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- FALKEBORN, M, et al.
(författare)
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Validity of information on gynecological operations in the Swedish in-patient registry
- 1995
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Ingår i: Scandinavian journal of social medicine. - : SAGE Publications. - 0300-8037. ; 23:3, s. 220-224
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Tidskriftsartikel (refereegranskat)abstract
- In order to validate information held at the Swedish Inpatient Registry on oophorectomy and/or hysterectomy procedures, the register codes were compared with data from the medical records in a random sample of 1,338 women. Only 1% of these codes were missing but 5% were erroneous, which in most cases meant that the oophorectomy had been misclassified. The positive predictive value of operation codes was high, ranging from 86 to 100% of the registered events. The actual procedures among women registered with a code for hysterectomy with or without oophorectomy comprised hysterectomy alone in 47% of the women and hysterectomy with a bilateral or unilateral oophorectomy in 30% and 20%, respectively. The reliability of register codes for major gynecological surgical procedures is good, but when the code for hysterectomy is used, medical record data are needed to ascertain the ovarian status. Revised codes are therefore recommended.
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- Falken, Y., et al.
(författare)
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Intravenous ghrelin accelerates postoperative gastric emptying and time to first bowel movement in humans
- 2013
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Ingår i: Neurogastroenterology and Motility. - : Wiley. - 1350-1925 .- 1365-2982. ; 25:6, s. 474-480
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Tidskriftsartikel (refereegranskat)abstract
- Background Ghrelin has been shown to stimulate gastric emptying in healthy humans and patients with delayed gastric emptying. The aim of this study is to assess the effect of ghrelin on gastric emptying on day 2 after open colorectal surgery. Methods Twenty-four patients (mean age 69.2 +/- 1.4, BMI 25.8 +/- 0.8kgm2) were randomized to saline or ghrelin infusion (15pmolkg1min1) during 3h before and on day 2 after open colorectal surgery. Of these, 20 were assessed both before and after surgery. At start of infusion, a liquid meal (480kcal, 200mL) was administered together with 1.5g acetaminophen. Plasma was obtained at regular intervals together with visual analogue scales for hunger, satiety and nausea. Acetaminophen was analyzed as a marker of gastric emptying. Plasma glucose, insulin, acyl-ghrelin, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinoptrophic peptide (GIP), pancreatic polypeptide and peptide YY (PYY) were analyzed. Key Results Gastric emptying was faster during ghrelin infusion compared to saline before and after surgery (P<0.02). In addition, plasma glucose was increased (P<0.05). With ghrelin infusion, plasma insulin was unchanged except for lower values postoperatively (P<0.05). Ghrelin did not alter plasma concentrations of gut peptides. After surgery, ghrelin shortened the time to first bowel movement compared to saline (2.1 +/- 0.3 vs 3.5 +/- 0.4days, P=0.02). Conclusions & Inferences A 3-h ghrelin infusion increased the gastric emptying rate and hastened the time to first bowel movement after surgery. Ghrelin/ghrelin receptor agonists have a therapeutic potential in postoperative ileus; Karolinska Clinical Trial Registry nr CT20110084.
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- Kressner, U, et al.
(författare)
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Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer
- 1998
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Ingår i: BRITISH JOURNAL OF CANCER. - : CHURCHILL LIVINGSTONE. - 0007-0920. ; 77:11, s. 1848-1851
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Tidskriftsartikel (refereegranskat)abstract
- Serum p53 antibody levels were analysed using an enzyme-linked immunosorbent assay in serum samples obtained before surgery from 184 consecutive patients with primary colorectal cancer. Possible associations with tumour stage and tumour differentiation an
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- Kressner, U, et al.
(författare)
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Intraoperative colonic lavage and primary anastomosis--an alternative to Hartmann procedure in emergency surgery of the left colon.
- 1994
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Ingår i: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 160:5, s. 287-92
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess whether intraoperative lavage and primary resection with anastomosis is a safe alternative to a Hartmann procedure in emergency surgery of the left colon.DESIGN: Retrospective study.SETTING: University hospital.MATERIAL: 101 consecutive patients (39 emergency and 62 elective) who underwent a left-sided colonic resection during a 3-year-period.INTERVENTIONS: 17 of the emergency procedures comprised an intraoperative lavage followed by resection and primary anastomosis without faecal diversion; 17 were Hartmann procedures and 5 patients had primary resection without lavage.MAIN OUTCOME MEASURES: Postoperative mortality, morbidity and duration of hospital stay in these two groups compared with these after a contemporary series of elective resections.RESULTS: There were no postoperative deaths and no clinical anastomotic leaks in the lavage group. The duration of hospital stay (median 11 days) was similar in both groups (overall and sigmoid resection respectively). In the Hartmann group, there were two deaths and the postoperative stay in hospital was significantly longer.CONCLUSIONS: Primary resection with intraoperative lavage can be done successfully in patients with acute obstruction of the left colon and the duration of hospital stay and morbidity are similar to those seen in patients operated on electively.
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- Kressner, U, et al.
(författare)
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Stromal tenascin distribution as a prognostic marker in colorectal cancer
- 1997
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Ingår i: BRITISH JOURNAL OF CANCER. - : CHURCHILL LIVINGSTONE. - 0007-0920. ; 76:4, s. 526-530
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Tidskriftsartikel (refereegranskat)abstract
- A total of 169 colorectal adenocarcinomas, obtained from patients with a median follow-up of 6.5 years, were studied with immunohistochemical staining on cryosections using a monoclonal anti-tenascin antibody to evaluate the possible association between t
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- Lindmark, G, et al.
(författare)
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Limited clinical significance of the serum tumour marker CA 72-4 in colorectal cancer
- 1996
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Ingår i: ANTICANCER RESEARCH. - : INT INST ANTICANCER RESEARCH. - 0250-7005. ; 16:2, s. 895-898
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Tidskriftsartikel (refereegranskat)abstract
- Background: We explored the potential value of CA 72-4 in the staging and prognostic prediction of colorectal cancer, as compared to six previously investigated serum tumour markers - CEA, Ca 19-9, CA 50, CA 242, TPA, and TPS. Materials and Methods: CA 72
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