| 1. |
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| 2. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 3. |
- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 4. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
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| 6. |
- Caronna, Edoardo, et al.
(författare)
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Redefining migraine prevention: early treatment with anti-CGRP monoclonal antibodies enhances response in the real world
- 2024
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Ingår i: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. - 0022-3050 .- 1468-330X.
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Tidskriftsartikel (refereegranskat)abstract
- Background Anti-CGRP monoclonal antibodies (anti-CGRP MAbs) are approved and available treatments for migraine prevention. Patients do not respond alike and many countries have reimbursement policies, which hinder treatments to those who might respond. This study aimed to investigate clinical factors associated with good and excellent response to anti-CGRP MAbs at 6 months. Methods European multicentre, prospective, real-world study, including high-frequency episodic or chronic migraine (CM) patients treated since March 2018 with anti-CGRP MAbs. We defined good and excellent responses as >= 50% and >= 75% reduction in monthly headache days (MHD) at 6 months, respectively. Generalised mixed-effect regression models (GLMMs) were used to identify variables independently associated with treatment response. Results Of the 5818 included patients, 82.3% were females and the median age was 48.0 (40.0-55.0) years. At baseline, the median of MHD was 20.0 (14.0-28.0) days/months and 72.2% had a diagnosis of CM. At 6 months (n=4963), 56.5% (2804/4963) were good responders and 26.7% (1324/4963) were excellent responders. In the GLMM model, older age (1.08 (95% CI 1.02 to 1.15), p=0.016), the presence of unilateral pain (1.39 (95% CI 1.21 to 1.60), p<0.001), the absence of depression (0.840 (95% CI 0.731 to 0.966), p=0.014), less monthly migraine days (0.923 (95% CI 0.862 to 0.989), p=0.023) and lower Migraine Disability Assessment at baseline (0.874 (95% CI 0.819 to 0.932), p<0.001) were predictors of good response (AUC of 0.648 (95% CI 0.616 to 0.680)). These variables were also significant predictors of excellent response (AUC of 0.691 (95% CI 0.651 to 0.731)). Sex was not significant in the GLMM models. Conclusions This is the largest real-world study of migraine patients treated with anti-CGRP MAbs. It provides evidence that higher migraine frequency and greater disability at baseline reduce the likelihood of responding to anti-CGRP MAbs, informing physicians and policy-makers on the need for an earlier treatment in order to offer the best chance of treatment success.
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| 7. |
- Colins, Olivier F., et al.
(författare)
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The Prognostic Usefulness of Multiple Specifiers for Subtyping Conduct Problems in Early Childhood
- 2024
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Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier. - 0890-8567 .- 1527-5418. ; 63:4, s. 443-453
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To better describe and treat children with conduct problems (CP), grandiose-manipulative and daring-impulsive traits are proposed for subtyping CP, instead of using only a callous-unemotional specifier. However, the acclaimed benefits of having multiple specifiers for CP remain largely untested and therefore highly speculative. To fill this gap, this study tested longitudinal relations between these 3 specifiers and developmental outcomes in childhood and adolescence, independent of early childhood CP.METHOD: Longitudinal data from 2 community studies were used. Teacher ratings were used to measure CP and the specifiers in 3- to 5-year-olds from Sweden (n = 2,064) and Spain (n = 2,055). Developmental outcomes were assessed by multiple informants (ie, teachers, parents, and children) 1 to 8 years later. RESULTS: Early childhood CP were predictive of all outcomes. Callous-unemotional traits predicted low levels of social competence and prosocial behavior, independent of CP (and age, gender, and socioeconomic status). Grandiose-manipulative and daring-impulsive traits were predictive of aggression and violent delinquency, respectively, independent of CP, but also of higher levels of prosocial behavior or social competence.CONCLUSION: The 3 specifiers are predictive of different outcomes, independent of CP, which is thought to form the basis for developing specifiers for CP. Findings tentatively challenge the centrality of callous-unemotional traits for subtyping CP, but it is premature to conclude that grandiose-manipulative and daring-impulsive specifiers are needed in future revisions of DSM and ICD. Efforts to systematically evaluate the utility of these specifiers should be welcomed to inform ongoing debates on this matter.
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| 8. |
- Colins, Olivier F., et al.
(författare)
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The Prognostic Usefulness of Multiple Specifiers for Subtyping Conduct Problems in Early Childhood
- 2023
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Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier. - 0890-8567 .- 1527-5418. ; 62:10S, s. S160-S161
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: Better descriptions and treatment of children with conduct problems (CP) grandiose-manipulative (GM) and daring-impulsive (DI) traits are proposed for subtyping CP, instead of only using a callous-unemotional (CU) specifier. Unfortunately, the acclaimed benefits of having multiple specifiers for CP remain largely untested and, therefore, highly speculative. To fill this gap, we tested longitudinal relations between these 3 specifiers and developmental outcomes in childhood and adolescence, independent of early childhood CP.Methods: We relied on longitudinal data from 2 community studies. Teacher-ratings were used to measure CP and the specifiers in 3- to 5-year-olds from Sweden (N = 2064) and Spain (N = 2055). Developmental outcomes were assessed by multiple informants (ie, teachers, parents, and children) 1 to 8 years later.Results: Early childhood CP were predictive of all outcomes. CU traits predicted low levels of social competence and prosocial behavior, independent of CP (and age, gender, and socioeconomic status). GM and DI traits were predictive of aggression and violent delinquency, respectively, independent of CP, but also of higher levels of prosocial behavior or social competence.Conclusions: The 3 specifiers are predictive of different outcomes, independent of CP, which is thought to form the basis for developing specifiers for CP. Findings tentatively challenge the centrality of CU traits for subtyping CP, but it is premature to conclude that GM and DI specifiers are needed in future revisions of the DSM and ICD. Efforts to systematically evaluate the utility of these specifiers should be welcomed to inform ongoing debates on this matter.
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| 9. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 10. |
- Fanti, Kostas A., et al.
(författare)
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Fearlessness as an Underlying Mechanism Leading to Conduct Problems : Testing the INTERFEAR Model in a Community Sample in Spain
- 2024
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Ingår i: Children. - : MDPI. - 2227-9067. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- Conduct problems (CP) in childhood and adolescence have a significant impact on the individual, family, and community. To improve treatment for CP, there is a need to improve the understanding of the developmental pathways leading to CP in boys and girls. Prior research has linked the child's fearlessness and callous-unemotional (CU) traits, as well as experiences of parental warmth and punitive parenting, to CP. However, few studies have tested the interplay of these factors in contributing to future CP development. The present study aimed to test the InterFear model, which suggests that fearlessness in early childhood leads to CP through an indirect pathway involving low positive parenting, high negative/punitive parenting, and callous-unemotional (CU) traits. The sample included 2467 Spanish children (48.1% girls; Mage = 4.25; SD = 0.91), followed up across a five-year period. Besides a direct association between fearlessness in early childhood and future CP, the results found an indirect pathway whereby fearlessness reduces positive parenting and increases punitive parenting, which contributes to the development of CU traits and sets the stage for CP in later childhood. The specific indirect effect from fearlessness to CP via CU traits accounted for most of the variance, suggesting the existence of a temperamental pathway independent of parental variables. Further, two additional indirect pathways, exclusive of fearlessness, were identified, which started with low parental warmth and positive parenting, leading to CP via CU traits. These findings support the InterFear model, demonstrating multiple pathways to CP with the involvement of fearlessness, parenting practices, and CU traits. This model might play a pivotal role in the development of targeted prevention and intervention strategies for CP.
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| 11. |
- Lopez-Romero, Laura, et al.
(författare)
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Conduct problems in childhood and adolescence : developmental trajectories, predictors and outcomes in a six-year follow up
- 2015
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Ingår i: Child Psychiatry and Human Development. - : Springer Science and Business Media LLC. - 0009-398X .- 1573-3327. ; 46:5, s. 762-773
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Tidskriftsartikel (refereegranskat)abstract
- Understanding youth conduct problems requires examination from a developmental perspective, analyzing distinctive pathways across childhood and adolescence, and identifying early predictors which will lead to specific adolescent outcomes. Bearing this in mind, developmental trajectories of conduct problems were identified from a person-oriented perspective, and using data collected from three waves over a six-year period, in a sample of Spanish children aged 6-11 at the onset of the study. Conduct problems showed five distinctive trajectories which were grouped into three major pathways in further analyses: Stable low, Stable high, and Decreasing. Associations with early personality and psychopathic traits, as well as with a wide range of adolescent behavioral and psychosocial outcomes were examined, revealing the Stable high group as exhibiting the highest risk profile. These results contribute to improving our knowledge about one of the most relevant problems in youth populations, and will help in refining interventions strategies by recognizing the developmental heterogeneity of the construct.
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| 12. |
- López-Romero, Laura, et al.
(författare)
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In Search of Conceptual Clarity About the Structure of Psychopathic Traits in Children : A Network-Based Proposal
- 2024
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Ingår i: Child Psychiatry and Human Development. - : Springer. - 0009-398X .- 1573-3327.
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Tidskriftsartikel (refereegranskat)abstract
- Psychopathic traits in childhood have been revealed as potential identifiers of risk, being predictive of later forms of behavioral maladjustment. Yet, it is still under debate how psychopathic traits in children should be best conceptualized and which are the core dimensions for construct definition and prediction. The present study aims to examine the structure of psychopathic traits in childhood, and its predictive value, by using a combination of traditional factor analysis and more recent network-based methods. Data on psychopathic traits, as measured by the Child Problematic Traits Inventory (CPTI), were collected in a large sample of children (n = 2454; 48.2% girls), aged 3 to 6 at the onset of the study (Mage = 4.26; SD = 0.91), who were followed-up one and two years later using parent- and teacher-reports. Results showed that psychopathic traits measured via CPTI are best conceptualized as five latent factors encompassing grandiosity, deceitfulness, callousness, impulsivity and need of stimulation, a result that converged across informants and time. Callousness and grandiosity emerged as central traits using network analysis of parent-reports, while deceitfulness was most central using teacher-reports. Finally, callousness, impulsivity and deceitfulness emerged as the best predictors of concurrent, prospective and stable conduct problems. These results provide a refined structure of psychopathic traits in children that better accounts for the core elements of the construct. Additional theoretical and practical implications will be discussed in terms of assessment, diagnostic classification and tailored prevention/intervention.
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| 13. |
- Lopez-Romero, Laura, et al.
(författare)
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Proposed Specifiers for Conduct Disorder (PSCD) : Preliminary Validation of the Parent Version in a Spanish Sample of Preschoolers
- 2019
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Ingår i: Psychological Assessment. - : American Psychological Association. - 1040-3590 .- 1939-134X. ; 31:11, s. 1357-1367
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Tidskriftsartikel (refereegranskat)abstract
- The Proposed Specifiers for Conduct Disorder (PSCD) scale (Salekin & Hare, 2016) was developed as a measure of the broader construct of psychopathy in childhood and adolescence. In addition to conduct disorder (CD) symptoms, the PSCD addresses the interpersonal (grandiose-manipulative), affective (callous-unemotional). and lifestyle (daring-impulsive) traits of psychopathic personality. The PSCD can be scored by parents and teachers. The present study is a preliminary test of the psychometric properties of the PSCD-Parent Version in a sample of 2,229 children aged 3 to 6 years. Confirmatory factor analyses supported both a 3- and 4-factor structure being invariant across gender groups. The validity of the PSCD was also supported by convergent-divergent associations with an alternative measure of psychopathic traits as well as by the expected relations with fearlessness, conduct problems, reactive and proactive aggression, attention-deficit hyperactivity disorder and oppositional defiant disorder symptoms, and social competence skills. Overall, the PSCD is a promising alternative measure for assessing early manifestation of the broader construct of psychopathy in children. Its use should facilitate discussion of the conceptualization, assessment, predictive value, and clinical usefulness of the psychopathic construct as it relates to CD at early developmental stages.
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| 14. |
- Lopez-Romero, Laura, 1984-, et al.
(författare)
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Psychometric Properties of the Spanish Version of the Child Problematic Traits Inventory in 3-to 12-Year-Old Spanish Children
- 2019
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Ingår i: European Journal of Psychological Assessment. - : Hogrefe & Huber Publishers. - 1015-5759 .- 2151-2426. ; 35:6, s. 842-854
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to test the reliability and validity of the Spanish teacher-rated Child Problematic Traits Inventory (CPTI) in two community samples of 3- to 12-year-old children. Confirmatory Factor Analysis (CFA) supported the three-factor structure of the CPTI (Grandiose-Deceitful: GD; Callous-Unemotional: CU; Impulsive-Need for Stimulation: INS), being invariant across gender and age groups. The CPTI total and factor scores showed excellent internal consistencies (> .90) in the total group, and across gender and age groups. In support of their criterion validity, the CPTI scores were positively related to psychopathy scores as measured by an alternative teacher-rated measure. In support of their convergent validity, the CPTI scores showed the expected relations to variables that have been linked to psychopathic personality, including fearlessness, conduct problems, aggression, and low prosocial behavior. Overall, these findings suggest that the Spanish teacher-rated version of the CPTI has good psychometric properties and seems to be a promising tool for studying psychopathic traits in children.
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| 15. |
- López-Romero, Laura, et al.
(författare)
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Psychopathic Personality Configurations in Early Childhood : A Response to Dvoskin et al. (2022)
- 2022
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Ingår i: Journal of Personality Disorders. - : Guilford Publications. - 0885-579X .- 1943-2763. ; 36:3, s. 254-263
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Tidskriftsartikel (refereegranskat)abstract
- Dvoskin et al. (2022) offered a cautionary comment on an article published in the Journal of Personality Disorders (López-Romero et al., 2021). This comment was focused on the scientific and policy grounds of our study, and cautioned against the use of the "putative psychopathic personality" label for applied purposes. While we agree with most of their concerns and cautions, we aim to provide additional clarification on the raised concerns, noting that the purpose of our study is purely exploratory, and that its findings are not intended for applied purposes. We do expect that our study and this commentary will further clarify the importance of examining psychopathic personality from a developmental perspective, opening new ways of discussion regarding how to best conceptualize and study a construct that, while waiting for additional longitudinal research, has been shown as relevant in identifying a group of children and adolescents at increased risk for maladjustment.
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| 16. |
- Lopez Romero, Laura, 1984-, et al.
(författare)
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Psychopathic Traits in Early Childhood : Further Multi-informant Validation of the Child Problematic Traits Inventory (CPTI)
- 2019
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Ingår i: Journal of Psychopathology and Behavioral Assessment. - : Springer. - 0882-2689 .- 1573-3505. ; 41:3, s. 366-374
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Tidskriftsartikel (refereegranskat)abstract
- The present study aimed to further test the teacher- and parent-versions of the Child Problematic Traits Inventory (CPTI) in Spain, with a special focus on gender differences. Data were collected in a sample of 2467 preschool children (48.1% girls) aged three to six (mean age = 4.25; SD = 0.91). Results supported the proposed three-factor structure of the CPTI (Grandiose-deceitful, GD; Callous-unemotional, CU; and Impulsive-need of stimulation, INS), being invariant across gender, and with good-to-excellent internal consistency values. CPTI scores showed the expected associations with fearlessness, conduct problems, reactive and proactive aggression, hyperactivity and prosocial behavior, thereby supporting the external validity of the CPTI scores. This pattern of associations also held when cross-informant correlations were explored, although correlation values were lower in magnitude. Some different patterns of correlations were also found across gender groups. Overall, the CPTI reveals as a promising, psychometrically sound measure for assessing psychopathic traits in very young children using both parents' and teachers' reports.
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| 17. |
- López-Romero, Laura, et al.
(författare)
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Studying Configurations of Psychopathic Traits : Exploring the Viability of Psychopathic Personality in Early Childhood
- 2021
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Ingår i: Journal of Personality Disorders. - : Guilford Publications. - 0885-579X .- 1943-2763. ; 35, s. 97-U141
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Tidskriftsartikel (refereegranskat)abstract
- The idea that very young children can manifest a constellation of personality traits that looks like psychopathy has rarely been explored. To fill this void, data from 2,247 children, aged 3-6 years (M = 4.25; SD = 0.91), from the Estudio Longitudinal para una Infancia Saludable (ELISA) were utilized. Parents and teachers completed questionnaires at baseline and at 1-year follow-up. Using three parent-rated psychopathy dimensions as indicators, the authors conducted latent profile analysis and arrived at five latent classes: Control (39.2%), Impulsive-Need for Stimulation (34.8%), Grandiose-Deceitful (16.5%), Callous-Unemotional (6.2%), and Putative Psychopathic Personality (PP, 3.3%). Children in the PP class, overall, engaged in higher levels of concurrent, future, and stable conduct problems and reactive and proactive aggression, and lower levels of prosocial behavior, as rated by parents or teachers. Findings also revealed meaningful differences between the remaining four classes. Person-oriented analyses seem to offer a fruitful avenue to identify 3- to 6-year-olds who exhibit a putative psychopathic personality and are at risk for future maladjustment.
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| 18. |
- López-Romero, Laura, et al.
(författare)
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Testing the predictive and incremental validity of callous-unemotional traits versus the multidimensional psychopathy construct in preschool children
- 2022
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Ingår i: Journal of criminal justice. - : Elsevier. - 0047-2352 .- 1873-6203. ; 80
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to test the predictive and incremental value of psychopathic trait dimensions in early childhood. To this end, a callous-unemotional (CU)-based approach was compared to the multidimensional psychopathic personality approach in predicting future and stable conduct problems (CP) and aggression, whilst controlling for well-established risk factors for child CP. Prospective longitudinal data were collected from a community sample of 2247 children (48.6% girls) aged three to six (Mage = 4.25; SD = 0.91) at the initial assessment. Participants were followed annually for two years, with information provided by parents. Children were assigned to six mutually exclusive groups based on their baseline levels of psychopathic traits and conduct problems. Results showed that, after accounting for sociodemographic variables, temperamental features (e.g., fearlessness), and ADHD symptoms, children scoring high in all psychopathic traits and high in CP were at increased risk to display future and stable CP, reactive and proactive aggression, followed by the group of children high in CU traits and CP. Future research on child psychopathy may benefit from considering the constellation of co-occurring interpersonal, affective and behavioral psychopathic traits, and could inform developmental models aiming to explain heterogeneity in child CP.
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| 19. |
- Maneiro, Lorena, et al.
(författare)
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Pursuing the Dark Triad Psychometric properties of the Spanish Version of the Dirty Dozen
- 2019
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Ingår i: Journal of Individual Differences. - : Hogrefe & Huber Publishers. - 1614-0001 .- 2151-2299. ; 40:1, s. 36-44
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Tidskriftsartikel (refereegranskat)abstract
- The Dirty Dozen scale is a short measure developed to assess the Dark Triad traits, namely Machiavellianism, psychopathy, and narcissism, which has previously shown good psychometric properties. The aim of this study was to validate a Spanish version of the Dirty Dozen through the assessment of its psychometric properties in a sample constituted by 326 young adults aged 18-34 (M = 20.55; SD = 1.89) from Spain. The Spanish version of the Dirty Dozen showed good internal consistency and acceptable test-retest stability. Likewise, the analysis of the factorial structure supported the three-factor solution and showed a best fit for the bifactorial model. The latent factor of the general Dark Triad was associated with low levels of Honesty/Humility, psychopathic traits, impulsivity, and sensation seeking; whereas a differential pattern of associations between the three specific Dark Triad latent factors and the nomological network was found. Furthermore, the Dark Triad traits showed differential relations with reactive and proactive aggression, verifying the external validity of the Spanish version of the Dirty Dozen. Results support the distinctiveness of the Dark Triad traits and justify the Dirty Dozen as an efficient measure for dark personalities in Spanish-speaking contexts.
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| 20. |
- Colins, Olivier F., et al.
(författare)
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A New Measure to Assess Psychopathic Personality in Children : The Child Problematic Traits Inventory
- 2014
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Ingår i: Journal of Psychopathology and Behavioral Assessment. - : Springer. - 0882-2689 .- 1573-3505. ; 36:1, s. 4-21
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the development of psychopathic personality from childhood to adulthood is crucial for understanding the development and stability of severe and long-lasting conduct problems and criminal behavior. This paper describes the development of a new teacher rated instrument to assess psychopathic personality from age three to 12, the Child Problematic Traits Inventory (CPTI). The reliability and validity of the CPTI was tested in a Swedish general population sample of 2,056 3- to 5-year-olds (mean age = 3.86; SD = .86; 53 % boys). The CPTI items loaded distinctively on three theoretically proposed factors: a Grandiose-Deceitful Factor, a Callous-Unemotional factor, and an Impulsive-Need for Stimulation factor. The three CPTI factors showed reliability in internal consistency and external validity, in terms of expected correlations with theoretically relevant constructs (e.g., fearlessness). The interaction between the three CPTI factors was a stronger predictor of concurrent conduct problems than any of the three individual CPTI factors, showing that it is important to assess all three factors of the psychopathic personality construct in early childhood. In conclusion, the CPTI seems to reliably and validly assess a constellation of traits that is similar to psychopathic personality as manifested in adolescence and adulthood.
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| 21. |
- Colins, Olivier F., et al.
(författare)
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Assessing Psychopathic Traits Among Children : The First Validation Study of the Child Problematic Traits Inventory in a Clinical Sample
- 2020
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Ingår i: Assessment. - : Sage Publications. - 1073-1911 .- 1552-3489. ; 27:6, s. 1242-1257
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Tidskriftsartikel (refereegranskat)abstract
- This is the first study that tested the psychometric properties of the Child Problematic Traits Inventory (CPTI) in clinic-referred children (ages 6-13 years). Teachers ( N = 159) and parents ( N = 173) completed the CPTI and various other measures. Confirmatory factor analyses supported the CPTI's three-factor structure when teachers and parents rated the 28 CPTI items. Teacher- and parent-reported CPTI scores showed the expected relations with external correlates (e.g., conduct problems and proactive aggression). Crucially, the validity of the CPTI scores was also supported across informants (i.e., when linking teacher-reported CPTI scores to parent-reported external correlates, and vice versa) and across methods (i.e., regardless if a questionnaire or a diagnostic interview was used to measure external correlates). We conclude that the CPTI holds promise as a research tool for assessing psychopathic traits in clinic-referred children. Until our findings have been replicated and extended, the CPTI should not be used for clinical decision making.
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| 22. |
- del Mar Gallego-Matellan, Maria, et al.
(författare)
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Socioemotional development in children with callous-unemotional traits : A case study of a multimodal intervention
- 2019
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Ingår i: Revista de Psicología Clínica con Niños y Adolescentes. - : Universidad Miguel Hernández, Departamento de Psicología de la Salud. - 2340-8340. ; 6:1, s. 57-63
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Tidskriftsartikel (refereegranskat)abstract
- A subgroup of children with conduct disorder (CD) has callous unemotional traits (CU, e.g., lack of empathy, caring behaviours and remorse), which predicts a negative evolution of this disorder. Responses to empirically supported interventions are very low in children with CD and CU traits. This case study presents an individualized intervention with an 11-year-old child who shows a stable and aggressive pattern of disruptive behaviour (CD and attention-deficit/hyperactivity disorder) and severe CU traits. The goals of the intervention focused on both emotion recognition and parent training. The results of the treatment presented in this case study show advances in socioemotional development along with a decrease of problematic conduct, which improve the child's ability to adapt to his environment. The need of personalizing and adjusting treatments aimed at modifying problematic conduct in children with CU is discussed to shed light on future approaches to clinical intervention
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| 23. |
- Hellfeldt, Karin, 1985-, et al.
(författare)
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Cyberbullying and Psychological Well-being in Young Adolescence : The Potential Protective Mediation Effects of Social Support from Family, Friends, and Teachers
- 2019
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- In the current study, we tested the relations between cyberbullying roles and several psychological well-being outcomes, as well as the potential mediation effect of perceived social support from family, friends, and teachers in school. This was investigated in a cross-sectional sample of 1707 young adolescents (47.5% girls, aged 10-13 years, self-reporting via a web questionnaire) attending community and private schools in a mid-sized municipality in Sweden. We concluded from our results that the Cyberbully-victim group has the highest levels of depressive symptoms, and the lowest of subjective well-being and family support. We also observed higher levels of anxiety symptoms in both the Cyber-victims and the Cyberbully-victims. Moreover, we conclude that some types of social support seem protective in the way that it mediates the relationship between cyberbullying and psychological well-being. More specifically, perceived social support from family and from teachers reduce the probability of depressive and anxiety symptoms, and higher levels of social support from the family increase the probability of higher levels of subjective well-being among youths being a victim of cyberbullying (i.e., cyber-victim) and being both a perpetrator and a victim of cyber bullying (i.e., cyberbully-victim). Potential implications for prevention strategies are discussed.
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| 24. |
- Insausti, Ricardo, et al.
(författare)
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Ex vivo, in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies
- 2023
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Ingår i: Frontiers in Neuroanatomy. - : Frontiers Media SA. - 1662-5129. ; 17
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Tidskriftsartikel (refereegranskat)abstract
- We present a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used to perfuse the body with 10% formalin, to allow further use of the body for anatomical research or teaching. The aim of our method is to develop a vascular fixation protocol for the human brain, by adapting protocols that are commonly used in experimental animal studies. We show that a variety of histological procedures can be carried out (cyto- and myeloarchitectonics, histochemistry, immunohistochemistry, intracellular cell injection, and electron microscopy). In addition, ex vivo, ex situ high-resolution MRI (9.4T) can be obtained in the same specimens. This procedure resulted in similar morphological features to those obtained by intravascular perfusion in experimental animals, provided that the postmortem interval was under 10 h for several of the techniques used and under 4 h in the case of intracellular injections and electron microscopy. The use of intravascular fixation of the brain inside the skull provides a fixed whole human brain, perfectly fitted to the skull, with negligible deformation compared to conventional techniques. Given this characteristic of ex vivo, in situ fixation, this procedure can probably be considered the most suitable one available for ex vivo MRI scans of the brain. We describe the compatibility of the method proposed for intravascular fixation of the human brain and fixation of the donor’s body for anatomical purposes. Thus, body donor programs can provide human brain tissue, while the remainder of the body can also be fixed for anatomical studies. Therefore, this method of human brain fixation through the carotid system optimizes the procurement of human brain tissue, allowing a greater understanding of human neurological diseases, while benefiting anatomy departments by making the remainder of the body available for teaching purposes.
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| 25. |
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| 26. |
- Menkveld, Albert J., et al.
(författare)
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Nonstandard Errors
- 2024
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Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
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Tidskriftsartikel (refereegranskat)abstract
- In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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| 27. |
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| 28. |
- Roh, Hyung S., et al.
(författare)
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Integrating Color Deconvolution Thresholding and Weakly Supervised Learning for Automated Segmentation of Neurofibrillary Tangle and Neuropil Threads
- 2023
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Ingår i: Medical Imaging 2023 : Digital and Computational Pathology - Digital and Computational Pathology. - 1605-7422. - 9781510660472 ; 12471
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Konferensbidrag (refereegranskat)abstract
- Abnormally phosphorylated tau proteins are known to be a major indicator of Alzheimer's Disease (AD) with strong association with memory loss and cognitive decline. Automated generation of pixel-wise accurate neurofibrillary tangles (NFTs) and neuropil threads (NTs) segmentation is a challenging task, due to lack of ground truth segmentation data of these abnormal tau pathology. This problem is most prominent in the case of segmenting NTs, where the small threadlike morphology makes pixel-wise labeling a laborious task and unrealistic for large-scale studies. Lack of ground truth data poses a significant limitation for many learning-based methods to generate accurate segmentations of NFTs and NTs. This work presents an automated pipeline for pixel level segmentation of NFTs and NTs that does not rely on ground truth segmentation data. The pipeline is composed of four main steps: (1) color deconvolution is used to separate histopathology images into staining channels (DAB, Hematoxylin, and Eosin), (2) Otsu's thresholding is used on the DAB stain channel to generate pixel level segmentation of abnormal tau proteins staining, (3) a weakly-supervised learning paradigm (WildCat), using only global descriptors of images, is used to generate density maps of potential regions of NFTs and NTs, and (4) density maps and segmentations are then integrated using connected component analysis to localize NFTs and NTs in the detected tau segmentations. Our results show high global classification accuracy for NFTs (Acc:0.96) and NTs (Acc:0.91), and statistically significant distinctions when evaluating the percent area occupied of the detected NTs relative to expert ratings of NTs severity. Qualitative assessment of the NFTs and NTs results showed accurate pixel-level segmentations of the NFTs, while modest performance for NTs.
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| 29. |
- Yushkevich, Paul A., et al.
(författare)
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Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
- 2021
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Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 144:9, s. 2784-2797
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Tidskriftsartikel (refereegranskat)abstract
- Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe specimens (age 75.3 ± 11.4 years, range 45 to 93) were used to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels. Group-level maps were obtained in the space of an in vivo brain template, and neurofibrillary tangles were measured in specific anatomical regions defined in this template. Three-dimensional maps of neurofibrillary tangle burden revealed significant variation along the anterior-posterior axis. While early neurofibrillary tangle pathology is thought to be confined to the transentorhinal region, we found similar levels of burden in this region and other medial temporal lobe subregions, including amygdala, temporopolar cortex, and subiculum/cornu ammonis 1 hippocampal subfields. Overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in Alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers.
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