| 1. |
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| 2. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 3. |
- Rheinbay, E, et al.
(författare)
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 102-
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Tidskriftsartikel (refereegranskat)abstract
- The discovery of drivers of cancer has traditionally focused on protein-coding genes1–4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers6,7, raise doubts about others and identify novel candidates, including point mutations in the 5′ region of TP53, in the 3′ untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available.
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| 4. |
- Arshad, Wajiha, et al.
(författare)
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A rare case of retropharyngeal liposarcoma : a rare location of a rare diagnosis
- 2023
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Ingår i: Journal of Surgical Case Reports. - : Oxford University Press (OUP). - 2042-8812. ; 2023:3
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Tidskriftsartikel (refereegranskat)abstract
- We report a case of retropharyngeal liposarcoma in a 53-year-old female, who had complaints of neck swelling accompanied with dysphagia, orthopnea and dysphonia. Clinical examination revealed huge multinodular swelling in front of neck with bilateral extension, more prominent on left side and moving with deglutition. The diagnosis of retropharyngeal liposarcoma was established following CT scan, MRI and incisional biopsy. Surgical excision of mass along with near total thyroidectomy was performed. Postoperative hospital stay was uneventful. She remained well in follow-up period of 1 year as well. In conclusion, retropharyngeal liposarcoma is a rare tumor. A review of the literature explores the reasons behind the late presentation as well as the difficulties in diagnosis and treatment of this rare tumor.
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| 5. |
- Arshad, W., et al.
(författare)
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Rare case of mixed epithelial and stromal tumor (MEST) of the kidney and its diagnostic and therapeutic approach : A case report
- 2023
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Ingår i: International Journal of Surgery Case Reports. - : Elsevier BV. - 2210-2612. ; 102
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Tidskriftsartikel (refereegranskat)abstract
- Introduction and importance: Mix epithelial and stromal tumor (MEST) is a benign biphasic renal lesion composed of solid as well as cystic components lining tubular and cystic spaces of kidney. There are very few cases of such variety have been reported with perspective to renal involvement. Herein we have reported a rare case of MEST involving left renal tissue and sparing surrounding tissues. Case presentation: A 20 years old female presented to surgical outpatient department with complaint of amenorrhea and left flank pain as well as heaviness for 1 year. Patient was vitally stable and cooperative. On physical examination left flank mass was palpated and ultrasound and CT scan imaging was also showing left renal mass confined to upper, middle and lower portion of the kidney while renal capsule, adrenal gland and ureter were spared. On histological examination showed multi-cystic structures with variably sized simple cysts lined by hobnailed epithelium with clear cells. Septa show ovarian type fibrous stroma with variable inflammation and immature nephrogenic elements. A final diagnosis of MEST was made. Therefore, radical nephrectomy with trans-peritoneal approach was done. Clinical discussion: MEST is a benign tumor of renal tissue that is confined to the renal parenchyma rather than involvement of surrounding structures as occurred in our case. Due to benign nature of the disease involvement of renal capsule and adrenal gland is less likely. The choice of treatment is radical nephrectomy through transperitoneal approach. Conclusion: MEST is a rare diagnosis thought case now start reporting since last decade, however, it's still a rare entity to be reported. USG and CT scan are investigating modalities along with histopathological correlation to reach the diagnosis.
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| 6. |
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| 7. |
- Bali, A. O., et al.
(författare)
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Public engagement in government officials' posts on social media during coronavirus lockdown
- 2023
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 18:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Social media has been a common platform to disseminate health information by government officials during the COVID-19 pandemic. However, little is known about the determinants of public engagement in officials' posts on social media, especially during lockdown. OBJECTIVES: This study aims to investigate how the public engages in officials' posts about COVID-19 on social media and to identify factors influencing the levels of engagement. METHODS: A total of 511 adults aged 18 or over completed an online questionnaire during lockdown in Iraq. Levels of engagement in officials' posts on social media, trust in officials and compliance of government instructions were assessed. RESULTS: Fear of COVID-19 and trust in officials were positively associated with compliance of government instructions. Trust in officials was also associated with active engagement in officials' posts on social media, including commenting, posting and sharing of the posts. CONCLUSIONS: Trust in government has been established during the COVID-19 pandemic. Public engagement in officials' posts is crucial to reinforce health policies and disseminate health information.
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| 8. |
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| 9. |
- Cheema, H. A., et al.
(författare)
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Colchicine for the treatment of patients with COVID-19 : an updated systematic review and meta-analysis of randomised controlled trials
- 2024
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 14:4
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Forskningsöversikt (refereegranskat)abstract
- OBJECTIVES: We conducted an updated systematic review and meta-analysis to investigate the effect of colchicine treatment on clinical outcomes in patients with COVID-19. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We searched PubMed, Embase, the Cochrane Library, medRxiv and ClinicalTrials.gov from inception to January 2023. ELIGIBILITY CRITERIA: All randomised controlled trials (RCTs) that investigated the efficacy of colchicine treatment in patients with COVID-19 as compared with placebo or standard of care were included. There were no language restrictions. Studies that used colchicine prophylactically were excluded. DATA EXTRACTION AND SYNTHESIS: We extracted all information relating to the study characteristics, such as author names, location, study population, details of intervention and comparator groups, and our outcomes of interest. We conducted our meta-analysis by using RevMan V.5.4 with risk ratio (RR) and mean difference as the effect measures. RESULTS: We included 23 RCTs (28 249 participants) in this systematic review. Colchicine did not decrease the risk of mortality (RR 0.99; 95% CI 0.93 to 1.05; I2=0%; 20 RCTs, 25 824 participants), with the results being consistent among both hospitalised and non-hospitalised patients. There were no significant differences between the colchicine and control groups in other relevant clinical outcomes, including the incidence of mechanical ventilation (RR 0.75; 95% CI 0.48 to 1.18; p=0.22; I2=40%; 8 RCTs, 13 262 participants), intensive care unit admission (RR 0.77; 95% CI 0.49 to 1.22; p=0.27; I2=0%; 6 RCTs, 961 participants) and hospital admission (RR 0.74; 95% CI 0.48 to 1.16; p=0.19; I2=70%; 3 RCTs, 8572 participants). CONCLUSIONS: The results of this meta-analysis do not support the use of colchicine as a treatment for reducing the risk of mortality or improving other relevant clinical outcomes in patients with COVID-19. However, RCTs investigating early treatment with colchicine (within 5 days of symptom onset or in patients with early-stage disease) are needed to fully elucidate the potential benefits of colchicine in this patient population. PROSPERO REGISTRATION NUMBER: CRD42022369850.
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| 10. |
- Cheema, H. A., et al.
(författare)
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In-hospital mortality of COVID-19 patients hospitalized with ST-segment elevation myocardial infarction : A meta-analysis
- 2022
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Ingår i: IJC Heart & Vasculature. - : Elsevier BV. - 2352-9067. ; 43
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Coronavirus Disease 2019 (COVID-19) has been associated with an increased risk of adverse cardiovascular events including arteriovenous thrombosis, myocarditis and acute myocardial injury. Relevant literature to date has reported widely varying estimates of mortality, ranging from approximately 2 to 11 times higher odds of mortality in COVID-19-positive STEMI (ST-segment elevation myocardial infarction) patients. Hence, we conducted this meta-analysis to resolve these inconsistencies and assess the impact of COVID-19 infection on mortality and other clinical outcomes in patients presenting with STEMI. Methods: This meta-analysis was registered in PROSPERO (CRD42021297458) and performed according to the Cochrane Handbook for Systematic Reviews of Interventions. PubMed and Embase were searched from inception to November 2021 (updated on April 2022) using a search strategy consisting of terms relating to COVID-19, STEMI, and mortality. Results: We identified 435 studies through our initial search. After screening according to our eligibility criteria, a total of 11 studies were included. Compared with the non-COVID-19 STEMI patients, the in-hospital mortality rate was higher in COVID-19-positive STEMI patients. Similarly, the risk of cardiogenic shock was higher in the COVID-19-positive patients. Length of hospital stay was longer in STEMI patients with COVID-19. Conclusions: Our study highlights the necessity for early evaluation of COVID-19 status in all STEMI patients followed by risk stratification, prompt reperfusion and more aggressive management of COVID-19-positive patients. Further research is needed to elucidate the mechanisms behind poorer prognosis in such patients.
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| 11. |
- Cheema, H. A., et al.
(författare)
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Molnupiravir for the treatment of COVID-19 outpatients : An updated meta-analysis
- 2024
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Ingår i: Journal of Microbiology, Immunology and Infection. - : Elsevier BV. - 1684-1182. ; 57:3, s. 396-402
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Tidskriftsartikel (refereegranskat)abstract
- Background: The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence from recent randomized controlled trials (RCTs) as well as observational studies stratified by vaccination status to determine the clinical efficacy and safety of molnupiravir in COVID-19 outpatients. Methods: We searched PubMed, Embase, the Cochrane Library, medRxiv, and ClinicalTrials.gov from inception to November 2023. We conducted our meta-analysis using RevMan 5.4 with risk ratio (RR) as the effect measure. Results: We included 8 RCTs and 5 observational studies in our meta-analysis. Molnupiravir reduced the risk of all-cause mortality (RR 0.28; 95% CI: 0.20–0.79, I2 = 0%) but did not decrease the hospitalization rate (RR 0.67; 95% CI: 0.45–1.00, I2 = 53%) in the overall population; in the immunized population, no benefits were observed. Molnupiravir lowered the rate of no recovery (RR 0.78; 95% CI: 0.76–0.81, I2 = 0%) and increased virological clearance at day 5 (RR 2.68; 95% CI: 1.94–4.22, I2 = 85%). There was no increase in the incidence of adverse events. Conclusions: Molnupiravir does not decrease mortality and hospitalization rates in immunized patients with COVID-19. However, it does shorten the disease course and increases the recovery rate. The use of molnupiravir will need to be considered on a case-by-case basis in the context of the prevailing social circumstances, the resource setting, drug costs, and the healthcare burden.
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| 12. |
- Cheema, Huzaifa Ahmad, et al.
(författare)
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Vitamin D supplementation for the prevention of total cancer incidence and mortality : An updated systematic review and meta-analysis
- 2022
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Ingår i: Heliyon. - : Elsevier BV. - 2405-8440. ; 8:11
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionPrevious randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.MethodsWe searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.ResultsWe included 13 RCTs in our study. Vitamin D supplementation had no effect on the risk of total cancer incidence (RR 0.99, 95% CI: 0.94–1.04; I2 = 0%), total cancer mortality (RR 0.93, 95% CI: 0.84–1.03; I2 = 24%) and total mortality (RR 0.92, 95% CI: 0.82–1.04; I2 = 36%). The overall quality of evidence was high for all outcomes.DiscussionVitamin D supplementation is ineffective in reducing total cancer incidence and mortality in largely vitamin D-replete older adult populations. Future research should be based on populations with a higher prevalence of vitamin D deficiency and should involve more extended follow-up periods.
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| 13. |
- Dick-Sagoe, C., et al.
(författare)
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Facilitators of tertiary students' entrepreneurial intentions : Insights for Lesotho's national entrepreneurship policy
- 2023
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Ingår i: Heliyon. - : Elsevier. - 2405-8440. ; 9:6
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Tidskriftsartikel (refereegranskat)abstract
- This study provides insightful information to guide the Lesotho government's drive to address rising youth unemployment. Through quota sampling technique, this study selected 930 students from 31 departments at National University of Lesotho. Grounded in the theory of planned behaviour (TPB), the study examined the facilitators of students' entrepreneurial intentions using mean, standard deviation, mean rank, correlation, and Mann-Whitney U test. Structural equation modelling was used to determine the relationship between the three components of TPB (attitudes, perceived behavioural control, and subjective norm), and students' entrepreneurial intention. The findings show that attitudes and perceived behavioural control were positive predictors of entrepreneurial intention while subjective norm was a negative predictor. The major findings indicate that students from Business and Management Development, Business Administration, Economics, Nutrition, and Pharmacy departments had higher entrepreneurial intentions, with postgraduate students (at master level) having higher entrepreneurial decisions than undergraduate students. Policy, practice, and research implications are teased out from the findings to improve entrepreneurial education.
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| 14. |
- Dick-Sagoe, Christopher, et al.
(författare)
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Stakeholder perceptions on causes and effects of public project failures in Ghana
- 2023
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Ingår i: Humanities and Social Sciences Communications. - : Springer Science and Business Media LLC. - 2662-9992. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Factors responsible for the failure of most development projects are multifaceted. This study focused on unearthing the causes and effects of public project failure from the perspective of project stakeholders. Sixty stakeholders working on different public projects in the Greater Accra Region of Ghana completed a questionnaire. This study found that major causes of project failure were related to corruption, payment delays, procurement processes, planning, monitoring, bureaucracy, communication, and supervision. The perceived effects of project failure included revenue loss, discouraged investment, and unemployment. Project failure increased the initial cost of projects, impacted economic growth, led to the provision of substandard infrastructure and service relocation. Other effects of project failure were loss of capacity for public projects and emotional stress experienced by project stakeholders. The government of Ghana should adopt strategies to overcome corruption, bureaucracy, and unnecessary political influence. Finally, the government should cooperate with relevant stakeholders to implement measures geared towards improving the current system for procurement, supervision, monitoring, planning, and management practices.
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| 15. |
- Farhan, Muhammad, et al.
(författare)
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Pattern of neurosurgical cases and procedures in Gilgit Baltistan : two-year experience at a newly established neurosurgical department
- 2022
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Ingår i: Hospital Practice. - : Informa UK Limited. - 2154-8331 .- 2377-1003. ; 50:5, s. 368-372
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIn Pakistan, there are a total of 160 neurosurgeons that constitute a ratio of one neurosurgeon for a 5.5 million population. Gilgit Baltistan being a backward region does not have a single tertiary care facility. A new department of neurosurgery was established at Regional Headquarter City Hospital (RHQ) Gilgit with only one neurosurgeon. This study aimed to determine which neurosurgical diagnoses are common and which surgical interventions were performed at RHQ.MethodsThis is a retrospective cross-sectional study conducted at Regional Headquarter Hospital (RHQ) Gilgit in which data of patients operated for neurosurgical diseases between January 2020 and January 2022 was collected from patient record books.ResultsOf the total of 223 patients, 148 (66.3%) were males and 75 (33.6%) were females. A total of 92(41.2%) belonged to the pediatric age group. The top most diagnosis included Neurotrauma (46.6%), NTDs (13.9%) and CSDH (10.3%) while the most routinely performed procedures were craniotomy & hematoma evacuation (22.9%), debridement & elevation of DSF (20.6%), and burrhole evacuation (13.9%). In the pediatric age group, the top diagnosis was Neurotrauma (43.5%), NTDs (32.6%), and Hydrocephalus (19.6%) while in adults, neurotrauma (48.9%) was the leading diagnosis followed by CSDH (17.6%). In the pediatric age group, repair of NTDs (32.6%) was the most frequently performed procedure.ConclusionThis study shows different kinds of neurosurgical cases but because of a lack of diagnostic and therapeutic facilities, very limited operations were performed and many cases were referred to metropolitan cities. The hospitals in the region need further up-gradation to cater to the presenting burden.
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| 16. |
- Fawzy, N. A., et al.
(författare)
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Incidence and factors associated with burnout in radiologists : A systematic review
- 2023
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Ingår i: European Journal of Radiology Open. - : Elsevier BV. - 2352-0477. ; 11
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Forskningsöversikt (refereegranskat)abstract
- Rationale and objectives: Burnout among physicians has a prevalence rate exceeding 50%. The radiology department is not immune to the burnout epidemic. Understanding and addressing burnout among radiologists has been a subject of recent interest. Thus, our study aims to systematically review studies reporting the prevalence of burnout in physicians in the radiology department while providing an overview of the factors associated with burnout among radiologists. Materials and methods: The search was conducted from inception until November 13th, 2022, in PubMed, Embase, Education Resources Information Center, PsycINFO, and psycArticles. Studies reporting the prevalence of burnout or any subdimensions among radiology physicians, including residents, fellows, consultants, and attendings, were included. Data on study characteristics and estimates of burnout syndrome or any of its subdimensions were collected and summarized. Results: After screening 6379 studies, 23 studies from seven countries were eligible. The number of participants ranged from 26 to 460 (median, 162; interquartile range, 91–264). In all, 18 studies (78.3%) employed a form of the Maslach Burnout Inventory. In comparison, four studies (17.4%) used the Stanford Professional Fulfillment Index, and one study (4.3%) used a single-item measure derived from the Zero Burnout Program survey. Overall burnout prevalence estimates were reported by 14 studies (60.9%) and varied from 33% to 88%. High burnout prevalence estimates were reported by only five studies (21.7%) and ranged from 5% to 62%. Emotional exhaustion and depersonalization prevalence estimates were reported by 16 studies (69.6%) and ranged from 11%−100% and 4%−97%, respectively. Furthermore, 15 studies (65.2%) reported low personal accomplishment prevalence, ranging from 14.7% to 84%. There were at least seven definitions for overall burnout and high burnout among the included studies, and there was high heterogeneity among the cutoff scores used for the burnout subdimensions. Conclusion: Burnout in radiology is increasing globally, with prevalence estimates reaching 88% and 62% for overall and high burnout, respectively. A myriad of factors has been identified as contributing to the increased prevalence. Our data demonstrated significant variability in burnout prevalence estimates among radiologists and major disparities in burnout criteria, instrument tools, and study quality.
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| 17. |
- Gondal, Mudassar Fiaz, et al.
(författare)
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Appendiceal band syndrome as a cause of mechanical intestinal obstruction : A case report
- 2022
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Ingår i: Journal of Pediatric Surgery Case Reports. - : Elsevier BV. - 2213-5766. ; 87
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Tidskriftsartikel (refereegranskat)abstract
- Introduction and importanceAcute appendicitis is a common surgical emergency we encounter on surgical floor. Adynamic obstruction due to appendicitis and its related complications are seen very often; however, the mechanical obstruction is a rare happening associated with acute appendicitis.Case presentationWe reported a case of 7 years old boy, who presented with generalized abdominal pain more marked in right iliac fossa and abdominal distension as well. On clinical examination tenderness in RIF and guarding in lower abdomen was present. Complete blood picture was showing the leucocytosis and neutrophilia and rest of the laboratory findings were reference ranges. After making the patient clinically stable the retrograde appendectomy was performed. At operation, the vermiform appendix was found encircling a loop of terminal ileum like a band. The tip of appendix was gangrenous. The postoperative recovery was uneventful.Clinical discussionThis case was a rare happening of appendiceal band syndrome which is a rare diagnosis because its been not considered to have mechanical intestinal obstruction following a appendicular pathology. And having appendiceal band syndrome or tie it self is rare happening, however; having association with mechanical intestinal obstruction make this case even more interesting that need emergency appendectomy to relieve the symptoms and prevent complications.ConclusionAppendiceal band syndrome is a rare happening that may cause acute intestinal obstruction and gut may become gangrenous due to break in blood supply and should be diagnosed at earliest and treated with open appendectomy.
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| 18. |
- Hadi, B., et al.
(författare)
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Compliance with World Health Organization's COVID-19 guidelines among Iraqi health workers
- 2023
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Ingår i: World Medical & Health Policy. - : Wiley. - 2153-2028 .- 1948-4682. ; 15:4, s. 537-543
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Tidskriftsartikel (refereegranskat)abstract
- During the COVID-19 pandemic, the World Health Organization (WHO) introduced guidelines with respect to hygiene practices, quarantine policies, and medical practices for health institutions to follow. Most studies examining compliance with WHO guidelines have been conducted at individual level but not at institutional level. This study investigates the availability of resources of health institutions in Iraq and their compliance with WHO COVID-19 guidelines. A total of 234 health workers, including physicians, nurses and medical technicians, were recruited in Babylon, Iraq. Self-reported number of health workers available in the health centre and the levels of compliance with the WHO's guidelines were assessed. Implementation of preventive measures for infected persons, fogging procedures, and having a crisis management team in the health centre were the top three common practices as recommended by WHO. There was a weak but significant positive relationship between the number of health workers in the healthcare centre and the levels of compliance with the WHO's COVID-19 guidelines (ρ = 0.243, p < 0.05), indicating that manpower may determine the implementation of these guidelines. There is a correlation between the quantity of health workers and the levels of compliance with the WHO's COVID-19 guidelines, showing that it is important to ensure sufficient human resources available in the health centre to implement the standard practices. In addition, more financial resources are needed to provide sufficient protective equipment and disposable supplies to health workers in Iraq.
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| 19. |
- Hashim, Ahmed, et al.
(författare)
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Pattern of novel psychoactive substance use among patients presented to the poison control centre of Ain Shams University Hospitals, Egypt : A cross-sectional study
- 2022
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Ingår i: Heliyon. - : Elsevier BV. - 2405-8440. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Novel psychoactive substances (NPSs) are relatively new substances in the illicit drug market, notpreviously listed in the United Nations Office on Drugs and Crime (UNDOC). Strox and Voodoo are consideredsome of the most popular blends of NPS in the Egyptian drug market.Objectives: The current study was conducted to assess NPS's use pattern: Voodoo and Strox among acutelyintoxicated patients presented to the poison control center of Ain Shams University Hospitals (PCC- ASUH).Methods: A single center based cross-sectional study was carried out in the PCC-ASUH among acutely intoxicatedpatients presenting to the emergency department (ED) over four months (from January–April 2019. using apreviously adopted and validated Fahmy and El-Sherbini socioeconomic scale (SES). Data were presented asmean, median and range as appropriate. Both smoking and crowding indexes were calculated and presented aspreviously reported.Results: Fifty-one patients were presented to the ED of PCC-ASUH during the study period. A total of 96.1% (n ¼49) were males. The mean age was 25 7.5 years. The most common NPS used was Strox: 54.9% (n ¼ 28),followed by Voodoo: 27.4% (n ¼ 14). Neurological and gastrointestinal (GI) symptoms were the most frequentpresentations. The most common motive behind NPS use was the desire to give a trial of new psychoactivesubstances. The mean SES score was 35.1 13.17. Most patients have the preparatory as the highest education36.0% (n ¼ 18).Conclusions: NPS use is common among young males in preparatory education from different social classes,starting it most commonly as a means to experiencing a new high. Neurological and GI manifestations are themost common presenting symptoms of NPS intoxication.
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| 20. |
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| 21. |
- Imran, Laiba, et al.
(författare)
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How Universal Health Coverage can curb the escalating antimicrobial resistance in Pakistan : a call to action for the country's healthcare system
- 2022
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Ingår i: Tropical Medicine and Health. - : Springer Science and Business Media LLC. - 1348-8945 .- 1349-4147. ; 50:1
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Tidskriftsartikel (refereegranskat)abstract
- Antimicrobial resistance (AMR) has emerged as a major threat to the global healthcare economy during Coronavirus disease 2019 (COVID-19), especially in developing countries like Pakistan where the healthcare facilities are already substandard. To combat AMR, the World Health Organization (WHO) has taken several initiatives including the establishment of a sustainable Universal Health Coverage (UHC) system. The implementation of UHC could eliminate various factors that contribute to a high AMR rate including self-medication. Our commentary explores in depth the current UHC system in Pakistan and how UHC could be the answer to Pakistan’s AMR crisis.
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| 22. |
- Iqbal, J., et al.
(författare)
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Cardioprotective Effects of Nanoparticles in Cardiovascular Diseases : A State-of-the-Art Review
- 2023
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Ingår i: Current problems in cardiology. - : Elsevier BV. - 0146-2806 .- 1535-6280. ; 48:8
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Forskningsöversikt (refereegranskat)abstract
- It has been reported that death related to cardiovascular disease has increased up to 12.5% just in the past decade alone with various factors playing a role. In 2015 alone, it has been estimated that there were 422.7 million cases of CVD with 17.9 million deaths. Various therapies have been discovered to control and treat CVDs and their complications including reperfusion therapies and pharmacological approaches but many patients still progress to heart failure. Due to these proven adverse effects of existing therapies, various novel therapeutic techniques have emerged in the near past. Nano formulation is one of them. It is a practical therapeutic strategy to minimize pharmacological therapy's side effects and nontargeted distribution. Nanomaterials are suitable for treating CVDs due to their small size, which enables them to reach more sites of the heart and arteries. The biological safety, bioavailability, and solubility of the drugs have been increased due to the encapsulation of natural products and their derivatives of drugs.
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| 23. |
- Khan, Munema, et al.
(författare)
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Jejunal diverticulosis presenting as intestinal obstruction-A case report of a rare association
- 2023
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Ingår i: Clinical Case Reports. - : Wiley. - 2050-0904. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Jejunal diverticula are rare medical conditions with an incidence of 0.3%-2.5%, mostly discovered perioperatively. Our patient, 60 years old female, presented in an emergency with complaints of constipation, vomiting, abdominal pain, and distension. On examination, her abdomen was markedly distended with generalized tenderness. An erect abdominal X-ray revealed multiple air-fluid levels, which suggests small bowel obstruction. A diagnosis of jejunal diverticula was made on exploratory laparotomy. No evidence of granuloma or malignancy was seen on histopathological examination. Segmental resection of the affected jejunum was carried out, followed by end-to-end primary anastomosis. The patient was discharged on postoperative Day 6 with complete recovery at 2 weeks follow-up visit.
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| 24. |
- Khuzaiyah, Siti, et al.
(författare)
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A qualitative study on mothers' experiences attending an online infant massage class : "It is funny! I feel close to my baby!"
- 2022
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Ingår i: BMC Nursing. - : Springer Science and Business Media LLC. - 1472-6955. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background The coronavirus disease 2019 (COVID-19) pandemic impacts maternal and perinatal health. Fear of COVID-19 transmission may lead to psychological disorders among mothers, such as anxiety and depression, which might affect the infant's health. Innovation is needed to address problems related to this condition. This study aimed to explore the experiences of mothers who had attended online infant massage classes. Methods This qualitative survey recruited 12 Indonesian mothers who had infants aged < 12 months and joined the online infant massage class. An open-ended question form was used to collect data, which were analyzed using thematic content analysis. Results There were six themes related to the experiences of mothers attending online infant massage classes: favorite session, new knowledge and skills, benefits, barriers during infant massage class, factors related to infant massage practice, and mother's hope. Conclusions Mothers had a good experience learning infant massage and had better interaction with their infants after the class. The findings show that an online infant massage class could benefit both mothers and infants.
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| 25. |
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| 26. |
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| 27. |
- Magtalas, M. C., et al.
(författare)
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A systematic review of ethnomedicinal plants used for pregnancy, childbirth, and postpartum care in the Philippines
- 2023
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Ingår i: Phytomedicine Plus. - : Elsevier BV. - 2667-0313. ; 3:1
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Forskningsöversikt (refereegranskat)abstract
- Background: Medicinal plants are still widely used in rural areas of the Philippines. Among the conditions treated with medicinal plants are those related to pregnancy, childbirth, and postpartum care. This systematic review identified the medicinal plants used for obstetric care in the country. Methods: The study was conducted based on the PRISMA flow diagram, starting with a data search using three databases. The necessary information was extracted from the eligible research papers, and the studies' quality was assessed through a developed quality assessment tool. Results: This study included 38 ethnobotanical studies with 153 plant species used for pregnancy and postpartum care. Most of the studies were conducted in Northern Mindanao, in the Philippines. The most common pregnancy-related indications for the medicinal plants were postpartum care, and postpartum bleeding topped the list. The most common plant family, genus, and species were Fabaceae, Ficus, and Moringa oleifera Lam, respectively. The leaf was the most common single plant part used for pregnancy and postpartum care. Only 80 medicinal plants had toxicologic and teratogenic data. Conclusion: Women from different ethnic groups widely utilized medicinal plants to treat pregnancy-related conditions. Further research on toxicology and teratogenicity is necessary to ensure the safety of their users.
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| 28. |
- Magtalas, M. C., et al.
(författare)
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A systematic review of medicinal plants used in the treatment of gynecologic diseases in the Philippines
- 2023
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Ingår i: Phytomedicine Plus. - : Elsevier. - 2667-0313. ; 3:3
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Forskningsöversikt (refereegranskat)abstract
- Background: Different indigenous peoples in the Philippines still utilize medicinal plants in treating gynecologic diseases. However, there is a lack of information regarding these medicinal plants used in treating gynecologic conditions in the Philippines. Hence, this systematic review compiled the available literature on medicinal plants used for gynecologic healthcare by various indigenous groups in the Philippines. Methods: Ethnobotanical studies that reported medicinal plants used for gynecologic diseases were obtained from OVID Medline, Scopus, and EBSCO CINAHL. A review of titles, abstracts, and articles was done independently by four reviewers. The quality of the studies was assessed using the quality assessment tool for ethnobotanical studies. Results: A total of 27 studies, including 98 different records, that cited the use of medicinal plants to treat gynecologic diseases were included in the qualitative synthesis. Most ethnobotanical studies were conducted in Northern Mindanao, Central Luzon, and Caraga, Philippines. The most common plant family, genus, and species were Fabaceae, Mimosa, and Mimosa pudica L., respectively. Leaves, roots, and stems were predominantly used, commonly prepared by decoction. Medicinal plants reported in ethnobotanical studies were widely used to treat dysmenorrhea (34 ssp.), irregular menstruation (28 spp.), myoma (four spp.), and infertility (four spp.). A significant proportion of medicinal plants used to treat gynecologic diseases in the Philippines had records of toxicologic (18 spp., 31.03%) or teratogenic (one sp., 1.72%) properties. Other species were reported as both nontoxic and toxic (five spp., 8.62%) and toxic and teratogenic (one sp., 1.72%). However, some were nontoxic or teratogenic (11 sp., 18.97%). In addition, 22 plant species had no data on toxicity or teratogenicity. Conclusion: This systematic review showed that medicinal plants and traditional healing practices are crucial in gynecologic healthcare in the Philippines.
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| 29. |
- Magtalas, M. C., et al.
(författare)
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Ethnomedicinal plants used for the prevention and treatment of anemia in the Philippines : a systematic review
- 2023
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Ingår i: Tropical Medicine and Health. - 1348-8945 .- 1349-4147. ; 51:1
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Forskningsöversikt (refereegranskat)abstract
- Background: Medicinal plants are still used in developing countries, including the Philippines, to treat common diseases in the community. Anemia is a common disease encountered in the community. It is characterized by a lower-than-normal level of red blood cell count. This systematic review identified the medicinal plants used for anemia treatment in the Philippines. Methods: The study was conducted based on the PRISMA flow diagram, starting with a data search on electronic databases. The collected studies were screened based on the inclusion and exclusion criteria. The necessary information was extracted from the eligible research papers, and the studies’ quality was assessed through a developed quality assessment tool. Results: A total of 20 ethnobotanical studies on medicinal plants used for anemia treatment were obtained from different provinces within the 12 regions of the Philippines. Most ethnobotanical studies were conducted in Region X (Northern Mindanao), CAR (Cordillera Administrative Region), and Region XIII (CARAGA), Philippines. The most common plant family is Convovulaceae, with nine records (21.95%), followed by Cucurbitaceae, with six records (14.63%), and Moringaceae, with five records (12.2%). The most common plant part used was the leaves. Others involved mixing different plant parts, with fruits and leaves being the most common combination. The most common route of administration utilized was drinking the decoction, followed by eating the plant. Most medicinal plants used to treat anemia in the Philippines had records of toxicologic (four species, 15.38%) or teratogenic (one species, 3.85%) properties. Eight plant species were reported as nontoxic (30.77%). In addition, ten plant species (38.46%) had no data on toxicity or teratogenicity. Conclusion: There were only 20 ethnobotanical studies that documented the use of plants in treating anemia in the Philippines. This study listed several medicinal plants used in treating anemia in the Philippines. However, pharmacological and toxicological studies are still needed to determine their safety and efficacy in treating anemia in the community.
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| 30. |
- Maqbool, S., et al.
(författare)
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Engraftment syndrome following Hematopoietic stem cell transplantation : a systematic approach toward diagnosis and management
- 2023
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Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 40:1
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Forskningsöversikt (refereegranskat)abstract
- Engraftment syndrome (ES) is a non-infectious complication seen both in autologous and allogeneic hematopoietic stem cell transplants and is characterized by the presence of non-infectious fever, diarrhea, skin rash, pulmonary infiltration, pulmonary edema, and deranged renal and liver function tests This review will be delineating the incidence of ES, important differential diagnoses to be considered and management options. The literature search was done through various databases like PubMed, Google scholar, Cochrane library, and EMBASE. The incidence of engraftment syndrome was ranging from 8 to 50% in patients undergoing Autologous stem cell transplantation while the incidence was 10–77% in patients undergoing Allogeneic stem cell transplantation. Fever was the most commonly observed symptom of ES in both Autologous and Allogeneic stem cell transplantation while the second most frequently reported symptom was non-infectious diarrhea in patients undergoing autologous stem cell transplantation and Skin rash in patients with Allogeneic stem cell transplantation. Pro-inflammatory cytokines and immune response dysregulation were highlighted as the mechanism behind ES development. The significant difference between ES and aGVHD was observed based on cytokines, with IL-12, IL-1β, IL-6, TNF-α, and IFN-γ levels in plasma being higher in patients with ES as compared to patients with aGVHD. Intravenous methylprednisolone was used as the treatment of choice in the majority of the studies. Overall the incidence of ES was high in patients undergoing allogeneic hematopoietic stem cells transplantation. The survival in patients developing ES was less compared to those who did not develop ES. Engraftment syndrome is one of the complications following hematopoietic stem cell transplantation that need early identification, differentiation from infectious complications, and aGVHD and timely initiation of corticosteroids therapy.
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| 31. |
- Maqbool, S., et al.
(författare)
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Left Ventricular Hypertrophy (LVH) and Left Ventricular Geometric Patterns in Patients with Chronic Kidney Disease (CKD) Stage 2-5 With Preserved Ejection Fraction (EF) : A Systematic Review to Explore CKD Stage-wise LVH Patterns
- 2023
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Ingår i: Current problems in cardiology. - : Elsevier BV. - 0146-2806 .- 1535-6280. ; 48:4
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Forskningsöversikt (refereegranskat)abstract
- Left ventricular hypertrophy (LVH) is the most common structural abnormality associated with CKD patients accounting for 70% of the patients suffering LVH with ESRD. This art of the state review is first of its nature which aimed to analyze the studies involving LVH in CKD patients, and stage-wise association of CKD with various geometrical patterns of LVH. The literature search was done through various databases like PubMed, EMBASE, CINAHIL, Web of Science, and Cochrane Library. After careful quality assessment a total of 7 studies, and 2121 patients were included in our study. The mean age of the patients was 61.5±12.4 years. Similarly, the mean value of eGFR was 39.81±13.71 ml/min. The incidence of LVH was 47.05%, and on stage-wise analysis, the higher CKD stage was associated with eccentric LVH as compared to lower stages. The ejection fraction (EF) values were showing preserved EF in all included studies. ESRD was showing more preponderance towards eccentric LVH as compared to other stages of CKD.
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| 32. |
- Maqbool, S., et al.
(författare)
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Ovary and fallopian tube as contents of indirect inguinal hernia : A case report
- 2022
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Ingår i: International Journal of Surgery Case Reports. - : Elsevier BV. - 2210-2612. ; 100
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Tidskriftsartikel (refereegranskat)abstract
- Introduction and importance: Ovarian and fallopian tube indirect inguinal hernias are rare hernias encountered on surgical floor. Herein, we are reporting a rare happening of obstructed ovarian and fallopian tube indirect inguinal hernia in an unmarried female. Presentation of case: A 19 years old unmarried female presented to surgical emergency with complain of swelling in left inguinal region that was about 3 × 3 cm on visual inspection from last 4 days that was associated with menstruation. Abdominal ultrasound (USG) was showing left ovarian and fallopian tube indirect inguinal hernia with preserved internal follicles and intact vasculature. The diagnosis of obstructed ovarian and fallopian tube indirect inguinal hernia was made and diagnostic laparoscopy and left sided hernioplasty was performed. Ovary was retrieved back into abdominal cavity and stitched to lateral pelvic wall. Discussion: Inguinal hernia itself is a rare happening in females and the presence of ovary and fallopian tube along with other hernial content can become a topic of discussion due to rarity of this case. It is of paramount significance to diagnose such cases with great expertise in order to avoid long term complications in terms of preserving fertility among females. Early utilization of radiological investigations like USG abdomen and laparoscopic retrieval of adnexal structures are standard approach in management of such cases. Conclusion: Presence of ovary and fallopian tube in indirect inguinal hernia is a rare happening that need to be diagnosed and treated at earliest to avoid infertility among females.
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| 33. |
- Memon, M. A., et al.
(författare)
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Aetiology and associations of halitosis : A systematic review
- 2023
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Ingår i: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 29:4, s. 1432-1438
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Forskningsöversikt (refereegranskat)abstract
- Halitosis is a term that refers to an unpleasant or foul odour originating from the oral cavity that can be caused by either intra-oral or extra-oral factors. Despite the fact that halitosis has multifactorial aetiology, intra-oral factors play a significant role in the majority of cases. This systematic review assesses halitosis's intra-oral and extra-oral associations. An electronic search through MEDLINE (PubMed), Google Scholar and the Wiley Online Library was conducted to identify relevant manuscripts. A keywords-based search was performed, using the terms ‘halitosis’, ‘bad-breath’, and ‘oral malodour causes and aetiology’. Articles published from January 2014 to December 2020 were included. We selected studies evaluating the intra-oral and extra-oral factors that induce oral malodour, as well as the factors associated with systemic diseases. Eighty to ninety percent of halitosis is caused by intra-oral factors, with coated tongue, periodontal diseases and poor oral hygiene practices being the principal factors. Ten to twenty percent of halitosis is induced by extra-oral factors associated with systemic diseases. Multiple factors can cause halitosis, but most of the aetiology is intra-oral. Increased medical awareness is needed to determine the actual pathophysiological process of oral malodour in otherwise healthy individuals.
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| 34. |
- Memon, Maaz A., et al.
(författare)
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Assessing salivary matrix metalloproteinase-8 in prostate cancer patients undergoing androgen deprivation therapy
- 2022
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Ingår i: Clinical and Experimental Dental Research. - : Wiley. - 2057-4347. ; 8:5, s. 1277-1283
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Matrix metalloproteinase-8 (MMP-8) is considered as one of the most promising diagnostic markers for periodontal disease. Androgen deprivation therapy (ADT) has been correlated with impaired collagen synthesis and an increase in periodontal tissue susceptibility to pathogenic microorganisms. Objective: This study aims to investigate the impact of ADT on salivary MMP-8 level and periodontal parameters, which might be useful in monitoring periodontal disease in prostate cancer patients undergoing ADT. Materials and Methods: A total of 88 subjects were selected and were divided into two groups: Group I included n = 78 PC patients who have been undergoing ADT); Group II included n = 10 healthy individuals. Periodontal parameters such as plaque index (PI), gingival index (GI), periodontal probing depth (PPD), and clinical attachment level (CAL) were examined. The salivary MMP-8 level was estimated by using the sandwich enzyme-linked immunosorbent assay method. Results: Significant differences in mean salivary MMP-8 level were found between PC patients undergoing ADT and healthy individuals. Salivary MMP-8 levels of all individuals were positively correlated with GI, PI, PPD, and CAL. Salivary MMP-8 can distinguish between periodontitis and healthy individuals with an accuracy of about 80%. Conclusion: Salivary MMP-8 levels were found to be higher in prostate cancer patients undergoing ADT compared to healthy individuals.
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| 35. |
- Mitropoulou, Maria-Andriani, et al.
(författare)
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Quality of Life in Patients With Inflammatory Bowel Disease : Importance of Psychological Symptoms
- 2022
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Ingår i: Cureus. - : Cureus, Inc.. - 2168-8184. ; 14:8
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Tidskriftsartikel (refereegranskat)abstract
- Background Depressive, anxiety, and stress symptoms are prevalent in patients with inflammatory bowel disease (IBD) and may negatively influence the disease course and quality of life. The study aimed to assess the relationship between psychological factors and patients’ quality of life (QoL).Materials and methods A cross-sectional study with the use of a structured questionnaire among 38 patients with Crohn’s disease and 30 with ulcerative colitis was conducted. The inflammatory bowel disease questionnaire (IBDQ-32) was used to evaluate the patients’ quality of life, and the Depression, Anxiety, Stress Scale (DASS21) was used to evaluate these psychological factors. Pearson descriptive statistics and multiple regression analyses were performed.Results According to the findings of the multiple regression analysis, depressive, anxiety, and stress symptoms were negatively associated with quality of life. Participants with higher scores of anxiety had inferior QoL in intestinal symptoms (p=0.013) and in systemic symptoms (p=0.013), with higher scores of depression had inferior QoL in emotional function (p<0.001), and higher scores of stress had inferior QoL in the domain of social support (p=0.002). Psychological symptoms of emotional disorders appear to be associated with lower quality of life in IBD patients.Conclusion This study examined levels of depression, anxiety, and stress in Greek patients with IBD, which were associated with lower levels of their quality of life. Interventions to improve QoL in patients with IBD should consider the effect of psychological symptoms.
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| 36. |
- Odoom, D., et al.
(författare)
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Examining the level of public awareness on the Sustainable Development Goals in Africa : An empirical evidence from Ghana
- 2024
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Ingår i: Environment, Development and Sustainability. - : Springer Nature. - 1387-585X .- 1573-2975. ; 26:3, s. 6221-6238
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Tidskriftsartikel (refereegranskat)abstract
- Nations which are part of the United Nations are required to institute appropriate measures to fulfil the vision of the Sustainable Development Goals (SDGs). However, for this to be possible, all stakeholders including the general public need to be fully aware of the SDGs. This research examined the level of public awareness about the SDGs among Ghanaians based on the views of 431 respondents. Means, standard deviation, Mann–Whitney U test, Kruskal Wallis and Pearson Product-Moment Correlations were used for data analysis. The study found that awareness level on SDG 1 (ending poverty), SDG 2 (zero hunger, food security, nutrition and sustainable agriculture), SDG 3 (health and well-being), SDG 5 (gender equality), and SDG 6 (clean water and sanitation) was high among Ghanaians. However, awareness level on SDG 9 (industry, innovation and infrastructure), SDG 14 (conservation of life below water), and SDG 16 (peace, justice and strong institutions) was very low among Ghanaians. No significant difference manifested in the level of awareness among male and female Ghanaians. There were statistically significant differences in educational levels of respondents and their overall level of awareness of the SDGs. Also, there was a low, negative correlation between overall level of awareness and the effectiveness of the communication strategies used in creating awareness about the SDGs. Government should re-examine its communication strategies on the SDGs and put in place a more effective communication policy framework which involves grassroots populations and local communities.
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| 37. |
- Omar Bali, A., et al.
(författare)
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Public engagement with pictures and videos about COVID-19 vaccination on social media : A cross-sectional study in a developing country
- 2024
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Ingår i: International Journal of Healthcare Management. - : Informa UK Limited. - 2047-9700 .- 2047-9719.
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Tidskriftsartikel (refereegranskat)abstract
- Vaccination is a critical component of preventing infectious diseases and is one of the most effective public health interventions. While social media is an essential source of health and medical information, it is crucial to understand the link between social media involvement and vaccination engagement. This study examines the relationship between COVID-19 vaccination and social media in Iraq. A web-based questionnaire was administered through Google Forms to elicit responses from a total of 2088 Iraqi social media users aged 18 years and over. The findings suggested significant differences in vaccination engagement due to the level of use of social media and demographic backgrounds, particularly age, educational attainment, and income. Active users and young-aged groups with less educational level and income were more likely to have a positive attitude toward vaccination. Future studies should address demographics and the extent of using social media factors in public health studies. Our findings support the use of social media in raising health awareness.
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| 38. |
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| 39. |
- Rehman, I. -U, et al.
(författare)
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Port site tuberculosis a rare post operation entity : A case report
- 2022
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Ingår i: Annals of Medicine and Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 2049-0801. ; 78
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Tidskriftsartikel (refereegranskat)abstract
- Laparoscopic cholecystectomy is one of the most common procedures done worldwide. Post-surgical site infections are common, yet there are occurrences of uncommon complications, including port site tuberculosis (TB). We report a case of a 62-year-old man who was the victim of post-surgical site infection of port sites caused probably by improper sterilization. The patient lacked any common symptoms of tuberculosis and his initial lab investigations were not affirmative. A biopsy depicting the growth of multiple epithelioid granulomas finally led to the diagnosis of port site tuberculosis. The patient was treated by incision and drainage followed by anti-tubercular therapy. This treatment regime showed complete resolution of disease on follow-ups. Such cases require multidisciplinary team (Surgery, Pathology and Infectious disease department in our case) inputs for prompt diagnosis and treatment.
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| 40. |
- Saeed, Sajeel, et al.
(författare)
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Impact of COVID-19 on palliative care of cancer patients : Perspectives from Pakistan
- 2022
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Ingår i: Annals of Medicine and Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 2049-0801. ; 78
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic has adversely affected the survival rate and palliative care of cancer patients all over the globe. In Pakistan, there are only a few institutions and organizations which provide specialized facilities for palliative care. During the pandemic, these specialized facilities were further limited. As only less than one percent of people had access to palliative care across Pakistan in the pandemic, the situation can be improved by establishing more such departments, providing telemedicine, increasing social media campaigns, and highlighting the importance of palliative care among cancer patients.
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| 41. |
- Sarder, M. A., et al.
(författare)
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A multilevel analysis of individual and community-level factors associated with childhood immunisation in Bangladesh : Evidence from a pooled cross-sectional survey
- 2023
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Ingår i: Vaccine: X. - : Elsevier BV. - 2590-1362. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Previous studies on childhood vaccinations in Bangladesh relied on single-level analyses and ignored the clustering and hierarchical structure of data collected from people living in different geographical units. This study, therefore, aimed to investigate the association between individual and community-level factors of full childhood immunisation with an improved analytical approach. Methods: Participants were 13,752 children aged 12–59 months. Data were extracted from the Bangladesh Demographic and Health Survey (BDHS) conducted in 2007, 2011, 2014, and 2017–18. A two-level multilevel logistic regression method was used to analyse the data. Results: Approximately 87% of the children were fully immunised. In the fully adjusted model, at the individual level, mothers who had primary and above education (Adjusted odds ratio [AOR] = 1.78; 95% Confidence Interval [CI]: 1.57, 2.01), mass media exposure (AOR = 1.14; 95% CI: 1.00, 1.30), having vaccination cards (AOR = 3.65; 95% CI: 3.23, 4.14), and having at least 4 antenatal care (ANC) visits (AOR = 1.24; 95% CI: 1.06, 1.44) were strongly associated with full childhood immunisation. At community-level, rural residency (AOR = 1.25; 95% CI: 1.08, 1.44), community women's education (AOR = 1.24; 95% CI: 1.07, 1.43), and community ANC utilisation (AOR = 1.38; 95% CI: 1.19, 1.61) were significantly associated with full childhood immunisation. Conclusion: Along with individual-level factors, community-level factors have a significant effect on childhood immunisation. Policymakers should target improving community-level characteristics, such as community poverty, education levels, and the number of community-level ANC visits, to increase the national level of childhood immunisation. Public health intervention programs aiming at increasing awareness of childhood immunisation should include elements at both individual and community levels. © 2023 The Author(s)
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| 42. |
- Sathi, N. J., et al.
(författare)
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Socioeconomic inequalities in low birth weight in South Asia : A comparative analysis using Demographic and Health Surveys
- 2022
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Ingår i: SSM - Population Health. - : Elsevier BV. - 2352-8273. ; 20
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Tidskriftsartikel (refereegranskat)abstract
- Background: Low Birth Weight (LBW) continues to be a prominent universal cause of various short- and long-term health hazards throughout infancy and adulthood. However, no study has revealed the socioeconomic inequalities in LBW among South Asian countries. This study assesses the socioeconomic inequalities among under-five South Asian children with LBW. Methods: Secondary data were derived from six (Afghanistan, Bangladesh, India, Maldives, Nepal, and Pakistan) nationally representative South Asian Demographic and Health Surveys conducted between 2015 and 2021, and included 170,547 under-five years of age children. The study employed the concentration curve and concentration index to assess the socioeconomic inequalities of those with LBW. Additionally, mixed-effect logistic regression was applied to determine the factors associated with LBW. Results: A significant negative concentration index indicates the wealth-related and education-related inequalities of LBW among under-five South Asian children. LBW is highly concentrated in the socio-economically poor section of the society. Our study found statistically significant negative concentration index in all South Asian countries: Afghanistan (Education: -0.108), Bangladesh (wealth: -0.070 & education: -0.083), India (wealth: -0.059 & education: -0.052), Nepal (by wealth: -0.064 & by education: -0.080), and Pakistan (by wealth: -0.080 & by education: -0.095). Findings from the mixed-effects logistic regression model also show that children from the poorest quintiles (AOR: 1.53, 95% CI: 1.41–1.67) and illiterate mothers (AOR: 1.39, 95% CI: 1.29–1.51) had higher odds of being afflicted with LBW compared to the wealthiest quintiles and educated mothers respectively. Women's pregnancy assessments, such as antenatal care utilisation, iron supplementation intake, and normal delivery mode, are significantly correlated with decreased odds of children's LBW. Conclusion: There exists a strong association between LBW cases and socioeconomic inequalities among South-Asian children below five years of age. This indicates the urgent need for health education and prenatal care services for women from Afghanistan, Bangladesh, India, Nepal, and Pakistan, especially those with lower socioeconomic status.
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| 43. |
- Shah, Syed Muhammad Ismail, et al.
(författare)
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COVID‐19 and myasthenia gravis : A review of neurological implications of the SARS‐COV‐2
- 2022
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Ingår i: Brain and Behavior. - : Wiley. - 2162-3279 .- 2162-3279. ; 12:12
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Forskningsöversikt (refereegranskat)abstract
- IntroductionThis review highlights the potential mechanisms of neuromuscular manifestation of COVID-19, especially myasthenia gravis (MG).MethodsAn extensive literature search was conducted by two independent investigators using PubMed/MEDLINE and Google Scholar from its inception to December 2020.ResultsExacerbations of clinical symptoms in patients of MG who were treated with some commonly used COVID-19 drugs has been reported, with updated recommendations of management of symptoms of neuromuscular disorders. Severe acute respiratory syndrome coronavirus 2 can induce the immune response to trigger autoimmune neurological disorders.ConclusionsFurther clinical studies are warranted to indicate and rather confirm if MG in the setting of COVID-19 can pre-existent subclinically or develop as a new-onset disease.
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| 44. |
- Shirin Sara, S., et al.
(författare)
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Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh : Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
- 2023
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Ingår i: Diabetes & Metabolic syndrome. - : Elsevier BV. - 1871-4021 .- 1878-0334. ; 17:2
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Prevalence of type 2 diabetes has been rising rapidly especially in low- and middle-income countries. The purpose of this study is to analyze the prevalence of type 2 diabetes in 2011 and 2017–18, and the risk factors based on the Bangladesh Demographic and Health Surveys (BDHS). Methods: The study comprised of data from the BDHS 2011 and the BDHS 2017–18 with 7565 (50.6% female) and 12,299 respondents (56.9% female) respectively. The plasma blood glucose was classified into normal, pre-diabetes, and diabetes categories. While univariate analysis was performed to determine the data, Chi-square and gamma analyses were used for bivariate estimation of the correlation between diabetes status and other comorbidities. Multinomial and ordinal logistic regression were also performed to trace the link between diabetes and various risk factors. Results: The 2011 BDHS survey indicated that nearly half of the participants (47.6%) had pre-diabetic condition, while 10.2% were diagnosed with diabetes. On the other hand, the BDHS 2017-18 demonstrated that 28.6% and 8.6% of participants had pre-diabetes and diabetes, respectively. Results of inferential statistics showed that gender (p<0.05), age, wealth status, physical activity, BMI (p<0.01), and caffeinated beverages (p<0.05), were significantly linked with diabetes status. Conclusion: According to our findings, older people and people with lower education are more likely to develop diabetes. BMIˏ Physically active, wealth status, diet and lifestyle were significant predictors of type 2 diabetes. Healthy lifestyle, physical activities, proper knowledge and awareness can reduce the risk of T2D.
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| 45. |
- Solidum, J. G. N., et al.
(författare)
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Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery
- 2023
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Ingår i: Maxillofacial Plastic and Reconstructive Surgery. - : Springer Science and Business Media LLC. - 2288-8586. ; 45:1
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Forskningsöversikt (refereegranskat)abstract
- Background: Nanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues. Main body: In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression. Conclusions: Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS.
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| 46. |
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| 47. |
- Swed, S., et al.
(författare)
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Monkeypox in Syria : Highlighting an awareness issue
- 2023
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Ingår i: IJID Regions. - : Elsevier BV. - 2772-7076. ; 7, s. 271-276
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Tidskriftsartikel (refereegranskat)abstract
- Background: The World Health Organization (WHO) verified 780 cases of monkeypox across 27 countries between 13 May 2022 and 2 June 2022. The aim of our study was to assess the level of awareness of human monkeypox virus among Syrian medical students, general practitioners, medical residents, and specialists. Methods: A cross-sectional online survey was performed in Syria between May 2 and September 8, 2022. The survey consisted of 53 questions within the following three categories: demographic information, work-related details, and monkeypox knowledge. Results: In total, 1257 Syrian healthcare workers and medical students were enrolled in our study. The animal host and incubation time for monkeypox were correctly identified by just 2.7% and 33.3% of responders, respectively. Sixty percent of the study sample thought that the symptoms of monkeypox and smallpox are identical. No statistically significant associations were found between predictor variables and knowledge regarding monkeypox (p-value > 0.05). Conclusion: Education and awareness regarding monkeypox vaccinations are of paramount importance. It is essential that clinical doctors are adequately aware of this disease, in order to avoid an uncontrolled situation, as experienced with COVID-19.
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| 48. |
- Swed, S., et al.
(författare)
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NHANES cross sectional study of aspirin and fractures in the elderly
- 2023
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017–2020 and 2013–2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08–1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81–1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden.
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| 49. |
- Swed, Sarya, et al.
(författare)
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Parents' acceptance to vaccinate children against COVID-19 : A Syrian online survey
- 2022
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Ingår i: Frontiers In Public Health. - : Frontiers Media SA. - 2296-2565. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- After the widespread of COVID-19 virus worldwide, vaccination targeted reducing spread of cases and mortality rates. However, vaccination hesitancy was observed among the communities worldwide. Vaccination hesitancy involved parents regarding the decision of vaccinating their children- After obtaining ethical approval, an online cross-sectional study was conducted from 1 March to 22 April 2021 to evaluate the parents' acceptance of vaccinating their children against the COVID-19 virus in Syria. Data were analyzed using descriptive and multivariate logistic regression analysis in IBM, SPSS V. 28.0 package program (IBM Corporation, Armonk, NY, USA). Among 283 participants, 105 participants agreed to vaccinate their children, and 178 were not. A significant correlation between age and vaccine willingness was found (P-value < 0.0001*), especially in the age group between 18 and 30 years old (45.2%). Parents who accepted vaccinating themselves were more willing to vaccinate their children (34.6%). According to our results, there is a greater need to enhance awareness and knowledge programs about the vaccine's effectiveness and encourage parents to accept giving the vaccine to their children.
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| 50. |
- Swed, S., et al.
(författare)
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Syrians' awareness of cardiovascular disease risk factors and warning indicators : a descriptive cross-sectional study
- 2023
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Ingår i: Scientific Reports. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The awareness of cardiovascular diseases (CVDs) contributes to the complications and fatality rates from these diseases among individuals; however, no previous study in Syria was conducted on this topic; thus, this study aims to assess Syrians' awareness of CVDs warning symptoms and risk factors. This online cross-sectional study was performed in Syria between the 1st and 25th of August 2022. The inclusion criteria for the sample were citizens of Syria over 18 who currently reside in Syria. The questionnaire included open- and closed-ended questions to assess the awareness of CVDs. A total of 1201 participants enrolled in the study with a response rate of 97.2%; more than half of the participants (61.4%) were aged 18–24. The most recognizable risk factors and warning signs when asking close-ended and open-ended questions were smoking (95.2%, 37.1%) and chest pain (87.8%, 24.8%), respectively. Overall knowledge scores for risk factors and warning signs were (61.5%). Regarding knowledge score of CVDs risk factors and warning signs, participants aged 45–54 scored higher than other age groups, and respondents with a university education level had a higher score than other educational levels (15.7 ± 0.3), (14.5 ± 0.1), respectively. Participants aged 45–54 have a higher probability of good knowledge of CVDs risk factors and warning signs than participants aged 18–24 (OR = 4.8, P value < 0.001), while participants living in the countryside were less likely to have good knowledge of CVDs risk factors and warning signs than city residents (OR = 0.6, P value < 0.05). According to our results, there is inadequate knowledge of the risk factors and warning signs of CVDs. Consequently, there is a greater need to raise CVD awareness and learning initiatives on the disease's risk factors and symptoms.
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