| 1. |
- Gunnbjornsdottir, M. I., et al.
(författare)
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Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms
- 2004
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Ingår i: Eur Respir J. - : European Respiratory Society (ERS). ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have identified obesity as a risk factor for asthma in both children and adults. An increased prevalence of asthma in subjects with gastro-oesophageal reflux (GOR) and obstructive sleep apnoea syndrome has also been reported. The aim of this investigation was to study obesity, nocturnal GOR and snoring as independent risk factors for onset of asthma and respiratory symptoms in a Nordic population. In a 5-10 yr follow-up study of the European Community Respiratory Health Survey in Iceland, Norway, Denmark, Sweden and Estonia, a postal questionnaire was sent to previous respondents. A total of 16,191 participants responded to the questionnaire. Reported onset of asthma, wheeze and night-time symptoms as well as nocturnal GOR and habitual snoring increased in prevalence along with the increase in body mass index (BMI). After adjusting for nocturnal GOR, habitual snoring and other confounders, obesity (BMI >30) remained significantly related to the onset of asthma, wheeze and night-time symptoms. Nocturnal GOR was independently related to the onset of asthma and in addition, both nocturnal GOR and habitual snoring were independently related to onset of wheeze and night-time symptoms. This study adds evidence to an independent relationship between obesity, nocturnal gastro-oesophageal reflux and habitual snoring and the onset of asthma and respiratory symptoms in adults.
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| 2. |
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| 3. |
- Sandstrom, T, et al.
(författare)
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Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study
- 1991
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Ingår i: European Respiratory Journal. - 1399-3003. ; 4:3, s. 332-339
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Tidskriftsartikel (refereegranskat)abstract
- The combination of environmental chamber exposure and bronchoalveolar lavage (BAL) was used to study the effects of the common air pollutant nitrogen dioxide (NO2). Eighteen healthy nonsmokers were exposed to NO2 during 20 min in an exposure chamber during light bicycle ergometer work. All subjects were examined with BAL at least 3 wks before exposure, as a reference. The subjects were re-examined with BAL, in groups of eight, 24 h after exposure to 4, 7 and 10 mg NO2.m.3 (2.25, 4.0 and 5.5 ppm), respectively. An inflammatory cell response was found after exposure to all concentrations. An increase in the number of lymphocytes in BAL fluid was observed after 7 and 10 mg.m.3 (p less than 0.05 and 0.02, respectively). An increase in the number of mast cells, that appears to be dose-dependent, was found after exposure to all concentrations. The proportion of lysozyme positive alveolar macrophages was elevated after exposure to 7 mg.m.3. The inflammatory mediators fibronectin, hyaluronan, angiotensin converting enzyme (ACE) and beta 2-microglobulin were unchanged by exposure. Due to the findings of inflammatory cell changes far below the peak exposure limits for work places in industrialized countries, 9-18 mg.m.3, the safety of these limits is questioned. Studies are in progress in our laboratory using BAL to evaluate the effects of repeated NO2 exposure.
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| 4. |
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| 5. |
- Heath, E., et al.
(författare)
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Inter-laboratory exercise on steroid estrogens in aqueous samples
- 2010
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 158:3, s. 658-662
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Tidskriftsartikel (refereegranskat)abstract
- An inter-laboratory comparison exercise was organized among European laboratories, under the aegis of EU COST Action 636: ""Xenobiotics in Urban Water Cycle"" The objective was to evaluate the performance of testing laboratories determining ""Endocrine Disrupting Compounds"" (EDC) in various aqueous matrices. As the main task three steroid estrogens. 17 alpha-ethinylestradiol, 17 beta-estradiol and estrone were determined in four spiked aqueous matrices' tap water, river water and wastewater treatment plant influent and effluent using GC-MS and LC-MS/MS Results were compared and discussed according to the analytical techniques applied, the accuracy and reproducibility of the analytical methods and the nature of the sample matrices. Overall, the results obtained in this inter-laboratory exercise reveal a high level of competence among the participating laboratories for the detection of steroid estrogens in water samples indicating that GC-MS as well as LC-MS/MS can equally be employed for the analysis of natural and synthetic hormones.
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| 6. |
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| 7. |
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| 8. |
- Ledin, T., et al.
(författare)
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Dynamic posturography and aging
- 1991
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Ingår i: Vertigo, nausea, tinnitus, and hypoacusia due to head and neck trauma. - Amsterdam : Excerpta Medica. - 0444811508 ; , s. 229-232
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Konferensbidrag (refereegranskat)
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| 9. |
- Ledin, T., et al.
(författare)
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Dynamic posturography in assessment of polyneuropathic disease
- 1991
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Ingår i: Journal of Vestibular Research-Equilibrium & Orientation. - 0957-4271 .- 1878-6464. ; 1:2, s. 123-128
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Tidskriftsartikel (refereegranskat)abstract
- Twenty-eight patients with polyneuropathy aged 49-82 years (mean 67 years) were assessed by dynamic posturography. The patient group was compared to a control group comprising 29 healthy controls aged 70 through 75 years (mean 73 years). The dynamic posturography method comprises a sensory organization part in which the platform and visual surround are either stable or referenced to the patient's sway; furthermore, the eyes are open or closed. In a movement coordination part the platform makes active movements. In the sensory organization part of the dynamic posturography the patient group showed significantly lower equilibrium performance compared to the control group in the test conditions with absent vision, sway-referenced surrounding, and, finally, sway referenced platform and surrounding. In these conditions the influx of somatosensory information is of paramount importance for stable posture. In the movement coordination test, the patient group showed prolonged muscular response latencies in both forward and backward platform perturbations compared to the control group. It is concluded that dynamic posturography is a valuable diagnostic tool in assessment of the dynamic equilibrium performance in patients with polyneuropathy.
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| 10. |
- Ledin, T., et al.
(författare)
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Dynamic posturography in psychoorganic syndrome
- 1991
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Ingår i: Vertigo, nausea, tinnitus and hypoacusia due to head and neck trauma. - Amsterdam : Excerpta Medica. - 0444811508 ; , s. 367-369
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Konferensbidrag (refereegranskat)
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| 11. |
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| 12. |
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| 13. |
- Ledin, T., et al.
(författare)
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Effects of balance training in elderly evaluated by clinical tests and dynamic posturography
- 1991
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Ingår i: Journal of Vestibular Research-Equilibrium & Orientation. - 0957-4271 .- 1878-6464. ; 1:2, s. 129-138
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Tidskriftsartikel (refereegranskat)abstract
- All persons aged 70 through 75 years (N = 457) in a Swedish community were invited to participate in a 9 week balance training study. Out of 55 interested subjects, 15 were chosen at random for a study group; 15 matched controls were also selected. Before and after the investigation period the balance function was assessed by clinical balance tests and dynamic posturography. In the clinical balance tests, the training group significantly improved their balance standing on one leg with eyes closed as well as standing on one leg while shaking the head; they also walked 15 m back and forth faster. In the dynamic posturography the training group significantly improved their equilibrium scores in the 3 most difficult test conditions. The results of the control group were unchanged except for one test condition in the dynamic posturography. The differences in one-leg standing with head shaking, walking 2 x 15 m, and the equilibrium score using sway-referenced platform in dynamic posturography were proved to be attributable to the training. The first investigation in all 29 subjects formed normative dynamic posturography data for the age group 70 through 75 years. The normative posturographic data of this age group differed from previously obtained data in the age groups 20 through 59 and 60 through 69 years. It is concluded that elderly may improve their balance by regular balance training exercises for as short a period as 9 weeks. This might prove to be of great value in improving balance and thereby preventing accidental falls and subsequent fractures in elderly.
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| 14. |
- Ledin, T., et al.
(författare)
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Effects of loratadine on postural control
- 1992
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Ingår i: Conservative versus surgical treatment of sensorineural hearing loss, tinnitus, vertigo and nausea. Vol. 19. - Hamburg : Werner Rudat. - 3922326374 ; , s. 175-181
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 15. |
- Ledin, T., et al.
(författare)
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Effects of loratadine on postural control
- 1994
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Ingår i: Acta oto-laryngologica. Supplementum. - 0365-5237 .- 1651-2464. ; 520:Pt 2, s. 310-312
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Tidskriftsartikel (refereegranskat)abstract
- The effects of classical sedating antihistamines on cognitive and perceptual functions are well known. Loratadine is a new antihistamine without sedative effects. In this study, loratadine 10 and 40 mg daily, clemastine 2 mg twice daily and placebo were evaluated in 8 healthy subjects in terms of effects on equilibrium as measured with dynamic posturography. Dynamic posturography comprises a sensory organization part in which the support surface and visual surround are either stable or referenced to the patient's sway, with eyes open or closed. In a movement coordination part, the platform makes active movements. Analysis of variance showed no effects on equilibrium attributable to loratadine. Comparing substances pairwise, however, a significant difference between loratadine and clemastine was displayed in 2 out of 6 sensory test conditions. In conclusion, loratadine can be considered safe regarding balance functions.
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| 16. |
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| 21. |
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Surano, Solmaz, et al.
(författare)
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Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial
- 2022
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also associated with excessive use of diagnostic imaging and emergency care and decreased productivity, primarily because of work absenteeism. Vestibular rehabilitation is an evidence-based treatment for chronic dizziness and supervised group exercise therapy has recently been shown to be effective after vestibular neuritis, a common cause of acute onset vertigo. However, such interventions are not readily available and there is a need for more easily accessible tools. The purpose of this study is to investigate the effects on vestibular symptoms of a 6-week online vestibular rehabilitation tool after acute onset vertigo, with the aim of aiding vestibular rehabilitation by presenting a more accessible tool that can help to reduce recovery time. Methods: Three hundred twenty individuals diagnosed with acute vestibular syndrome (AVS) will be recruited from multiple hospitals in Sweden and the effects of an online vestibular rehabilitation tool, YrselTraning, on vestibular symptoms after acute onset vertigo will be compared to standard care (written instructions leaflet) in a two-armed, evaluator-blinded, multicenter randomized controlled trial. The primary outcome will be the Vertigo Symptom Scale Short Form (VSS-SF) score at 6 weeks after symptom onset. Secondary outcomes include effects of the intervention on activities of daily living, mood and anxiety, vestibular function recovery, mobility measures, health economic effects, and the reliability of the Swedish VSS-SF translation. Discussion: Participants using the online vestibular rehabilitation tool are expected to recover earlier and to a greater extent from their symptoms as compared to standard care. Since up to 50% of people with AVS without treatment develop persistent symptoms, effective treatment of AVS will likely lead to a higher quality of life and help reduce the societal costs associated with dizziness and vertigo.
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| 26. |
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| 27. |
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| 28. |
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| 29. |
- Ålund, M., et al.
(författare)
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Dynamic posturography in cervical vertigo
- 1991
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Ingår i: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 111:s481, s. 601-602
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Tidskriftsartikel (refereegranskat)abstract
- Cervical vertigo, the entity of neck disorder and associated vestibular symptoms, was investigated in 15 suspected subjects and results were compared with 15 age-matched controls. A modified dynamic posturography investigation with different head positions was used. Head position was recorded 3-dimensionally with electrogoniometry. Differences on a sway-referenced forceplate were found.
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| 30. |
- Ödkvist, L. M., et al.
(författare)
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Dynamic posturography
- 1990
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Ingår i: Wissenschaftliche Zeitschrift der Humboldt-Universität zu Berlin : Neurootologie I. ; 39, s. 359-360
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Tidskriftsartikel (refereegranskat)
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| 31. |
- Ödkvist, L. M., et al.
(författare)
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Dynamic posturography
- 1991
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Ingår i: Vestibular diagnosis and neuro-otosurgical management of the skull base. - : Demeter Verlag. - 3893830278 ; , s. 90-98
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Konferensbidrag (refereegranskat)
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| 32. |
- Ödkvist, L. M., et al.
(författare)
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Dynamic posturography in polyneuropathy
- 1992
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Ingår i: Diagnostic procedures and imaging techniques used in neurootology. - Hamburg : Edition M + P. - 3922326366 ; , s. 167-172
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Konferensbidrag (refereegranskat)
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| 33. |
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| 34. |
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| 35. |
- Ödkvist, L., et al.
(författare)
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The role of osturography and ENG in whiplash injuries
- 1995
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Ingår i: Vertigo, nausea, tinnitus, and hearing loss in central and peripheral vestibular diseases. - Amsterdam : Elsevier. - 9780444821935 ; , s. 259-262
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Konferensbidrag (refereegranskat)
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