (i.e., what is remembered and not disclosed) shows mixed results. Lack of disclosure of information can be accompanied, or not, by remembering. Thus, not reporting may lead to forgetting, but also to memory facilitation (Stone, Coman, Brown, Koppel & Hirst, 2012). As this is an exploratory study, no directional hypotheses are formulated. Preliminary data will be presented during the conference. Discussion Learning about how interview cooperation style affects memory and how this can be best recalled at a later stage is of particular relevance.
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| 15. |
- De La Fuente Vilar, Alejandra, 1988, et al.
(författare)
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Uncooperative Witnesses and their Inclination to Disclose Information
- 2018
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Ingår i: European Association of Psychology and Law (EAPL) Conference. Turku, Finland: 26-29 June 2018.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objectives Police rely on witness testimony to advance criminal investigations; however, witnesses do not always cooperate. Despite the importance of witness cooperation for gathering information during investigative interviews, it has received little scrutiny. We examined the extent to which witness cooperation affects information disclosure, and how lack of cooperation affects the reliability of witness testimony. Method Participants (N=139) watched a mock-crime video and were interviewed twice over a two-week period. They were randomly assigned to one of four experimental conditions: control, cooperative and two uncooperative groups. In the cooperative group, participants were informed they were key witnesses, whereas those in the control condition did not receive especial instructions. Participants in the uncooperative groups were told the police believed they participated in the crime, but before the second interview one of the uncooperative groups was informed they were not longer incriminated. The amount of information disclosed was measured in both interviews. Results Data is currently being analysed and will be presented at the conference. We predict that witness cooperation level will affect information disclosure during investigative interviews. Specifically, uncooperative interviewees will disclose less detailed information, and will omit crime relevant facts, compared to those in the cooperative and control conditions. Additionally, we will examine whether memory for initially unreported information is impaired by an initial uncooperative interview. Conclusion Understanding how witness cooperation affects information gathering during investigative interviews is relevant to examine the reliability of testimonies from uncooperative witnesses, and to inform interviewing practice that promotes cooperative reporting and facilitates disclosure.
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| 16. |
- De La Fuente Vilar, Alejandra, 1988, et al.
(författare)
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What if Witnesses are Uncooperative? – A Glimpse on Current Interviewing Practice in The Netherlands.
- 2018
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Ingår i: 11th Annual Conference & Masterclas of the International Investigative Interviewing Research Group (iIIRG). Porto, Portugal: July 2018.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objectives Research has informed best practice guidelines to interview witnesses however, their efficacy and application are highly dependent on the level of cooperation from the interviewee, questioning their suitability when witnesses do not cooperate. Despite its importance, how to best interview uncooperative witnesses has received little attention. We aimed to obtain an insight into current interviewing practice when conducting investigative interviews with uncooperative witnesses. Method Semi-structured interviews were conducted with ten police officers working as interviewers, interviewing instructors, and researchers. Transcribed interviews were analysed following a thematic analysis. Results Witness cooperation had a significant impact on interviewing style. Officers identified the lack of a specific interviewing protocol and training to gain witness cooperation challenging. This leads to intuitive interviewing, and great variance in preferred interviewing strategies and question type. While some focus on building rapport and facilitate witness protection to promote disclosure, others focus on confronting witnesses with the legal consequences of lack of cooperation and making moral appeals to overcome witness resistance. Conclusion Witnesses’ unwillingness to disclose information during investigative interviews can hinder criminal investigations. Understanding how uncooperative witnesses are interviewed informs how to improve interviewing practice that promotes cooperative reporting and facilitate eliciting complete and accurate witness accounts.
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| 17. |
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| 18. |
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| 19. |
- Koppen, Arjen, et al.
(författare)
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Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is'-down-regulated by MYCN
- 2008
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 122:7, s. 1455-1464
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Tidskriftsartikel (refereegranskat)abstract
- Neuroblastoma and ganglioneuroma are neuroblastic tumors originating from the developing sympathetic peripheral nervous system. Ganglioneuromas are usually benign, while neuroblastomas have a variable prognosis and include very aggressive tumors. Examples exist of neuroblastomas regressing to ganglioneuromas and ganglioneuromas progressing to neuroblastomas. Little is known of the molecular differences between the tumor types. Here we report that Dickkopf-3 (DKK3), a putative extra cellular inhibitor of the Wnt/beta-catenin pathway, showed a strongly differential expression between neuroblastoma and ganglioneuroma. Microarray analyses of 109 neuroblastic tumors revealed that DKK3 is strongly expressed in ganglioneuroma but only weakly in neuroblastoma. Low DKK3 expression in neuroblastoma correlated with a poor prognosis. The expression of DKK3 in the tumor series and in neuroblastoma cell lines was inversely correlated with the expression of the MYCN oncogene. Analysis of, 2 neuroblastoma cell lines with inducible activity of MYCN showed that DKK3 is down-regulated by MYCN. We subsequently generated cell lines with inducible expression of DKK3, which revealed an inhibitory effect of DKK3 on proliferation. High DKK3 expression in the benign ganglioneuromas and down-regulation of DKK3 by MYCN in neuroblastoma might contribute to the strongly different clinical behavior of both neuroblastic tumor types.
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| 20. |
- Koppen, Arjen, et al.
(författare)
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Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma
- 2007
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 43:16, s. 2413-2422
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Tidskriftsartikel (refereegranskat)abstract
- The c-Myc and MYCN oncogenes strongly induce cell proliferation. Although a limited series of cell cycle genes were found to be induced by the myc transcription factors, it is still unclear how they mediate the proliferative phenotype. We therefore analysed a neuroblastoma cell line with inducible MYCN expression. We found that all members of the minichromosome maintenance complex (MCM2 - 7) and MCM8 and MCM10 were up-regulated by MYCN. Expression profiling of 110 neuroblastoma tumours revealed that these genes strongly correlated with MYCN expression in vivo. Extensive chromatin immunoprecipitation experiments were performed to investigate whether the MCM genes were primary MYCN targets. MYCN was bound to the proximal promoters of the MCM2 to -8 genes. These data suggest that MYCN stimulates the expression of not only MCM7, which is a well defined MYCN target gene, but also of the complete minichromosome maintenance complex. (c) 2007 Elsevier Ltd. All rights reserved.
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| 21. |
- Maegherman, Enide, et al.
(författare)
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Accountability in legal decision-making
- 2022
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Ingår i: Psychiatry, Psychology and Law. - : Informa UK Limited. - 1321-8719 .- 1934-1687. ; 29:3
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Tidskriftsartikel (refereegranskat)abstract
- Having to explain a decision has often been found to have a positive effect on the quality of a decision. We aimed to determine whether different accountability requirements for judges (i.e., having to justify their decision or having to explicate their decision) affect evidence use. Those requirements were compared to instructions based on the falsification principle and a control condition. Participants (N = 173) decided on the defendant’s guilt in a murder case vignette and explained their decision according to the instructions. The explication and falsification (but not the justification) instructions increased the use of exonerating evidence. There was no significant difference between the groups in guilt perception. The use of exonerating evidence was a significant positive predictor of acquittal rates. The implications for the different forms of instructions in practice are positive, but suggest a difference between the evidence considered and the evidence used to account for the decision. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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| 22. |
- Maegherman, Enide, et al.
(författare)
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Law and order effects: on cognitive dissonance and belief perseverance
- 2022
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Ingår i: Psychiatry Psychology and Law. - : Informa UK Limited. - 1321-8719 .- 1934-1687. ; 29:1, s. 33-52
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Tidskriftsartikel (refereegranskat)abstract
- Order of evidence presentation affects the evaluation and the integration of evidence in mock criminal cases. In this study, we aimed to determine whether the order in which incriminating and exonerating evidence is presented influences cognitive dissonance and subsequent display of confirmation bias. Law students (N = 407) were presented with a murder case vignette, followed by incriminating and exonerating evidence in various orders. Contrary to a predicted primacy effect (i.e. early evidence being most influential), a recency effect (i.e. late evidence being most influential) was observed in ratings of likelihood of the suspect's guilt. The cognitive dissonance ratings and conviction rates were not affected by the order of evidence presentation. The effects of evidence presentation order may be limited to specific aspects of legal decisions. However, there is a need to replicate the results using procedures and samples that are more representative of real-life criminal law trials.
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| 23. |
- Maegherman, Enide, et al.
(författare)
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Test of the analysis of competing hypotheses in legal decision-making
- 2021
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Ingår i: Applied Cognitive Psychology. - : Wiley. - 0888-4080 .- 1099-0720. ; 35:1, s. 62-70
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Tidskriftsartikel (refereegranskat)abstract
- The analysis of competing hypotheses (ACH) has been suggested to be a method that can protect against confirmation bias in the context of intelligence analysis. In the current study, we aimed to determine whether ACH could counter confirmation bias in the reasoning with evidence in the context of criminal law proceedings. Law students (N = 191) received information about the ACH method or general information about biases. They were given a case vignette with a main suspect and a list of 24 questions, 6 of which they could ask about the case. Half of the questions related to incriminating information, whereas the other half related to exonerating information. Contrary to our expectations, participants in both conditions favoured questions relating to exonerating information and rated the exonerating evidence as being more important for their decision. Despite the lack of bias observed, it seems participants failed to properly apply the ACH method.
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| 24. |
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| 25. |
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| 26. |
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| 27. |
- van Veldhuizen, Tanja, 1990, et al.
(författare)
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Establishing Origin: Analysing the Questions Asked in Asylum Interviews
- 2018
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Ingår i: Psychiatry Psychology and Law. - : Informa UK Limited. - 1321-8719 .- 1934-1687. ; 25:2, s. 283-302
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Tidskriftsartikel (refereegranskat)abstract
- In the absence of evidence, asylum seekers are interviewed to assess the credibility of their stories. Few studies have examined whether or not the questions asked in such interviews stimulate the applicant to give lengthy, detailed, and accurate answers. The style, type, and content of the questions asked in order to assess a claim about origin were analysed in 40 case files from the Dutch Immigration Service. A large proportion of the questions were closed and fact-checking questions. Less than one fifth of questions were open or cued recall questions. The results show that to assess credibility of origin, knowledge questions were posed about the immediate living environment, flight to Europe, identity documents, country of origin, and personal background of applicants. Possibilities for increasing the quantity and quality of information obtained in asylum interviews are discussed. Future research should validate the assumption that truthful claimants have substantial knowledge about their country and town of origin.
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| 28. |
- van Veldhuizen, Tanja, 1990, et al.
(författare)
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Interviewing asylum seekers: A vignette study on the questions asked to assess credibility of claims about origin and persecution
- 2017
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Ingår i: Journal of Investigative Psychology and Offender Profiling. - : Wiley. - 1544-4759 .- 1544-4767. ; 14:1, s. 3-22
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Tidskriftsartikel (refereegranskat)abstract
- © 2016 John Wiley & Sons, Ltd.The aim of the current vignette study is to map the style, type, and themes of questions that are asked when assessing the credibility of asylum seekers' claims. Sixty-five officials from the Swedish Migration Agency (Migrationsverket), were asked to respond to one out of four different vignettes that contained fictitious asylum narratives. Each vignette presented the types of problems often encountered by officials at the migration board. Two of the vignettes contained no evidence of the origin of the asylum seeker. The other two contained no evidence for the claim of persecution. The asylum officials were asked to formulate five questions that would help them to assess the veracity of the applicant's claim. Our analyses showed that they mainly formulated open questions in an information gathering style. A thematic analysis of the questions revealed that when a claim about origin was assessed, asylum officials mostly asked questions about life in the country of origin, identity documents, and the flight to Europe. When the claim about persecution was assessed, in contrast, asylum officials mostly formulated case-specific questions (e.g., how the applicant was arrested). Hence, when the credibility of claims about origin is assessed, there seems to be a typical set of questions that asylum officials use. The asylum officials seem to assume that if the applicant is truly originating from a specific country or area, he or she should have ample knowledge about that area, its customs, and frequently encountered objects.
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| 29. |
- van Veldhuizen, Tanja, 1990, et al.
(författare)
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The provenance of émigrés: the validity of measuring knowledge of places
- 2017
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Ingår i: Psychology, Crime and Law. - 1068-316X .- 1477-2744. ; 23:6, s. 553-574
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis GroupEstablishing the origin of those seeking asylum is essential but difficult as asylum seekers often cannot corroborate their origin claim with documents. The aim of the present study was to assess whether asking knowledge questions, sketch questions and impossible questions are valid methods to determine the veracity of an origin claim. Participants (N=105) from Tilburg (truth-tellers), Maastricht (partial liars) and Gothenburg (full liars) were asked to convince an interviewer that they originated from Tilburg. Half of them prepared and half of them did not prepare themselves for the interview. They were asked 10 knowledge questions typically asked to assess the credibility of origin claims, 4 impossible questions and 1 sketch question. Participants from Tilburg answered more questions correctly than participants from Maastricht and Gothenburg. Performance also improved with preparation. Even though the results did provide some support for the validity of assessing claims about origin by asking knowledge questions, the differences between the groups were modest, and it was impossible to correctly identify all truth-tellers and liars. Changing the output modality from verbal answering to sketching contributed to the credibility assessment of origin claims, whereas impossible questions were not discriminatory.
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| 30. |
- Van Velthoven, Arianne J. H., et al.
(författare)
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Future directions in managing aniridia-associated keratopathy
- 2023
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Ingår i: Survey of ophthalmology. - : ELSEVIER SCIENCE INC. - 0039-6257 .- 1879-3304. ; 68:5, s. 940-956
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Forskningsöversikt (refereegranskat)abstract
- Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of vision. Currently, there is no approved therapy to delay or prevent its progression, and clinical management is challenging because of phenotypic variability and high risk of complications after interventions; however, new insights into the molecular pathogenesis of AAK may help improve its management. Here, we review the current understanding about the pathogenesis and management of AAK. We highlight the biological mechanisms involved in AAK development with the aim to develop future treatment options, including surgical, pharmacological, cell therapies, and gene therapies.
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| 31. |
- Vogel, N, et al.
(författare)
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Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative
- 2023
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Ingår i: Toxics. - : MDPI AG. - 2305-6304. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across Europe is challenging. They differ widely in time periods, study samples, degree of geographical coverage, design, analytical methodology, biomarker selection, and analytical quality assurance level. The HBM4EU initiative has gathered existing HBM data of 29 studies from participating countries, covering all European regions and Israel. The data were prepared and aggregated by a harmonized procedure with the aim to describe—as comparably as possible—the EU-wide general population’s internal exposure to phthalates from the years 2005 to 2019. Most data were available from Northern (up to 6 studies and up to 13 time points), Western (11; 19), and Eastern Europe (9; 12), e.g., allowing for the investigation of time patterns. While the bandwidth of exposure was generally similar, we still observed regional differences for Butyl benzyl phthalate (BBzP), Di(2-ethylhexyl) phthalate (DEHP), Di-isononyl phthalate (DiNP), and Di-isobutyl phthalate (DiBP) with pronounced decreases over time in Northern and Western Europe, and to a lesser degree in Eastern Europe. Differences between age groups were visible for Di-n-butyl phthalate (DnBP), where children (3 to 5-year olds and 6 to 11-year olds) had lower urinary concentrations than adolescents (12 to 19-year-olds), who in turn had lower urinary concentrations than adults (20 to 39-year-olds). This study is a step towards making internal exposures to phthalates comparable across countries, although standardized data were not available, targeting European data sets harmonized with respect to data formatting and calculation of aggregated data (such as developed within HBM4EU), and highlights further suggestions for improved harmonization in future studies.
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| 32. |
- Vogel, N, et al.
(författare)
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Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative
- 2023
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Ingår i: Toxics. - : MDPI AG. - 2305-6304. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across Europe is challenging. They differ widely in time periods, study samples, degree of geographical coverage, design, analytical methodology, biomarker selection, and analytical quality assurance level. The HBM4EU initiative has gathered existing HBM data of 29 studies from participating countries, covering all European regions and Israel. The data were prepared and aggregated by a harmonized procedure with the aim to describe—as comparably as possible—the EU-wide general population’s internal exposure to phthalates from the years 2005 to 2019. Most data were available from Northern (up to 6 studies and up to 13 time points), Western (11; 19), and Eastern Europe (9; 12), e.g., allowing for the investigation of time patterns. While the bandwidth of exposure was generally similar, we still observed regional differences for Butyl benzyl phthalate (BBzP), Di(2-ethylhexyl) phthalate (DEHP), Di-isononyl phthalate (DiNP), and Di-isobutyl phthalate (DiBP) with pronounced decreases over time in Northern and Western Europe, and to a lesser degree in Eastern Europe. Differences between age groups were visible for Di-n-butyl phthalate (DnBP), where children (3 to 5-year olds and 6 to 11-year olds) had lower urinary concentrations than adolescents (12 to 19-year-olds), who in turn had lower urinary concentrations than adults (20 to 39-year-olds). This study is a step towards making internal exposures to phthalates comparable across countries, although standardized data were not available, targeting European data sets harmonized with respect to data formatting and calculation of aggregated data (such as developed within HBM4EU), and highlights further suggestions for improved harmonization in future studies.
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| 33. |
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