| 1. |
- Abarenkov, Kessy, et al.
(författare)
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Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard – a report from a May 23-24, 2016 workshop (Gothenburg, Sweden)
- 2016
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Ingår i: MycoKeys. - : Pensoft Publishers. - 1314-4057 .- 1314-4049. ; 16, s. 1-15
-
Tidskriftsartikel (refereegranskat)abstract
- Recent molecular studies have identified substantial fungal diversity in indoor environments. Fungi and fungal particles have been linked to a range of potentially unwanted effects in the built environment, including asthma, decay of building materials, and food spoilage. The study of the built mycobiome is hampered by a number of constraints, one of which is the poor state of the metadata annotation of fungal DNA sequences from the built environment in public databases. In order to enable precise interrogation of such data – for example, “retrieve all fungal sequences recovered from bathrooms” – a workshop was organized at the University of Gothenburg (May 23-24, 2016) to annotate public fungal barcode (ITS) sequences according to the MIxS-Built Environment annotation standard (http://gensc.org/mixs/). The 36 participants assembled a total of 45,488 data points from the published literature, including the addition of 8,430 instances of countries of collection from a total of 83 countries, 5,801 instances of building types, and 3,876 instances of surface-air contaminants. The results were implemented in the UNITE database for molecular identification of fungi (http://unite.ut.ee) and were shared with other online resources. Data obtained from human/animal pathogenic fungi will furthermore be verified on culture based metadata for subsequent inclusion in the ISHAM-ITS database (http://its.mycologylab.org).
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| 2. |
- Bertoni, Marco, et al.
(författare)
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The Rise of Social Product Development
- 2012
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Ingår i: International Journal of Networking and Virtual Organisations. - Australia : Inderscience Publishers. - 1741-5225 .- 1470-9503. ; 11:2, s. 188-207
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the paper is to discuss the rising potential of social software to increase the knowledge management capabilities of virtual product development teams. It presents six fundamental transitions, elaborated from the empirical findings, which justify the rise of a more bottom-up, social creation and sharing of engineering knowledge in the virtual organisation. The study suggests that traditional engineering knowledge management approaches alone are not sufficient to support development activities in the virtual organisation, and that such teams display an increasing demand for social, comparatively lightweight and remixable platforms for bottom-up, social creation and sharing of knowledge.
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| 3. |
- Ericson, Åsa, et al.
(författare)
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Revisiting the Research Field of Product-Service Systems Development
- 2012
-
Ingår i: Proceedings of the ASME 2012 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference : IDETC/CI. - New York : American Society of Mechanical Engineers. - 9780791845028 ; 3, s. 1043-1049
-
Konferensbidrag (refereegranskat)abstract
- The research within the Product-Service Systems (PSS) field aims to support manufacturing industries’ ability to provide value in terms of a service offer to its customers, simultaneously taking a more holistic approach to eco-sustainability. The industrial idea of providing customer benefits in parallel with robust products is not new, yet equipping engineers to conduct innovation and applying a service perspective in the early design stages is noticed as fairly radical. The purpose in this paper is two-fold. First, to describe research efforts within the PSS field seen through our engineering design lenses, second, to explore and discuss plausible directions and by that identify “white spots” on the map, which may be seen as relevant directions for futureresearch.
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| 4. |
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| 5. |
- Johansson, Christian, et al.
(författare)
-
Gated maturity assessment : supporting gate review decision documents with maturity of knowledge assessment
- 2008
-
Ingår i: CIRP Design Conference 2008. - Enschede : Laboratory of Design, Production and Management, Faculty of Engineering Technology, Univ. of Twente. - 9789036526340
-
Konferensbidrag (refereegranskat)abstract
- In aeronautics industry today, companies collaborate closely in virtual enterprises to develop products and solutions that are more integrated and more complex, and that aims to target larger responsibilities regarding the product life-cycle. On top of this, lead-time and development costs needs to be reduced.The 7 Day Proposal (7DP) is the conceptual name of a framework wherein a customized proposal is produced by a virtual enterprise consortium within seven days from a received request for proposal. This is substantially shorter than what is current practice today and implies that new methods, tools and ways of working are needed. Today, in offer processes, time is lost because of insufficient, or immature, available information and knowledge at gate reviews when decisions are due, causing time consuming iterations. The Gated Maturity Assessment (GMA) concept is intended to help reduce these costly iterations by targeting the ambiguity at these gate reviews in order to reduce the uncertainty in decision base. Other frameworks using maturity include Technology Readiness Levels (TRL) and the Capability Maturity Model (CMM). TRL is an artefact-focused framework developed by NASA to assess space technology maturity. CMM is a process-focused framework for assessing organisations' software development process capability (maturity). The GMA is a concept for assessing the maturity of the knowledge that goes into a gate review (i.e. a decision document). The GMA is intended to support decision makers by assuring confidence in these decision points and thereby reducing the number of iterations, hereby reducing lead-time and increases the quality of the process.This paper reports on the development of the GMA concept from the 7DP use case, and also the development of a support tool intended for use in the 7DP process. Essentially, the 7DP process is a stage-gate process like many corporate product development processes with a number of decision gates. Therefore there is a future wish to move towards an engineering design context with this concept. The work is part of the 70 million € European project VIVACE where GMA is part of a Knowledge Enabled Engineering solution to the 7DP use case.
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| 6. |
- Johansson, Christian, et al.
(författare)
-
Gated maturity assessment - Supporting Gate Review Decisions with Knowledge Maturity Assessment
- 2008
-
Konferensbidrag (refereegranskat)abstract
- In aeronautics industry today, companies collaborate closely in virtual enterprises to develop products and solutions that are more integrated and more complex, and that aims to target larger responsibilities regarding the product life-cycle. On top of this, lead-time and development costs needs to be reduced.The 7 Day Proposal (7DP) is the conceptual name of a framework wherein a customized proposal is produced by a virtual enterprise consortium within seven days from a received request for proposal. This is substantially shorter than what is current practice today and implies that new methods, tools and ways of working are needed. Today, in offer processes, time is lost because of insufficient, or immature, available information and knowledge at gate reviews when decisions are due, causing time consuming iterations. The Gated Maturity Assessment (GMA) concept is intended to help reduce these costly iterations by targeting the ambiguity at these gate reviews in order to reduce the uncertainty in decision base. Other frameworks using maturity include Technology Readiness Levels (TRL) and the Capability Maturity Model (CMM). TRL is an artefact-focused framework developed by NASA to assess space technology maturity. CMM is a process-focused framework for assessing organisations' software development process capability (maturity). The GMA is a concept for assessing the maturity of the knowledge that goes into a gate review (i.e. a decision document). The GMA is intended to support decision makers by assuring confidence in these decision points and thereby reducing the number of iterations, hereby reducing lead-time and increases the quality of the process.This paper reports on the development of the GMA concept from the 7DP use case, and also the development of a support tool intended for use in the 7DP process. Essentially, the 7DP process is a stage-gate process like many corporate product development processes with a number of decision gates. Therefore there is a future wish to move towards an engineering design context with this concept. The work is part of the 70 million € European project VIVACE where GMA is part of a Knowledge Enabled Engineering solution to the 7DP use case.
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| 7. |
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| 8. |
- Karlsson, Lennart, et al.
(författare)
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Information driven collaborative engineering : enabling functional product innovation
- 2005
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Ingår i: Challenges in Collaborative Engineering - CCE '05. - Jönköping, Sweden : Department of Computer & Electrical Engineering, School of Engineering, Jönköping University. - 9197560413
-
Konferensbidrag (refereegranskat)abstract
- This paper discusses Information Driven Collaborative Engineering (IDCE) as an enabler of Functional Product Innovation (FPI). It discusses challenges that arise in functional product development and how distributed collaborative work will be affected. Finally the paper proposes bringing the domains of Distributed Collaborative Engineering (DCE) and Knowledge Enabled Engineering (KEE) together to form IDCE, in order to meet these challenges.
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| 9. |
- Larsson, Andreas, et al.
(författare)
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Engineering 2.0 : exploring lightweight technologies for the virtual enterprise
- 2010
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Ingår i: From CSCW to Web 2.0. - London : Encyclopedia of Global Archaeology/Springer Verlag. - 9781848829640 - 9781848829657 ; , s. 173-191
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In a traditional business partnership, the partner companies are under contractual obligation to share data, information, and knowledge through one or several information systems that the leading firm decides. In such a case, the issue of sharing "whatever needs to be shared" is settled in contracts before any action is taken, however, also giving the implications that sharing expertise becomes a heavy and time-consuming activity. In turn, it can be argued that the heavy administration affects the lead time of product development negatively since the necessary input flows are delayed. In addition, the adaptation to certain predefined collaborative information systems is both expensive and resource-consuming (e.g., educating staff to use them). Also, the system might not be adaptable to the existing internal technology structure, causing a "translation" procedure, again taking up resources. Another structure for collaboration is a network or alliance of independent partner companies. One motivation for a network structure is that the partners can join or leave it more easily. A reason for joining and staying is an implicit sense of knowledge sharing (Tomkins 2001) and access to a "win-win" environment. Furthermore, the partners can be linked by information technology, i.e., forming a virtual structure rather than a physical one. The technologies provide the channels with additional knowledge. In a best-case scenario, a company would get access to a wide range of useful competences, and in a worst-case scenario the company would be drained of its core competences. Accordingly, at least two considerations for joining a partner network can be considered. First, the resources needed to couple the technologies have to be reasonable, due to the underpinning logic of going in and out of more than one network. Second, the company has to identify its knowledge base and evaluate the prospective gains and losses of sharing its expertise.
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| 10. |
- Larsson, Andreas, et al.
(författare)
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Rethinking virtual teams for streamlined development
- 2008
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Ingår i: Virtual technologies. - Hershey PA : Information Science Reference. - 9781599049557 - 9781599049557 ; , s. 1646-1664
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Drawing from experiences in automotive and aerospace development, the authors argue that it is time to radically progress our current understanding of how creativity could be introduced in organizations where factors like legal demands and contractual agreements severely restrict ‘outside-the-box' thinking, and where well-known creativity enablers such as trust, shared goals, and shared culture are becoming increasingly difficult to accomplish.
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| 11. |
- Larsson, Andreas, et al.
(författare)
-
Rethinking virtual teams for streamlined development
- 2007
-
Ingår i: Higher creativity for virtual teams. - Hershey, PA : Information Science Reference. - 9781599041292 - 1599041294 - 9781599041315 - 1599041316 ; , s. 138-156
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Drawing from experiences in automotive and aerospace development, the authors argue that it is time to radically progress our current understanding of how creativity could be introduced in organizations where factors like legal demands and contractual agreements severely restrict ‘outside-the-box' thinking, and where well-known creativity enablers such as trust, shared goals, and shared culture are becoming increasingly difficult to accomplish.
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| 12. |
- Larsson, Gunilla, 1960-
(författare)
-
Ship and Society : Maritime Ideology in Late Iron Age Sweden
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyses the relation between ship and society against a background of ideological and technological changes in Late Iron Age Sweden. It discusses the factors behind the development of ‘a maritime society’, why ships and seafaring came to play an important role that was also reflected in the use of the ship as a symbol and a metaphor in a military context, as well as in religion, administration, jurisdiction and social life. The author argues that this society is disappearing when it is first encountered in the Early Middle Ages, because of a fundamental ideological change.There is a myth about the appearance of the ‘Viking ship’ and the Iron Age seafarer. The ships are supposed to be big and wide. An analysis of the archaeological material presented here shows that this picture is not correct. Instead the ships of the Svear were quite small and built in a way that made them very light. This was a result of shipbuilding methods introduced in the Late Iron Age, and it had consequences for the trade communication network as well as for naval operations. Because of the light ships, it was possible to land on any shallow shore and navigate the shallow rivers in the East.The ship became a key symbol used by the authorities to structure the society for administrative and military purposes, using a terminology based on the Late Iron Age warship.In the Middle Ages, ideology, shipbuilding and seafaring changed. New key symbols were introduced, and they were used by an increasing royal power to consolidate what would become a united Sweden, inspired by feudal Europe.
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| 13. |
- Larsson, Tobias, et al.
(författare)
-
Project: ProViking THINK - Team för Heterogen Innovationskunskap
- 2008
-
Annan publikation (populärvet., debatt m.m.)abstract
- Begreppet product-service systems (PSS), eller funktionella produkter, förutspås ha betydande påverkan för ett framtida hållbart samhälle. Ett PSS-synsätt kommer att förändra hur produkter och tjänster används, men också förändra tillvägagångssättet i utvecklingen, eftersom ansvaret för den fysiska produkten genom hela dess livscykel kvarstår hos företaget eller konsortiet som utvecklar PSS-lösningen. I och med detta kan aktiviteterna med omkonstruktion, återanvändning och återvinning, utföras på ett totalt annorlunda sätt än i dag. I den här situationen blir kapaciteten att ständigt förbättra kundupplevt värde genom nya lösningar en viktig förmåga. Således står utvecklingsteam idag inför två stora utmaningar; dels ska de kunna hantera mer abstrakta kundbehov, dels ska de på ett effektivt sätt ständigt bidra till nya lösningar. Det här projektets mål är att stödja PSS-utvecklingsteamets innovationsprocess genom att föreslå faciliterande metoder och verktyg. Specifikt fokus ligger på följande aspekter för att bidra till utvecklingen av en sammanhängande metodologi för team-baserad innovation:- Identifiering, analys och kommunikation av kundbehov samt modellering av värde- Tvärfunktionella team- Effektiv kunskapsdelning- Modellering och visualisering av lösningar baserat på ett kunskapslivscykel perspektiv Projektet kommer att vara en gemensam prestation av industri- och akademirepresentanter. Det praktiska arbetet kommer att utföras i ett nära samarbete. I stort vägleds projektet av antagandet att – visualisering av affärs- och utvecklingsrelaterad kunskap samt snabba modellerings- och simuleringsmöjligheter i tidiga faser stödjer PSS-teamets förmåga att finna nya lösningar och genomföra hållbar utveckling. Förutom ökad kunskap om strategier och tillvägagångssätt för team-baserad innovation kommer demonstratorer av verktyg och metoder vara ett resultat av projektarbetet.
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| 14. |
- Larsson, Tobias, et al.
(författare)
-
Project: VIVACE - Value Improvement Through a Virtual Aeronautical Collaborative Enterprise
- 2006
-
Annan publikation (populärvet., debatt m.m.)abstract
- VIVACE is an Aeronautical Collaborative Design Environment with associated Processes, Models and Methods. This environment will help to design an aircraft and its engines as a whole, providing to the aeronautics supply chain in an extended enterprise, virtual products with all requested functionality and components in each phase of the product engineering life cycle
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| 15. |
- Larsson, Tobias, et al.
(författare)
-
Value Simulation in Conceptual Phases of PSS Design
- 2012
-
Konferensbidrag (refereegranskat)abstract
- This paper discuss the change in early design imposed by a Product-Service Systems (PSS) perspective onto the design and development phases of engineering design and how this affects the today de-facto standard of virtual modelling of product properties. The approach is exemplified via PSS situations related to aerospace and automotive industry in order to clarify “parameters of change” due to PSS reasoning, and challenges are displayed regarding early modelling and simulation.
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| 16. |
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| 17. |
- Wallin, Johanna, 1981, et al.
(författare)
-
Measuring Innovation Capability – Assessing Collaborative Performance
- 2011
-
Ingår i: Proceedings of the 3rd CIRP International Conference on Industrial Product Service Systems, Braunschweig, Germany.
-
Konferensbidrag (refereegranskat)abstract
- This paper reports on a qualitative study, carried out at a Swedish aero engine manufacturer. The study was initiated to explore key indicators related to innovation capability in a Product-Service System (PSS) context. Developing PSS changes the dynamics of collaboration, since the offering of such systems usually involves a network of partners sharing the responsibility for a delivered function over a full lifecycle. In particular, this paper focuses on describing aspects related to external and internal collaboration, and it further discusses how to measure the company’s collaborativeperformance, taking into account both activity and effect measures.
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| 18. |
- Wallin, Johanna, et al.
(författare)
-
Measuring Innovation Capability – Assessing Collaborative Performance in Product-Service System Innovation
- 2011
-
Ingår i: - Braunschweig, Germany : Springer. ; , s. 207-2012
-
Konferensbidrag (refereegranskat)abstract
- This paper reports on a qualitative study, carried out at a Swedish aero engine manufacturer. The study was initiated to explore key indicators related to innovation capability in a Product-Service System (PSS) context. Developing PSS changes the dynamics of collaboration, since the offering of such systems usually involves a network of partners sharing the responsibility for a delivered function over a full lifecycle. In particular, this paper focuses on describing aspects related to external and internal collaboration, and it further discusses how to measure the company’s collaborative performance, taking into account both activity and effect measures.
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| 19. |
- Wallin, Johanna, et al.
(författare)
-
Measuring innovation capability in technology-focused development
- 2010
-
Ingår i: 17th International Product Development Management Conference. - : University of Murcia.
-
Konferensbidrag (refereegranskat)abstract
- Product development in the aerospace industry is associated with relatively long lead times and product lifecycles, which means that it takes years and even decades to find out if a novel product or technology concept fully realizes its potential and becomes an innovation on the market. How can a company in such an industry context know, preferably already in the conceptual stages, that they are on the path to innovation? How do they know how innovative they are? How can they increase their innovation capability? A project together with Volvo Aero, an aero engine manufacturer, was initiated to explore potential answers to these questions. The paper reports on an ongoing study of the company’s current state-of-practice with regard to measuring innovation capability, starting from a range of innovation indicators provided within a previous research project, which Volvo Aero contributed to. Based on interviews with project managers of advanced engineering projects within the company, six areas were found to be of importance in order to more effectively measure the innovation capability at Volvo Aero: Project selection, Customer involvement, Interaction between functions, Team climate, Innovation methodology and Innovation rewards.Within these areas a selection of preliminary metrics was established, which will be presented in this article along with a discussion on the advantages and drawbacks of combining activity and effect measures to better relate particular activities to particular outcomes.
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| 20. |
- Aaltonen, Kristina E., et al.
(författare)
-
Molecular characterization of circulating tumor cells from patients with metastatic breast cancer reflects evolutionary changes in gene expression under the pressure of systemic therapy
- 2017
-
Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:28, s. 45544-45565
-
Tidskriftsartikel (refereegranskat)abstract
- Resistance to systemic therapy is a major problem in metastatic breast cancer (MBC) that can be explained by initial tumor heterogeneity as well as by evolutionary changes during therapy and tumor progression. Circulating tumor cells (CTCs) detected in a liquid biopsy can be sampled and characterized repeatedly during therapy in order to monitor treatment response and disease progression. Our aim was to investigate how CTC derived gene expression of treatment predictive markers (ESR1/HER2) and other cancer associated markers changed in patient blood samples during six months of first-line systemic treatment for MBC. CTCs from 36 patients were enriched using CellSearch (Janssen Diagnostics) and AdnaTest (QIAGEN) before gene expression analysis was performed with a customized gene panel (TATAA Biocenter). Our results show that antibodies against HER2 and EGFR were valuable to isolate CTCs unidentified by CellSearch and possibly lacking EpCAM expression. Evaluation of patients with clinically different breast cancer subgroups demonstrated that gene expression of treatment predictive markers changed over time. This change was especially prominent for HER2 expression. In conclusion, we found that changed gene expression during first-line systemic therapy for MBC could be a possible explanation for treatment resistance. Characterization of CTCs at several time-points during therapy could be informative for treatment selection.
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| 21. |
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| 22. |
- Ahmed, Laeeq, et al.
(författare)
-
Predicting target profiles with confidence as a service using docking scores
- 2020
-
Ingår i: Journal of Cheminformatics. - : Springer Nature. - 1758-2946. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Identifying and assessing ligand-target binding is a core component in early drug discovery as one or more unwanted interactions may be associated with safety issues. Contributions: We present an open-source, extendable web service for predicting target profiles with confidence using machine learning for a panel of 7 targets, where models are trained on molecular docking scores from a large virtual library. The method uses conformal prediction to produce valid measures of prediction efficiency for a particular confidence level. The service also offers the possibility to dock chemical structures to the panel of targets with QuickVina on individual compound basis. Results: The docking procedure and resulting models were validated by docking well-known inhibitors for each of the 7 targets using QuickVina. The model predictions showed comparable performance to molecular docking scores against an external validation set. The implementation as publicly available microservices on Kubernetes ensures resilience, scalability, and extensibility.
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| 23. |
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| 24. |
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| 25. |
- Alexius, Susanna, 1976-, et al.
(författare)
-
Market Means to Political Mission Ends : Scrutinizing the Social Meaning of Moneyin the Swedish Federation for Sexual Education (RFSU)
- 2019
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In the nonprofit debate, there is an assumption that market means lead to market ends, oftentimes with grim consequences for nonprofit organizations. By drawing on a theoretical framework related to the social meaning of money in hybrid organizations, and by applying the framework to a longitudinal mixedmethod single case study ofmoneymanagement in the Swedish Federation for Sexual Education (RFSU), we argue in this paper instead that management of market means may also promote political mission ends. Empirical findings suggest that there are different social currencies at play that help explain why some money (income of a lower perceived social status) may be used by the organization simply as a means to get access to higher status money (and the legitimacy that comes with it). Hence, contrary to common assumptions of mission-drift as a consequence of market means, in this case study, business dividends and royalties commercially generated in fully owned subsidiaries have been informally and formally earmarked as lower status money and then used as means to secure higher status political mission ends.
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| 26. |
- Alexius, Susanna, et al.
(författare)
-
Vad har ni för värden på kontot?
- 2017
-
Ingår i: Kurage. - Stockholm : Idealistas förlag. - 2001-175X. ; :23
-
Tidskriftsartikel (populärvet., debatt m.m.)
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| 27. |
- Alexius, Susanna, et al.
(författare)
-
Vad har ni för värden på kontot?
- 2017
-
Ingår i: Kurage. - 2001-175X.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Kan en organisations olika intäkter användas till samma saker? Eller är det skillnad på en medlemsavgift och ett testamente? Eller ett offentligt bidrag? Ledare i organisationer verkar värdera olika intäkter på olika sätt och frågan är om en krona alltid är en krona. Forskarna Susanna Alexius och Ola Segnestam Larsson funderar på om pengar har olika värden.
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| 28. |
- Alrutz, Marie, et al.
(författare)
-
Projektledning
- 2013
-
Bok (populärvet., debatt m.m.)abstract
- Projektledning är ett yrke med egen certifiering. Det pågår en spännande utveckling inom området och det blir allt viktigare att hålla sig ajour med utvecklingen.Det övergripande målet med den här handboken är att vara en ständigt aktuell heltäckande bok om projektarbete. Innehållsmässigt täcker den både frågor som har med struktur och styrning att göra och frågor om ledning av människor och mänskliga processer i grupp. Kompetens inom projekt byggs av både kunskap och erfarenhet. Vi följer kontinuerligt aktuell forskning inom dessa områden och bjuder in intressanta forskare att medverka som författare. Vi skildrar verkliga projekt och låter erfarenheterna få plats, både de bästa erfarenheterna och de utmaningar som man tagit sig igenom.Handboken är levande och det innebär att artiklar tas bort för att ge plats för nya, i takt med att den uppdateras fortlöpande.
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| 29. |
- Alvarsson, Jonathan, et al.
(författare)
-
Brunn : an open source laboratory information system for microplates with a graphical plate layout design process
- 2011
-
Ingår i: BMC Bioinformatics. - : Springer Science and Business Media LLC. - 1471-2105. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background:Compound profiling and drug screening generates large amounts of data and is generally based on microplate assays. Current information systems used for handling this are mainly commercial, closed source, expensive, and heavyweight and there is a need for a flexible lightweight open system for handling plate design, and validation and preparation of data.Results:A Bioclipse plugin consisting of a client part and a relational database was constructed. A multiple-step plate layout point-and-click interface was implemented inside Bioclipse. The system contains a data validation step, where outliers can be removed, and finally a plate report with all relevant calculated data, including dose-response curves.Conclusions:Brunn is capable of handling the data from microplate assays. It can create dose-response curves and calculate IC50 values. Using a system of this sort facilitates work in the laboratory. Being able to reuse already constructed plates and plate layouts by starting out from an earlier step in the plate layout design process saves time and cuts down on error sources.
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| 30. |
- Andersen, Rebecka, et al.
(författare)
-
Att göra frivilligt arbete ekonomiskt värdefullt : En litteraturöversikt av internationell forskning och policy-relaterade rapporter
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapports syfte har varit att genomföra en litteraturöversikt av internationell forskning och policy-relaterade dokument som behandlar frågor relaterade till att värdera frivilligt arbete i ekonomiska termer. Utifrån ett antal forskningsfrågor sammanställdes och analyserades de empiriska resultaten i relation till exempel till de definitioner, metoder och resultat som presenterades i materialet. För- och nackdelar med olika metoder samt med att värdera icke-monetära värden har också diskuteras. De empiriska resultaten analyserades sedan i ett andra steg med hjälp av ett ramverk om hur värden skapas, befästs och kommuniceras i allmänhet och mer specifikt utifrån frågan om vilken idealtypisk relation som bäst kan beskriva eventuella samband mellan olika metoder för att värdera det frivilliga arbetet och det frivilliga arbetet i sig.En sammanfattning av de empiriska resultaten visar för det första att det finns ett antal förespråkare och argument till varför frivilligt arbete bör värderas i ekonomiska termer. Ett par av argumenten är exempelvis att synliggöra och uppmärksamma det frivilliga arbetet samt att identifiera dess bidrag till samhällsekonomin. Följaktligen har forskare och policyprofessionella ägnat tid och resurser åt att utveckla olika metoder och tillvägagångssätt för att genomföra denna typ av värderingar. Tre övergripande metoder lyfts fram som konkurrerande alternativ, inklusive frivilligarbetaren som ersättare, som tidsdonator och som samhällsnyttig. En integrerad del av presentationen av de olika metoderna verkar vara att identifiera specifika eller allmänna utmaningar med en viss eller alla försök till att värdera det frivilliga arbetet. Några exempel på dessa utmaningar är risken med att överskatta värdet på det frivilliga arbetet eller problematiken med att beräkna och fastställa ett generellt och applicerbart marknadsvärde på det arbetet som utförs av frivilliga.I den analytiska delen av rapporten framkommer det att de flesta artiklarna och rapporterna härbärgerar fler än en definition av det frivilliga arbetet och fler än en metod för att värdera det frivilliga arbetet. Vidare visar analysen att det finns stora likheter samt till och med överlapp mellan de olika metoderna i form av likartade utgångspunkter och tillvägagångssätt för att värdera det frivilliga arbetet. Utifrån dessa analytiska resultat argumenterar denna rapport för att relationen mellan de tre metoderna som förordas och det frivilliga arbetet i hög grad präglas av en omvänd relation. Det vill säga att de tre övergripande metoderna i första hand verkar ha utvecklats i relation till tidigare versioner av metoderna och konkurrerande metoder snarare än till det frivilliga arbetet i sig och dess egenskaper.Tolkningen att de metoder som figurerar för att ekonomiskt värdera frivilligt arbete i första hand präglas av en omvändrelation kan förklaras på två kompletterande vis. Den första förklaringen är att de som arbetar med att utveckla metoder kopierar och översätter värderingsmekanismer från andra fält. Den andra är att aktörer inom området strävar efter att framstå som innovativa och originella. Båda förklaringarna lyfter fram hur fler studier behövs för att studera och analysera detta fält som exempelvis en teater eller ett skådespel, med tillhörande praktiker, mekanismer och teknologier, som alla är mer eller mindre oberoende av eller till och med särkopplat från det frivilliga arbetet i sig.Ett antal mer praktiknära förslag till framtida forskning och utredningsarbete kan också identifieras. Ett förslag skulle vara att genomföra ytterligare översikter av metoder och resultat för att värdera objekt som saknar antingen värderings-, kalkyler- eller jämförbara egenskaper eller en marknad där objektets värde kan bestämmas i ett utbyte mellan olika aktörer. Med största sannolikhet finns det områden och fält där denna typ av metoder har utvecklats och prövats i en högre utsträckning än de som återfinns inom området för frivilligt 4 arbete. Ett annat förslag är att applicera de tre metoderna, inklusive de olika tillvägagångssätten som förordas, på data och forskning från Sverige. Vilken andel av det svenska BNP skulle det frivilliga arbetet kunna utgöra? Vilken avkastning ger investeringar i det frivilliga arbetet i Sverige? Vad är en rimlig timpeng för det frivilliga arbetet i Sverige? Slutligen, med tanke på både de processuella och principiella invändningar som återfinns i det empiriska materialet, vore det värdefullt och relevant att genomföra en receptionsstudie av hur frivilliga och andra aktörer inom fältet skulle reagera på och påverkas av olika försök till att ekonomiskt värdera frivilligt arbete.Avslutningsvis, utifrån denna rapports inledande citat om de tre domarna, och baserat på rapportens empiriska och analytiska resultat, kan en fjärde domare introduceras. Till skillnad från den första domarens objektivistiska, den andra domarens subjektivistiska eller den tredje domarens relativistiska position, skulle den fjärde domaren antagligen förorda en mer omvänd position i relation till exempelvis det frivilliga arbetet. En position som skulle härbärgera de praktiker, mekanismer och processer som konstituerar frivilligt arbete och som i sin tur skapar, befäster och kommunicerar värden, inklusive huruvida frivilligt arbete är meningsfullt för de som utför det eller bör ses som en gemensam och kollektiv nytta i samhällets tjänst. Denna position ger också utrymme till undersökningar om i vilken grad det frivilliga arbetet främst konstitueras av samtal och konflikter forskare och policyprofessionella emellan.
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| 31. |
- Andersen, Rebecka, et al.
(författare)
-
Svenska ideella organisationers mervärde i biståndet
- 2014
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att beskriva och analysera olika aktörers uppfattningar om svenska ideella organisationers mervärde inom biståndet. Med hjälp av intervjuer med ett antal representanter för olika aktörer med kunskap och erfarenhet av det svenska biståndsarbetet och analyser av existerande dokument behandlas i denna rapport de svenska ideella organisationernas roller, särarter och mervärden inom det svenska biståndet. De empiriska resultaten visar att organisationernas roller visserligen har förändrats över tid, från att fungera som pionjärer till att mer fungera som röstbärare och organisatörer av tjänster, men att de ideella organisationerna anses vara fortsatt betydelsefulla i biståndet, även i framtiden. Särarterna framträder tydligast i jämförelser med antingen ideella organisationer i andra länder eller med företag och offentliga organisationer i Sverige, och inkluderar alltifrån organisationernas historia och folkrörelsebakgrund till den icke‐vinstdrivna profilen, organisationernas värdegrund samt förmågan att kunna agera autonomt och verka i olika kontexter. Ett antal mervärden identifieras också, till exempel den svenska kontexten och folkrörelseförankring, mångfalden i det svenska civila samhället, arbetet med demokratiska och mänskliga rättigheter, röstbärarrollen och påverkansarbetet, effektivitet till följd av lång erfarenhet och kunskap, lokal förankring och välutvecklade nätverk samt ett partnerskap där stödet sträcker sig utöver det finansiella och långsiktigheten i partnerskapen. Rapporten visar också hur det förekommer föreställningar om att särarterna och mervärdena har förändrats över tid. Det är dock oklart om de minskar eller ökar i kraft eller om det mer handlar om förändringar från en form till en annan. Avslutningsvis efterlyses ett mer nyanserat förhållningssätt till svenska ideella organisationers mervärde i biståndet.
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| 32. |
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| 33. |
- Andersson, Martin N, et al.
(författare)
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Characterization of olfactory sensory neurons in the white clover seed weevil, Apion fulvipes (Coleoptera: Apionidae).
- 2012
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Ingår i: Journal of Insect Physiology. - : Elsevier BV. - 1879-1611 .- 0022-1910. ; 58:10, s. 1325-1333
-
Tidskriftsartikel (refereegranskat)abstract
- Seed-eating Apion weevils (Coleoptera: Apionidae) cause large economic losses in white and red clover seed production across Europe. Monitoring and control of clover weevils would be facilitated by semiochemical-based methods. Until now, however, nothing was known about physiological or behavioral responses to semiochemicals in this insect group. Here we analyzed the antenna of the white clover (Trifolium repens L.) specialist Apion fulvipes Geoffroy with scanning electron microscopy, and used single sensillum recordings with a set of 28 host compounds to characterize 18 classes of olfactory sensory neurons (OSNs). Nine of the OSN classes responded strongly to synthetic compounds with high abundance in clover leaves, flowers, or buds. Eight classes responded only weakly to the synthetic stimuli, whereas one collective class responded exclusively to volatiles released from a crushed clover leaf. The OSNs showed a remarkable degree of specificity, responding to only one or a few chemically related compounds. In addition, we recorded a marked difference in the temporal dynamics of responses between different neurons, compounds, and doses. The identified physiologically active compounds will be screened for behavioral activity, with the ultimate goal to develop an odor-based control strategy for this pest.
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| 34. |
- Andersson, Niklas, et al.
(författare)
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Calibration of a polyethylene plant for grade change optimisations
- 2011
-
Ingår i: 21ST European Symposium on Computer Aided Process Engineering. - 1570-7946. - 9780444538956 ; 29, s. 673-677
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Konferensbidrag (refereegranskat)abstract
- A polyethylene plant model coded in Modelica and based on a nonlinear MPC model currently used at Borealis AB is considered for calibration. A case study of model calibration at steady-state for four different operating points are analysed, both when looking at one operating point separately, but also to calibrate several simultaneously. Both model parameters and reactor inputs are calibrated for true plant measurement data. To solve the parameter estimation problem, the JModelica.org platform is used, offering tools to express and solve calibration problems. Calibration was obtained with narrow confidence intervals and shows a potential to improve the model accuracy by changing the parameter values. The results will be used for dynamic optimisations of grade changes.
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| 35. |
- Andersson, Niklas, et al.
(författare)
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Parameter Selection in the Parameter Estimation of Grade Transitions in a Polyethylene Plant
- 2015
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Ingår i: Studies in Engineering and Technology. - : Redfame Publishing. - 2330-2038 .- 2330-2046. ; 3:1, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- A polyethylene plant at Borealis AB is modelled in the Modelica language and considered for parameter estimations at grade transitions. Parameters have been estimated for both the steady-state and the dynamic case using the JModelica.org platform, which offers tools for steady-state parameter estimation and supports simulation with parameter sensitivies. The model contains 31 candidate parameters, giving a huge amount of possible parameter combinations. The best parameter sets have been chosen using a parameter-selection algorithm that identified parameter sets with poor numerical properties. The parameter-selection algorithm reduces the number of parameter sets that is necessary to explore. The steady-state differs from the dynamic case with respect to parameter selection. Validations of the parameter estimations in the dynamic case show a significant reduction in an objective value used to evaluate the quality of the solution from that of the nominal reference, where the nominal parameter values are used.
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| 36. |
- Andersson, Petter, et al.
(författare)
-
A case study of how knowledge based engineering tools support experience re-use
- 2011
-
Ingår i: Research into Design. - Bangalore, India : Research Publishing Services. - 9789810877217
-
Konferensbidrag (refereegranskat)abstract
- A manufacturing company’s unique intellectual capital is to a large extent built on experience from its own product development and manufacturing processes. Thus, methods and tools to utilize and benefit from this experience in an efficient way have an impact on a company’s ability to stay competitive and advance on the global market. Knowledge Based Engineering (KBE) is an engineering methodology to capture engineering knowledge systematically into the design system. Hence, KBE tools are considered to support experience re-use and improve engineering activities. This paper presents the results from a study where the objective was to investigate the support for experience re-use in KBE applications in an aerospace company. A proposed framework is presented to analyze the capturing and use of experience in a company’s processes identifying gaps and propose improvements. The study revealed weaknesses in the process steps for experience feedback which can be used to improve KBE applications further.
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| 37. |
- Andersson, Petter, et al.
(författare)
-
Project: Robust Machining
- 2010
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Annan publikation (populärvet., debatt m.m.)abstract
- New generations of environmentally friendly and safe vehicles require manufacturing of light weight materials with higher strength and, as a consequence, tougher machining conditions and increased machining robustness. There is a lack of practical and reliable methods and tools to meet these challenges in the automotive industry. The very complex system of machine tool, fixture, cutting tools and the machined part is almost impossible to model without complementary measurements of the real system at the factory floor in full production. Using Virtual Engineering together with studies of machining processes the project team will assess these challenges.
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| 38. |
- Andersson, Petra, et al.
(författare)
-
Safe introduction of battery propulsion at sea
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Electric propulsion using batteries as energy storage has the potential to significantly reduce emissions from shipping and thus the environmental impact. The battery type that is currently on the top of the agenda to be used for ship propulsion applications is Li-ion batteries. Li-ion batteries pose different safety issues than e.g. other propulsion technologies and other batteries such as lead-acid batteries. It is essential that the safety level on board, including fire safety, is maintained, when introducing electric propulsion with energy storage in batteries. This report discusses the different regulations and guidelines available today for fire safety of batteries on board in relation to current knowledge about Li-ion batteries. Also fire safety measures available on board ships today and their applicability for Li-ion batteries is discussed, as well as the different test methods available and their applicability. A workshop gathering different stakeholders from Sweden, Norway and Finland identified fire safety as the main challenge for the introduction of battery propulsion at sea. The workshop concluded that future work is desired in order to increase knowledge and to develop publicly available strategies, training and designs.
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| 39. |
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| 40. |
- Asad, Samina, et al.
(författare)
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HTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13
- 2012
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 7:5
-
Tidskriftsartikel (refereegranskat)abstract
- Background: We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD less than= 2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D susceptibility genes. Methodology/Principal Findings: Microsatellites were genotyped in the Scandinavian families to fine-map the previously linked region. Further, SNPs were genotyped in Swedish and Danish families as well as Swedish sporadic cases. In the Swedish families we detected genome-wide significant linkage to the 5-hydroxytryptamine receptor 1A (HTR1A) gene (LOD 3.98, pless than9.8x10(-6)). Markers tagging two separate genes; the ring finger protein 180 (RNF180) and HTR1A showed association to T1D in the Swedish and Danish families (pless than0.002, pless than0.001 respectively). The association was not confirmed in sporadic cases. Conditional analysis indicates that the primary association was to HTR1A. Quantitative PCR show that transcripts of both HTR1A and RNF180 are present in human islets of Langerhans. Moreover, immunohistochemical analysis confirmed the presence of the 5-HTR1A protein in isolated human islets of Langerhans as well as in sections of human pancreas. Conclusions: We have identified and confirmed the association of both HTR1A and RFN180, two genes in high linkage disequilibrium (LD) to T1D in two separate family materials. As both HTR1A and RFN180 were expressed at the mRNA level and HTR1A as protein in human islets of Langerhans, we suggest that HTR1A may affect T1D susceptibility by modulating the initial autoimmune attack or either islet regeneration, insulin release, or both.
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| 41. |
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| 42. |
- Berg, Johan, et al.
(författare)
-
Umbilical cord clamping in the early phases of the COVID-19 era - A systematic review and meta-analysis of reported practice and recommendations in guidelines
- 2023
-
Ingår i: International Journal of Infectious Diseases. - 1878-3511. ; 137, s. 63-70
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during the early phases of the pandemic.METHODS: Major databases were searched December 1, 2019 to July 20, 2021.INCLUSION: studies and guidelines describing cord clamping practice in women with SARS-CoV-2 infection during pregnancy until two postnatal days, giving birth to live born neonates.EXCLUSION: no extractable data. Two reviewers independently screened studies for eligibility and assessed study quality. Pooled prevalence rates were calculated.RESULTS: Forty-eight studies (1476 neonates) and 40 guidelines were included. Delayed CC was recommended in 70.0% of the guidelines. Nevertheless, delayed CC was reported less often than early CC: 262/1476 (17.8%) vs. 511/1476 (34.6%). Neonatal SARS-CoV-2 positivity rates were similar following delayed (1.2%) and early CC (1.3%). Most SARS-CoV-2 transmissions (93.3%) occurred in utero.CONCLUSION: Delayed CC did not seem to increase mother-to-neonate SARS-CoV-2 transmission. Due to its benefits, it should be encouraged even in births where the mother has a SARS-CoV-2 infection.
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| 43. |
- Bergmann, Astrid, 1972-
(författare)
-
Remote Ischemic Preconditioning and its Effects on the Respiratory System
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Mechanical ventilation in itself can lead to pulmonary damage, and one-lung ventilation (OLV), necessary for thoracic surgery, accentuates this injury. Remote ischemic preconditioning (RIP) is a potential tool to reduce lung injury after mechanical ventilation, including OLV. However, current data on pulmonary RIP-effects are contradictory. Therefore, the overall purpose of this Ph.D. project was to assess the effects of RIP on the respiratory system. In Study I, in healthy spontaneously breathing volunteers, oxygenation was impaired early after RIP, which was possibly induced by transient ventilation-perfusion inequality. Studies II, III, and IV were performed in a porcine OLV model. In Study II, we found that RIP possibly enhances alveolar injury, but attenuates the immune response. In Study III, we confirmed that an immune response to RIP takes place, which shows a different time pattern in each cytokine, depending on the site of measurement as well. In Study IV, we studied the porcine model for eight hours and found that RIP improved oxygenation after two hours of OLV and impeded the decline of exhaled nitric oxide (NO) during and after OLV. These findings indicate that RIP mitigates hypoxic pulmonary vasoconstriction (HPV).In summary, RIP has a complex effect on the respiratory system, which partly explains the previous contradictory findings.
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| 44. |
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| 45. |
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| 46. |
- Bertoni, Alessandro, et al.
(författare)
-
Assessing the Value of Sub-System Technologies including Life Cycle Alternatives - an aerospace investigation
- 2011
-
Ingår i: Glocalized Solutions for Sustainability in Manufacturing. - : Springer. - 9783642196911 ; , s. 669-674
-
Konferensbidrag (refereegranskat)abstract
- Emerging from an industrial case study in the aerospace industry, the paper proposes an approach to evaluate sub- system technology concepts from a life cycle perspective. The approach is composed by 5 main phases that aims to drive product designers towards more value-oriented design decisions. It is shown how different life cycle alternatives, such as the selling of a Product-Service-System instead of a traditional product, deeply impact the value of design alternatives. The described approach has been developed in collaboration with industrial partners and represents a potential instrument to enhance value-driven product design.
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| 47. |
- Bertoni, Alessandro, et al.
(författare)
-
Virtual Modeling for Lifecycle Performance Assessment in Aerospace Design
- 2016
-
Ingår i: Procedia CIRP. - Elsevier : Elsevier BV. - 2212-8271. ; 47, s. 335-340, s. 335-340
-
Konferensbidrag (refereegranskat)abstract
- The aim of the paper is to present an approach for the multidisciplinary evaluation of alternative modular concepts in preliminary design with the intent of enhancing engineers’ capability to simulate alternative scenarios with different design configurations, so to derive decisions about the most valuable design concepts to further develop. The research contribution is novel in the way that it expands the Set-Based-Engineering approach by addressing the “servitization” challenge in two ways: firstly by the use of value models and sustainability models as decision making support, making possible a preliminary assessment of the value contribution and of the sustainability performances of a design concept; secondly, by the use of functional modelling modules and configurable systems elements for platform-based design, to manage the complex relationships within and between parts of the platform throughout the lifecycle. The paper presents the main features of the approach and introduces an industrial case concerning the development of a module component for an aircraft engine in which the approach is applied for demonstration. The paper finally elaborates on the benefits and implications of the approach in the design process.
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| 48. |
- Bertoni, Marco, et al.
(författare)
-
A methodology for KEE systems target cascading
- 2008
-
Ingår i: Proceedings of the 7th International Symposium on Tools and Methods of Competitive Engineering - TMCE 2008. - : Delft University of Technology. - 9789051550443
-
Konferensbidrag (refereegranskat)abstract
- The main aim of this paper is to present a methodology developed within the European Project VIVACE to guide the design and implementation of a Knowledge Enabled Engineering (KEE) system in a Virtual Enterprise. The proposed methodology tries to overcome some of the limitations which characterise traditional methods for Target Cascading, promoting a more collaborative and iterative approach to derive system specifications (in terms of advanced knowledge functionalities) from initial high-level targets. Social and behavioural aspects of Knowledge Management play a crucial role when many different users, knowledge experts, and process owners are involved in the Knowledge Management System (KMS) development. A well designed methodology is needed, therefore, to enhance communication and information sharing among design teams, to promote requirements merging and to take care both of the technological and behavioural aspects of the implementation. Initial business targets have been step-by-step decomposed into a set of sub-problems (Service Requirements, Knowledge Issues, and Knowledge Challenges) in the form of simple sentences in natural language. Then Quality Function Deployment (QFD) matrixes have been used to identify the set of functionalities to be implemented in the system, addressing the most important knowledge-related problems outlined in the cascading activity.
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| 49. |
- Bertoni, Marco, et al.
(författare)
-
A methodology for KEE systems target cascading
- 2008
-
Ingår i: Tools and methods of competitive engineering. - Delft : Delft university of technology. - 9789051550443 - 9051550448 - 9789051550450
-
Konferensbidrag (refereegranskat)
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| 50. |
- Bjerselius, Rickard, et al.
(författare)
-
Persistenta organiska miljöföroreningar i fisk från Östersjöregionen 2000-2002
- 2004
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) are still an environmental problem in Sweden, although the use and production of PCBs have been banned for decades and the release of PCDD/DFs have decreased significantly. In general, the concentrations in food have declined since the 1970s. However, in fish from some parts of the Baltic Sea, the decline of PCBs and PCDD/DFs appears to have ceased in the 1990s (Bignert, 2002). For risk assessment purposes, the Swedish National Food Administration has conducted a fish survey 2000-2002 of levels of selected persistent organic pollutants (POPs), PCBs, PCDD/DFs and persistent pesticides, in fish from the Baltic Sea region. Also polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD), ubiquitously used flame retardants, have been added to this list because of results suggesting the PBDE group as candidate for a new environmental hazard. The aim is to get relevant data to be used in the continuous evaluation of the dietary recommendations and to follow changes in the levels of these environmental contaminants in fish. The ambition is to use the data as a basis for intake estimations for human body burdens and compare with internationally established tolerable weekly intakes (TWI). In addition, in November 2001, the European Commission (EC) published legislation aimed at achieving a reduction in human exposure to PCDD/DFs and PCBs (Council Regulation 2375/01/EC). One of the strategies to reduce the human exposure for PCDD/DFs and dioxin-like PCBs has been to set maximum levels for PCDD/DFs in foodstuffs. Sweden and Finland currently have a derogation from the Council regulation that allows national marketing of fish that exceed the maximum level for PCDD/DF. The legislation came into force from 1 July 2002. The Council Regulation also carries with it an obligation for Member States to monitor the levels of dioxin-like PCBs and PCDD/DFs in foodstuffs and to report the levels to the EC. These data will ultimately be used to both review the maximum limits and measure the effectiveness of the reduction strategy and set new maximum limits. For example, during 2004 the Commission is planning to set maximum levels for dioxin-like PCBs based on reported background levels from the member states. The following report includes results from parts of the sampling carried out in the Baltic Sea area in 2000-2002. Only results of PCBs, persistent pesticides, PBDEs and HBCD are reported here. The corresponding PCDD/DF levels are reported on www.slv.se in three interim reports.
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