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| 9. |
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| 10. |
- Shrine, N, et al.
(författare)
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
- 2023
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 410-
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Tidskriftsartikel (refereegranskat)abstract
- Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
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| 11. |
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| 12. |
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| 13. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 14. |
- Gladyshev, VN, et al.
(författare)
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Selenoprotein Gene Nomenclature
- 2016
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Ingår i: The Journal of biological chemistry. - 1083-351X. ; 291:46, s. 24036-24040
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Tidskriftsartikel (refereegranskat)
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| 15. |
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| 16. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 17. |
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| 20. |
- ASZTALOS, SJ, et al.
(författare)
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CONFIRMATION OF THE SUPERDEFORMED BAND IN PB-192
- 1995
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Ingår i: Zeitschrift für Physik A Hadrons and Nuclei. - 0939-7922 .- 1431-5831. ; 352:3, s. 239-240
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Pb-192 were populated via the reaction Yb-173(Mg-24,5n) at a beam energy of 140 MeV, and the resulting gamma-rays were deteced using GAMMA-SPHERE. A previously observed superdeformed band in Pb-192 has been confirmed.
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| 21. |
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| 22. |
- BERNSTEIN, LA, et al.
(författare)
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ONSET OF COLLECTIVITY IN NEUTRON-DEFICIENT PO-196,PO-198
- 1995
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:2, s. 621-627
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Tidskriftsartikel (refereegranskat)abstract
- We have studied via in-beam gamma-ray spectroscopy Po-196 and Po-198, which are the first neutron-deficient Po isotopes to exhibit a collective low-lying structure. The ratios of yrast state energies and the E2 branching ratios of transitions from non-yrast to yrast states are indicative of a low-lying vibrational structure. The onset of collective motion in these isotopes can be attributed to the opening of the neutron i(13/2) orbital at N approximate to 112 and the resulting large overlap between the two valence protons in the h(9/2) orbital and the valence neutrons in the i(13/2) orbital.
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| 23. |
- BERNSTEIN, LA, et al.
(författare)
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SUPERDEFORMATION IN ER-154
- 1995
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:3, s. R1171-R1174
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Tidskriftsartikel (refereegranskat)abstract
- A superdeformed (SD) band consisting of 13 gamma-ray transitions has been observed in Er-154, an isotone of Dy-152(66). The experiment was performed using the Sn-118(Ar-40,4n) reaction at E(Ar-40)=185 MeV and the early implementation of GAMMASPHERE. This is an observation of a SD band in the A approximate to 150 region with a proton number greater than 66. The J((2)) moment of inertia of the band is constant above ($) over bar h omega=0.45 MeV and shows a sharp rise below this value suggesting a paired band crossing. These results suggest that total Routhian surface calculations fail to accurately predict the deformation of the band.
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| 24. |
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| 25. |
- Cederwall, Bo, et al.
(författare)
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MEASUREMENT OF ULTRA-FAST GAMMA-RAY TRANSITIONS FROM HEAVY-ION COMPOUND NUCLEUS REACTIONS
- 1995
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 354:2-3, s. 591-594
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Tidskriftsartikel (refereegranskat)abstract
- A method for correcting target-thickness-induced Doppler broadening in gamma-ray spectra from weakly populated, very short-lived (femtosecond) states is presented. The method is illustrated by an analysis of superdeformed transitions in Dy-152,Dy-153 for which the validity of the procedure could be verified consistently from previous lifetime measurements in Dy-152. Furthermore, estimates of the superdeformed lifetimes, previously not measured in Dy-153, are obtained.
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| 26. |
- Cederwall, Bo, et al.
(författare)
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NEW FEATURES OF SUPERDEFORMED BANDS IN HG-194
- 1994
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 72:20, s. 3150-3153
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Tidskriftsartikel (refereegranskat)abstract
- Two new features of superdeformed (SD) bands in the A almost-equal-to 190 region emerge from a study of Hg-194 with the Gammasphere detector array. A decrease of the dynamic moment of inertia is observed for rotational frequencies HBARomega greater-than-or-equal-to 0.4 MeV, confirming long standing expectations based on mean field calculations with pairing. Evidence for a small staggering in the SD transition energies is also observed, suggesting the presence of terms with fourfold symmetry in the SD Hamiltonian.
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| 27. |
- Cederwall, Bo, et al.
(författare)
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NEW OBLATE BAND IN HG-196 WITH QUENCHED M1 STRENGTH
- 1993
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 47:6, s. R2443-R2446
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in the nucleUs Hg-196 were populated in the reaction (Os(Be,5n))-Os-192 at a beam energy of 65 MeV. A regular rotational-like DELTAI = 1 band has been observed up to an excitation energy of E* almost-equal-to 8.7 MeV and spin I almost-equal-to 30hBAR. This is the second observation of a band of this character in a mercury isotope. The experimental results are compared with mean field calculations and semiclassical estimates based on the Donau-Frauendorf formalism. The mercury bands show significantly lower B(M1)/B(E2) branching ratios as compared with similar bands in light lead nuclei. This difference may be more readily explained by a difference in single-particle structure rather than by large differences in deformation between the lead and mercury configurations.
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| 28. |
- Cederwall, Bo, et al.
(författare)
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PROPERTIES OF SUPERDEFORMED BANDS IN DY-153
- 1995
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 346:3-4, s. 244-250
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Tidskriftsartikel (refereegranskat)abstract
- Two new superdeformed (SD) bands in Dy-153, in addition to the three previously observed, have been studied with the GAMMASPHERE detector array. Assignments to single-neutron orbits in the SD potential are made based on the band properties. Evidence for a band interaction at very high spins, possibly involving the first N = 7 proton intruder orbital, is observed in the strongest populated SD band. Furthermore, evidence far a Delta I = 2 staggering is also found in this SD band.
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| 29. |
- CLARK, RM, et al.
(författare)
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A PAIR OF IDENTICAL SUPERDEFORMED BANDS IN ND-136
- 1995
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 343:1-4, s. 59-63
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Nd-136 were populated via the Mo-100(Ar-40, 4n) reaction at beam energies of 176 and 182 MeV, and resulting gamma-rays were detected using the GAMMASPHERE spectrometer. Analysis of the data has revealed the existence of an excited superdeformed (SD) band in Nd-136. Th, yrast SD band in Nd-136 has been extended by the addition of four (possibly five) transitions at high frequency. The new band displays the remarkable property of having transition energies identical (to within +/- 1 keV) to those of the half-points of the yrast SD band of Nd-136. Possible explanations in terms of cranked Woods-Saxon single-particle calculations are discussed.
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| 30. |
- CLARK, RM, et al.
(författare)
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SUPERDEFORMATION IN THE BISMUTH NUCLEI
- 1995
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 51:3, s. R1052-R1056
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Tidskriftsartikel (refereegranskat)
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| 31. |
- CRISTANCHO, F, et al.
(författare)
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MULTIPLE SUPERDEFORMED BANDS IN SR-81
- 1995
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 357:3, s. 281-286
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Tidskriftsartikel (refereegranskat)abstract
- Four superdeformed bands extending over five to twelve transitions have been identified in Sr-81 from a study With the Gammasphere array and the Microball charged-particle array, One of the bands shows an upbend in the dynamic moment of inertia at a rotational frequency of 1.2 MeV and all bands exhibit a nearly constant moment of inertia below that frequency.
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| 32. |
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| 33. |
- DELEPLANQUE, MA, et al.
(författare)
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LOW-SPIN TERMINATION OF THE SUPERDEFORMED BAND IN ND-135
- 1995
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:5, s. R2302-R2305
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Tidskriftsartikel (refereegranskat)abstract
- The decay of the superdeformed (SD) band in Nd-135 was studied with the early implementation of gamma-sphere. The results suggest that the SD band ''terminates'' at spin 25/2. This termination is explained by a change of the SD minimum toward a triaxial lower deformation. Ultimate cranker calculations with the i(13/2) orbital occupied relate this change to a shift of a proton and neutron pair out of deformation-driving Nilsson orbitals. This is a completely new and unexpected mechanism for the decay of SD bands.
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| 34. |
- Evans, AO, et al.
(författare)
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High-spin structure beyond band termination in Er-157
- 2004
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Ingår i: Physical Review Letters. - 1079-7114. ; 92:25
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Tidskriftsartikel (refereegranskat)abstract
- The angular-momentum induced transition from a deformed state of collective rotation to a noncollective configuration has been studied. In Er-157 this transition manifests itself as favored band termination near I=45 (h) over bar. The feeding of these band terminating states has been investigated for the first time using the Gammasphere spectrometer. Many weakly populated states lying at high excitation energy that decay into these special states have been discovered. Cranked Nilsson-Strutinsky calculations suggest that these states arise from weakly collective "core-breaking" configurations.
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| 35. |
- Evans, AO, et al.
(författare)
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High-spin structure in Er-157 up to and above band termination
- 2006
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 73:6
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Tidskriftsartikel (refereegranskat)abstract
- The high-spin structure of Er-157 has been greatly expanded using the Gammasphere spectrometer to investigate the Cd-114(Ca-48,5n) reaction at 215 MeV. Many new transitions have been placed in a greatly augmented level scheme up to spin 40h with many collective rotational sequences established. With increasing angular momentum, this nucleus undergoes a Coriolis-induced shape transition from a deformed state of collective rotation to a noncollective configuration. This transition manifests itself as favored band termination near I=45h in three rotational structures. Many weakly populated states lying at high excitation energy that decay into the terminating states have been discovered. Cranked-Nilsson-Strutinsky calculations suggest that the levels that feed the terminating states arise from weakly collective configurations that break the Z=64 semimagic core.
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| 36. |
- Evans, AO, et al.
(författare)
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Magnetic properties of smooth terminating dipole bands in Te-110,Te-112
- 2006
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 636:1, s. 25-30
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Tidskriftsartikel (refereegranskat)abstract
- Three strongly coupled sequences have been established in Te-110,Te-112 up to high spins. They are interpreted in terms of deformed structures built on proton 1-particle-1-hole excitations that reach termination at I similar to 40h. This is the first observation of smooth terminating dipole structures in this mass region. Lifetime measurements have allowed the extraction of experimental B(M 1; 1 -> I - 1) and B(E2; I -> I - 2) reduced transition rates for one of the dipole bands in Te-110. The results support the deformed interpretation. (c) 2006 Elsevier B.V. All rights reserved.
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| 37. |
- FALLON, P, et al.
(författare)
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EVIDENCE FOR M1 TRANSITIONS BETWEEN SUPERDEFORMED STATES IN HG-193
- 1993
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 70:18, s. 2690-2693
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Tidskriftsartikel (refereegranskat)abstract
- Two-way decay has been observed between superdeformed bands in Hg193. it is proposed the decays have M 1 multipolarity and connect signature partner bands. Candidates for the two-way gamma decays connecting superdeformed bands are observed for the first time.
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| 38. |
- FALLON, P, et al.
(författare)
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PROTON AND NEUTRON EXCITATIONS IN SUPERDEFORMED TB-150
- 1995
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:1, s. 93-98
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Tidskriftsartikel (refereegranskat)abstract
- Two new superdeformed (SD) bands have been observed in Tb-150 using the reaction P-31 + Sn-124 and the GAMMASPHERE detector array. These new bands are interpreted as being excited SD configurations involving a proton and a neutron particle-hole excitation, respectively. The configurations are discussed in terms of the occupancy of high-N intruder orbitals. These data are used to provide information on (i) the contribution to the dynamic moments of inertia due to the occupation of specific orbitals, (ii) the deformation driving effects of the particle-hole states, and (iii) the consequences of these effects on pairing and band crossings.
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| 39. |
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| 40. |
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| 41. |
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| 42. |
- Gorgen, A, et al.
(författare)
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Quadrupole moments of wobbling excitations in Lu-163
- 2004
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 69:3
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of states in the triaxial strongly deformed bands of Lu-163 have been measured with the Gammasphere spectrometer using the Doppler-shift attenuation method. The bands have been interpreted as wobbling-phonon excitations from the characteristic electromagnetic properties of the transitions connecting the bands. Quadrupole moments are extracted for the zero-phonon yrast band and, for the first time, for the one-phonon wobbling band. The very similar results found for the two bands suggest a similar intrinsic structure and support the wobbling interpretation. While the in-band quadrupole moments for the bands show a decreasing trend towards higher spin, the ratio of the interband to the in-band transition strengths remains constant. Both features can be understood by a small increase in triaxiality towards higher spin. Such a change in triaxiality is also found in cranking calculations, to which the experimental results are compared.
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| 43. |
- HENRY, EA, et al.
(författare)
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COLLECTIVE OBLATE BANDS IN PB NUCLEI
- 1993
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Ingår i: Abstracts of Papers of the American Chemical Society. - 0065-7727. ; 206, s. 58-NUCL
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Tidskriftsartikel (refereegranskat)
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| 44. |
- Howe, LJ, et al.
(författare)
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Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
- 2022
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:65, s. 581-
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Tidskriftsartikel (refereegranskat)abstract
- Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.
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| 45. |
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| 46. |
- HUGHES, JR, et al.
(författare)
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EXCITATIONS IN DOUBLY-MAGIC SUPERDEFORMED PB-194
- 1994
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 50:3, s. R1265-R1269
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Tidskriftsartikel (refereegranskat)abstract
- A new superdeformed band with an intensity similar to 5% relative to the yrast superdeformed band has been observed in Pb-194. Evidence for a second new band corresponding to the signature partner is also presented. These bands were observed with GAMMASPHERE early implementation via the Yb-174(Mg-25, 5n) reaction at a beam energy of 130 MeV. The rotational characteristics of the new bands suggest an interpretation involving particle-hole excitations in the doubly-magic Pb-194 superdeformed core. The results are compared to neighboring nuclei and recent theoretical calculations, and possible configurations are suggested.
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| 47. |
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| 48. |
- HUGHES, JR, et al.
(författare)
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LIFETIME MEASUREMENT IN EXCITED AND YRAST SUPERDEFORMED BANDS IN HG-194
- 1994
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 72:6, s. 824-827
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear level lifetimes have been measured in two superdeformed bands in Hg-194 using the Doppler-shift attenuation method. Average transition quadrupole moments derived from the life-times of an excited and yrast superdeformed bands are Q(t) = 17.6(30) and 17.2(20) eb, respectively. The Doppler shifts of the excited band relative to the yrast band indicate a slight difference in quadrupole moments [+4(5)%], assuming similar side feeding. These results imply that the second well is stable and rigid with respect to the particle excitation responsible for this excited band.
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| 49. |
- HUGHES, JR, et al.
(författare)
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LIFETIME MEASUREMENTS IN THE REGULAR DELTA-I = 1 OBLATE BAND IN PB-197
- 1993
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 48:5, s. R2135-R2139
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of states in the regular DELTAI = 1 band in 197Pb have been measured with the Doppler-shift attenuation method. Excited states in 197Pb were populated using the Sm-154(48Ca, 5n) reaction at E(b) = 210 MeV. The target consisted of 1 mg/cm2 Sm-154 evaporated onto a 10 mg/cm2 Au backing. Discernible lineshapes for gamma rays in the energy range 300 < E(gamma) < 500 keV in the regular band were observed in a spectroscopic study with the 20 Ge-detector array, HERA. Level lifetimes were obtained from a lineshape analysis. Averaged reduced transition strengths, B(M1) approximately 1.7 W.u. and B(E2) approximately 18 W.u., are deduced and these are compared with theoretical predictions for the suggested configuration of this band.
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| 50. |
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