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Sökning: WFRF:(Lampinen V)

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  • Ling Lundström, Maria, et al. (författare)
  • Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease
  • 2023
  • Ingår i: Clinical and Translational Gastroenterology. - : Nature Publishing Group. - 2155-384X. ; 14:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Fecal calprotectin (FC) is anoninvasive tool for examining response to biologics in inflammatory boweldisease (IBD), but its performance in relation to other novel fecal markers of various cellular origins is unknown.Methods: We performed a prospective multicenter cohort study and included patients with active IBD who provided a fecal sample at initiation of biological therapy. Levels of FC, myeloperoxidase (MPO), human neutrophil lipocalin (HNL), and eosinophil-derived neurotoxin (EDN) were analyzed and related to clinical remission status at 3 months. Changes in levels of markers at 3 months were calculated, and the impact of concomitant use of corticosteroids at baseline was estimated.Results: In patients achieving clinical remission (n = 27), a decrease in levels of FC (P = 0.005), MPO (P < 0.001), HNL (P < 0.001), and EDN (P < 0.001) was observed, whereas no significant decrease was seen in patients not achieving remission (n = 39). There was a significant difference in the change in the level of MPO (P = 0.01) and HNL (P = 0.02) between patients achieving clinical remission and those who did not, but changes in FC and EDN could not differentiate between these groups. Patients with concomitant systemic corticosteroids at inclusion had lower levels of HNL (P = 0.01) and EDN (P < 0.001) at baseline, compared with patients without corticosteroids.Discussion: Fecal MPO, HNL, and EDN are all promising biomarkers for assessing the treatment outcome of biologics in patients with IBD. Fecal levels of EDN and HNL are significantly affected by corticosteroids indicating a greater sensitivity to the effects of corticosteroids compared with levels of FC and MPO.
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3.
  • Sizov, Vladimir V., et al. (författare)
  • Molecular dynamics simulation of oxygen diffusion in cubic yttria-stabilized zirconia : Effects of temperature and composition
  • 2014
  • Ingår i: Solid State Ionics. - : Elsevier BV. - 0167-2738 .- 1872-7689. ; 266, s. 29-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Diffusion of oxygen ions in yttria-stabilized zirconia was studied using constant-volume molecular dynamics simulations for temperatures ranging from 1000 K to 2000 K and for varied compositions between 4 and 12 mol% Y2O3. Non-monotonic dependence of diffusion coefficients on yttria content was observed with a maximum at 5-7 mol%. With increasing temperature the position of diffusion maximum was drifting towards higher Y2O3 content The highest oxygen diffusion coefficients were obtained for Y2O3 concentrations close to the limit of cubic phase stability region. Diffusion activation energies increased monotonically with increasing concentration of the dopant.
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