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- Korytár, P, et al.
(författare)
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Separation of seventeen 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and dibenzofurans and 12 dioxin-like polychlorinated biphenyls by comprehensive two-dimensional gas chromatography with electron-capture detection
- 2004
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Ingår i: Journal of Chromatography A. - Amsterdam : Elsevier. - 0021-9673 .- 1873-3778. ; 1038:1-2, s. 189-199
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Tidskriftsartikel (refereegranskat)abstract
- Comprehensive two-dimensional gas chromatography (GC×GC) with electron-capture detection (ECD) has been optimized for the separation of seventeen 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and dibenzofurans and 12 dioxin-like polychlorinated biphenyls, with emphasis on the selection of the first- and second-dimension, commercially available, columns. When eight second-dimension columns were subsequently combined with a 100% methylpolysiloxane stationary phase (DB-1) in the first dimension to create orthogonal conditions, a complete separation of all congeners with different TEF values was obtained with two column combinations, DB-1 × VF-23 and DB-1 × LC-50. When other types of first-dimension columns were used (and orthogonality was partly sacrificed), a DB-XLB column combined with 007-65HT, VF-23 and LC-50 was found to provide a complete separation of all 29 priority congeners. Next, the potential of these three column combinations for real-life analysis was preliminarily studied. With a spiked and fractionated milk extract, DB-XLB × LC-50 was found to be the most powerful column combination, because of the good separation of the 29 priority congeners from each other as well as from the matrix constituents. Quantitative performance (close to three-order linearity; LODs, 30–150 fg injected; R.S.D.s, 1.5–6.5% (n=10)) was satisfactory.
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- Winkle, Katie, et al.
(författare)
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Assessing and addressing ethical risk from anthropomorphism and deception in socially assistive robots
- 2021
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Ingår i: ACM/IEEE International Conference on Human-Robot Interaction. - New York, NY, USA : IEEE Computer Society. ; , s. 101-109
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Konferensbidrag (refereegranskat)abstract
- In this paper we apply the recent concept of robot Ethical Risk Assessment to an exemplar Socially Assistive Robot (SAR); specif-cally considering ethical risks posed by anthropomorphism in this context. We draw on two complimentary studies to demonstrate that anthropomorphism is important to overall SAR function and overall relatively low ethical risk. As such, rather than avoiding an-thropomoprhism all together (as suggested in a recently published standard on robot ethics), we suggest anthropomorphism in SARs should be a customisable trait that can be adapted to the user.
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- Holmquist, Hanna, 1982, et al.
(författare)
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Properties, performance and associated hazards of state-of-the-art durable water repellent (DWR) chemistry for textile finishing
- 2016
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Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 91, s. 251-264
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Forskningsöversikt (refereegranskat)abstract
- Following the phase-out of long-chain per- and polyfluoroalkyl substances (PFASs), the textile industry had to find alternatives for side-chain fluorinated polymer based durable water repellent (DWR) chemistries that incorporated long perfluoroalkyl side chains. This phase-out and subsequent substitution with alternatives has resulted in a market where both fluorinated and non-fluorinated DWRs are available. These DWR alternatives can be divided into four broad groups that reflect their basic chemistry: side-chain fluorinated polymers, silicones, hydrocarbons and other chemistries (including dendrimer and inorganic nanoparticle chemistries). In this critical review, the alternative DWRs are assessed with regard to their structural properties and connected performance, loss and degradation processes resulting in diffuse environmental emissions, and hazard profiles for selected emitted substances. Our review shows that there are large differences in performance between the alternative DWRs, most importantly the lack of oil repellency of non-fluorinated alternatives. It also shows that for all alternatives, impurities and / or degradation products of the DWR chemistries are diffusively emitted to the environment. Our hazard ranking suggests that hydrocarbon based DWR is the most environmentally benign, followed by silicone and side-chain fluorinated polymer-based DWR chemistries. Industrial commitments to reduce the levels of impurities in silicone based and side-chain fluorinated polymer based DWR formulations will lower the actual risks. There is a lack of information on the hazards associated with DWRs, in particular for the dendrimer and inorganic nanoparticle chemistries, and these data gaps must be filled. Until environmentally safe alternatives, which provide the required performance, are available our recommendation is to choose DWR chemistry on a case-by-case basis, always weighing the benefits connected to increased performance against the risks to the environment and human health.
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- Ricklund, N., 1979-, et al.
(författare)
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Bioaccumulation of decabromodiphenyl ethane (dbdpe) in the Western Scheldt estuary
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Decabromodiphenyl ethane (dbdpe) is a brominated flame retardant (BFR) with both a similar chemical structure and similar technical applications to a chemical of recognized environmental concern, decabromodiphenyl ether (decaBDE). Bioaccumulation has been one of the most controversial issues in the risk assessment of decaBDE, but it has not been measured for dbdpe. During the last several years, dbdpe has been detected in a variety of biota, which suggests that it is bioavailable. In this work, dbdpe was analyzed together with decaBDE in a benthic and pelagic food web in the Western Scheldt estuary, an environment known to be contaminated with the two BFRs. The biota-sediment accumulation factors for benthic invertebrates were low (0.0008-0.005) for both chemicals. This weak bioaccumulation into the lowest trophic levels of the food web may have been due to a poor bioavailability of the BFRs into the estuary. Both chemicals were transferred up through the food web, but biodilution was observed, not biomagnification (BMFs 0.2-0.8). The bioaccumulation behavior of dbdpe was similar to that of decaBDE.
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- Weiss, Jana M, et al.
(författare)
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Competitive Binding of Poly- and Perfluorinated Compounds to the Thyroid Hormone Transport Protein Transthyretin
- 2009
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Ingår i: Toxicological sciences : an official journal of the Society of Toxicology. - : Oxford University Press of the Society of Toxicology. - 1096-0929. ; 109:2, s. 206-16
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Tidskriftsartikel (refereegranskat)abstract
- Due to their unique surfactant properties, poly- and perfluorinated compounds (PFCs) have been extensively used, and can be found all over the environment.. Concern about their environmental fate and toxicological properties have initiated several research projects. In the present study, we investigated if PFCs can compete with thyroxin (T4, i.e. the transport form of thyroid hormone) for binding to the human thyroid hormone transport protein transthyretin (TTR). Such competitive capacity may lead to decreased thyroid hormone levels as previously reported for animals exposed to PFCs. Twenty four PFCs, together with six structurally similar natural fatty acids, were tested for binding capacity in a radioligand binding assay. The binding potency decreased in the order: PFHxS>PFOS/PFOA>PFHpA>L-PFOSi>PFNA, with TTR binding potencies 12.5-50 times lower than the natural ligand thyroxine (T4). Some lower molecular weight compounds with structural similarity to these PFCs were >100 times less potent than T4. Simple descriptors based on the two dimensional molecular structures of the compounds were used to visualize the chemical variation and to model the structure-activity relationship for the competitive potencies of the TTR-binding compounds. The models indicated the dependence on molecular size and functional group(s), but demanded a more detailed description of the chemical properties and data for validation and further QSAR development. Competitive binding of PFCs to TTR as observed for human TTR in the present study, may explain altered thyroid hormone levels described for PFC-exposed rats and monkeys. Median human blood levels of the most potent TTR-binding PFCs are 1-2 orders of magnitude lower than IC50-values determined in the present study. In addition, this study contributes to the understanding of the bioaccumulation of PFCs in man and possibly in other wildlife species.
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