SwePub - search: WFRF:(Lappalainen J)

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1.	Kulmala, M., et al. (author) General overview: European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) - integrating aerosol research from nano to global scales 2011 In: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 11:24, s. 13061-13143 Journal article (peer-reviewed)abstract In this paper we describe and summarize the main achievements of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI). EUCAARI started on 1 January 2007 and ended on 31 December 2010 leaving a rich legacy including: (a) a comprehensive database with a year of observations of the physical, chemical and optical properties of aerosol particles over Europe, (b) comprehensive aerosol measurements in four developing countries, (c) a database of airborne measurements of aerosols and clouds over Europe during May 2008, (d) comprehensive modeling tools to study aerosol processes fron nano to global scale and their effects on climate and air quality. In addition a new Pan-European aerosol emissions inventory was developed and evaluated, a new cluster spectrometer was built and tested in the field and several new aerosol parameterizations and computations modules for chemical transport and global climate models were developed and evaluated. These achievements and related studies have substantially improved our understanding and reduced the uncertainties of aerosol radiative forcing and air quality-climate interactions. The EUCAARI results can be utilized in European and global environmental policy to assess the aerosol impacts and the corresponding abatement strategies.
2.	Lappalainen, H. K., et al. (author) Overview: Recent advances in the understanding of the northern Eurasian environments and of the urban air quality in China - a Pan-Eurasian Experiment (PEEX) programme perspective 2022 In: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 22:7, s. 4413-4469 Journal article (peer-reviewed)abstract The Pan-Eurasian Experiment (PEEX) Science Plan, released in 2015, addressed a need for a holistic system understanding and outlined the most urgent research needs for the rapidly changing Arctic-boreal region. Air quality in China, together with the long-range transport of atmospheric pollutants, was also indicated as one of the most crucial topics of the research agenda. These two geographical regions, the northern Eurasian Arctic-boreal region and China, especially the megacities in China, were identified as a "PEEX region". It is also important to recognize that the PEEX geographical region is an area where science-based policy actions would have significant impacts on the global climate. This paper summarizes results obtained during the last 5 years in the northern Eurasian region, together with recent observations of the air quality in the urban environments in China, in the context of the PEEX programme. The main regions of interest are the Russian Arctic, northern Eurasian boreal forests (Siberia) and peatlands, and the megacities in China. We frame our analysis against research themes introduced in the PEEX Science Plan in 2015. We summarize recent progress towards an enhanced holistic understanding of the land-atmosphere-ocean systems feedbacks. We conclude that although the scientific knowledge in these regions has increased, the new results are in many cases insufficient, and there are still gaps in our understanding of large-scale climate-Earth surface interactions and feedbacks. This arises from limitations in research infrastructures, especially the lack of coordinated, continuous and comprehensive in situ observations of the study region as well as integrative data analyses, hindering a comprehensive system analysis. The fast-changing environment and ecosystem changes driven by climate change, socio-economic activities like the China Silk Road Initiative, and the global trends like urbanization further complicate such analyses. We recognize new topics with an increasing importance in the near future, especially "the enhancing biological sequestration capacity of greenhouse gases into forests and soils to mitigate climate change" and the "socio-economic development to tackle air quality issues".
3.	Boy, M., et al. (author) Interactions between the atmosphere, cryosphere, and ecosystems at northern high latitudes 2019 In: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 19:3, s. 2015-2061 Journal article (peer-reviewed)abstract The Nordic Centre of Excellence CRAICC (Cryosphere-Atmosphere Interactions in a Changing Arctic Climate), funded by NordForsk in the years 2011-2016, is the largest joint Nordic research and innovation initiative to date, aiming to strengthen research and innovation regarding climate change issues in the Nordic region. CRAICC gathered more than 100 scientists from all Nordic countries in a virtual centre with the objectives of identifying and quantifying the major processes controlling Arctic warming and related feedback mechanisms, outlining strategies to mitigate Arctic warming, and developing Nordic Earth system modelling with a focus on short-lived climate forcers (SLCFs), including natural and anthropogenic aerosols. The outcome of CRAICC is reflected in more than 150 peer-reviewed scientific publications, most of which are in the CRAICC special issue of the journal Atmospheric Chemistry and Physics. This paper presents an overview of the main scientific topics investigated in the centre and provides the reader with a state-of-the-art comprehensive summary of what has been achieved in CRAICC with links to the particular publications for further detail. Faced with a vast amount of scientific discovery, we do not claim to completely summarize the results from CRAICC within this paper, but rather concentrate here on the main results which are related to feedback loops in climate change-cryosphere interactions that affect Arctic amplification.
4.	Lindford, A, et al. (author) Prospective randomised non-inferiority Nordic frostbite treatment study comparing tPA and iloprost. 2018 Conference paper (other academic/artistic)
5.	Torbert, R. B., et al. (author) The FIELDS Instrument Suite on MMS : Scientific Objectives, Measurements, and Data Products 2016 In: Space Science Reviews. - : Springer Science+Business Media B.V.. - 0038-6308 .- 1572-9672. ; 199:1-4, s. 105-135 Research review (peer-reviewed)abstract The FIELDS instrumentation suite on the Magnetospheric Multiscale (MMS) mission provides comprehensive measurements of the full vector magnetic and electric fields in the reconnection regions investigated by MMS, including the dayside magnetopause and the night-side magnetotail acceleration regions out to 25 Re. Six sensors on each of the four MMS spacecraft provide overlapping measurements of these fields with sensitive cross-calibrations both before and after launch. The FIELDS magnetic sensors consist of redundant flux-gate magnetometers (AFG and DFG) over the frequency range from DC to 64 Hz, a search coil magnetometer (SCM) providing AC measurements over the full whistler mode spectrum expected to be seen on MMS, and an Electron Drift Instrument (EDI) that calibrates offsets for the magnetometers. The FIELDS three-axis electric field measurements are provided by two sets of biased double-probe sensors (SDP and ADP) operating in a highly symmetric spacecraft environment to reduce significantly electrostatic errors. These sensors are complemented with the EDI electric measurements that are free from all local spacecraft perturbations. Cross-calibrated vector electric field measurements are thus produced from DC to 100 kHz, well beyond the upper hybrid resonance whose frequency provides an accurate determination of the local electron density. Due to its very large geometric factor, EDI also provides very high time resolution (similar to 1 ms) ambient electron flux measurements at a few selected energies near 1 keV. This paper provides an overview of the FIELDS suite, its science objectives and measurement requirements, and its performance as verified in calibration and cross-calibration procedures that result in anticipated errors less than 0.1 nT in B and 0.5 mV/m in E. Summaries of data products that result from FIELDS are also described, as well as algorithms for cross-calibration. Details of the design and performance characteristics of AFG/DFG, SCM, ADP, SDP, and EDI are provided in five companion papers.
6.	Kukkola, J, et al. (author) Novel printed nanostructured gas sensors 2011 In: Procedia Engineering. - : Elsevier. - 1877-7058. ; 25, s. 896-899 Journal article (peer-reviewed)abstract There is a need for low-cost mass-production circuits on various substrates, possibly performing some simple functions as switches, antennas, displays, and sensors. Also in the field of gas sensors widely used in several applications there is a need for such novel fabrication technologies and materials. In this paper, we present three gas sensor structures fabricated using novel printing techniques. Inkjet and gravure printing techniques were used for fabrication of resistive WO3 nanoparticle gas sensors for detection of NO, and inkjet printing was utilized for fabrication of solid electrolyte (mixture of H3PW12O40 and PVC) in a nanostructured Metal-Electrolyte-Insulator- Semiconductor (MEIS) transistor for detection of H2. The sensor structures were found to be sensitive for detection of NO below 10 ppm, and H2 below 100 ppm concentrations in synthetic air, respectively.
7.	Saarikangas, J, et al. (author) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia 2011 In: Journal of cell science. - : The Company of Biologists. - 1477-9137 .- 0021-9533. ; 124:8Pt 8, s. 1245-1255 Journal article (peer-reviewed)abstract MIM/MTSS1 is a tissue-specific regulator of plasma membrane dynamics, whose altered expression levels have been linked to cancer metastasis. MIM deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. Here, we generated MIM mutant mice and found that full-length MIM protein is dispensable for embryonic development. However, MIM-deficient mice displayed a severe urinary concentration defect caused by compromised integrity of kidney epithelia intercellular junctions, which led to bone abnormalities and end-stage renal failure. In cultured kidney epithelial (MDCK) cells, MIM displayed dynamic localization to adherens junctions, where it promoted Arp2/3-mediated actin filament assembly. This activity was dependent on the ability of MIM to interact with both membranes and actin monomers. Furthermore, results from the mouse model and cell culture experiments suggest that full-length MIM is not crucial for Shh signaling, at least during embryogenesis. Collectively, these data demonstrate that MIM modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia.
8.	Andersson, Mike, et al. (author) Field Effect Based Gas Sensors, from Basic Mechanisms to the Latest Commercial Device Designs 2016 In: SENSORS AND ELECTRONIC INSTRUMENTATION ADVANCES (SEIA). - : INT FREQUENCY SENSOR ASSOC-IFSA. - 9788460899631 ; , s. 19-21 Conference paper (peer-reviewed)abstract This contribution treats the latest developments in the understanding of basic principles regarding device design, transduction mechanisms, gas-materials-interactions, and materials processing for the tailored design and fabrication of SiC FET gas sensor devices, mainly intended as products for the automotive sector.
9.	Huotari, J., et al. (author) Separation of valence states in thin films with mixed V2O5 and V7O16 phases 2016 In: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 211, s. 47-54 Journal article (peer-reviewed)abstract Among the other applications, vanadium oxide thin films are considered to be excellent candidates for gas sensing. To understand the origins of the sensing capability, we carried out X-ray photoelectron and X-ray absorption spectroscopy measurements to determinate the surface valence states of thin films with mixed V7O16 and V2O5 compounds. Thin films were fabricated by pulsed laser deposition, and the crystal structure and symmetry of the deposited films was studied using grazing incidence X-ray diffraction and Raman spectroscopy. These results together with X-ray photoelectron and absorption spectra showed that the thin-film crystal structures varied between orthorhombic V2O5 phase and another phase of triclinic V7O16. X-ray photoelectron spectroscopy was used to quantitatively confirm the high amount of V4+ ions on surfaces of the films, especially of films with V7O16 phase present. This result was confirmed in the quantitative analysis of the V2p near-edge X-ray absorption spectra. Through the observed electronic structures, it was found that in addition to unique crystal structure and morphology, the enhanced gas sensitivity of these layers is attributed to the increase in the amount of surface oxygen vacancies.
10.	Huotari, J., et al. (author) Synthesis of nanostructured solid-state phases of V7O16 and V2O5 compounds for ppb-level detection of ammonia 2016 In: Journal of Alloys and Compounds. - : ELSEVIER SCIENCE SA. - 0925-8388 .- 1873-4669. ; 675, s. 433-440 Journal article (peer-reviewed)abstract Solid state phase of V7O16 with separate V2O5 phase were fabricated by pulsed laser deposition. The crystal structure and symmetry of the deposited films were studied with X-ray diffraction and Raman spectroscopy, respectively. Rietveld analysis was performed to the X-ray diffraction measurement results. The surface potentials and morphologies of the films were studied with atomic force microscopy, and microstructure of the thin films was analysed by transmission electron microscopy. Raman spectroscopy and Rietveld refinement results confirmed that the thin-film crystal structures varied between orthorombic V2O5 phase and another phase, triclinic V2016, previously found only in the walls of vanadium oxide nanotubes (VOx, -NT), bound together with organic amine. We have earlier presented the first results of stable and pure metal -oxide solid-state phase of V2016 manufactured from ceramic V205 target. Here we show more detailed study of these structures. The microstructure studies showed a variation on the porosity of the films according to crystal structures and also some fibre -like nanostructures were found in the films. The surface morphology depended strongly on the crystal structure and the surface potential studies showed 50 meV difference in the work function values between the phases. Compounds were found to be extremely sensitive towards ammonia, NH3, down to 40 ppb concentrations, and have shown to have the stability and selectivity to control the Selective Catalytic Reduction process, where nitrogen oxides are reduced by ammonia in, e.g. diesel exhausts.
11.	Järvelä-Reijonen, E., et al. (author) The effects of acceptance and commitment therapy on eating behavior and diet delivered through face-to-face contact and a mobile app : A randomized controlled trial 2018 In: International Journal of Behavioral Nutrition and Physical Activity. - : BioMed Central Ltd.. - 1479-5868. ; 15:22, s. -14 Journal article (peer-reviewed)abstract Background: Internal motivation and good psychological capabilities are important factors in successful eating-related behavior change. Thus, we investigated whether general acceptance and commitment therapy (ACT) affects reported eating behavior and diet quality and whether baseline perceived stress moderates the intervention effects. Methods: Secondary analysis of unblinded randomized controlled trial in three Finnish cities. Working-aged adults with psychological distress and overweight or obesity in three parallel groups: (1) ACT-based Face-to-face (n = 70; six group sessions led by a psychologist), (2) ACT-based Mobile (n = 78; one group session and mobile app), and (3) Control (n = 71; only the measurements). At baseline, the participants' (n = 219, 85% females) mean body mass index was 31.3 kg/m2 (SD = 2.9), and mean age was 49.5 years (SD = 7.4). The measurements conducted before the 8-week intervention period (baseline), 10 weeks after the baseline (post-intervention), and 36 weeks after the baseline (follow-up) included clinical measurements, questionnaires of eating behavior (IES-1, TFEQ-R18, HTAS, ecSI 2.0, REBS), diet quality (IDQ), alcohol consumption (AUDIT-C), perceived stress (PSS), and 48-h dietary recall. Hierarchical linear modeling (Wald test) was used to analyze the differences in changes between groups. Results: Group x time interactions showed that the subcomponent of intuitive eating (IES-1), i.e., Eating for physical rather than emotional reasons, increased in both ACT-based groups (p = .019); the subcomponent of TFEQ-R18, i.e., Uncontrolled eating, decreased in the Face-to-face group (p = .020); the subcomponent of health and taste attitudes (HTAS), i.e., Using food as a reward, decreased in the Mobile group (p = .048); and both subcomponent of eating competence (ecSI 2.0), i.e., Food acceptance (p = .048), and two subcomponents of regulation of eating behavior (REBS), i.e., Integrated and Identified regulation (p = .003, p = .023, respectively), increased in the Face-to-face group. Baseline perceived stress did not moderate effects on these particular features of eating behavior from baseline to follow-up. No statistically significant effects were found for dietary measures. Conclusions: ACT-based interventions, delivered in group sessions or by mobile app, showed beneficial effects on reported eating behavior. Beneficial effects on eating behavior were, however, not accompanied by parallel changes in diet, which suggests that ACT-based interventions should include nutritional counseling if changes in diet are targeted.
12.	Lindqvist, Per-Arne, 1954-, et al. (author) The Spin-Plane Double Probe Electric Field Instrument for MMS 2016 In: Space Science Reviews. - : Springer Science+Business Media B.V.. - 0038-6308 .- 1572-9672. ; 199:1-4, s. 137-165 Research review (peer-reviewed)abstract The Spin-plane double probe instrument (SDP) is part of the FIELDS instrument suite of the Magnetospheric Multiscale mission (MMS). Together with the Axial double probe instrument (ADP) and the Electron Drift Instrument (EDI), SDP will measure the 3-D electric field with an accuracy of 0.5 mV/m over the frequency range from DC to 100 kHz. SDP consists of 4 biased spherical probes extended on 60 m long wire booms 90(a similar to) apart in the spin plane, giving a 120 m baseline for each of the two spin-plane electric field components. The mechanical and electrical design of SDP is described, together with results from ground tests and calibration of the instrument.
13.	Nordanstig, Annika, 1974, et al. (author) EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry. 2021 In: BMJ open. - : BMJ. - 2044-6055. ; 11:8 Journal article (peer-reviewed)abstract The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.
14.	Rivas, Manuel A., et al. (author) A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis 2016 In: Nature Communications. - London, United Kingdom : Nature Publishing Group. - 2041-1723. ; 7 Journal article (peer-reviewed)abstract Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against inflammatory bowel disease exploiting knowledge of common variants associated with the same disease. Through replication genotyping and imputation we found that a predicted protein-truncating variant (rs36095412, p.R179X, genotyped in 11,148 ulcerative colitis patients and 295,446 controls, MAF=up to 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, protects against ulcerative colitis (overall P=6.89 × 10(-7), odds ratio=0.30). We further demonstrate that the truncated protein exhibits reduced expression and altered subcellular localization, suggesting the protective mechanism may reside in the loss of an interaction or function via mislocalization and/or loss of an essential transmembrane domain.
15.	Barbero-López, A., et al. (author) Characterization and antifungal properties against wood decaying fungi of hydrothermal liquefaction liquids from spent mushroom substrate and tomato residues 2024 In: Biomass and Bioenergy. - : Elsevier BV. - 0961-9534 .- 1873-2909. ; 181 Journal article (peer-reviewed)abstract This study aimed to investigate the potential of converting bio-based residues from industrial production of mushrooms and tomatoes into more valuable chemicals with antifungal properties using hydrothermal liquefaction (HTL). Liquid fractions were obtained from HTL of spent substrate of Agaricus bisporus (Lange) Imbach and Pleurotus ostreatus (jacq.) P. kumm., recomposted Agaricus bisporus spent substrate, and tomato residues. The quantitative 1H NMR spectroscopy analysis revealed that the HTL liquids of all residues contained antifungal constituents like phenols and organic acids. The HTL liquids at dilutions of 10 % were able to inhibit the fungi by over 80 %. Interestingly, the fungus P. ostreatus showed tolerance to these constituents as its growth was promoted at the lowest concentration of all the HTL liquids. The HTL liquids had lower ecotoxicity than the commercial wood preservative. These results suggest that the tested residues could be a promising source of preservative chemical constituents for the wood industry.
16.	Bastuck, Manuel, et al. (author) Exploring the selectivity of WO3 with iridium catalyst in an ethanol/naphthalene mixture using multivariate statistics 2016 In: Thin Solid Films. - : ELSEVIER SCIENCE SA. - 0040-6090 .- 1879-2731. ; 618, s. 263-270 Journal article (peer-reviewed)abstract Temperature cycled operation and multivariate statistics have been used to compare the selectivity of two gate (i.e. sensitive) materials for gas-sensitive, silicon carbide based field effect transistors towards naphthalene and ethanol in different mixtures of the two substances. Both gates have a silicon dioxide (SiO2) insulation layer and a porous iridium (Ir) electrode. One of it has also a dense tungsten trioxide (WO3) interlayer between Ir and SiO2. Both static and transient characteristics play an important role and can contribute to improve the sensitivity and selectivity of the gas sensor. The Ir/SiO2 is strongly influenced by changes in ethanol concentration, and is, thus, able to quantify ethanol in a range between 0 and 5 ppm with a precision of 500 ppb, independently of the naphthalene concentrations applied in this investigation. On the other hand, this sensitivity to ethanol reduces its selectivity towards naphthalene, whereas Ir/WO3/SiO2 shows an almost binary response to ethanol. Hence, the latter has a better selectivity towards naphthalene and can quantify legally relevant concentrations down to 5 ppb with a precision of 2.5 ppb, independently of a changing ethanol background between 0 and 5 ppm. (C) 2016 Elsevier B.V. All rights reserved.
17.	Brandt, E, et al. (author) A novel SERPINA12 variant and first European patients with diffuse palmoplantar keratoderma 2024 In: Journal of the European Academy of Dermatology and Venereology : JEADV. - 1468-3083. ; 38:2, s. 413-418 Journal article (peer-reviewed)
18.	Frantti, J, et al. (author) A structural study of lead titanate based ceramics 2001 In: J. Phys.: Condensed Matter. ; submitted Journal article (peer-reviewed)
19.	Frantti, J., Ivanov,S. A., Eriksson, .S- G. Rundlöf, H. Lantto, V. Lappalainen, J. and Kakihana, M. (author) High resolution neutron powder diffraction study of the microstrain contributions in Pb(ZrxTi1 2002 In: Proceeding at the Electroceramics VIII Conference, August 25-28 2002, Rome, Italy. Conference paper (other academic/artistic)
20.	Frantti, J., Ivanov, S. A., Eriksson, S.- G., Rundlöf, H., Lantto,V.Lappalainen, J. and Kakihana, M. (author) On the phase transitions of Pb(ZrxTi1 2002 In: Phys. Rev.. ; B66, s. 64108- Journal article (peer-reviewed)
21.	Frantti, J., Ivanov, S., Eriksson, S.- G., Lappalainen, J., Lantto, V. and Kakihana, M. (author) Neutron Diffraction and Bond-valence Calulation studies of Pb(ZrxTi1 2002 In: Ferroelectrics. ; 272, s. 51- Journal article (peer-reviewed)
22.	Frantti, J., Ivanov, S., Eriksson, S., Rundlöf, H., Lantto, V., Lappalainen, J. and Kakihana, M. (author) Phase transitions of Pb(ZrxTi1 2002 In: Phys. Rev.. ; B66, s. 64108- Journal article (peer-reviewed)
23.	Frantti, J., Ivanov S., Lappalainen, J., Eriksson, S., Lantto, V., Nishio, S., Kakihana, M. and Rundlöf, H. (author) Local and average structure of lead titanate based ceramics 2002 In: Ferroelectrics. ; 266, s. 73- Journal article (peer-reviewed)
24.	Frantti, J, et al. (author) Local and average structure of lead titanate based ceramics 2002 In: Ferroelectrics. - : Informa UK Limited. - 0015-0193 .- 1563-5112. ; 266:1, s. 73-90 Journal article (peer-reviewed)abstract The revised lattice dynamics of Pb(Zr x Ti 1 -x )O 3 (PZT) with 0.10 ≤ x ≤0.54 ceramics is reported. The phase transition from tetragonal phase to the monoclinic phase is proposed to occur via locally distorted regions. Neutron diffraction data suggests that these local regions transform to the monoclinic phase with decreasing temperature, when x ≈0.50.
25.	Frantti, J, et al. (author) Neutron diffraction and Raman scattering studies of Pb(ZrxTi1-x)O3 ceramics 2001 Other publication (other academic/artistic)
26.	Frantti, J, et al. (author) Neutron diffraction studies of Pb(ZrxTi1-x)O-3 ceramics 2000 In: JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS. - : INST PURE APPLIED PHYSICS. - 0021-4922. ; 39:9B, s. 5697-5703 Journal article (peer-reviewed)abstract Neutron diffraction studies of lead zirconate titanate Pb(ZrxT1-x)O-3 (PZT) powders, 0.20 less than or equal to x less than or equal to 0.54, were carried out at 10 K and 297 K, The phase transition predicted by our earlier Raman observations (J. Frantti,
27.	Frantti, J, et al. (author) Phase transitions of Pb(ZrxTi1-x)O3 ceramics 2002 In: Phys. Rev. B. ; 66, s. 064108- Journal article (peer-reviewed)
28.	Gustafsson, G, et al. (author) The electric field and wave experiment for the Cluster mission 1997 In: Space Science Reviews. - 0038-6308 .- 1572-9672. ; 79, s. 137-156 Journal article (peer-reviewed)abstract The electric-field and wave experiment (EFW) on Cluster is designed to measure the electric-field and density fluctuations with sampling rates up to 36 000 samples s(-1). Langmuir probe sweeps can also be made to determine the electron density and temperature. The instrument has several important capabilities. These include (1) measurements of quasi-static electric fields of amplitudes lip to 700 mV m(-1) with high amplitude and time resolution, (2) measurements over short periods of time of up to five simualtaneous waveforms (two electric signals and three magnetic signals from the seach coil magnetometer sensors) of a bandwidth of 4 kHz with high time resolution, (3) measurements of density fluctuations in four points with high time resolution. Among the more interesting scientific objectives of the experiment are studies of nonlinear wave phenomena that result in acceleration of plasma as well as large- and small-scale interferometric measurements. By using four spacecraft for large-scale differential measurements and several Langmuir probes on one spacecraft for small-scale interferometry, it will be possible to study motion and shape of plasma structures on a wide range of spatial and temporal scales. This paper describes the primary scientific objectives of the EFW experiment and the technical capabilities of the instrument.
29.	Hicks, AU, et al. (author) Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery 2009 In: The European journal of neuroscience. - : Wiley. - 1460-9568 .- 0953-816X. ; 29:3, s. 562-574 Journal article (peer-reviewed)
30.	Huotari, J., et al. (author) Pulsed Laser Deposited Nanostructured Vanadium Oxide Thin Films Characterized as Ammonia Sensors 2015 In: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 217, s. 22-29 Journal article (peer-reviewed)abstract Vanadium oxide thin films were fabricated by pulsed laser deposition. The microstructure and crystal symmetry of the deposited films were studied with X-ray diffraction, scanning electron microscopy (SEM), and Raman spectroscopy, respectively. The films surface morphology was examined by atomic force microscopy. Raman spectroscopy and XRD results showed that the thin film phase-structure was composed of pure orthorhombic V2O5 phase, or they had a mixed phase structure of orthorhombic V2O5 and triclinic V7O16. Surface morphology of the films consisted of nanosized particles, although in pure V2O5 films some bigger agglomerates and flakes were also seen. The conductivity based gas sensing measurements showed a clear response already at ppb-levels of NH3 and strong selectivity to ammonia was found when compared to NO and CO gases. Also, the films showed promising gas sensing behavior in cross-sensitivity measurements between NO and NH3, being able to sense ammonia even in the presence of NO. This is an important property when considering possible sensing applications to control Selective Catalytic Reduction processes, e.g. in diesel engine exhausts, where introduced ammonia, or urea, transforms nitrogen oxide gases in a catalytic converter to nitrogen and water. (C) 2015 Elsevier B.V. All rights reserved.
31.	Kines, P., et al. (author) Safety climate in the Nordic construction industries 2008 In: Procedings of 4th International Conference Working on Safety, Crete, Sept 30-Oct 3.. Conference paper (other academic/artistic)
32.	Kuokkanen, R, et al. (author) A Pilot Study of Group Administered Metacognitive Training (MCT) for Schizophrenia Patients in a High-Security Forensic Setting: Subjective Training Success and Health-Related Quality of Life 2015 In: JOURNAL OF FORENSIC PSYCHOLOGY PRACTICE. - : Informa UK Limited. - 1522-8932 .- 1522-9092. ; 15:4, s. 344-362 Journal article (other academic/artistic)
33.	Kyostila, K, et al. (author) A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease 2015 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 11:4, s. e1005169- Journal article (peer-reviewed)
34.	Pulkkinen, V, et al. (author) A novel screening method detects herpesviral DNA in the idiopathic pulmonary fibrosis lung 2012 In: Annals of medicine. - : Informa UK Limited. - 1365-2060 .- 0785-3890. ; 44:2, s. 178-186 Journal article (peer-reviewed)
35.	't Hoen, Peter A C, et al. (author) Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories 2013 In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 31:11, s. 1015-1022 Journal article (peer-reviewed)abstract RNA sequencing is an increasingly popular technology for genome-wide analysis of transcript sequence and abundance. However, understanding of the sources of technical and interlaboratory variation is still limited. To address this, the GEUVADIS consortium sequenced mRNAs and small RNAs of lymphoblastoid cell lines of 465 individuals in seven sequencing centers, with a large number of replicates. The variation between laboratories appeared to be considerably smaller than the already limited biological variation. Laboratory effects were mainly seen in differences in insert size and GC content and could be adequately corrected for. In small-RNA sequencing, the microRNA (miRNA) content differed widely between samples owing to competitive sequencing of rRNA fragments. This did not affect relative quantification of miRNAs. We conclude that distributing RNA sequencing among different laboratories is feasible, given proper standardization and randomization procedures. We provide a set of quality measures and guidelines for assessing technical biases in RNA-seq data.
36.	Törner, Marianne, 1953, et al. (author) A Nordic questionnaire for assessing safety climate (NOSACQ) 2008 In: Procedings of 4th International Conference Working on Safety, Crete, Sept 30-Oct 3. Conference paper (peer-reviewed)abstract There is increasing scientific support for the causal relation between safety climate and safety performance. Many safety climate questionnaires are available, but their theoretical basis is sometimes unclear, and different types of psychological constructs intermixed. A questionnaire with documented validity and reliability in different contexts would make for better co-ordination of research in comparative studies. Theoretical advances concerning safety climate are also a prerequisite for effective practical use in working life. The aim of the present work was to develop a Nordic questionnaire for measuring safety climate, based on theory and previous empirical research. The Nordic development team of the Nordic Safety Climate Questionnaire (NOSACQ) had participants from all five Nordic countries. The work commenced in 2000 and was based on consensus meetings. Based on literature, safety climate was defined as shared perceptions among the members of a social unit, of policies, procedures and practices at management and group level, influencing safety in the organization at a given time. Dimensions to be included were to be selected on the criterion of substantial theoretical or empirical support for their validity for safety motivation or safety outcome. Items were compiled from literature and additional items were construed, when needed. The prototype questionnaire was administered in the construction industry in all five Nordic countries, in three consecutive pilot tests. The questionnaire was subsequently also tested in a sample of workers in the Swedish food processing industry. Instrument reliability was tested using structural equation modeling and Rasch analysis. The results of the pilot tests confirmed reliability and validity of the questionnaire. This supports the generic value of NOSACQ and that it has a potential for use in different industrial contexts. The instrument was also found to be valid for predicting self rated safety behavior, a proximal criterion of safety performance.
37.	D'Amato, M, et al. (author) Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease 2007 In: Gastroenterology. - : Elsevier BV. - 0016-5085. ; 133:3, s. 808-817 Journal article (peer-reviewed)
38.	Flynn, E. D., et al. (author) Transcription factor regulation of eQTL activity across individuals and tissues 2022 In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 18:1, s. e1009719- Journal article (peer-reviewed)abstract Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have been discovered in the human population. These eQTLs are active in various tissues and contexts, but the molecular mechanisms of eQTL variability are poorly understood, hindering our understanding of genetic regulation across biological contexts. Since many eQTLs are believed to act by altering transcription factor (TF) binding affinity, we hypothesized that analyzing eQTL effect size as a function of TF level may allow discovery of mechanisms of eQTL variability. Using GTEx Consortium eQTL data from 49 tissues, we analyzed the interaction between eQTL effect size and TF level across tissues and across individuals within specific tissues and generated a list of 10,098 TF-eQTL interactions across 2,136 genes that are supported by at least two lines of evidence. These TF-eQTLs were enriched for various TF binding measures, supporting with orthogonal evidence that these eQTLs are regulated by the implicated TFs. We also found that our TF-eQTLs tend to overlap genes with gene-by-environment regulatory effects and to colocalize with GWAS loci, implying that our approach can help to elucidate mechanisms of context-specificity and trait associations. Finally, we highlight an interesting example of IKZF1 TF regulation of an APBB1IP gene eQTL that colocalizes with a GWAS signal for blood cell traits. Together, our findings provide candidate TF mechanisms for a large number of eQTLs and offer a generalizable approach for researchers to discover TF regulators of genetic variant effects in additional QTL datasets.
39.	Hannelius, U, et al. (author) Population substructure in Finland and Sweden revealed by the use of spatial coordinates and a small number of unlinked autosomal SNPs 2008 In: BMC genetics. - : Springer Science and Business Media LLC. - 1471-2156. ; 9, s. 54- Journal article (peer-reviewed)
40.	Hannula-Jouppi, Katariina, et al. (author) Nagashima-type palmoplantar keratosis in Finland caused by a SERPINB7 founder mutation 2020 In: The Journal of American Academy of Dermatology. - : Mosby-Elsevier. - 0190-9622 .- 1097-6787. ; 83:2, s. 643-645 Journal article (peer-reviewed)
41.	Hytonen, MK, et al. (author) Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes 2016 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 12:5, s. e1006037- Journal article (peer-reviewed)
42.	Jalkanen, Pinja, et al. (author) A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 Serodiagnostics 2021 In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 224:2, s. 218-228 Journal article (peer-reviewed)abstract Background. Primary diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is based on detection of virus RNA in nasopharyngeal swab samples. In addition, analysis of humoral immunity against SARS-CoV-2 has an important role in viral diagnostics and seroprevalence estimates. Methods. We developed and optimized an enzyme immunoassays (EIA) using SARS-CoV-2 nucleoprotein (N), Si and receptor binding domain (RBD) of the viral spike protein, and N proteins from SARS, Middle East respiratory syndrome (MERS), and 4 low-pathogenic human CoVs. Neutralizing antibody activity was compared with SARS-CoV-2 IgG, IgA, and IgM EIA results. Results. The sensitivity of EIA for detecting immune response in COVID-19 patients (n = 101) was 77% in the acute phase and 100% in the convalescent phase of SARS-CoV-2 infection when N and RBD were used as antigens in IgG and IgA specific EIAs. SARS-CoV-2 infection significantly increased humoral immune responses against the 229E and NL63 N proteins. Si and RBD-based EIA results had a strong correlation with microneutralization test results. Conclusions. The data indicate a combination of SARS-CoV-2 Si or RBD and N proteins and analysis of IgG and IgA immunoglobulin classes in sera provide an excellent basis for specific and sensitive serological diagnostics of COVID-19.
43.	Jucaite, A, et al. (author) GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans 2017 In: Psychopharmacology. - : Springer Science and Business Media LLC. - 1432-2072 .- 0033-3158. ; 234:4, s. 707-716 Journal article (peer-reviewed)
44.	Jucaite, A, et al. (author) Relationship between dose, plasma concentration and GABA-A receptor occupancy by partial GABA-A receptor modulators 2015 In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - 0924-977X. ; 25, s. S274-S274 Conference paper (other academic/artistic)
45.	Jääskeläinen, Anne J, et al. (author) Evidence of ljungan virus specific antibodies in humans and rodents, Finland. 2013 In: Journal of Medical Virology. - : Wiley. - 0146-6615 .- 1096-9071. ; 85:11, s. 2001-2008 Journal article (peer-reviewed)abstract Ljungan virus (LV, genus Parechovirus, family Picornaviridae) is considered currently to be a rodent-borne virus. Despite suggested human disease associations, its zoonotic potential remains unclear. To date, LV antibody prevalence in both humans and rodents has not been studied. In this study, two different LV immunofluorescence assays (LV IFAs) were developed with LV genotypes 1 (LV strain 87-012G) and 2 (LV strain 145SLG), and cross-neutralization and -reaction studies were carried out with LV strain 145SLG. Finally, a panel of 37 Finnish sera was screened for anti-LV antibodies using two different LV IFAs (LV 145SLG and LV 87-012G) and a neutralization (NT) assay (LV 145SLG), and 50 samples from Myodes glareolus by LV IFA (LV 145SLG). The LV seroprevalence study showed 38% and 18% positivity in humans and M. glareolus, respectively. LV IFAs and NT assays were compared, and the results were in good agreement. The data are the first evidence of humans and rodents coming into contact with LV in Finland. Additional studies are required in order to acquire a better understanding of the prevalence, epidemiological patterns and possible disease association of LV infections.
46.	Kaartokallio, T, et al. (author) Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes 2016 In: Annals of medicine. - : Informa UK Limited. - 1365-2060 .- 0785-3890. ; 48:5, s. 330-336 Journal article (peer-reviewed)
47.	Kohonen-Corish, MRJ, et al. (author) Deciphering the colon cancer genes--report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010 2011 In: Human mutation. - : Hindawi Limited. - 1098-1004 .- 1059-7794. ; 32:4, s. 491-494 Journal article (other academic/artistic)
48.	Koskenvuo, M, et al. (author) Viremic co-infections in children with allogeneic haematopoietic stem cell transplantation are predominated by human polyomaviruses 2017 In: Infectious diseases (London, England). - : Informa UK Limited. - 2374-4243 .- 2374-4235. ; 49:1, s. 35-41 Journal article (peer-reviewed)
49.	Kulmala, M., et al. (author) Introduction : The Pan-Eurasian Experiment (PEEX) - multidisciplinary, multiscale and multicomponent research and capacity-building initiative 2015 In: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 15:22, s. 13085-13096 Journal article (peer-reviewed)abstract The Pan-Eurasian Experiment (PEEX) is a multidisciplinary, multiscale and multicomponent research, research infrastructure and capacity-building program. PEEX has originated from a bottom-up approach by the science communities and is aiming at resolving the major uncertainties in Earth system science and global sustainability issues concerning the Arctic and boreal pan-Eurasian regions, as well as China. The vision of PEEX is to solve interlinked, global grand challenges influencing human well-being and societies in northern Eurasia and China. Such challenges include climate change; air quality; biodiversity loss; urbanization; chemicalization; food and freshwater availability; energy production; and use of natural resources by mining, industry, energy production and transport sectors. Our approach is integrative and supra-disciplinary, recognizing the important role of the Arctic and boreal ecosystems in the Earth system. The PEEX vision includes establishing and maintaining long-term, coherent and coordinated research activities as well as continuous, comprehensive research and educational infrastructure and related capacity-building across the PEEX domain. In this paper we present the PEEX structure and summarize its motivation, objectives and future outlook.
50.	Kulmala, M., et al. (author) Introduction: European Integrated Project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) : integrating aerosol research from nano to global scales 2009 In: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 9, s. 2825-2841 Journal article (peer-reviewed)abstract The European Aerosol Cloud Climate and Air Quality Interactions project EUCAARI is an EU Research Framework 6 integrated project focusing on understanding the interactions of climate and air pollution. EUCAARI works in an integrative and multidisciplinary way from nano-to global scale. EUCAARI brings together several leading European research groups, state-of-the-art infrastructure and some key scientists from third countries to investigate the role of aerosol on climate and air quality. Altogether 48 partners from 25 countries are participating in EUCAARI. During the first 16 months EUCAARI has built operational systems, e. g. established pan-European measurement network for Lagrangian studies and four stations in developing countries. Also an improved understanding of nanoscale processes (like nucleation) has been implemented in global models. Here we present the research methods, organisation, operations and first results of EUCAARI.

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