| 1. |
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| 2. |
- Porcu, E, et al.
(författare)
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Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3300-
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and multiple gene expression traits as exposures, simultaneously. Applied to 43 human phenotypes, it uncovers 3,913 putatively causal gene–trait associations, 36% of which have no genome-wide significant SNP nearby in previous GWAS. Using independent association summary statistics, we find that the majority of these loci were missed by GWAS due to power issues. Noteworthy among these links is educational attainment-associated BSCL2, known to carry mutations leading to a Mendelian form of encephalopathy. We also find pleiotropic causal effects suggestive of mechanistic connections. TWMR better accounts for pleiotropy and has the potential to identify biological mechanisms underlying complex traits.
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| 3. |
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| 4. |
- Carter, J. A., et al.
(författare)
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Ground-based and additional science support for SMILE
- 2024
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Ingår i: Earth and Planetary Physics. - : Science Press. - 2096-3955. ; 8:1, s. 275-298
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Tidskriftsartikel (refereegranskat)abstract
- The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions, and simultaneously monitor the auroral response of the Northern Hemisphere ionosphere. Combining these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE mission. Here, we describe current community efforts to prepare for SMILE, and the benefits and context various experiments that have explicitly expressed support for SMILE can offer. A dedicated group of international scientists representing many different experiment types and geographical locations, the Ground-based and Additional Science Working Group, is facilitating these efforts. Preparations include constructing an online SMILE Data Fusion Facility, the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar, and the consideration of particular observing strategies and spacecraft conjunctions. We anticipate growing interest and community engagement with the SMILE mission, and we welcome novel ideas and insights from the solar-terrestrial community.
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| 5. |
- Nakamura, R., et al.
(författare)
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Flow bouncing and electron injection observed by Cluster
- 2013
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Ingår i: Journal of Geophysical Research-Space Physics. - : American Geophysical Union (AGU). - 2169-9380. ; 118:5, s. 2055-2072
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Tidskriftsartikel (refereegranskat)abstract
- Characteristics of particles and fields in the flow-bouncing region are studied based on multipoint observations from Cluster located at 13-15R(E) downtail during a substorm event around 12:50 UT on 7 September 2007. The Cluster spacecraft were separated by a distance of up to 10,000 km and allowed to determine the mesoscale evolution of the current sheet as well as the development of the dipolarization front. We show that the flow bouncing took place associated with a tailward-directed j x B force in a disturbed current sheet in addition to an enhanced tailward pressure gradient force. Multiple Earthward propagating dipolarization fronts accompanied by enhanced flux of energetic electrons were observed before the flow bouncing. The sequence of events started with a localized dipolarization front and ended with a large scale (>10R(E)) dipolarization front accompanied by a major increase in energetic electrons at all spacecraft and immediately followed by flow bouncing. Multiple dipolarization fronts result in the formation of compressed magnetic field with a plasma bulge bounded by thin ion-scale current layers, a favorable condition for flow bouncing. These observations suggest that to understand the flow bouncing and related acceleration of plasma in the near-Earth tail, both the large-scale MHD properties and the transient and small-scale effect of the plasma interaction with the Earth-dipole field need to be taken into account.
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| 6. |
- Branduardi-Raymont, G., et al.
(författare)
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Exploring solar-terrestrial interactions via multiple imaging observers
- 2022
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Ingår i: Experimental astronomy. - : Springer Nature. - 0922-6435 .- 1572-9508. ; 54:2-3, s. 361-390
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Tidskriftsartikel (refereegranskat)abstract
- How does solar wind energy flow through the Earth's magnetosphere, how is it converted and distributed? is the question we want to address. We need to understand how geomagnetic storms and substorms start and grow, not just as a matter of scientific curiosity, but to address a clear and pressing practical problem: space weather, which can influence the performance and reliability of our technological systems, in space and on the ground, and can endanger human life and health. Much knowledge has already been acquired over the past decades, particularly by making use of multiple spacecraft measuring conditions in situ, but the infant stage of space weather forecasting demonstrates that we still have a vast amount of learning to do. A novel global approach is now being taken by a number of space imaging missions which are under development and the first tantalising results of their exploration will be available in the next decade. In this White Paper, submitted to ESA in response to the Voyage 2050 Call, we propose the next step in the quest for a complete understanding of how the Sun controls the Earth's plasma environment: a tomographic imaging approach comprising two spacecraft in highly inclined polar orbits, enabling global imaging of magnetopause and cusps in soft X-rays, of auroral regions in FUV, of plasmasphere and ring current in EUV and ENA (Energetic Neutral Atoms), alongside in situ measurements. Such a mission, encompassing the variety of physical processes determining the conditions of geospace, will be crucial on the way to achieving scientific closure on the question of solar-terrestrial interactions.
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| 7. |
- Grigorenko, E. E., et al.
(författare)
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Intense Current Structures Observed at Electron Kinetic Scales in the Near-Earth Magnetotail During Dipolarization and Substorm Current Wedge Formation
- 2018
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 45:2, s. 602-611
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Tidskriftsartikel (refereegranskat)abstract
- We use data from the 2013-2014 Cluster Inner Magnetosphere Campaign, with its uniquely small spacecraft separations (less than or equal to electron inertia length, lambda(e)), to study multiscale magnetic structures in 14 substorm-related prolonged dipolarizations in the near-Earth magnetotail. Three time scales of dipolarization are identified: (i) a prolonged growth of the B-Z component with duration <= 20 min; (ii) B-Z pulses with durations <= 1 min during the B-Z growth; and (iii) strong magnetic field gradients with durations <= 2 s during the dipolarization growth. The values of these gradients observed at electron scales are several dozen times larger than the corresponding values of magnetic gradients simultaneously detected at ion scales. These nonlinear features in magnetic field gradients denote the formation of intense and localized (approximately a few lambda(e)) current structures during the dipolarization and substorm current wedge formation. These observations highlight the importance of electron scale processes in the formation of a 3-D substorm current system.
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| 8. |
- Andersson, M., et al.
(författare)
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A New Class of Labile Surfactants that Break Down to Non-surface Active Products upon Heating or after a Pre-set Time, without the Need for a pH Change
- 2007
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Ingår i: Tenside Surfactants Detergents. - : Walter de Gruyter GmbH. - 0932-3414 .- 2195-8564. ; 44:6, s. 366-372
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Tidskriftsartikel (refereegranskat)abstract
- A new class of labile surfactants that break down at a controllable rate without the need for a change in pH will be presented. The invention has been patented by YKI Institute for Surface Chemistry, and is based on use of β-keto acids or their salts as surface-active compounds. These surfactants spontaneously break down through decarboxylation, to form an oil-like ketone and CO 2/HCO 3 -/CO 32 - depending on pH. The rate of breakdown can be controlled within a wide range by temperature or by certain additives, but, unlike most cleavable surfactants, a change in pH is not needed. Furthermore the surfactants can be conveniently activated from a stabile precursor just before use, and one (of many possible) precursors of this kind is already available on the industrial scale in the form of a wellknown chemical that is FDA-approved in other, non-surfactant, applications. The compound in question, alkyl ketene dimer (AKD), is produced in large scale by a number of large chemical producers today, and used for hydrophobization of paper. The present article gives an overview of the surfactant chemistry, with focus on recent studies of the kinetics of activation of the surfactant precursor and breakdown kinetics of the labile surfactant at different conditions. Furthermore, possible industrial applications of the surfactant will be discussed, with one example taken from a recent feasibility study performed within the car washing area. © Carl Hanser Publisher.
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| 9. |
- Kronberg, E. A., et al.
(författare)
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Comparing and contrasting dispersionless injections at geosynchronous orbit during a substorm event
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 122:3, s. 3055-3072
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Tidskriftsartikel (refereegranskat)abstract
- Particle injections in the magnetosphere transport electrons and ions from the magnetotail to the radiation belts. Here we consider generation mechanisms of dispersionless injections, namely, those with simultaneous increase of the particle flux over a wide energy range. In this study we take advantage of multisatellite observations which simultaneously monitor Earth's magnetospheric dynamics from the tail toward the radiation belts during a substorm event. Dispersionless injections are associated with instabilities in the plasma sheet during the growth phase of the substorm, with a dipolarization front at the onset and with magnetic flux pileup during the expansion phase. They show different spatial spread and propagation characteristics. Injection associated with the dipolarization front is the most penetrating. At geosynchronous orbit (6.6R(E)), the electron distributions do not have a classic power law fit but instead a bump on tail centered on similar to 120keV during dispersionless electron injections. However, electron distributions of injections associated with magnetic flux pileup in the magnetotail (13R(E)) do not show such a signature. We surmise that an additional resonant acceleration occurs in between these locations. We relate the acceleration mechanism to the electron drift resonance with ultralow frequency waves localized in the inner magnetosphere.
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| 10. |
- Fu, H. S., et al.
(författare)
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Pitch angle distribution of suprathermal electrons behind dipolarization fronts : A statistical overview
- 2012
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Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 117:12
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Tidskriftsartikel (refereegranskat)abstract
- We examine the pitch angle distribution (PAD) of suprathermal electrons (> 40 keV) inside the flux pileup regions (FPRs) that are located behind the dipolarization fronts (DFs), in order to better understand the particle energization mechanisms operating therein. The 303 earthward-propagating DFs observed during 9 years (2001-2009) by Cluster 1 have been analyzed and divided into two groups according to the differential fluxes of the > 40 keV electrons inside the FPR. One group, characterized by the low flux (F < 500/cm(2) , s . sr . keV), consists of 153 events and corresponds to a broad distribution of IMF Bz components. The other group, characterized by the high flux (F >= 500/cm(2) . s . sr . keV), consists of 150 events and corresponds to southward IMF Bz components. Only the high-flux group is considered to investigate the PAD of the > 40 keV electrons as the low-flux situation may lead to large uncertainties in computing the anisotropy factor that is defined as A = F-perpendicular to/F-parallel to - 1 for F-perpendicular to > F-parallel to, and A = -F-parallel to/F-perpendicular to + 1 for F-perpendicular to < F-parallel to. We find that, among the 150 events, 46 events have isotropic distribution (vertical bar A vertical bar <= 0.5); 60 events have perpendicular distribution (A > 0.5), and 44 events have field-aligned distribution inside the FPR (A < -0.5). The perpendicular distribution appears mainly inside the growing FPR, where the flow velocity is increasing and the local flux tube is compressed. The field-aligned distribution occurs mainly inside the decaying FPR, where the flow velocity is decreasing and the local flux tube is expanding. Inside the steady FPR, we observed primarily the isotropic distribution of suprathermal electrons. This statistical result confirms the previous case study and gives an overview of the PAD of suprathermal electrons behind DFs.
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| 11. |
- Li, Kun, et al.
(författare)
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Estimating the Kinetic Energy Budget of the Polar Wind Outflow
- 2018
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 123:9, s. 7917-7929
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Tidskriftsartikel (refereegranskat)abstract
- Ionospheric outflow from the polar cap through the polar wind plays an important role in the evolution of the atmosphere and magnetospheric dynamics. Both solar illumination and solar wind energy input are known to be energy sources of the polar wind. However, observational studies of the energy transfer from these two energy sources to the polar wind are difficult. Because of their low energy, polar wind ions are invisible to regular ion detectors onboard a positively charged spacecraft. Using a new technique that indirectly measures these low-energy ions, we are able to estimate the energy budget of the polar wind. Our results show that solar illumination provides about 10(7) W of the kinetic energy of the polar wind, in addition to the energy transferred from the solar wind with a maximum rate of about 10(8) W. The energy transfer efficiency of solar illumination to the kinetic energy of the polar wind is about 6 to 7 orders of magnitude lower than that of the solar wind. Moreover, daily and seasonal changes in the orientation of the geomagnetic dipole axis control solar illumination over the polar cap, modulating both energies of the polar wind and energy transfer efficiencies from the two energy sources.
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| 12. |
- Li, K., et al.
(författare)
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On the ionospheric source region of cold ion outflow
- 2012
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 39, s. L18102-
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have shown that low energy ions constitute a significant part of the total ion population in the Earth's magnetosphere. In this study, we have used a comprehensive data set with measurements of cold (total energy less than 70 eV) ion velocity and density to determine their source. This data set is derived from Cluster satellite measurements combined with solar wind and interplanetary magnetic field measurements and geomagnetic indices. By using the guiding center equation of motion, we were able to calculate the trajectories and thus determine the source region of the cold ions. Our results show that the polar cap region is the primary source for cold ions. We also found that the expansion and contraction of the polar cap as a consequence of changes in solar wind parameters were correlated with the source region size and intensity of the cold ion outflow. Elevated outflow fluxes near the nightside auroral zone and the dayside cusps during disturbed conditions suggest that energy and particle precipitation from the magnetosphere or directly from the solar wind can enhance the outflow of cold ions from the ionosphere. Citation: Li, K., et al. (2012), On the ionospheric source region of cold ion outflow, Geophys. Res. Lett., 39, L18102, doi:10.1029/2012GL053297.
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| 13. |
- Retino, A., et al.
(författare)
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Cluster observations of energetic electrons and electromagnetic fields within a reconnecting thin current sheet in the Earth's magnetotail
- 2008
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 113:A12
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Tidskriftsartikel (refereegranskat)abstract
- We study the acceleration of energetic electrons during magnetotail reconnection by using Cluster simultaneous measurements of three-dimensional electron distribution functions, electric and magnetic fields, and waves in a thin current sheet. We present observations of two consecutive current sheet crossings where the flux of electrons 35 127 keV peaks within an interval of tailward flows. The first crossing shows the signatures of a tailward moving flux rope. The observed magnetic field and density indicate that the flux rope was very dynamic, and a comparison with numerical simulation suggests a crossing right after coalescence of smaller flux ropes. The second crossing occurs within the ion diffusion region. The flux of electrons is largest within the flux rope where they are mainly directed perpendicular to the magnetic field. At the magnetic separatrices, the fluxes are smaller, but the energy spectra are harder and electrons are mainly field aligned. Reconnection electric fields E-Y similar to 7 mV/m are observed within the diffusion region, whereas in the flux rope, EY are much smaller. Waves around lower hybrid frequency do not show a clear correlation with energetic electrons. We interpret the field-aligned electrons at the separatrices as directly accelerated by the reconnection electric field in the diffusion region, whereas we interpret the perpendicular electrons as trapped within the flux rope and accelerated by a combination of betatron acceleration with nonadiabatic pitch-angle scattering. Our observations indicate that thin current sheets during dynamic reconnection are important for in situ production of energetic electrons and that simultaneous measurements of electrons and electromagnetic fields within thin sheets are crucial to understand the acceleration mechanisms.
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| 14. |
- Vaivads, Andris, et al.
(författare)
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Cluster Observations of Energetic Electron Acceleration Within Earthward Reconnection Jet and Associated Magnetic Flux Rope
- 2021
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 126:8
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Tidskriftsartikel (refereegranskat)abstract
- We study acceleration of energetic electrons in an earthward plasma jet due to magnetic reconnection in the Earth magnetotail for one case observed by Cluster. The case has been selected based on the presence of high fluxes of energetic electrons, Cluster being in the burst mode and Cluster separation being around 1,000 km that is optimal for studies of ion scale physics. We show that two characteristic acceleration mechanisms are operating during this event. First, significant acceleration is achieved inside the magnetic flux pile-up of the jet, the acceleration mechanism being consistent with betatron acceleration. Second, strong energetic electron acceleration occurs in magnetic flux rope like structure forming in front of the magnetic flux pile-up region. Energetic electrons inside the magnetic flux rope are accelerated predominantly in the field-aligned direction and the acceleration can be due to Fermi acceleration in a contracting flux rope.
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| 15. |
- Yamauchi, M., et al.
(författare)
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Magnetospheric solitary structure maintained by 3000 km/s ions as a cause of westward moving auroral bulge at 19 MLT
- 2009
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 27:7, s. 2947-2969
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Tidskriftsartikel (refereegranskat)abstract
- In the evening equatorial magnetosphere at about 4 R-E geocentric distance and 19 MLT, the four Cluster spacecraft observed a solitary structure with a width of about 1000 similar to 2000 km in the propagation direction. The solitary structure propagates sunward with about 5 similar to 10 km/s carrying sunward electric field (in the propagation direction) of up to about 10 mV/m (total potential drop of about 5 similar to 10 kV), depletion of magnetic field of about 25%, and a duskward E x B convection up to 50 km/s of He+ rich cold plasma without O+. At the same time, auroral images from the IMAGE satellite together with ground based geomagnetic field data showed a westward (sunward at this location) propagating auroral bulge at the magnetically conjugate ionosphere with the solitary structure. The solitary structure is maintained by flux enhancement of selectively 3000 km/s ions (about 50 keV for H+, 200 keV for He+, and 750 keV for O+). These ions are the main carrier of the diamagnetic current causing the magnetic depletion, whereas the polarization is maintained by different behavior of energetic ions and electrons. Corresponding to aurora, field-aligned accelerated ionospheric plasma of several keV appeared at Cluster from both hemispheres simultaneously. Together with good correspondence in location and propagation velocity between the auroral bulge and the solitary structure, this indicates that the sunward moving auroral bulge is caused by the sunward propagation of the solitary structure which is maintained by energetic ions. The solitary structure might also be the cause of Pi2-like magnetic variation that started simultaneously at Cluster location.
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| 16. |
- Li, Kun, et al.
(författare)
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Cold Ion Outflow Modulated by the Solar Wind Energy Input and Tilt of the Geomagnetic Dipole
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 122:10, s. 10658-10668
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Tidskriftsartikel (refereegranskat)abstract
- The solar wind energy input into the Earth's magnetosphere-ionosphere system drives ionospheric outflow, which plays an important role in both the magnetospheric dynamics and evolution of the atmosphere. However, little is known about the cold ion outflow with energies lower than a few tens of eV, as the direct measurement of cold ions is difficult because a spacecraft gains a positive electric charge due to the photoemission effect, which prevents cold ions from reaching the onboard detectors. A recent breakthrough in the measurement technique using Cluster spacecraft revealed that cold ions dominate the ion population in the magnetosphere. This new technique yields a comprehensive data set containing measurements of the velocities and densities of cold ions for the years 2001-2010. In this paper, this data set is used to analyze the cold ion outflow from the ionosphere. We found that about 0.1% of the solar wind energy input is transformed to the kinetic energy of cold ion outflow at the topside ionosphere. We also found that the geomagnetic dipole tilt can significantly affect the density of cold ion outflow, modulating the outflow rate of cold ion kinetic energy. These results give us clues to study the evolution of ionospheric outflow with changing global magnetic field and solar wind condition in the history.
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| 17. |
- Li, Kun, et al.
(författare)
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Transport of cold ions from the polar ionosphere to the plasma sheet
- 2013
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Ingår i: Journal of Geophysical Research: Space Physics. - : American Geophysical Union (AGU). - 2169-9380. ; 118:9, s. 5467-5477
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Tidskriftsartikel (refereegranskat)abstract
- Ionospheric outflow is believed to be a significant contribution to the magnetospheric plasma population. Ions are extracted from the ionosphere and transported downtail by the large-scale convection motion driven by dayside reconnection. In this paper, we use a comprehensive data set of cold ion (total energy less than 70 eV) measurements combined with simultaneous observations from the solar wind to investigate the fate of these ions. By tracing the trajectories of the ions, we are able to find out where in the magnetotail ions end up. By sorting the observation according to geomagnetic activity and solar wind parameters, we then generate maps of the fate regions in the magnetotail and investigate the effects of these drivers. Our results suggest that, on overall, for about 85% of the cases, the outflowing ions are transported to the plasma sheet. The region where the ions are deposited into the plasma sheet is larger during geomagnetic quiet time than during disturbed conditions. A persistent dawn-dusk asymmetry in the plasma sheet deposition is also observed.
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| 18. |
- Wang, Rongsheng, et al.
(författare)
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Observation of multiple sub-cavities adjacent to single separatrix
- 2013
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 40:11, s. 2511-2517
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Tidskriftsartikel (refereegranskat)abstract
- We investigate a direct south-north crossing of a reconnection ion diffusion region in the magnetotail. During this crossing, multiple electron density dips with a further density decrease within the cavity, called sub-cavities, adjacent to the northern separatrix are observed. The correlation between electron density sub-cavities and strong electric field fluctuations is obvious. Within one of the sub-cavities, a series of very strong oscillating perpendicular electric field and patchy parallel electric field are observed. The parallel electric field is nearly unipolar and directs away from X line. In the same region, inflow electrons with energy up to 100keV are injected into the X line. Based on the observations, we conclude that the high-energy inflowing electrons are accelerated by the patchy parallel electric field. Namely, electrons have been effectively accelerated while they are flowing into the X line along the separatrix. The observations indicate that the electron acceleration region is widely larger than the predicted electron diffusion region in the classical Hall magnetic reconnection model.
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