| 1. |
- Johansson, Malin E V, 1971, et al.
(författare)
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Composition and functional role of the mucus layers in the intestine.
- 2011
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Ingår i: Cellular and Molecular Life Sciences. - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 68, s. 3635-3641
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Forskningsöversikt (refereegranskat)abstract
- In discussions on intestinal protection, the protective capacity of mucus has not been very much considered. The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this. The intestinal enterocytes have their apical surfaces covered by transmembrane mucins and the whole intestinal surface is further covered by mucus, built around the gel-forming mucin MUC2. The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.
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| 2. |
- Andersson, Mats X., 1977, et al.
(författare)
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Phosphate-deficient oat replaces a major portion of the plasma membrane phospholipids with the galactolipid digalactosyldiacylglycerol.
- 2003
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Ingår i: FEBS letters. - 0014-5793. ; 537:1-3, s. 128-32
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Tidskriftsartikel (refereegranskat)abstract
- The plasma membranes of oat normally resemble those of other eukaryotes in containing mainly phospholipids and sterols. We here report the novel finding that the galactolipid digalactosyldiacylglycerol (DGDG) can constitute a substantial proportion of oat plasma membrane lipids, in both shoots and roots. When oat was cultivated under severe phosphate limitation, up to 70% of the plasma membrane phosphoglycerolipids were replaced by DGDG. Our finding not only reflects a far more developed potential for plasticity in plasma membrane lipid composition than often assumed, but also merits interest in the context of the limited phosphate availability in many soils.
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| 3. |
- Bergenstråhle, Malin, 1977-, et al.
(författare)
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Dynamics of Cellulose-Water Interfaces : NMR Spin-Lattice Relaxation Times Calculated from Atomistic Computer Simulations
- 2008
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Ingår i: Journal of Physical Chemistry B. - Washington : ACS Publications. - 1520-6106 .- 1520-5207. ; 112:9, s. 2590-2595
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Tidskriftsartikel (refereegranskat)abstract
- Solid-state nuclear magnetic resonance (CP/MAS 13C NMR) spectroscopy has often been used to study cellulose structure, but some features of the cellulose NMR spectrum are not yet fully understood. One such feature is a doublet around 84 ppm, a signal that has been proposed to originate from C4 atoms at cellulose fibril surfaces. The two peaks yield different T1, differing by approximately a factor of 2 at 75 MHz. In this study, we calculate T1 from C4-H4 vector dynamics obtained from molecular dynamics computer simulations of cellulose Iβ-water interfacial systems. Calculated and experimentally obtained T1 values for C4 atoms in surface chains fell within the same order of magnitude, 3-20 s. This means that the applied force field reproduces relevant surface dynamics for the cellulose-water interface sufficiently well. Furthermore, a difference in T1 of about a factor of 2 in the range of Larmor frequencies 25-150 MHz was found for C4 atoms in chains located on top of two different crystallographic planes, namely, (110) and (10). A previously proposed explanation that the C4 peak doublet could derive from surfaces parallel to different crystallographic planes is herewith strengthened by computationally obtained evidence. Another suggested basis for this difference is that the doublet originates from C4 atoms located in surface anhydro-glucose units with hydroxymethyl groups pointing either inward or outward. This was also tested within this study but was found to yield no difference in calculated T1.
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| 4. |
- Eriksson, Anna, 1977-, et al.
(författare)
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AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
- 2014
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Ingår i: Biochemical Pharmacology. - : Elsevier. - 0006-2952 .- 1356-1839. ; 87:2, s. 284-291
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Tidskriftsartikel (refereegranskat)abstract
- AKN-028 is a novel tyrosine kinase inhibitor with preclinical activity in acute myeloid leukemia (AML), presently undergoing investigation in a phase I/II study. It is a potent inhibitor of the FMS-like kinase 3 (FLT3) but shows in vitro activity in a wide range of AML samples. In the present study, we have characterized the effects of AKN-028 on AML cells in more detail. AKN-028 induced a dose-dependent G(0)/arrest in AML cell line MV4-11. Treatment with AKN-028 caused significantly altered gene expression in all AML cell types tested (430 downregulated, 280 upregulated transcripts). Subsequent gene set enrichment analysis revealed enrichment of genes associated with the proto-oncogene and cell cycle regulator c-Myc among the downregulated genes in both AKN-028 and midostaurin treated cells. Kinase activity profiling in AML cell lines and primary AML samples showed that tyrosine kinase activity, but not serine/threonine kinase activity, was inhibited by AKN-028 in a dose dependent manner in all samples tested, reaching approximately the same level of kinase activity. Cells sensitive to AKN-028 showed a higher overall tyrosine kinase activity than more resistant ones, whereas serine/threonine kinase activity was similar for all primary AML samples. In summary, AKN-028 induces cell cycle arrest in AML cells, downregulates Myc-associated genes and affect several signaling pathways. AML cells with high global tyrosine kinase activity seem to be more sensitive to the cytotoxic effect of AKN-028 in vitro.
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| 5. |
- Franco, Irene, et al.
(författare)
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Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
- 2019
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of somatic mutation patterns, based on both types and genomic distribution of variants, can shed light on specific processes active in different human tissues and their effect on the transition to cancer. Results: To analyze somatic mutation patterns, we compile a comprehensive genetic atlas of somatic mutations in healthy human cells. High-confidence variants are obtained from newly generated and publicly available whole genome DNA sequencing data from single non-cancer cells, clonally expanded in vitro. To enable a well-controlled comparison of different cell types, we obtain single genome data (92% mean coverage) from multi-organ biopsies from the same donors. These data show multiple cell types that are protected from mutagens and display a stereotyped mutation profile, despite their origin from different tissues. Conversely, the same tissue harbors cells with distinct mutation profiles associated to different differentiation states. Analyses of mutation rate in the coding and non-coding portions of the genome identify a cell type bearing a unique mutation pattern characterized by mutation enrichment in active chromatin, regulatory, and transcribed regions. Conclusions: Our analysis of normal cells from healthy donors identifies a somatic mutation landscape that enhances the risk of tumor transformation in a specific cell population from the kidney proximal tubule. This unique pattern is characterized by high rate of mutation accumulation during adult life and specific targeting of expressed genes and regulatory regions.
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| 6. |
- Garcia, Maxime, et al.
(författare)
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Sarek: A portable workflow for whole-genome sequencing analysis of germline and somatic variants
- 2020
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Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Whole-genome sequencing (WGS) is a fundamental technology for research to advance precision medicine, but the limited availability of portable and user-friendly workflows for WGS analyses poses a major challenge for many research groups and hampers scientific progress. Here we present Sarek, an open-source workflow to detect germline variants and somatic mutations based on sequencing data from WGS, whole-exome sequencing (WES), or gene panels. Sarek features (i) easy installation, (ii) robust portability across different computer environments, (iii) comprehensive documentation, (iv) transparent and easy-to-read code, and (v) extensive quality metrics reporting. Sarek is implemented in the Nextflow workflow language and supports both Docker and Singularity containers as well as Conda environments, making it ideal for easy deployment on any POSIX-compatible computers and cloud compute environments. Sarek follows the GATK best-practice recommendations for read alignment and pre-processing, and includes a wide range of software for the identification and annotation of germline and somatic single-nucleotide variants, insertion and deletion variants, structural variants, tumour sample purity, and variations in ploidy and copy number. Sarek offers easy, efficient, and reproducible WGS analyses, and can readily be used both as a production workflow at sequencing facilities and as a powerful stand-alone tool for individual research groups. The Sarek source code, documentation and installation instructions are freely available at https://github.com/nf-core/sarek and at https://nf-co.re/sarek/.
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| 7. |
- Hafstað, Völundur, et al.
(författare)
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Regulatory networks and 5 partner usage of miRNA host gene fusions in breast cancer
- 2022
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 151:1, s. 95-106
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Tidskriftsartikel (refereegranskat)abstract
- Genomic rearrangements in cancer cells can create gene fusions where the juxtaposition of two different genes leads to the production of chimeric proteins or altered gene expression through promoter-swapping. We have previously shown that fusion transcripts involving microRNA (miRNA) host genes contribute to deregulation of miRNA expression regardless of the protein-coding potential of these transcripts. Many different genes can also be used as 5 partners by a miRNA host gene in what we named recurrent miRNA-convergent fusions. Here, we have explored the properties of 5 partners in fusion transcripts that involve miRNA hosts in breast tumours from The Cancer Genome Atlas (TCGA). We hypothesised that firstly, 5 partner genes should belong to pathways and transcriptional programmes that reflect the tumour phenotype and secondly, there should be a selection for fusion events that shape miRNA expression to benefit the tumour cell through the known hallmarks of cancer. We found that the set of 5 partners in miRNA host fusions is non-random, with overrepresentation of highly expressed genes in pathways active in cancer including epithelial-to-mesenchymal transition, translational regulation and oestrogen signalling. Furthermore, many miRNAs were upregulated in samples with host gene fusions, including established onco-genic miRNAs such as mir-21 and the mir-106b similar to mir-93 similar to mir-25 cluster. To the list of mechanisms for deregulation of miRNA expression, we have added fusion transcripts that change the promoter region. We propose that this adds material for genetic selection and tumour evolution in cancer cells and that miRNA host fusions can act as tumour drivers.
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| 8. |
- Kjellberg, Malin, 1974, et al.
(författare)
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Teacher Reflections on their Experiences Teaching Interdisciplinary Project-based Courses
- 2023
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Ingår i: Proceedings of the 51st Annual Conference of the European Society for Engineering Education (SEFI 2023). - 9782873520267 - 9782873520267 ; , s. 652-661
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Konferensbidrag (refereegranskat)abstract
- In project-based, interdisciplinary engineering courses, teachers face the challenge of not only imparting technical knowledge but also facilitating effective project- and teamwork. In this study we conducted a thematic qualitative analysis of 11 teachers' reflections on interdisciplinary project-based learning (PjBL). The results show that teachers appreciated PjBL as a means to motivate students and that one challenge was handling differences in terms of student disciplinary background. While most teachers did not see a need for further training, teachers who did identify such needs also seemed to already apply a wider range of PjBL teaching strategies. We discuss the implication of our findings for both practitioners and researchers.
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| 9. |
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| 10. |
- Kumakech, Edward, 1977-, et al.
(författare)
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Significantly reduced genoprevalence of vaccine-type HPV-16/18 infections among vaccinated compared to non-vaccinated young women 5.5 years after a bivalent HPV-16/18 vaccine (Cervarix®) pilot project in Uganda
- 2016
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Ingår i: PLoS ONE. - San Francisco, USA : Public Library of Science (PLoS). - 1932-6203. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to determine the prevalence and some predictors for vaccine and non-vaccine types of HPV infections among bivalent HPV vaccinated and non-vaccinated young women in Uganda. This was a comparative cross sectional study 5.5 years after a bivalent HPV 16/18 vaccination (Cervarix®, GlaxoSmithKline, Belgium) pilot project in western Uganda. Cervical swabs were collected between July 2014-August 2014 and analyzed with a HPV genotyping test, CLART® HPV2 assay (Genomica, Madrid Spain) which is based on PCR followed by microarray for determination of genotype. Blood samples were also tested for HIV and syphilis infections as well as CD4 and CD8 lymphocyte levels. The age range of the participants was 15-24 years and mean age was 18.6(SD 1.4). Vaccine-type HPV-16/18 strains were significantly less prevalent among vaccinated women compared to non-vaccinated women (0.5% vs 5.6%, p 0.006, OR 95% CI 0.08 (0.01-0.64). At type-specific level, significant difference was observed for HPV16 only. Other STIs (HIV/syphilis) were important risk factors for HPV infections including both vaccine types and non-vaccine types. In addition, for non-vaccine HPV types, living in an urban area, having a low BMI, low CD4 count and having had a high number of life time sexual partners were also significant risk factors. Our data concurs with the existing literature from other parts of the world regarding the effectiveness of bivalent HPV-16/18 vaccine in reducing the prevalence of HPV infections particularly vaccine HPV- 16/18 strains among vaccinated women. This study reinforces the recommendation to vaccinate young girls before sexual debut and integrate other STI particularly HIV and syphilis interventions into HPV vaccination packages.
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| 11. |
- Larsson, Gerry, Professor, 1952-, et al.
(författare)
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Leadership through the subordinates' eye : perceptions of leader behaviors in relation to age and gender
- 2023
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Ingår i: Leadership & Organization Development Journal. - 0143-7739 .- 1472-5347. ; 44:1
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Tidskriftsartikel (refereegranskat)abstract
- PurposeThe study represents a theory-based leadership approach in exploring the subordinate's perceptions of leadership behaviors in relation to age, gender and type of work environment. The aim was (1) to compare subordinates' ratings of their respective leaders' leadership behaviors based on of the leaders' age and gender, controlling for type of work environment and (2) to analyze the relationship between the subordinates' ratings of their leaders' leadership behaviors and their ratings of the outcome of these leadership behaviors.Design/methodology/approachData were collected using the Developmental Leadership Questionnaire (DLQ) from a sample of Swedish leadership course participants (n = 10,869) and their respective subordinates (n = 97,943). The DLQ measures leadership behaviors designed to reflect the following leadership styles: developmental leadership, conventional-positive leadership, conventional-negative leadership and destructive leadership.FindingsResults showed that older leaders (51 years or older) were rated less favorably than younger (29 years or younger) and mid-aged leaders. Female leaders received more positive ratings than male leaders. A 3-way analysis-of-variance showed strong main effects for age, gender, and type of work environment and no significant interaction effects. A significant model with high equivalents of R2 coefficients (Cox and Snell, 1989; Nagelkerke, 1991) was obtained in a logistic regression analysis. Developmental leadership and conventional-positive leadership made significant positive contributions to the subordinates' ratings of the outcome of their leaders' leadership behaviors. Destructive leadership behaviors contributed negatively to the outcome ratings.Research limitations/implicationsWeaknesses include the cross-sectional study design. The large sample size is a strength, and the results have novel implications for leadership theory related to subordinates' view on leadership.Practical implicationsCounter-stereotype age and gender findings may have implications for organizational decisions and processes regarding selection of managers. Development programs are suggested for all categories but for older, male leaders with a focus on reducing their use of leadership behaviors perceived negatively by their subordinates, whereas younger female leaders should be encouraged to continue to develop their positive leadership behaviors.Originality/valueThe theory-based approach on subordinates' perceptions of leadership behaviors with a simultaneous focus on age, gender and type of work environment, based on a large-scale data set, is new.
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| 12. |
- Larsson, Pär, et al.
(författare)
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Canonical insertion-deletion markers for rapid DNA typing of Francisella tularensis
- 2007
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Ingår i: Emerging Infectious Diseases. - 1080-6040 .- 1080-6059. ; 13:11, s. 1725-1732
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Tidskriftsartikel (refereegranskat)abstract
- To develop effective and accurate typing of strains of Francisella tularensis, a potent human pathogen and a putative bioterrorist agent, we combined analysis of insertion-deletion (indel) markers with multiple-locus variable-number tandem repeat analysis (MLVA). From 5 representative F. tularensis genome sequences, 38 indel markers with canonical properties, i.e., capable of sorting strains into major genetic groups, were selected. To avoid markers with a propensity for homoplasy, we used only those indels with 2 allelic variants and devoid of substantial sequence repeats. MLVA included sequences with much diversity in copy number of tandem repeats. The combined procedure allowed subspecies division, delineation of clades A.I and A.II of subspecies tularensis, differentiation of Japanese strains from other strains of subspecies holarctica, and high-resolution strain typing. The procedure uses limited amounts of killed bacterial preparations and, because only 1 single analytic method is needed, is time- and cost-effective.
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| 13. |
- Larsson, Simon A., 1990-, et al.
(författare)
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Synchronous or Not? The Timing of the Younger Dryas and Greenland Stadial-1 Reviewed Using Tephrochronology
- 2022
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Ingår i: Quaternary. - : MDPI AG. - 2571-550X. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- The exact spatial and temporal behaviour of rapid climate shifts during the Last Glacial– Interglacial Transition are still not entirely understood. In order to investigate these events, it is necessary to have detailed palaeoenvironmental reconstructions at geographically spread study sites combined with reliable correlations between them. Tephrochronology, i.e., using volcanic ash deposits in geological archives as a dating and correlation tool, offers opportunities to examine the timing of events across wider regional scales. This study aims to review the posited asynchrony of the Younger Dryas stadial in comparison with Greenland Stadial-1 by correlating new proxy data from southernmost Sweden to previous palaeoclimate reconstructions in Europe based on the presence of the Hässeldalen Tephra, the Vedde Ash, and the Laacher See Tephra. µ-XRF core-scanning data were projected using a recently published age–depth model based on these tephras and several radiocarbon dates, and compared to previous findings, including by adapting previous chronologies to the recently proposed earlier date of the Laacher See Tephra (13,006 ± 9 cal. a BP). Although the results to some extent support the idea of a more synchronous Younger Dryas event than previously assumed, this issue requires further high-resolution proxy studies to overcome limitations of temporal precision.
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| 14. |
- Lindqvist, Helen, 1977, et al.
(författare)
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Influence of herring (Clupea harengus) and herring fractions on metabolic status in rats fed a high energy diet.
- 2009
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Ingår i: Acta physiologica (Oxford, England). - : Wiley. - 1748-1716 .- 1748-1708. ; 196:3, s. 303-14
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Few dietary studies have looked beyond fish oil to explain the beneficial metabolic effects of a fish-containing diet. Our aim was to study whether addition of herring, or sub-fractions of herring, could counteract negative metabolic effects known to be induced by a high-fat, high-sugar diet. METHODS: Rats were given six different diets: standard pellets; high energy diet with chicken mince (HiE control); high energy diet with herring mince (HiE herring); and high energy diet with chicken mince and either herring oil (HiE herring oil), herring press juice, PJ (HiE PJ) or herring low molecular weight PJ (HiE LMW-PJ). Factors associated with the metabolic syndrome were measured. RESULTS: There were no differences in energy intake or body weight between the groups, but animals fed high energy diets had a higher body fat content compared with the pellet group, although not statistically significant in all groups. Mesenteric adipocyte size was smaller in the HiE herring oil group compared with the HiE control. Glucose clamp studies showed that, compared with the pellet group, the HiE control and HiE herring diets, but not the HiE herring oil diet, induced insulin resistance. Addition of herring or herring oil to the high energy diet decreased total cholesterol levels, triacylglycerols and the atherogenic index compared with the HiE control group. CONCLUSIONS: The results suggest that addition of herring or herring oil counteracts negative effects on blood lipids induced by a high energy diet. The lipid component of herring thus seems to be responsible for these beneficial effects.
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| 15. |
- Lüking, Malin, et al.
(författare)
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Molecular Origins of Kinetics and Selectivity in the lac operon
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We address the question of specificity in protein-DNA interactions using the E. colitranscription factor LacI as an example. Switching between two conformations, one fornon-specific, transient and another for specific, long-lived interaction with DNA, has beensuggested to help DNA-binding proteins solve the conflict between fast search andstable, specific binding. We tested this idea by changing the ability of LacI to switchconformations. We used molecular simulation to select LacI variants with altered flexibilityin the region that is involved in LacI’s conformational change, the hinge helix. We thenused fluorescent microscopy to study the wild-type LacI and LacI variants when binding tonon-operator and operator-DNA in vivo. In fact, LacI with a more flexible hinge helix is aweaker binder that exhibits less off-target site binding. A more stable helix, in contrast,enhances the formation of long-lived protein-DNA complexes also with non-operatorDNA. We examined the effects of two allosteric factors of LacI, the inducer IPTG, whichreduces DNA affinity, and the ligand ONPG, which enhances DNA binding according toour finding. We found that wild-type LacI is optimised for high stability of the specificcomplex and sensitivity to induction.
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| 16. |
- Lundström, Sara, 1981, et al.
(författare)
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Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms
- 2016
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 553, s. 587-95
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Tidskriftsartikel (refereegranskat)abstract
- Selection pressure generated by antibiotics released into the environment could enrich for antibiotic resistance genes and antibiotic resistant bacteria, thereby increasing the risk for transmission to humans and animals. Tetracyclines comprise an antibiotic class of great importance to both human and animal health. Accordingly, residues of tetracycline are commonly detected in aquatic environments. To assess if tetracycline pollution in aquatic environments promotes development of resistance, we determined minimal selective concentrations (MSCs) in biofilms of complex aquatic bacterial communities using both phenotypic and genotypic assays. Tetracycline significantly increased the relative abundance of resistant bacteria at 10 μg/L, while specific tet genes (tetA and tetG) increased significantly at the lowest concentration tested (1 μg/L). Taxonomic composition of the biofilm communities was altered with increasing tetracycline concentrations. Metagenomic analysis revealed a concurrent increase of several tet genes and a range of other genes providing resistance to different classes of antibiotics (e.g. cmlA, floR, sul1, and mphA), indicating potential for co-selection. Consequently, MSCs for the tet genes of ≤ 1 μg/L suggests that current exposure levels in e.g. sewage treatment plants could be sufficient to promote resistance. The methodology used here to assess MSCs could be applied in risk assessment of other antibiotics as well.
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| 17. |
- Milani, Lili, et al.
(författare)
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Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells
- 2007
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 35:5, s. E34-
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Tidskriftsartikel (refereegranskat)abstract
- Using the relative expression levels of two SNIP alleles of a gene in the same sample is an effective approach for identifying cis-acting regulatory SNPs (rSNPs). In the current study, we established a process for systematic screening for cis-acting rSNPs using experimental detection of Al as an initial approach. We selected 160 expressed candidate genes that are involved in cancer and anticancer drug resistance for analysis of All in a panel of cell lines that represent different types of cancers and have been well characterized for their response patterns against anticancer drugs. Of these genes, 60 contained heterozygous SNPs in their coding regions, and 41 of the genes displayed imbalanced expression of the two cSNP alleles. Genes that displayed Al were subjected to bioinformatics-assisted identification of rSNPs that alter the strength of transcription factor binding. rSNPs in 15 genes were subjected to electrophoretic mobility shift assay, and in eight of these genes (APC, BCL2, CCND2, MLH1, PARP1, SLIT2, YES1, XRCC1) we identified differential protein binding from a nuclear extract between the SNIP alleles. The screening process allowed us to zoom in from 160 candidate genes to eight genes that may contain functional rSNPs in their promoter regions.
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| 18. |
- Molnar, Malin, 1977-, et al.
(författare)
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Facilitating and straining factors affecting the health and sustainability of young managers in a modern mining industry : Self-fulfilment and development - a buffer for young managers?
- 2023
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Ingår i: Arbetsliv i omvandling. - Lund : Lunds universitet. - 1404-8426. ; :2, s. 3-53
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Tidskriftsartikel (refereegranskat)abstract
- To be able to attract, retain and develop talented individuals to managerial positions is important for organizations. Recently, however, there are indications that young professionals are reluctant to accept a leadership role. There is a lack of research exploring the reasons for this reluctance and investigating the working conditions and health of young managers; especially within heavy industries such as mining. The aim of the study is to gain a deeper understanding of the factors affecting the health and sustainability of young managers in the mining industry. A qualitative case study is conducted based on in-depth interviews with 10 managers aged 35 years or younger at a large international mining company in Northern Europe. A content analysis indicated several straining and facilitating aspects of the work situation in terms of maintaining sustainability and good health. The resulting themes are analyzed and discussed through the lens of the Job-demand-control-support (JDCS) model. Perceived stimulation, growth, and development seems to have a facilitating role in promoting sustainability and health, and is one theme that stood out from complete adaptation to the model. The study contributes with insights into how this model can be applied to a specific professional group (young managers) and in a certain context (mining and similar heavy industry). The findings have practical implications for organizations regarding the ability to ensure good, healthy, attractive, and sustainable working conditions for young managers.
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| 19. |
- Rosengren, Jenny, 1976-, et al.
(författare)
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Hur hänger koldioxidutsläpp och BNP ihop? : Lärarhandledning till ett forskningsbaserat lektionsupplägg om sambandet mellan koldioxidutsläpp och BNP med hjälp av ett Gapminder-diagram
- 2024
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Annan publikation (populärvet., debatt m.m.)abstract
- Lektionsupplägget Hur hänger koldioxidutsläpp och BNP ihop? har utformats inom forskningsprojektet Säger bilden mer än tusen ord? Om utvecklingen av elevers visuella litteracitet i samhällskunskapsundervisningen. Lärares erfarenheter och tidigare forskning visar att elever har svårt för att läsa av och förstå diagram i samhällsvetenskapliga ämnen. Syftet med forskningsprojektet är därför att utveckla kunskap om hur elever förstår flödesscheman och plotdiagram, två vanligt förekommande visuella representationer i samhällskunskap, samt hur undervisning kan utformas för att skapa möjligheter för elever att utveckla sin visuella litteracitet i samhällskunskap.Forskare och lärare har arbetat tillsammans i projektet för att utforma, pröva och utvärdera undervisning.Lektionsupplägget Hur hänger koldioxidutsläpp och BNP ihop? har testats i grundskolan (åk 6 och 8) och på gymnasiet (åk 1).Ämne: Samhällskunskap, Geografi, Hållbart samhälleÅrskurs: 4-6, 7-9, GymnasietSyfte: Att kunna läsa av och använda ett Gapminder-diagram för att resonera om hur sambandet mellan koldioxidutsläpp och BNP kan förändras av människan
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| 20. |
- Rosengren, Jenny, 1976-, et al.
(författare)
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Hur hänger kvinnors utbildningsnivå ihop med barnafödande? : Lärarhandledning till ett forskningsbaserat lektionsupplägg om sambandet mellan antal födda barn och antal skolår per kvinna med hjälp av ett Gapminder-diagram
- 2024
-
Annan publikation (populärvet., debatt m.m.)abstract
- Lektionsupplägget Hur hänger kvinnors utbildningsnivå ihop med barnafödande? har utformats inom forskningsprojektet Säger bilden mer än tusen ord? Om utvecklingen av elevers visuella litteracitet i samhällskunskapsundervisningen. Lärares erfarenheter och tidigare forskning visar att elever har svårt för att läsa av och förstå diagram i samhällsvetenskapliga ämnen. Syftet med forskningsprojektet är därför att utveckla kunskap om hur elever förstår flödesscheman och plotdiagram, två vanligt förekommande visuella representationer i samhällskunskap, samt hur undervisning kan utformas för att skapa möjligheter för elever att utveckla sin visuella litteracitet i samhällskunskap.Forskare och lärare har arbetat tillsammans i projektet för att utforma, pröva och utvärdera undervisning.Lektionsupplägget Hur hänger kvinnors utbildningsnivå ihop med barnafödande? har testats i grundskolan (åk 6 och 8) och på gymnasiet (åk 1).Ämne: Samhällskunskap, Geografi, Hållbart samhälleÅrskurs: 4-6, 7-9, GymnasietSyfte: Kunna läsa av och använda ett Gapminder-diagram för att se mönster och resonera om hur sambandet mellan barnafödande och antal skolår per kvinna kan förändras
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| 21. |
- Rosengren, Jenny, 1976-, et al.
(författare)
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Hur kan politiker hantera höga bensin- och dieselpriser? : Lärarhandledning till ett forskningsbaserat lektionsupplägg om samhällsekonomi med hjälp av ett flödesschema
- 2024
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Annan publikation (populärvet., debatt m.m.)abstract
- Lektionsupplägget Hur kan politiker hantera höga bensin- och dieselpriser? har utformats inom forskningsprojektet Säger bilden mer än tusen ord? Om utvecklingen av elevers visuella litteracitet i samhällskunskapsundervisningen. Lärares erfarenheter och tidigare forskning visar att elever har svårt för att läsa av och förstå diagram i samhällsvetenskapliga ämnen. Syftet med forskningsprojektet är därför att utveckla kunskap om hur elever förstår flödesscheman och plotdiagram, två vanligt förekommande visuella representationer i samhällskunskap, samt hur undervisning kan utformas för att skapa möjligheter för elever att utveckla sin visuella litteracitet i samhällskunskap.Forskare och lärare har arbetat tillsammans i projektet för att utforma, pröva och utvärdera undervisning.Lektionsupplägget Hur kan politiker hantera höga bensin- och dieselpriser? har testats i grundskolan (åk 6 och 8) och på gymnasiet (åk 1).Ämne: SamhällskunskapÅrskurs: 4-6, 7-9, GymnasietSyfte: Att kunna läsa av och använda ett flödesschema för att resonera om hur politiker kan hantera höga bensin- och dieselpriser
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| 22. |
- Rosengren, Jenny, 1976-, et al.
(författare)
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Vilka kan göra något åt gängkriminaliteten? : Lärarhandledning till ett forskningsbaserat lektionsupplägg om Sveriges parlamentariska system med hjälp av ett flödesschema
- 2024
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Annan publikation (populärvet., debatt m.m.)abstract
- Lektionsupplägget Vilka kan göra något åt gängkriminaliteten? har utformats inom forskningsprojektet Säger bilden mer än tusen ord? Om utvecklingen av elevers visuella litteracitet i samhällskunskapsundervisningen.Lärares erfarenheter och tidigare forskning visar att elever har svårt för att läsa av och förstå diagram i samhällsvetenskapliga ämnen. Syftet med forskningsprojektet är därför att utveckla kunskap om hur elever förstår flödesscheman och plotdiagram, två vanligt förekommande visuella representationer i samhällskunskap, samt hur undervisning kan utformas för att skapa möjligheter för elever att utveckla sin visuella litteracitet i samhällskunskap.Forskare och lärare har arbetat tillsammans i projektet för att utforma, pröva och utvärdera undervisning.Lektionsupplägget Vilka kan göra något åt gängkriminaliteten? har testats i grundskolan (åk 6 och 8) och på gymnasiet (åk 1).Ämne: SamhällskunskapÅrskurs: 4-6, 7-9, GymnasietSyfte: Kunna läsa av och använda ett flödesschema för att resonera om hur relationerna mellan aktörer i Sveriges parlamentariska system ser ut och kan förändras av människan
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| 23. |
- Townsend, Philip, 1991, et al.
(författare)
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Stochastic modelling of 3D fiber structures imaged with X-ray microtomography
- 2021
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Ingår i: Computational materials science. - : Elsevier B.V.. - 0927-0256 .- 1879-0801. ; 194
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Tidskriftsartikel (refereegranskat)abstract
- Many products incorporate into their design fibrous material with particular levels of permeability as a way to control the retention and flow of liquid. The production and experimental testing of these materials can be expensive and time consuming, particularly if it needs to be optimised to a desired level of absorbency. We consider a parametric virtual fiber model as a replacement for the real material to facilitate studying the relationship between structure and properties in a cheaper and more convenient manner. 3D image data sets of a sample fibrous material are obtained using X-ray microtomography and the individual fibers isolated. The segmented fibers are used to estimate the parameters of a 3D stochastic model for generating softcore virtual fiber structures. We use several spatial measures to show the consistency between the real and virtual structures, and demonstrate with lattice Boltzmann simulations that our virtual structure has good agreement with respect to the permeability of the physical material. © 2021 The Author(s)
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