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Sökning: WFRF:(Löfgren P.)

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1.
  • Bull, Peter, et al. (författare)
  • Förstudie obemannade farkoster
  • 2012
  • Rapport (populärvet., debatt m.m.)abstract
    • Obemannade farkoster används allt oftare, och i allt fler roller, i dagens kon- flikter. Denna rapport ger en bred överblick över området militära obemannade farkoster, samt rekommendationer för inriktningen av framtida FoU-satsningar inom området.Överblicken över området har fokus på både system, förmågor och verksam- heter som är relevanta för Försvarsmakten. Genom att låta de insatsförmågor som definieras i FMUP (Försvarsmaktens utvecklingsplan) gå som en röd tråd genom rapporten, både när specifika system diskuteras och när möjliga scena- rier där obemannade farkoster kan vara till nytta beskrivs, har vi försökt hålla både bredd och relevans i dokumentet.Rekommendationerna vilar på en genomgång av de inriktningsdokument som producerats i Försvarsmakten, t.ex. Perspektivplanneringen och FMUP, besök vid de enheter som dagligen använder obemannade farkoster, UAV-enheten i Karlsborg och Swedec i Eksjö, samt den områdesöverblick som nämns ovan. Slutsatserna är att den effektivaste kompetensuppbyggnaden och kunskapsöver- föringen fås om man skapar breda tvärvetenskapliga projekt inom respektive systemkategori (UAV, UGV, etc) med nära kontakter till materielförsörjnings- processen och perspektivplaneringen. Dessa kan samla kompetensen inom FHS och FOI, övervaka forskningsfronten genom att bevaka tävlingar, konferenser samt delta i internationella samarbeten, samt överföra det samlade resultaten till Försvarsmakten genom demonstrationer av verkliga eller simulerade delsy- stem och interaktiva simuleringar av hela system. Just systemsimuleringar kan göras särskilt realistiska, eftersom interaktionen med de riktiga obemannade systemen till stor del sker igenom kontrollstationernas datorer. På så sätt ska- pas en känsla för både hot och möjligheter med de nya systemen, vilket gagnar både taktikutveckling och materielprocesser.
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2.
  • Chartkunchand, K. C., et al. (författare)
  • Lifetimes of bound excited states of Pt-
  • 2017
  • Ingår i: Journal of Physics: Conference Series, Vol. 875, no. 022051. - : IOP Publishing. - 1742-6588.
  • Konferensbidrag (refereegranskat)abstract
    • Measurements of the radiative lifetimes of the two excited states of the platinum anion Pt- are presented. Pt- ions stored in the cryogenic ion storage ring DESIREE were photodetached at different photon wavelengths and the resulting yield of neutral Pt measured as a function of time was recorded. Analysis of the neutral decay curves show a 2.54 +/- 0.10 s lifetime for the higher-lying 5d(10)6(s) S-2(1/2) excited state and a lifetime in the range of 50-200 ms for the lower- lying 5d(9)6(s)(2) D-2(3/2) excited state. This is the first study to report the lifetime of a bound anion excited state with an electron configuration different from that of the anion ground state.
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3.
  • Dahl, Martin, 1984-, et al. (författare)
  • A 2,000-Year Record of Eelgrass (Zostera marina L.) : Colonization Shows Substantial Gains in Blue Carbon Storage and Nutrient Retention
  • 2024
  • Ingår i: Global Biogeochemical Cycles. - : John Wiley & Sons. - 0886-6236 .- 1944-9224. ; 38:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Assessing historical environmental conditions linked to habitat colonization is important for understanding long-term resilience and improving conservation and restoration efforts. Such information is lacking for the seagrass Zostera marina, an important foundation species across cold-temperate coastal areas of the Northern Hemisphere. Here, we reconstructed environmental conditions during the last 14,000 years from sediment cores in two eelgrass (Z. marina) meadows along the Swedish west coast, with the main aims to identify the time frame of seagrass colonization and describe subsequent biogeochemical changes following establishment. Based on vegetation proxies (lipid biomarkers), eelgrass colonization occurred about 2,000 years ago after geomorphological changes that resulted in a shallow, sheltered environment favoring seagrass growth. Seagrass establishment led to up to 20- and 24-fold increases in sedimentary carbon and nitrogen accumulation rates, respectively. This demonstrates the capacity of seagrasses as efficient ecosystem engineers and their role in global change mitigation and adaptation through CO2 removal, and nutrient and sediment retention. By combining regional climate projections and landscape models, we assessed potential climate change effects on seagrass growth, productivity and distribution until 2100. These predictions showed that seagrass meadows are mostly at risk from increased sedimentation and hydrodynamic changes, while the impact from sea level rise alone might be of less importance in the studied area. This study showcases the positive feedback between seagrass colonization and environmental conditions, which holds promise for successful conservation and restoration efforts aimed at supporting climate change mitigation and adaptation, and the provision of several other crucial ecosystem services. © 2024. The Authors.
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4.
  • Flodin, P., et al. (författare)
  • Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy
  • 2015
  • Ingår i: NeuroImage. - : Elsevier Inc.. - 1053-8119 .- 1095-9572. ; 9, s. 134-139
  • Tidskriftsartikel (refereegranskat)abstract
    • Physical exercise is one of the most efficient interventions to mitigate chronic pain symptoms in fibromyalgia (FM). However, little is known about the neurophysiological mechanisms mediating these effects. In this study we investigated resting-state connectivity using functional magnetic resonance imaging (fMRI) before and after a 15 week standardized exercise program supervised by physical therapists. Our aim was to gain an understanding of how physical exercise influences previously shown aberrant patterns of intrinsic brain activity in FM. Fourteen FM patients and eleven healthy controls successfully completed the physical exercise treatment. We investigated post- versus pre-treatment changes of brain connectivity, as well as changes in clinical symptoms in the patient group. FM patients reported improvements in symptom severity. Although several brain regions showed a treatment-related change in connectivity, only the connectivity between the right anterior insula and the left primary sensorimotor area was significantly more affected by the physical exercise among the fibromyalgia patients compared to healthy controls. Our results suggest that previously observed aberrant intrinsic brain connectivity patterns in FM are partly normalized by the physical exercise therapy. However, none of the observed normalizations in intrinsic brain connectivity were significantly correlated with symptom changes. Further studies conducted in larger cohorts are warranted to investigate the precise relationship between improvements in fibromyalgia symptoms and changes in intrinsic brain activity. © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
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6.
  • Arvidsson, Anna, 1973, et al. (författare)
  • Characterisation of structures in salivary secretion film formation. An experimental study with atomic force microscopy
  • 2004
  • Ingår i: Biofouling. - : Informa UK Limited. - 0892-7014 .- 1029-2454. ; 20:3, s. 181-8
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of the present study was to characterise the structure dynamics of pure salivary secretions retained on controlled surfaces with different surface energies in the early stage of salivary film formation. Germanium prisms prepared to have either low surface energy or medium surface energy were incubated in fresh secretions of either human parotid saliva (HPS) or human submandibular/sublingual saliva (HSMSLS) for 15, 90, and 180 min. After controlled rinsing with distilled water, the surfaces were air dried and thereafter imaged with atomic force microscopy (AFM). The amount of adsorbed material and the size of the structures detected increased with increased saliva exposure time. The film thicknesses varied from 10 to 150 nm, and both HPS and HSMSLS films contained structures with diameters varying from 40 nm to 2 microm. Some of these were clustered into special formations. The HPS films exhibited a more granular morphology than the HSMSLS films. Furthermore, branched lines were detected on the low surface energy germanium prisms incubated in saliva. The results indicate that exposure time, surface energy, and type of salivary secretion all are factors affecting the adsorption characteristics of salivary films.
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7.
  • Chartkunchand, Kiattichart C., et al. (författare)
  • Radiative lifetimes of the bound excited states of Pt-
  • 2016
  • Ingår i: Physical Review A - Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 94:3
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2016 American Physical Society.The intrinsic radiative lifetimes of the 5d106sS1/22 and 5d96s2 D3/22 bound excited states in the platinum anion Pt- have been studied at cryogenic temperatures at the Double ElectroStatic Ion Ring Experiment (DESIREE) facility at Stockholm University. The intrinsic lifetime of the higher-lying 5d106s S1/22 state was measured to be 2.54±0.10s, while only a lifetime in the range of 50-200 ms could be estimated for the 5d96s2 D3/22 fine-structure level. The storage lifetime of the Pt- ion beam was measured to be a little over 15 min at a ring temperature of 13K. The present study reports the lifetime of an atomic negative ion in an excited bound state with an electron configuration different from that of the ground state.
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8.
  • Cherfan, P, et al. (författare)
  • Effects of simvastatin on human T cells in vivo
  • 2007
  • Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 193:1, s. 186-192
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The use of statins has shown several anti-inflammatory actions, including modulatory effects on T cells in vitro. Since the effects on human T cells in vivo are less clarified, our aim was to investigate the effects of simvastatin on human T cells in vivo and ex vivo. Methods and results: A randomized, double-blind, placebo-controlled study design was applied. Eighty volunteers with mild to moderate hypercholesterolemia received either simvastatin 40 mg or placebo for 6 weeks. The serum levels of C-reactive protein (CRP) were significantly reduced by simvastatin. The proportions of CD4+ and CD8+ T cell subsets expressing early (CD25) or late (HLA-DR) activation markers, as assessed by flow cytometry, were not changed by simvastatin. However, simvastatin tended to increase the density of HLA-DR and L-selectin per CD8+ T cell. The T helper(h)1/Th2 response was evaluated by stimulatory assays followed by intra-cellular staining of interferon-γ and interleukin-4. Simvastatin treatment did not affect the Th1 response but the results indicated a potential to suppress Th2. Conclusion: Simvastatin treatment resulted in a few discrete changes as regards peripheral T cells. However, the findings do not provide evidence that simvastatin-induced anti-inflammatory actions are related to any significant modulatory effects on human T cells in clinically healthy men with hypercholesterolemia. © 2006 Elsevier Ireland Ltd. All rights reserved.
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9.
  • Dahl, Martin, 1984-, et al. (författare)
  • First assessment of seagrass carbon accumulation rates in Sweden: A field study from a fjord system at the Skagerrak coast
  • 2023
  • Ingår i: PLoS Climate. - : Public Library of Science (PLoS). - 2767-3200. ; 2:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Seagrass meadows are globally important blue carbon sinks. In northern cold-temperate regions, eelgrass (Zostera marina) is the dominant seagrass species, and although their sedimentary carbon stocks have been quantified across regions, information regarding the CO2 withdrawal capacity as carbon sinks remains scarce. Here we assessed the carbon (Corg) accumulation rates (CARs) and stocks as well as the organic matter sources in five seagrass meadows in the Gullmar Fjord area on the Swedish Skagerrak coast. We found that the mean (±SD) CAR was 14 ± 3 g Corg m-2 yr-1 over the last ~120–140 years (corresponding to a yearly uptake of 52.4 ± 12.6 g CO2 m-2). The carbon sink capacity is in line with other Z. marina areas but relatively low compared to other seagrass species and regions globally. About half of the sedimentary carbon accumulation (7.1 ± 3.3 g Corg m-2 yr-1) originated from macroalgae biomass, which highlights the importance of non-seagrass derived material for the carbon sink function of seagrass meadows in the area. The Corg stocks were similar among sites when comparing at a standardized depth of 50 cm (4.6–5.9 kg Corg m-2), but showed large variation when assessed for the total extent of the cores (ranging from 0.7 to 20.6 kg Corg m-2 for sediment depths of 11 to at least 149 cm). The low sediment accretion rates (1.18–1.86 mm yr-1) and the relatively thick sediment deposits (with a maximum of >150 cm of sediment depth) suggests that the carbon stocks have likely been accumulated for an extended period of time, and that the documented loss of seagrass meadows in the Swedish Skagerrak region and associated erosion of the sediment could potentially have offset centuries of carbon sequestration.
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10.
  • Edén, J., et al. (författare)
  • Native milk fat globule size and its influence on whipping properties
  • 2016
  • Ingår i: International Dairy Journal. - : Elsevier BV. - 0958-6946. ; 61, s. 176-181
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this study was to investigate the influence of native milk fat globule size on the aeration of high fat dairy products with regard to maximum firmness time, gas inclusion and foam stability. The results showed that whipping time to maximum firmness was inversely proportional to mean fat globule size for both unhomogenised and slightly homogenised (2 MPa) creams. Additionally, increasing native mean fat globule size of the creams resulted in increased overrun. No significant differences in serum drainage were found between creams with different native milk fat globule size. Furthermore, when creams with native large mean fat globules were homogenised, the results showed that the maximum firmness time was in accordance with the mean fat globule size of non-aggregated creams. In the present study, cream fractionation was achieved by creaming or in a cost effective and fast manner using a modified centrifugal separator.
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12.
  • Ekström, Sara M., et al. (författare)
  • Increasing concentrations of iron in surface waters as a consequence of reducing conditions in the catchment area
  • 2016
  • Ingår i: Journal of Geophysical Research - Biogeosciences. - 2169-8953 .- 2169-8961. ; 121:2, s. 479-493
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent studies report trends of strongly increasing iron (Fe) concentrations in freshwaters. Since Fe is a key element with a decisive role in the biogeochemical cycling of major elements, it is important to understand the mechanisms behind these trends. We hypothesized that variations in Fe concentration are driven mainly by redox dynamics in hydraulically connected soils. Notably, Fe(III), which is the favored oxidation state except in environments where microbial activity provide strong reducing intensity, has several orders of magnitude lower water solubility than Fe(II). To test our hypothesis, seasonal variation in water chemistry, discharge, and air temperature was studied in three Swedish rivers. Methylmercury and sulfate were used as indicators of seasonal redox changes. Seasonal variability in water chemistry, discharge, and air temperature in the Eman and Lyckeby Rivers implied that the variation in Fe was primarily driven by the prevalence of reducing conditions in the catchment. In general, high Fe concentrations were observed when methylmercury was high and sulfate was low, indicative of reducing conditions. The Fe concentrations showed no or weak relationships with variations in dissolved organic matter concentration and aromaticity. The seasonal variation in Fe concentration of the Ume river was primarily dependent on timing of the snowmelt in high- versus low-altitude areas of the catchment. There were long-term trends of increasing temperature in all catchments and also trends of increasing discharge in the southern rivers, which should increase the probability for anaerobic conditions in space and time and thereby increase Fe transport to the aquatic systems.
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13.
  • Gottselig, N., et al. (författare)
  • Elemental Composition of Natural Nanoparticles and Fine Colloids in European Forest Stream Waters and Their Role as Phosphorus Carriers
  • 2017
  • Ingår i: Global Biogeochemical Cycles. - 0886-6236 .- 1944-9224. ; 31:10, s. 1592-1607
  • Tidskriftsartikel (refereegranskat)abstract
    • Biogeochemical cycling of elements largely occurs in dissolved state, but many elements may also be bound to natural nanoparticles (NNP, 1-100 nm) and fine colloids (100-450 nm). We examined the hypothesis that the size and composition of stream water NNP and colloids vary systematically across Europe. To test this hypothesis, 96 stream water samples were simultaneously collected in 26 forested headwater catchments along two transects across Europe. Three size fractions (~1-20 nm, >20-60 nm, and >60 nm) of NNP and fine colloids were identified with Field Flow Fractionation coupled to inductively coupled plasma mass spectrometry and an organic carbon detector. The results showed that NNP and fine colloids constituted between 2 ± 5% (Si) and 53 ± 21% (Fe; mean ± SD) of total element concentrations, indicating a substantial contribution of particles to element transport in these European streams, especially for P and Fe. The particulate contents of Fe, Al, and organic C were correlated to their total element concentrations, but those of particulate Si, Mn, P, and Ca were not. The fine colloidal fractions >60 nm were dominated by clay minerals across all sites. The resulting element patterns of NNP <60 nm changed from North to South Europe from Fe- to Ca-dominated particles, along with associated changes in acidity, forest type, and dominant lithology.
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14.
  • Gustavsson, Robert, et al. (författare)
  • In situ microscopy as online tool for detecting microbial contaminations in cell culture
  • 2019
  • Ingår i: Journal of Biotechnology. - : ELSEVIER SCIENCE BV. - 0168-1656 .- 1873-4863. ; 296, s. 53-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Microbial contamination in mammalian cell cultures causing rejected batches is costly and highly unwanted. Most methods for detecting a contamination are time-consuming and require extensive off-line sampling. To circumvent these efforts and provide a more convenient alternative, we used an online in situ microscope to estimate the cell diameter of the cellular species in the culture to distinguish mammalian cells from microbial cells depending on their size. A warning system was set up to alert the operator if microbial cells were present in the culture. Hybridoma cells were cultured and infected with either Candida utilis or Pichia stipitis as contaminant. The warning system could successfully detect the introduced contamination and alert the operator. The results suggest that in situ microscopy could be used as an efficient online tool for early detection of contaminations in cell cultures.
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15.
  • Hartel, Bas P., et al. (författare)
  • A combination of two truncating mutations in USH2A causes more severe and progressive hearing impairment in Usher syndrome type IIa
  • 2016
  • Ingår i: Hearing Research. - Amsterdam, Netherlands : Elsevier. - 0378-5955 .- 1878-5891. ; 339, s. 60-68
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: Usher syndrome is an inherited disorder that is characterized by hearing impairment (HI), retinitis pigmentosa, and in some cases vestibular dysfunction. Usher syndrome type IIa is caused by mutations in USH2A. HI in these patients is highly heterogeneous and the present study evaluates the effects of different types of USH2A mutations on the audiometric phenotype. Data from two large centres of expertise on Usher Syndrome in the Netherlands and Sweden were combined in order to create a large combined sample of patients to identify possible genotype-phenotype correlations.Design: A retrospective study on HI in 110 patients (65 Dutch and 45 Swedish) genetically diagnosed with Usher syndrome type IIa. We used methods especially designed for characterizing and testing differences in audiological phenotype between patient subgroups. These methods included Age Related Typical Audiograms (ARTA) and a method to evaluate the difference in the degree of HI developed throughout life between subgroups.Results: Cross-sectional linear regression analysis of last-visit audiograms for the best hearing ear demonstrated a gradual decline of hearing over decades. The congenital level of HI was in the range of 16-33 dB at 0.25-0.5 kHz, and in the range of 51-60 dB at 1-8 kHz. The annual threshold deterioration was in the range of 0.4-0.5 dB/year at 0.25-2 kHz and in the range of 0.7-0.8 dB/year at 4-8 kHz. Patients with two truncating mutations, including homozygotes for the common c.2299delG mutation, developed significantly more severe HI throughout life than patients with one truncating mutation combined with one nontruncating mutation, and patients with two nontruncating mutations.Conclusions: The results have direct implications for patient counselling in terms of prognosis of hearing and may serve as baseline measures for future (genetic) therapeutic interventions.
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  • Håkansson, P, et al. (författare)
  • Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice
  • 2002
  • Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 37:9, s. 1089-1096
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Although apoE-/- mice are characterized by hypercholesterolemia, the bile acid enterohepatic circulation, which plays a crucial role in cholesterol homeostasis, has not been examined in these mice. The differences between apoE-/- and C57BL/6 mice in expression of the ileal ASBT and ILBP and in intestinal bile acid absorption were studied.METHODS: The intestinal tissues of the fetal, neonatal and post-weaning mice were processed for immunohistochemistry. Body retention and fecal excretion of 75SeHCAT were measured. The bile acid pool size and its composition were analysed by HPLC.RESULTS: In apoE-/- and C57BL/6 mice, the bile acid pool size was 75 +/- 13 and 78 +/- 13 micromol/ 100 g body weight, respectively, while the ratio of cholic acid/beta-muricholic acid was 1.8 +/- 0.3 and 1.4 +/- 0.3 (P < 0.05), respectively. The daily body retention of 75SeHCAT was 48% = 1.8% in C57 black mice and 58.4% +/- 2.7% in apoE-/- mice (P < 0.05). In both mouse strains, ASBT expression in the small intestine was found in the near-term fetal and post-weaning mice, while ILBP expression was found in all postnatal mice. In the post-weaning mice, ILBP expression was limited to the distal 25%-30% of the small intestine, while ASBT expression was limited to the distal 18%.CONCLUSIONS: The bile acid enterohepatic circulation in apoE-/- mice probably does not differ greatly from that in C57BL/6 mice.
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18.
  • Kamińska, Magdalena, et al. (författare)
  • Lifetime of the bound excited level in Ni
  • 2016
  • Ingår i: Physical Review A. - 1050-2947 .- 1094-1622. ; 93:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The intrinsic lifetime of the upper level in the bound-bound 3d(9) 4s(2) D-2(3/2) -> 3d(9) 4s(2) D-2(5/2) radiative transition in Ni- was measured to be 15.1 +/- 0.4 s. The experiment was performed at cryogenic temperatures in one of the ion-beam storage rings of the Double ElectroStatic Ion Ring ExpEriment facility at Stockholm University. The storage lifetime of the Ni- ion beam was measured to be close to 5 min at a ring temperature of 13 K.
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19.
  • Kaminska, M, et al. (författare)
  • Storing keV negative ions for hours: Lifetime measurements in new time domains
  • 2015
  • Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 635
  • Konferensbidrag (refereegranskat)abstract
    • We have used one of the cryogenic ion storage rings of DESIREE to measure the lifetime of the 2P o 1/2 level in the sulfur anion to be 503 ± 43 seconds. This is orders of magnitude longer than any previously measured lifetime in a negatively charged ion.
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  • Löfgren, Anneli, et al. (författare)
  • Symmetry of Two-Terminal Nonlinear Electric Conduction
  • 2004
  • Ingår i: Physical Review Letters. - 1079-7114. ; 92:4, s. 1-046803
  • Tidskriftsartikel (refereegranskat)abstract
    • The well-established symmetry relations for linear transport phenomena cannot, in general, be applied in the nonlinear regime. Here we propose a set of symmetry relations with respect to bias voltage and magnetic field for the nonlinear conductance of two-terminal electric conductors. We experimentally confirm these relations using phase-coherent, semiconductor quantum dots.
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24.
  • Löfgren, J, et al. (författare)
  • [From articles to patient benefit]
  • 2017
  • Ingår i: Lakartidningen. - 1652-7518. ; 114
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Löfgren, Lars, et al. (författare)
  • Metalinguistic views of quantum mechanics and its formalizability
  • 1999
  • Ingår i: Metadebates on science : the blue book of "Einstein meets Magritte". - 0792357620 ; , s. 213-223
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Much like the way we distinguish between formalism and experimentalism, we distinguish between ascertainment by proof and ascertainment by measurement. We argue that quantum mechanics, which characteristically encompasses both kinds of ascertainment, is too complex to be fully captured by formalism alone, and needs relativization to language in its complementaristic conception. In particular, we argue that there is a partial tie between the two ascertainments. Although, at higher levels, inferences or proofs may well be accepted as less constructive than direct measurements, they are tied at a basic level of constructivity. An inference is here of the same constructive nature as that of a direct measurement. The levelled approach is helpful, e.g., for understanding Bohr´s wave-particle complementarity and its recent challenge by the double-prism experiment (as well as, e.g., for understanding a thesis of a programmable experimentability within "quantum computation").
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  • Löfgren, Ragnhild (författare)
  • Phagocytic-receptor signaling in human neutrophils
  • 1999
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The neutrophil granulocyte is one of the most mobile cells in the body and through a number of functions represents the first line of defense against invading pathogens. Adhesion and chemotactic receptors on the cell surface work together through modulation of the cytoskeleton, thereby enabling cell movement. Engulfment is facilitated by opsonization of the microbes with C3b or C3bi complement fragments or with immunoglobulins, proteins that respectively bind to complement receptors (CR) and Fey receptors (FcyR) on the neutrophil. The aim of the present study was to investigate the signal transduction properties of CR and FcyR on human neutrophils. In particular, the investigations focused on second messengers of importance for regulating actin polymerization and NADPH-oxidase activity. This was approached by selective activation of each receptor on non-adherent human neutrophils using specific antibodies that were either cross-linked or prefixed on bacterial particles.Both stimulation with f.MetLeuPhe and engagement of CR3 caused an increase in filamentous actin (F-actin) and activation of phosphatidylinositol 3-klnase with the subsequent formation of phosphatidylinositol trisphosphate (PIP,). We found that the F-actin response mediated by fMetLenPhe and CR3 were different. The F-actin response induced by fMetLeuPhe declined rapidly whereas the response induced by engagement of CR3 was more sustained. This is hypothesized to be due to the inability of CR3 to induce a cAMP signal, since direct addition of cAMP and 1-isobutyl-methylxantine (IBMX, a phosphodiesterase inhibitor) to electropermeabilized neutrophils caused a prompt reversal of the CR3-induced F-actin elevation.Engagement of CR3 and CR1 by antibody cross-linking induced a Ca2+ signal and phospholipase D (PLD) activation. Furthermore, the PLD response was potentiated by PMA pretreatment and was dependent on the form of ligand presentation. Both FcyR (FcyRITA and FcyRIIIB) and CR3 induced activation of NADPH-oxidase, a response that was dependent on intracellular Ca2+, tyrosine kinase activation and PLD activity. However, only FcyRllA induced a strong phosphorylation of p72''\ indicating that CR3 and FcyRliA might use different pathways leading to NADPH-oxidase activation.
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  • Pyszniak, Andrzej, et al. (författare)
  • Studies on implementation of pellet tracking in hadron physics experiments
  • 2014
  • Ingår i: Meson 2014 - 13th International Workshop on Production, Properties and Interaction of Mesons. - : EDP Sciences.
  • Konferensbidrag (refereegranskat)abstract
    • A system for optical tracking of frozen hydrogen microsphere targets (pellets) has been designed. It is intended for the upcoming hadron physics experiment PANDA at FAIR, Darmstadt, Germany. With such a tracking system one can reconstruct the positions of the individual pellets at the time of a hadronic interaction in the offline event analysis. This gives information on the position of the primary interaction vertex with an accuracy of a few 100 mu m, which is very useful e.g. for reconstruction of charged particle tracks and secondary vertices and for background suppression. A study has been done at the WASA detector setup (Forschungszentrum Julich, Germany) to check the possibility of classification of hadronic events as originating in pellets or in background. The study has been done based on the instantaneous rate a Long Range TDC which was used to determine if a pellet was present in the accelerator beam region. It was clearly shown that it is possible to distinguish the two event classes. Also, an experience was gained with operation of two synchronized systems operating in different time scales, as it will also be the case with the optical pellet tracking.
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36.
  • Rosenstock, Nicholas P., et al. (författare)
  • Base cations in the soil bank : Non-exchangeable pools may sustain centuries of net loss to forestry and leaching
  • 2019
  • Ingår i: Soil. - : Copernicus GmbH. - 2199-3971 .- 2199-398X. ; 5:2, s. 351-366
  • Tidskriftsartikel (refereegranskat)abstract
    • Accurately quantifying soil base cation pool sizes is essential to interpreting the sustainability of forest harvests from element mass-balance studies. The soil-exchangeable pool is classically viewed as the bank of "available" base cations in the soil, withdrawn upon by plant uptake and leaching and refilled by litter decomposition, atmospheric deposition and mineral weathering. The operational definition of this soil bank as the exchangeable (salt-extractable) pools ignores the potential role of "other" soil nutrient pools, including microbial biomass, clay interlayer absorbed elements, and calcium oxalate. These pools can be large relative to "exchangeable" pools. Thus neglecting these other pools in studies examining the sustainability of biomass extractions, or need for nutrient return, limits our ability to gauge the threat or risk of unsustainable biomass removals. We examine a set of chemical extraction data from a mature Norway spruce forest in central Sweden and compare this dataset to ecosystem flux data gathered from the site in previous research. The 0.2 M HCl extraction released large pools of Ca, K, Mg, and Na, considerably larger than the exchangeable pools. Where net losses of base cations are predicted from biomass harvest, exchangeable pools may not be sufficient to support more than a single 65-year forest rotation, but acid-extractable pools are sufficient to support many rotations of net-ecosystem losses. We examine elemental ratios, soil clay and carbon contents, and pool depth trends to identify the likely origin of the HCl-extractable pool. No single candidate compound class emerges, as very strongly supported by the data, as being the major constituent of the HCl-extractable fraction. A combination of microbial biomass, fine grain, potentially shielded, easily weatherable minerals, and non-structural clay interlayer bound potassium may explain the size and distribution of the acid-extractable base cation pool. Sequential extraction techniques and isotope-exchange measurements should be further developed and, if possible, complemented with spectroscopic techniques to illuminate the identity of and flux rates through these important, and commonly overlooked, nutrient pools.
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37.
  • Steiner, Ann, et al. (författare)
  • Sexualitet i ord och bild
  • 2010
  • Ingår i: Sexologi. - : Liber. - 9789147015450 ; , s. 155-160
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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38.
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39.
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40.
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41.
  • von Beckerath, Mathias P., 1966-, et al. (författare)
  • Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy
  • 2014
  • Ingår i: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 134:8, s. 852-858
  • Tidskriftsartikel (refereegranskat)abstract
    • Conclusion: Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments.Objectives: The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. Methods: We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs.Results: The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.
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42.
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43.
  • Zu Ermgassen, Erasmus K.H.J., et al. (författare)
  • Using supply chain data to monitor zero deforestation commitments: an assessment of progress in the Brazilian soy sector
  • 2020
  • Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326 .- 1748-9318. ; 15:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Zero deforestation commitments (ZDCs) are voluntary initiatives where companies or countries pledge to eliminate deforestation from their supply chains. These commitments offer much promise for sustainable commodity production, but are undermined by a lack of transparency about their coverage and impacts. Here, using state-of-the-art supply chain data, we introduce an approach to evaluate the impact of ZDCs, linking traders and international markets to commodity-associated deforestation in the sub-national jurisdictions from which they source. We focus on the Brazilian soy sector, where we find that ZDC coverage is increasing, but under-represents the Cerrado biome where most soy-associated deforestation currently takes place. Though soy-associated deforestation declined in the Amazon after the introduction of the Soy Moratorium, we observe no change in the exposure of companies or countries adopting ZDCs to soy-associated deforestation in the Cerrado. We further assess the formulation and implementation of these ZDCs and identify several systematic weaknesses that must be addressed to increase the likelihood that they achieve meaningful reductions in deforestation in future. As the 2020 deadline for several of these commitments approaches, our approach can provide independent monitoring of progress toward the goal of ending commodity-associated deforestation.
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44.
  • Östergren, Petra, et al. (författare)
  • Att förstå prostitution
  • 2010
  • Ingår i: Sexologi. - 9789147015450 ; , s. 192-197
  • Bokkapitel (refereegranskat)
  •  
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