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Search: WFRF:(Lahann J.)

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1.
  • Hao, J., et al. (author)
  • Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors
  • 2016
  • In: Advanced Materials. - : Wiley. - 0935-9648. ; 28:16, s. 3145-3151
  • Journal article (peer-reviewed)abstract
    • Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
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2.
  • Maekawa, S., et al. (author)
  • BMP Gene-Immobilization to Dental Implants Enhances Bone Regeneration
  • 2022
  • In: Advanced Materials Interfaces. - : Wiley. - 2196-7350. ; 9:22
  • Journal article (peer-reviewed)abstract
    • For individuals who have experienced tooth loss, dental implants are an important treatment option for oral reconstruction. For these patients, alveolar bone augmentation and acceleration of osseointegration optimize implant stability. Traditional oral surgery often requires invasive procedures, which can result in prolonged treatment time and associated morbidity. It has been previously shown that chemical vapor deposition (CVD) polymerization of functionalized [2.2]paracyclophanes can be used to anchor gene encoding vectors onto biomaterial surfaces and local delivery of a bone morphogenetic protein (BMP)-encoding vector can increase alveolar bone volume and density in vivo. This study is the first to combine the use of CVD technology and BMP gene delivery on titanium for the promotion of bone regeneration and bone to implant contact in vivo. BMP-7 tethered to titanium surface enhances osteoblast cell differentiation and alkaline phosphatase activity in vitro and increases alveolar bone regeneration and % bone to implant contact similar to using high doses of exogenously applied BMP-7 in vivo. The use of this innovative gene delivery strategy on implant surfaces offers an alternative treatment option for targeted alveolar bone reconstruction.
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