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1.	Marlin, R, et al. (author) Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques 2021 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 5215- Journal article (peer-reviewed)abstract Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Pantaleo, G (1); Wiedemann, A (1); Ellis, J (1); Liljestrom, P (1); Thiebaut, R (1); Levy, Y (1); show more...; van der Werf, S. (1); Dereuddre-Bosquet, N (1); Cavarelli, M (1); Szurgot, I (1); Schwartz, O (1); Godot, V (1); Dupaty, L (1); Zurawski, S (1); Cardinaud, S (1); Fenwick, C (1); Centlivre, M (1); Zurawski, G (1); Le Grand, R (1); Lemaitre, J. (1); Wang, ZQ (1); Marlin, R (1); Gallouet, AS (1); Galhaut, M (1); Coleon, S (1); Maisonnasse, P (1); Naninck, T (1); Gomez-Pacheco, M (1); Kahlaoui, N (1); Contreras, V (1); Relouzat, F (1); Fang, RHT (1); Chapon, C (1); Lacabaratz, C (1); Surenaud, M (1); Planas, D (1); Bruel, T (1); Prague, M (1); show less...

University: Karolinska Institutet (1)

Language: English (1)

Year: 2021 (1)

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