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- Krajangsri, Suppachai, 1955-, et al.
(författare)
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Chemoselective Iridium-catalysed Peterson olefination/Asymmetric Hydrogenation of beta-Hydroxy Silaned
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Herein we report the use of Ir-N,P catalysts for the asymmetric hydrogenation of β-hydroxy silanes via an in-situ generated olefin intermediate. The reaction proceeds via an acid catalysed Peterson olefination reaction and provides hydrogenated products in excellent ee’s of up to 99% accompanied with high isolated yields under mild reaction conditions and short reaction times. Modification of the reaction conditions provides a choice to hydrogenate either an olefin or a β-hydroxy silane in a chemo-selective manner leaving the other functionality unaffected in the product.
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