| 1. |
- Nilsson, Christa, et al.
(författare)
-
Characterization of Oil-Free and Oil-Loaded Liquid-Crystalline Particles Stabilized by Negatively Charged Stabilizer Citrem
- 2012
-
Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 28:32, s. 11755-11766
-
Tidskriftsartikel (refereegranskat)abstract
- The present study was designed to evaluate the effect of the negatively charged food-grade emulsifier citrem on the internal nanostructures of oil-free and oil-loaded aqueous dispersions of phytantriol (PHYT) and glyceryl monooleate (GMO). To our knowledge, this is the first report in the literature on the utilization of this charged stabilizing agent in the formation of aqueous dispersions consisting of well-ordered interiors (either inverted-type hexagonal (H2) phases or inverted-type microemulsion systems). Synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) were used to characterize the dispersed and the corresponding nondispersed phases of inverted-type nonlamellar liquid-crystalline phases and microemulsions. The results suggest a transition between different internal nanostructures of the aqueous dispersions after the addition of the stabilizer. In addition to the main function of citrem as a stabilizer that adheres to the surface of the dispersed particles, it has a significant impact on the internal nanostructures, which is governed by the following factors: (1) its penetration between the hydrophobic tails of the lipid molecules and (2) its degree of incorporation into the lipid–water interfacial area. In the presence of citrem, the formation of aqueous dispersions with functionalized hydrophilic domains by the enlargement of the hydrophilic nanochannels of the internal H2 phase in hexosomes and the hydrophilic core of the L2 phase in emulsified microemulsions (EMEs) could be particularly attractive for solubilizing and controlling the release of positively charged drugs.
|
|
| 2. |
|
|
| 3. |
- Arlien-Soborg, Mai C., et al.
(författare)
-
Acromegaly management in the Nordic countries: A Delphi consensus survey
- 2024
-
Ingår i: Clinical Endocrinology. - : WILEY. - 0300-0664 .- 1365-2265.
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
|
|
| 4. |
- Arlien-Soborg, Mai C., et al.
(författare)
-
Acromegaly management in the Nordic countries: A Delphi consensus survey
- 2024
-
Ingår i: CLINICAL ENDOCRINOLOGY. - : WILEY. - 0300-0664 .- 1365-2265.
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
|
|
| 5. |
- Arlien-Søborg, Mai C., et al.
(författare)
-
Acromegaly management in the nordic countries : a Delphi consensus survey
- 2024
-
Ingår i: Clinical Endocrinology. - : John Wiley & Sons. - 0300-0664 .- 1365-2265.
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
|
|
| 6. |
|
|
| 7. |
- Benner, Mats, et al.
(författare)
-
Are some technical universities better than others?
- 2020
-
Ingår i: Technical Universities : Past, Present and Future - Past, Present and Future. - Cham : Springer International Publishing. - 9783030505547 - 9783030505554 ; , s. 27-43
-
Bokkapitel (refereegranskat)abstract
- Technical universities is an omnibus concept, which may conceal variations. This is the fundamental assumption of this chapter, which deals with three technical universities in three European countries: KTH in Sweden, DTU in Denmark, and EPFL in Switzerland. Based on an analysis of scientific impact profiles and their alignment with government steering, funding and internal organisation and leadership, it is concluded that there are marked variations between the three technical universities. It cannot be said that one technical university is better than others; only that they configure tasks and roles differently.
|
|
| 8. |
|
|
| 9. |
- Berg Mårtensson, Hampus, et al.
(författare)
-
Investigating potential effects of mobility and accessibility services using the avoid-shift-improve framework
- 2023
-
Ingår i: Sustainable cities and society. - : Elsevier BV. - 2210-6707. ; 96, s. 104676-104676
-
Tidskriftsartikel (refereegranskat)abstract
- Mobility services and accessibility services could contribute to reduced car-dependency and a more sustainable transport system. However, uncertainty remains regarding what the effects will be and further research is needed. In this paper we examine potential effects on passenger car-travel in an urban context. To do so, we actuate the Avoid-Shift-Improve (ASI) framework using a System Dynamics approach and develop thematic Causal Loop Diagrams. We draw on the findings from a literature study and workshops engaging actors involved in creating visions and planning for the future of mobility and accessibility services in Stockholm, Sweden. The effects discovered are categorized as direct, enabling and structural/systemic, using a retrofitted version of the Three-Levels Model. Contributions include the mapping of mechanisms through which the services can have positive and negative effects in relation to ASI, demonstrating a high degree of interconnectedness. This includes potential synergetic and competitive relations between the services. In addition, the approach gives insight to potential cumulative impact of the services, relatable to Mobility as a Service, including ‘user near’ effects regarding, e.g., commuting and leisure travel, as well as systemic and structural level effects. A discussion is conducted on the implications for actors and policy-makers.
|
|
| 10. |
- Bienkowska, Dzamila, et al.
(författare)
-
Public-private innovation : Mediating roles and ICT niches of industrial research institutes
- 2010
-
Ingår i: INNOV-MANAG POLICY PRACT. - : Informa UK Limited. - 1447-9338. ; 12:2, s. 206-216
-
Tidskriftsartikel (refereegranskat)abstract
- Innovation processes involve diverse sets of organizations including universities, private firms, corporate research labs and public research institutes. Collaborative forms of knowledge production and innovative activity enable actors to reduce risk, specialize, and take advantage of knowledge internal and external to the own organization. This paper discusses interactions and collaborations between public and private sector innovation. This is done through an analysis of semi-public research institutes in Sweden and their roles as arenas for R&D processes involving industry, university and government in terms of funding, research and public-private innovation. Particular attention is paid to technological niches of research institutes and utilization of research findings from collaborative R&D. The results show that institutes occupy specific niches which influence their ways of transferring knowledge. It is argued that diversity among R&D performers as well as funding opportunities is paramount for innovation systems to thrive.
|
|
| 11. |
- Broström, Anders, Docent, 1978-, et al.
(författare)
-
Concluding Discussion : The Past, Present, and Future of Technical Universities
- 2020. - 1
-
Ingår i: Technical Universities. - Cham : Springer Nature. ; , s. 227-242
-
Bokkapitel (refereegranskat)abstract
- Higher education institutions identified as ‘technical universities’ enjoy considerable status in many countries. Yet studies of boundary negotiations from a range of settings suggest that opportunities to transform into a broader, research-based university often takes precedence over the alternative vision of remaining or moving towards becoming a focused technical university. In this chapter, we discuss alternative explanations for the lacklustre appeal of the latter type of institutional template, and outline a roadmap for how the historical legacy of the technical university may be cultivated.
|
|
| 12. |
- Bruno, Karl, et al.
(författare)
-
Knowledge production at industrial research institutes : Institutional logics and struggles for relevance in the Swedish Institute for Surface Chemistry, 1980-2005
- 2017
-
Ingår i: Research Evaluation. - : OXFORD UNIV PRESS. - 0958-2029 .- 1471-5449. ; 26:4, s. 337-348
-
Tidskriftsartikel (refereegranskat)abstract
- This article examines dynamics of knowledge production and discourses of basic-applied science and relevance at the Swedish Institute for Surface Chemistry, a semi-public industrially oriented research institute, from 1980 to 2005. We employ a three-pronged method, consisting of (1) an analysis of how the institute articulated its research priorities and goals in publications primarily directed to stakeholders, (2) an analysis of retrospective narratives by researchers and managers about research ideologies and priorities, and (3) a bibliometric analysis of the institute's scientific publications. Using a theoretical framework centered on the notions of institutional logics and struggles for relevance, we show how the transformations of the institute amount to a substitution of an internalized institutional logic of scientific autonomy with a new logic of industrial utility, and how the institute's knowledge production was managed during this change. We also point out various strategies used by the institute to preserve and advance its own goals while still remaining relevant with regard to changing policy objectives. Another important finding is that although the institute by the end of the study period was fully committed to an industrial service role, parts of the originally deeply entrenched scientific logic were still manifested, although then discussed in the new industrial terminology.
|
|
| 13. |
- Carr, Richard D., et al.
(författare)
-
Incretin and islet hormonal responses to fat and protein ingestion in healthy men
- 2008
-
Ingår i: American Journal of Physiology: Endocrinology and Metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 295:4, s. 779-784
-
Tidskriftsartikel (refereegranskat)abstract
- Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrients is not known. This study therefore examined integrated incretin and islet hormone responses to ingestion of pure fat (oleic acid; 0.88 g/kg) or protein (milk and egg protein; 2 g/kg) over 5 h in healthy men, aged 20-25 yr (n = 12); plain water ingestion served as control. Both intact (active) and total GLP-1 and GIP levels were determined as was plasma activity of dipeptidyl peptidase-4 (DPP-4). Following water ingestion, glucose, insulin, glucagon, GLP-1, and GIP levels and DPP-4 activity were stable during the 5-h study period. Both fat and protein ingestion increased insulin, glucagon, GIP, and GLP-1 levels without affecting glucose levels or DPP-4 activity. The GLP-1 responses were similar after protein and fat, whereas the early (30 min) GIP response was higher after protein than after fat ingestion (P < 0.001). This was associated with sevenfold higher insulin and glucagon responses compared with fat ingestion (both P < 0.001). After protein, the early GIP, but not GLP-1, responses correlated to insulin (r(2) = 0.86; P = 0.0001) but not glucagon responses. In contrast, after fat ingestion, GLP-1 and GIP did not correlate to islet hormones. We conclude that, whereas protein and fat release both incretin and islet hormones, the early GIP secretion after protein ingestion may be of primary importance to islet hormone secretion.
|
|
| 14. |
- Carr, Richard D, et al.
(författare)
-
Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men.
- 2010
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 95, s. 872-878
-
Tidskriftsartikel (refereegranskat)abstract
- Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secretion and metabolism is not known. Objective: The aim of the study was to assess incretin hormone secretion and degradation in lean and obese nondiabetic subjects. Design, Settings, and Participants: We studied the ingestion of a mixed meal (560 kcal) or oral glucose (2 g/kg) in healthy lean (n = 12; body mass index, 20-25 kg/m(2)) or obese (n = 13; body mass index, 30-35 kg/m(2)) males at a University Clinical Research Unit. Main Outcome Measures: We measured the area under the curve of plasma intact (i) and total (t) GIP and GLP-1 after meal ingestion and oral glucose. Results: Plasma DPP-4 activity was higher in the obese subjects (38.5 +/- 3.0 vs. 26.7 +/- 1.6 mmol/min . mul; P = 0.002). Although GIP secretion (AUCtGIP) was not reduced in obese subjects after meal ingestion or oral glucose, AUCiGIP was lower in obese subjects (8.5 +/- 0.6 vs. 12.7 +/- 0.9 nmol/liter x 300 min; P < 0.001) after meal ingestion. GLP-1 secretion (AUCtGLP-1) was reduced in obese subjects after both meal ingestion (7.3 +/- 0.9 vs. 10.0 +/- 0.6 nmol/liter x 300 min; P = 0.022) and oral glucose (6.6 +/- 0.8 vs. 9.6 +/- 1.1 nmol/liter x 180 min; P = 0.035). iGLP-1 was reduced in parallel to tGLP-1. Conclusions: 1) Release and degradation of the two incretin hormones show dissociated changes in obesity: GLP-1 but not GIP secretion is lower after meal ingestion and oral glucose, whereas GIP but not GLP-1 metabolism is increased after meal ingestion. 2) Increased plasma DPP-4 activity in obesity is not associated with a generalized augmented incretin hormone metabolism.
|
|
| 15. |
- Christensen, Miyase, et al.
(författare)
-
Environmental Themes in Popular Narratives
- 2018
-
Ingår i: Environmental Communication. - : Taylor & Francis. - 1752-4032 .- 1752-4040. ; 12:1
-
Tidskriftsartikel (refereegranskat)
|
|
| 16. |
-
Climate-Proof Planning : Creative Design Solutions in Stockholm
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- IntroductionThe waterfront of Stockholm, one of Europe's fastest-growing cities, stands at the forefront of climate change challenges. As such, there is a pressing need for innovative solutions and resilient urban design. The SOS Climate Waterfront research project gathered international experts and local representatives, coming from different disciplines to work together in May-June 2022 to discuss, explore proposals and design Sustainable Open Solutions (SOS).This book explores three urban sites in Stockholm, holding significant implications for the city's waterfront— Lövholmen, Frihamnen, and Södra Värtan. During the workshop, SOS Climate Waterfront participants, mainly European researchers, analyzed future challenges, raised new questions, and depicted solutions, which can now contribute to cross-country comparisons in a larger EU-framework.The three sites are not only driven by the demand for more housing but also face crucial issues related to cultural heritage, climate change, landscape ecology, and social development. Achieving a delicate balance between these aspects and economic interests presents a significant task for the city. The waterfront of Stockholm holds substantial relevance in the context of climate change and its impact on coastal areas. Thus, analysis of the Swedish context, based on data collected and on-site knowledge sustains a deeper understanding of the challenges and opportunities that lie ahead.Stockholm is expected to be affected by the impacts of climate change, including temperature increases, changing precipitation patterns, and the potential for more frequent cloudbursts. While the rising sea level is a long-term challenge rather than an immediate concern, increasing risks of extreme weather events and flooding were taken in consideration.Stockholm rests on two different bodies of water, at a location where the Baltic Sea (Östersjön in Swedish) with brackish water meets Lake Mälaren, which is an important provider of freshwater for the larger Stockholm area. As the lyrics of a popular contemporary Swedish song (by Robert Broberg) describe it: “the city is full of water”. However, to ensure that the ecological and chemical status will be maintained, in facing future challenges in terms of urbanisation and climate change, much attention has been paid to ensure the preservation of the water quality of the Mälaren Lake, a vital water source for two million people.The city values its water and continuously invests in improving the situation (e.g. the new sluice at Slussen). The activities carried out in the SOS Climate Waterfront workshop in Stockholm integrated this relationship to water as well as the continuing land-rise, the balance of which adds complexity to the sea level modelling and therefore also to the anticipations and scenarios for the future.In this book, the authors explore innovative strategies and design proposals to tackle these challenges while preserving the cultural identity and heritage value of the sites. Researchers from various European cities, supported by experts and academic lectures, analyze extensive input materials and information, ranging from planning documents and historical records to consultation reports and city visions. By drawing upon multidisciplinary backgrounds and experiences, the researchers identify the socioeconomic and environmental qualities of each site, ultimately developing site design concepts and solutions that address climate change challenges, the maintenance of cultural identities, and the protection of biodiversity.Throughout the book, the proposed designs emphasize the importance of finding a balance between preserving cultural heritage, the values of local communities, the stimulating economic growth, and promotion of sustainable urban development. Key elements include the reuse of existing infrastructure, the integration of green-blue schemes, the improvement of biodiversity, and the creation of vibrant and multi-functional neighbourhoods that connect people to each other and their surroundings.While design solutions present promising approaches, their implementation and the institutional challenges that may arise in specific city contexts remain external to the results presented here. The book acknowledges the need for further research and highlights the shared recognition among the workshop participants regarding the gaps and blind spots in their findings.The following chapters of the book delve into climate change in Sweden, the role of culture and arts in the environmental movement, and specific case studies and design proposals for each site. By exploring these diverse perspectives, this book aims to contribute to the ongoing discourse on sustainable urban design and planning, to inspire innovative approaches in addressing complex challenges faced by Stockholm in the future.PART 1 of the book offers a comprehensive understanding of climate change in Sweden, street fishing in Stockholm, and the role of culture and arts in the environmental movement in the Nordic Region and internationally. Furthermore, the lessons from Stockholm and its surroundings in this report draw on presentations, by professionals and researchers from various fields, made during the workshop. Some of these lessons have been written into interesting articles, introduced below.The chapter “Climate change in Sweden” by Magnus Joelsson from the Swedish Meteorological and Hydrological Institute (SMHI) provides an updated analysis with data and the context for discussing climate change in Sweden. The text makes the distinction between weather and climate, referring to the expression “Climate is what you expect, weather is what you get” that Mark Twain is said to have coined. Moreover, calling for actions by emphasising that the trend of climate change is expected to continue, both globally and in Sweden. What will happen in the far future still depends on our actions, now and in the future.The contribution entitled “Urban nature does not stop at the waterfront, neither should urban planning, a case study of street fishing in Stockholm” raises questions about how planning and strategies for waterfront areas in cities should consider more perspectives from a wider group of interests. It discusses how urban dwellers live with water, with a focus on recreational fishing and what this use entails. The authors (Anja Moum Rieser, from KTH Royal Institute of Technology, Wieben Johannes Boonstra and Rikard Hedling, both from Uppsala University) go beyond the human-centric view and expand the gaze to other species’ needs and also incorporating the body of water in planning for the urban waterfront areas.The chapter “The role of culture and arts in the environmental movement in the Nordic Region and internationally” by Elisavet Papageorgiou and Iwona Preis from Intercult, discusses artistic perspectives on sustainability and climate change. This focuses on how art and culture can raise awareness, provide inspiring actions, and promote social cohesion around sustainable practices. Drawing on experiences from projects aiming to invite and engage community dialogues, they argue that artistic strategies can challenge dominant narratives and promote alternative visions for a sustainable future.The contribution “Sense the Marsh” by Thelma Dethelfsen from KTH The Royal Institute of Technology, emphasises the importance of architecture and landscape design in creating adaptive and resilient strategies to manage flooding and sea level rise. The study focuses on how designs can encourage interaction and awareness with the surroundings. Thereby highlighting the interfaces between humans and nature and raising questions about how flooding can be used as a quality and catalyst to attract more people to an area. The resulting design provides an opportunity to experience nature though the design and architectural solutions, situated on the border between human, non-human species and nature.In PART 2, readers will explore the detailed design proposals developed by different groups for the urban sites in focus. These proposals aim to intertwine sustainability, cultural identity, and economic interests, offering insights into the potential for resilient and vibrant urban spaces.By assessing existing conditions on three sites analysed in Stockholm, including Lövholmen, Frihamnen, and Södra Värtan, the teams participating in the workshop actively contributed to the analysis of the sites and development of design solutions for the areas, in the end forming strategies for better preparedness for future challenges and better lives for the inhabitants.Lövholmen is located in the north-western part of Liljeholmen, one of the major developmental centres in Stockholm. The area is currently a closed-off industrial site, but the municipality’s intention is to redevelop it into a mixed urban space with homes, workplaces, shops, schools, and more. It's expected that 1500 new homes will be built in the area. Many of the current industrial buildings are empty and in bad shape. While some of these will be replaced with housing, other industrial buildings have heritage value and should be protected during the development, after which a new use should be found for them. Frihamnen is, together with the Södra Värtan project, part of the larger development of ”Norra Djurgårdsstaden”, the Stockholm Royal Seaport. Frihamnen is located to the south of Värtahamnen and is in turn strongly connected to Loudden in the south. The municipality plans for the area to contain approximately 1700 homes, 4000 workplaces and 75,000 m2 of retail and office space. Some of the existing businesses in Frihamnen will remain, but much of the existing infrastructure is planned to be removed. The harbour no longer handles freight shipping, but passenger ships will continue to depart from the harbour (Frihamnspiren).Södra Värtan is planned to contain 1
|
|
| 17. |
|
|
| 18. |
- Dawkins, Elena, et al.
(författare)
-
Retracing the footsteps: how do footprint indicators support learning about sustainable consumption among Swedish policymakers?
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Consumption-based or environmental footprint indicators give a sense of society’s progress towards sustainable consumption. Studies of the role that sustainability indicators play in policy making report that they contribute to learning and conceptual thinking. This literature provides insights into the types of learning outcome that indicators contribute to, such as instrumental, policy-oriented, governmental, political, or societal learning. But few studies have looked specifically at consumption-based indicators or at the learning process itself, of how indicator use supports different actors in changing their ideas, perceptions, and practices – and potentially affects wider social and organizational structures to prompt the desired move to sustainable consumption.To address this, we draw on the theory of expansive learning to investigate the potential for learning about sustainable consumption by Swedish public officials using consumption-based indicators. Data were collected in a series of interviews, focus groups and workshops. The results suggest that consumption-based indicators do help officials to learn about the concept of sustainable consumption and encourage them to push forward the sustainable consumption agenda. This is not, however, so much due to indicators per se, but rather to the creativity and agency of committed government officials. To enhance learning and change in practices further, public officials must be supported by the necessary institutions and authority to promote sustainable consumption.
|
|
| 19. |
- Frigotto, Laura, et al.
(författare)
-
Nobel Prizes as breakthrough innovators
- 2012
-
Ingår i: Sunbelt Conference, arranged by INSNA - International Network for Social Network Analysis.
-
Konferensbidrag (refereegranskat)
|
|
| 20. |
- Gunnarsson, Thomas, et al.
(författare)
-
Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.
- 2006
-
Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 147:7, s. 3173-3180
-
Tidskriftsartikel (refereegranskat)abstract
- Monounsaturated fatty acids, such as oleic acid (OA), and certain milk proteins, especially whey protein (WP), have insulinotropic effects and can reduce postprandial glycemia. This effect may involve the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). To explore this, we examined the release and inactivation of GIP and GLP-1 after administration of glucose with or without OA or WP through gastric gavage in anesthetized C57BL/6J mice. Insulin responses to glucose (75 mg) were 3-fold augmented by addition of WP (75 mg; P < 0.01), which was associated with enhanced oral glucose tolerance (P < 0.01). The insulin response to glucose was also augmented by addition of OA (34 mg; P < 0.05) although only 1.5-fold and with no associated increase in glucose elimination. The slope of the glucose-insulin curve was increased by OA (1.7-fold; P < 0.05) and by WP(4-fold; P < 0.01) compared with glucose alone, suggesting potentiation of glucose-stimulated insulin release. WP increased GLP-1 secretion (P < 0.01), whereas GIP secretion was unaffected. OA did not affect GIP or GLP-1 secretion. Nevertheless, WP increased the levels of both intact GIP and intact GLP-1 (both P < 0.01), and OA increased the levels of intact GLP-1 (P < 0.05). WP inhibited dipeptidyl peptidase IV activity in the proximal small intestine by 50% (P < 0.05), suggesting that luminal degradation of WP generates small fragments, which are substrates for dipeptidyl peptidase IV and act as competitive inhibitors. We therefore conclude that fat and protein may serve as exogenous regulators of secretion and inactivation of the incretin hormones with beneficial influences on glucose metabolism.
|
|
| 21. |
- Gunnarsson-Östling, Ulrika, 1977-, et al.
(författare)
-
Climate change scenarios and behavioural change : Navigating between heuristics of deliberative planning processes and astroturfing
- 2008
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In constructing normative scenarios images of the future are generated illustrating potential ways of living, travelling and consuming products and services where certain goals such as a reduced climate impact are fulfilled (Börjeson et al, 2006; Myers and Kitsuse, 2000). This paper analyses the sustainability framing of behavioural changes in such normative scenarios (Larsen and Höjer, 2007) and how it relates to the participatory processes used to generate the scenarios. We discuss this building on concepts of deliberative planning processes as a means to achieve legitimate, effective and sustainable futures (Connelly and Richardson, forthcoming; Hendriks et al., 2007). The theoretical arguments are combined with examples from environmental scenario construction in practice (Carlsson-Kanyama et al., 2003, Dreborg et al., forthcoming). This illustrates fields of tension arising when either sustainability or process values are veneering goals of a scenario making process. When focus is on content values such as reduced climate impact, the process values might be depreciated. On the other hand, when focus is on process values such as legitimacy, content sustainability and possibilities for actual change might be downgraded.
|
|
| 22. |
- Hollenberg, Jacob, et al.
(författare)
-
Dual dispatch early defibrillation in out-of-hospital cardiac arrest: the SALSA-pilot
- 2009
-
Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 30:14, s. 1781-9
-
Tidskriftsartikel (refereegranskat)abstract
- AIMS: Out-of-hospital cardiac arrest (OHCA) is a major public health problem. The objective of this study is to explore the effects of a dual dispatch early defibrillation programme. METHODS AND RESULTS: In this pilot study, automated external defibrillators (AEDs) were provided to all 43 fire stations in Stockholm during 2005. Fire-fighters were dispatched in parallel with traditional emergency medical responders (EMS) to all suspected cases of OHCA. Additionally, 65 larger public venues were equipped with AEDs. All 863 OHCA from December 2005 to December 2006 were included during the intervention, whereas all 657 OHCA from 2004 served as historical controls. Among dual dispatches, fire-fighters assisted with cardiopulmonary resuscitation (CPR) in 94% of the cases and arrived first on scene in 36%. The median time from call to arrival of first responder decreased from 7.5 min during the control period to 7.1 min during the intervention (P = 0.004). The proportion of patients in shockable rhythm remained unchanged. The proportion of patients alive 1 month after OHCA rose from 4.4 to 6.8% [adjusted odds ratio (OR): 1.6; 95% confidence interval (CI): 0.9-2.9]. One-month survival in witnessed cases rose from 5.7 to 9.7% (adjusted OR: 2.0; 95% CI: 1.1-3.7). Survival after OHCA in the rest of Sweden (Stockholm excluded) declined from 8.3 to 6.6% during the corresponding time period (unadjusted OR: 0.8; 95% CI: 0.6-1.0). Only three OHCA occurred at public venues equipped with AEDs. CONCLUSION: An introduction of a dual dispatch early defibrillation programme in Stockholm has shortened response times and is likely to have improved survival in patients with OHCA, especially in the group of witnessed cardiac arrests. The increase in survival is believed to be associated with improved CPR and shortened time intervals.
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
- Höjer, Mattias, et al.
(författare)
-
Sustainable communications and innovation : Different types of effects from collaborative research including university and companies in the ICT-sector
- 2012
-
Ingår i: ICT Critical Infrastructures and Society. - Berlin, Heidelberg : Springer. - 9783642333316 ; , s. 170-182
-
Konferensbidrag (refereegranskat)abstract
- This paper presents experiences from the Centre for Sustainable Communications (CESC) located at KTH – The Royal Institute of Technology in Stockholm. Since 2007, the centre has carried out research in collaboration with private firms in the information and communication technology (ICT) and media sectors as well as with public sector organizations in the city of Stockholm. The aim is to share experiences from how the partners of the centre describe benefits and effects from collaborative research. Since the centre is focusing on use of ICT and media technology, rather than technology development per se, this provides an account of a wide range of effects from university-industry collaborations and new insights into the innovation processes targeting sustainability in the ICT and media sectors. This is an important perspective of sustainable and responsible innovation that is not captured in traditional innovation surveys (counting the number of new products or patents). Areas examined here include: increased knowledge and competence, new contacts and networks, publications, methods and new technology as well as changes in business operations and behaviour targeting sustainable solutions. The results also confirm firm-level business value as a driver for sustainability and provide experiences from involving users in the quest for sustainable and responsible innovation.
|
|
| 26. |
- Janhager Stier, Jenny, 1973-, et al.
(författare)
-
Innovation ecosystem challenges : - Experiences from socially critical digitalization projects
- 2023
-
Ingår i: Proceedings of the XXXIV ISPIM Innovation Conference.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Solving many current societal challenges requires collaboration between numerous actors from different disciplines. However, there are several challenges in these interdisciplinary collaborations that have managerial implications, which this article aims to describe. The study is based on observations and fourteen interviews with actors from three innovation ecosystems (IES) that attack the challenges with the help of digitalization and enabling technology. Examples of identified challenges are difficulties for participating competitors to cooperate, that actors may feel threatened by the approaching result from the collaboration, that the actors may have different underlying motives for participating in the IES, and difficulties for actors to understand each other due to different domain knowledge.
|
|
| 27. |
|
|
| 28. |
- Larsen, Katarina, et al.
(författare)
-
Back to basics – revisiting rhetoric of competitive research funding allocation and impact agenda in Sweden
- 2016
-
Konferensbidrag (refereegranskat)abstract
- Science policy studies have traditionally been concerned with analysis of research programs, national science policy and their motivation for investments in science and in basic research in particular. As Keith Pavitt (1991) pointed out, the “market failure” line of argument has been in the limelight with less attention paid to other questions such as the following: “How does science contribute to technology?” In the Swedish context, this is a relevant question given that it is a nation with high share of investments in science and historically high level of industry investments in R&D. The aim of the current study is to analyse the rhetoric of science policy about how investments in scientific excellence contributes to industrially relevant output. We examine this by taking a closer look at different strands of arguments and assessment criteria used to support competitive funding allocation to university-based research. Particular attention is paid to examining centres of excellence (CoE) as a form of science policy of promoting both scientific excellence and interaction between academia and industry. Moreover the study examines consequences of interim evaluations and the policy advice given in assessments of centre activities. One conclusion is that the research funding agency assessment criteria have a strong influence on the direction on future centre activities but also that the range of present and future activities are determined by areas where the centre have internationally high quality research and the impact agenda defined by the centre in interaction with industry partners of ongoing research projects.
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
- Larsen, Katarina, et al.
(författare)
-
Climate change scenarios and citizen-participation : Mitigation and adaptation perspectives in constructing sustainable futures
- 2009
-
Ingår i: Habitat International. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0197-3975 .- 1873-5428. ; 33:3, s. 260-266
-
Tidskriftsartikel (refereegranskat)abstract
- This paper discusses adaptation and mitigation strategies as outlined in climate change scenarios. The adaptive perspective is closely connected to the concept of resilience understood as different views on nature's capacity to absorb shocks, renewal and re-organization. In constructing normative scenarios images of the future are generated illustrating potential ways of living, travelling and consuming products and services where certain goals such as a reduced climate impact are fulfilled. This paper argues that tension arising from climate strategies relying on either adaptation or mitigation strategies, or combining the two strategies, warrant further examination. In this paper the inter-relationships between adaptation and mitigation are discussed by examining processes of citizen-participation in constructing scenarios and applying the concepts of resilience, vulnerability and adaptive capacity. We discuss this using the concept of deliberative planning processes as a means to achieve legitimate, effective and sustainable futures. As a part of this approach, we argue that methods for citizen-participation applied in exploring different science and technology options also provide useful insight for this type of planning processes. The theoretical arguments are combined with examples from environmental scenario construction in practice. The paper brings attention to tensions between sustainability content values, such as reduced climate impact, and more process-oriented values such as legitimacy, learning and participatory scenario construction. Moreover, the concept of open innovation processes is introduced to the context of participatory scenario construction comparing shared ground in terms of user-involvement in search of novel solutions and also increasing robustness of action plans implemented to reduce climate change.
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
- Larsen, Katarina, et al.
(författare)
-
Co-creative processes between the arts, engineering, and science in constructing new imaginaries of critical infrastructures
- 2021
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we explore co-creative processes between researchers, art institutions and artists and new roles emerging for engineers in that process. The modern infrastructure ideal of universal, uniform, networked infrastructure has dominated the imagination of planners and engineers in the Global North and South for over a century. However, the dawn of the Anthropocene has triggered new concerns and challenges for critical infrastructures (water, electricity roads etc.) disrupting the modernist imagination. Somewhat unsurprisingly, these concerns have been translated into academic and policy discourses about the development of more resilient and socially inclusive critical infrastructures. In the ongoing project entitled Examining nature and society through urban infrastructure (NATURE) we develop an art exhibition in collaboration with the art institution Färgfabriken, in south of Stockholm. Sketches from the co-creative dialogues and interviews are used to illustrate how art can have a more central role the intellectual and public policy deliberations that shape new imaginaries of critical infrastructures. Future development of infrastructure may once again become trapped into a (less resilient and less inclusive) modernist pathway. In other words, today’s infrastructure challenges pose a threat to critical infrastructures but also a window of opportunity for environmental humanities propose strong and novel ideas shaping future infrastructures. In this paper, we will explore how the arts can help draw attention to the importance of the role of previously unarticulated socio-natures and the role of the non-human in infrastructure imaginaries. The aim of the paper is also to initiate a discussion about how arts can become catalytic for translating key insights on critical infrastructures from the environmental humanities into more widely accessible and publicly deliberated.
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
- Larsen, Katarina, 1974-, et al.
(författare)
-
Emerging technology and distributed innovation in solar cell technology : a study of topical islands,citation networks and the path most travelled
- 2011
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The methodology development in this the study contributes with an interesting new empirical settingfor using citation network analysis applied to solar cell technology that challenged prevailing regimeof understanding „how you make‟ solar cells. The preliminary results points to the usefulness ofcombining main path analysis with analysis of the topical islands of the citation network. Thecomplexity of the field of dye-sensitized solar cells itself can contribute to that new areas of inquirycan be shown, such as the example of the “organic dyes” discussed in the paper. Combiningquantitative data with a storyline of key events aims to provide a richer story of the history ofscientific discovery of nanostructured solar cell technology building on skills and knowledge that spandisciplinary boundaries. This particular type of solar cells is in the crossroads of chemistry, physicsand material sciences and can thereby also provide further insight into the dynamics ofinterdisciplinary technology.
|
|
| 41. |
- Larsen, Katarina, et al.
(författare)
-
Environmental scenarios and local-global level of communityengagement : Environmental justice, jams, institutions and innovation
- 2011
-
Ingår i: Futures. - : Elsevier. - 0016-3287 .- 1873-6378. ; 43:4, s. 413-423
-
Tidskriftsartikel (refereegranskat)abstract
- National climate change policy currently operates on a continuum from the local community to the supra-national level. These initiatives include local deliberative processes of low-carbon futures as well as local-global interactions in ‘eco-innovation jam’ dialogues carried out in a virtual space, but founded on communicating with local stakeholder groups. Experiences from national processes and international examples of these structured dialogues of community engagement raise important questions of environmental justice and deliberative processes that facilitate participation by some groups, but perhaps also neglect others. This is particularly relevant since the environmental justice discourse traditionally frames environmental concerns in a place-bound manner that includes local responses to environmental questions. In this paper we argue the importance of local and global forums and deliberative processes for community engagement in order to incorporate stakeholders’ perceptions of future options for low-carbon living, travelling and consuming services and products. Important policy transformations in planning for low-carbon societies are outlined and results from cases are discussed. We conclude with three remarks about the importance of citizen participation for understanding local conditions for change, processes of localized internationalization, and new roles for nation states facing the climate change challenge. We also recognise the importance of the local and global level of deliberative processes targeting sustainable urban futures.
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
- Larsen, Katarina, et al.
(författare)
-
Impact and beyond in research centres : university-industry collaboration in material sciences
- 2015
-
Ingår i: Proceedings XIII Triple Helix conference, Beijing, August 2015. Panel session: University-Industry relationships. - Beijing, China. ; , s. 158-177
-
Konferensbidrag (refereegranskat)abstract
- This study is concerned with the role of research centres in realising universities‟ impact strategy. From the university management‟s perspective, this raises questions about how a university more systematically can organize and manage effective environments to stimulate both academic excellence and societal impact. The analysis draws on experiences from a centre in the area of material sciences with an explicit ambition to generate impact through engaging in research and education activities together with industry. The study aims to build knowledge on what type of impact goals these centres are targeting and what impact mechanisms that are considered important in order to achieve these goals. The results show that the centre has established mechanisms for close-knitted collaborative research, which also create an in-depth understanding among collaborators about areas of application of new materials and the diverse range of research work in the centre. This facilitates translation activities to form more fundamental research questions from industry‟s practical needs. Four areas of impact are identified: 1) tools and methods saving time, money and materials 2) skilled people 3) solutions of theoretical problems; and 4) development of absorptive capacity and science-signalling trough co-publications between industry partners and centre researchers. Conclusions about scope of impact, in the Swedish case, are presented in relation to recent university policy in UK, also discussing key themes of centres as impact creators.
|
|
| 45. |
- Larsen, Katarina, 1974-, et al.
(författare)
-
Industrial research institutes' collaboration : a three-way solution to integrating new research skills
- 2009
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Innovation processes in emerging fields of technology frequently utilize scientific knowledge and technical skills from several research areas. Likewise, technological development frequently involves a diverse set of organizations including for example private firms, universities, corporate research labs and public or semi-public research and technology organizations (RTOs). These processes spur the need for both organizational and institutional change and adjustment, e.g. in order to facilitate research and development (R&D) and formation of innovation networks. The main question analyzed in the paper is how RTOs cope with integrating new skills in their competence base in the quest for exploring new emerging science fields and technology applications. The empirical setting consists of Swedish semi-public industrial research institutes active in the fields of pulp & paper technology and electronics, optics & communication technology respectively. The results of the study bring attention to three ways of integrating diverse skills and types of actors in R&D networks. These are: organization of collaborative research in formalized industry-specific R&D programs, purposeful organizational change also including redefinition of categories of core research competence and finally by targeting ‘open’ innovation processes characterized by incorporation of both end-users and skills of neighboring technology areas.
|
|
| 46. |
|
|
| 47. |
- Larsen, Katarina, 1974-
(författare)
-
Innovation Processes and Environmental Planning : Science and Technology Policies in a Regional Context
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The understanding of environmental change and how it is influenced by innovation processes and advances in science and technology is multifaceted given the inherent uncertainty of the pace and direction of technology change, but also given the limits to anticipate future environmental effects of new technology. The doctoral thesis is organised in two parts. The covering essay constitutes the first part and is aimed at introducing the scope of the research; outlining theoretical perspectives and central concepts and positioning the research to other research studies. Reprints of the six papers included in the thesis comprise the second part of the thesis. The first aim of this doctoral thesis is to contribute to an increased understanding of the conditions for environmental policy and planning through innovation, science policy and technological change. Particular attention is paid to the institutional frameworks for policy processes, public-private interactive policy and strategic planning with futures studies. The second aim is to explore and analyse approaches applied for assessing the output, impact and structure of science in the area of strategic environmental research. This includes an examination of research assessment criteria and an analysis of knowledge networks in strategic environmental research, characterised by socio-economic expectations of generating innovations that benefit the environment through the industrial application of science. Four types of environmental planning are studied using a combined qualitative and quantitative research approach. These are corporate environmental planning, public environmental planning, strategic long-term planning, and strategic science planning targeting advances in science and technology to attain environmental objectives. The findings of the study show that institutional frameworks of science and technology policy affecting environmental planning are found in organisational forms, such as science parks, but also in institutions understood as values and norms of the science system. With an increased focus on assessment of research as well as future technology, the findings of the study also contributes by examining approaches applied for assessing the output, structure and impact of research, using bibliometrics and social network analysis in the area of strategic environmental research.
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
- Larsen, Katarina
(författare)
-
Interdisciplinarity in environmental technology applications - Examining knowledge interaction between physics and chemistry research teams
- 2007
-
Ingår i: Proceedings of ISSI 2007. - LEUVEN : INTERNATIONAL SOCIETY FOR SCIENTOMETRICS & INFORMETRICS-ISSI. ; , s. 463-468
-
Konferensbidrag (refereegranskat)abstract
- This paper examines interdisciplinarity in science-based environmental technology applications including nanoscience applications in solar cell technology and sensor technology for pollution monitoring (of for example vehicle exhaust gas). Data and methods include analysis of co-authorship links, citation data combined with content analysis and interviews with researchers active in the field. Interdisciplinarity of science and technology areas has been analysed at the level of researcher affiliation, journal type and keywords. In addition to these measures of interdisciplinarity, this study acknowledges the importance to recognise the character of links. This includes both their content and the context that generates interdisciplinary links between research teams trough citations or co-authorships interaction. To illustrate this, the knowledge networks of two research teams from the same university are examined and visualised using bibliographic coupling and co-authorship networks. The findings show that although there are no direct co-authorship links between the two research teams in the dataset analysed, links were identified though bibliographic coupling. In examining the context generating a shared reference between the research teams, one of the teams show citation patterns described here as "interdisciplinary outlook" compared to the "intradisciplinary magnifier" pattern of the other research team.
|
|
