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- Lönnberg, Maria, et al.
(author)
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Patients with anaemia can shift from kidney to liver production of erythropoietin as shown by glycoform analysis
- 2013
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In: Journal of Pharmaceutical and Biomedical Analysis. - : Elsevier BV. - 0731-7085 .- 1873-264X. ; 81-82, s. 187-192
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Journal article (peer-reviewed)abstract
- The primary production site of erythropoietin (EPO) is shifted from the liver to the kidney shortly after birth. Under conditions of lost or reduced kidney production, it is valuable to measure the production capacity of the liver. However, there is a lack of urine or serum based methods that can distinguish endogenous EPO produced in different cell types. Here is presented a method based on chromatographic interaction with the lectin wheat germ agglutinin (WGA) that can distinguish presumably liver-produced EPO, found in anaemic patients receiving epoetin and darbepoetin, from kidney-produced EPO found in healthy individuals.All the tested samples from haemodialysis patients with end-stage renal disease showed a presence of liver EPO. In some samples, the liver-produced EPO made up 90–100% of total EPO at a concentration of 8–10 ng/L in urine, which indicates that the liver has a quite high production capacity, although not adequate for the degree of anaemia.This glycoform analysis has made it possible to affirm that some anaemic patients can increase their liver-production of EPO. The use of such a method can give better insight into the regulation of non-renal endogenous EPO production, a potential source of EPO intended to replace administration of exogenous EPO.
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| 3. |
- de Jong, Johnny, et al.
(author)
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Consequences of an increased extraction of forest biofuel in Sweden : a synthesis from the biofuel research programme 2007-2011
- 2014
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Reports (other academic/artistic)abstract
- EXECUTIVE SUMMARY.This report summarizes the state of knowledge with respect to possibilities for increasing the extraction of forest fuel in Sweden and the consequences of such increases on soil, water and biodiversity. It is based, above all, on research carried out within the Swedish Energy Agency’s research programme “the Bioenergy Feedstock Programme” (2007-2011), as well as on other, related projects financed by the Energy Agency. The goal of the study was to investigate and highlight1. New knowledge emerged from the Bioenergy Feedstock Programme;2. The link between research results and national environmental objectives and forestry guidelines;3. What questions remain to be answered in order to allow for a long-term and sustainable production and use of forest fuels.The result shows that there is a considerable potential for increasing forest fuel extraction without decreasing possibilities of achieving other societal, environmental and forest production objectives. The current extraction level of approximately 50 PJ can be increased to 87 PJ, at least. Branches and tops are the least problematic, while some questions remain regarding the consequences of stump extraction. Nevertheless, limited stump extraction should be possible. This increased extraction is linked to a number of conditions which must be fulfilled in order for negative effects to be avoided, i.e.:1. That the general environmental considerations in forestry are not negatively affected.2. That extracted branches, tops and stumps mainly comes from conifers.3. That compensation for loss of base cations by means of ash recycling is done where needed, using good-quality ash.4. That it is possible to limit soil damage as felling residues and stumps, when harvested, cannot be used to reinforce the strip roads (extraction of branches, tops and stumps can only be done on land with good load-bearing capacity).5. That extraction is not done near woodland key habitats and nature reserves, where an increase in the amount of deadwood exposed to sunlight is likely to be more beneficial for biodiversity than if it is left elsewhere in a managed forest landscape
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| 5. |
- Lönnberg, Lina, et al.
(author)
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Sand pits as habitats for beetles (Coleoptera): does area affect species number and composition?
- 2012
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In: Biodiversity and Conservation. - : Springer Science and Business Media LLC. - 0960-3115 .- 1572-9710. ; 21, s. 853-874
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Journal article (peer-reviewed)abstract
- Species living in open sandy habitats are declining in northern Europe because of habitat loss and degradation. However, mining of sand creates potential new habitats for these species in the form of sand pits. In this study we investigated the beetle fauna in sand pits in order to determine what kind of sand pits are the most valuable for conservation, in terms of sand pit area (primarily) and the proportion of sand material, vegetation cover, tree cover and edge habitats. Thirteen sand pits in Uppsala County, Sweden, ranging in size from 0.02 to 18 ha, were included in this study. A total of 2,500 individuals of beetles, belonging to 256 species, were sampled by pitfall traps. Thirty-nine of the species were classified as specialized sand-dwelling species and two were Swedish Red List species. We found that the area of sand pits affects both species number and species composition of beetles. A positive species-area relationship was found, best explained by a quadratic power function, for the habitat-specific species (i.e., sand species). Our recommendation is to prioritize sand pits with areas between 0.3 and 5 ha, with preference towards the lower end of this range, for conserving sand-dwelling beetles.
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| 6. |
- Rådmark, Lina, et al.
(author)
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Autonomic function and inflammation in pregnant women participating in a randomized controlled study of mindfulness based childbirth and parenting
- 2023
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In: BMC Pregnancy and Childbirth. - : BioMed Central (BMC). - 1471-2393 .- 1471-2393. ; 23:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: Pregnancy and childbirth are significant events in many women's lives, and the prevalence of depressive symptoms increases during this vulnerable period. Apart from well documented cognitive, affective, and somatic symptoms, stress and depression are associated with physiological changes, such as reduced heart-rate variability (HRV) and activation of the inflammatory response system. Mindfulness Based Interventions may potentially have an effect on both HRV, inflammatory biomarkers, and self-assessed mental health. Therefore, the aim of this study was to assess the effects of a Mindfulness Childbirth and Parenting (MBCP) intervention on HRV, serum inflammatory marker levels, through an RCT study design with an active control group.METHODS: This study is a sub-study of a larger RCT, where significant intervention effects were found on perinatal depression (PND) and perceived stress. Participants were recruited through eight maternity health clinics in Stockholm, Sweden. In this sub-study, we included altogether 80 women with increased risk for PND, and blood samples and HRV measures were available from 60 of the participants (26 in the intervention and 34 in the control group).RESULTS: Participants who received MBCP reported a significantly larger reduction in perceived stress and a significantly larger increase in mindfulness, compared to participants who received the active control treatment. However, in this sub-study, the intervention had no significant effect on PND, inflammatory serum markers or measures of HRV.CONCLUSIONS: No significant differences were found regarding changes in HRV measures and biomarkers of inflammation, larger studies may be needed in the future.
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