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- de Jong, S, et al.
(författare)
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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
- 2018
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
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- Ganna, A., et al.
(författare)
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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 365:6456
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Tidskriftsartikel (refereegranskat)abstract
- Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
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- Beaudry, G, et al.
(författare)
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Ms. Beaudry et al. Reply
- 2021
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Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier BV. - 1527-5418 .- 0890-8567. ; 60:2, s. 203-204
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Fazel, S, et al.
(författare)
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Risk factors for criminal recidivism in older sexual offenders
- 2006
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Ingår i: Sexual abuse : a journal of research and treatment. - : SAGE Publications. - 1079-0632. ; 18:2, s. 159-167
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Tidskriftsartikel (refereegranskat)abstract
- Sexual offenders constitute a substantial proportion of the older male prison population. Recent research findings, with potential consequences for risk management, indicate that recidivism risk might be lower in older sexual offenders. We followed up all adult male sexual offenders released from prison in Sweden during 1993-1997 (N =1,303) for criminal reconviction for an average of 8.9 years. We studied rates of repeat offending (sexual and any violent) by four age bands (<25, 25-39, 40-54, and 55 +years), and examined whether risk factors for recidivism remained stable across age groups. Results showed that recidivism rates decreased significantly in older age bands. In addition, the effect of certain risk factors varied by age band. These findings on recidivism rates in older sexual offenders concur with studies from the United Kingdom, United States, and Canada and may suggest some generalizability in Western settings. Further research is needed to address underlying mechanisms.
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| 41. |
- Imamura, K, et al.
(författare)
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Reduced activity in the extrastriate visual cortex of individuals with strabismic amblyopia
- 1997
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Ingår i: NEUROSCIENCE LETTERS. - : ELSEVIER SCI IRELAND LTD. - 0304-3940. ; 225:3, s. 173-176
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In order to examine the relationship between reduced visual acuity in human strabismic amblyopia and the cortical activation pattern, we studied, by use of positron emission tomography (PET) and the (H2O)-O-15 bolus technique, changes in the regional cer
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| 42. |
- Jacobson, GB, et al.
(författare)
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Synthesis of C-11-labeled guanidines in supercritical ammonia
- 1996
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : AMER CHEMICAL SOC. - 0002-7863. ; 118:29, s. 6868-6872
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of ten C-11-labeled aromatic and aliphatic guanidines in supercritical ammonia is described. The corresponding amines were first converted into cyanamides by reactions with [C-11]cyanogen bromide. The aliphatic amines gave high yields of C-
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- Langstrom, N, et al.
(författare)
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Psychiatric disorders and recidivism in sexual offenders
- 2004
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Ingår i: Sexual abuse : a journal of research and treatment. - : SAGE Publications. - 1079-0632. ; 16:2, s. 139-150
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Tidskriftsartikel (refereegranskat)abstract
- Research on psychiatric morbidity in sexual offenders (SOs) has mostly been based on small, selected samples. We studied psychiatric disorders and their relationship with criminal recidivism in a nationwide, representative cohort of SOs. Data on ICD-9 and -10 psychiatric and neurologic morbidity diagnosed during hospital admissions 1987-1997, but prior to sexual offending, were retrieved for all adult male SOs released from Swedish prisons 1993-1997 (N = 1215). Preoffending disorder prevalence and associations between morbidity and criminal reconvictions during a 5-year postdetainment follow-up were explored. Alcohol use disorder was the most frequent diagnosis, followed by drug use disorder, personality disorder, and psychosis. Morbidity requiring admission to hospital was more common in rapists as compared to child molesters. Alcohol use disorder, drug use disorder, personality disorder, and psychosis all increased the risk for sexual recidivism whereas alcohol use disorder and personality disorder predicted violent nonsexual recidivism. Controlling for sociodemographic confounds changed the risk estimates only marginally. Because disorders were identified among only those who had been admitted to psychiatric hospitals as inpatients, underestimation of true prevalence rates was inevitable. However, our findings support psychiatric consultation for improved assessment and management of mental health needs and recidivism risk in SOs.
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| 50. |
- Lundgren, T, et al.
(författare)
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Pet in clinical islet transplantation
- 2009
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Ingår i: XENOTRANSPLANTATION. - 0908-665X. ; 16:5, s. 295-295
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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