| 1. |
- Mishra, A, et al.
(author)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Journal article (peer-reviewed)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 2. |
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| 3. |
- Heyckendorf, J, et al.
(author)
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Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
- 2021
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 58:3
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Journal article (peer-reviewed)abstract
- The World Health Organization recommends standardised treatment durations for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a biomarker for individualised therapy durations for patients with drug-susceptible (DS)- and multidrug-resistant (MDR)-TB.MethodsAdult patients with pulmonary TB were prospectively enrolled into five independent cohorts in Germany and Romania. Clinical and microbiological data and whole blood for RNA transcriptomic analysis were collected at pre-defined time points throughout therapy. Treatment outcomes were ascertained by TBnet criteria (6-month culture status/1-year follow-up). A whole-blood RNA therapy-end model was developed in a multistep process involving a machine-learning algorithm to identify hypothetical individual end-of-treatment time points.Results50 patients with DS-TB and 30 patients with MDR-TB were recruited in the German identification cohorts (DS-GIC and MDR-GIC, respectively); 28 patients with DS-TB and 32 patients with MDR-TB in the German validation cohorts (DS-GVC and MDR-GVC, respectively); and 52 patients with MDR-TB in the Romanian validation cohort (MDR-RVC). A 22-gene RNA model (TB22) that defined cure-associated end-of-therapy time points was derived from the DS- and MDR-GIC data. The TB22 model was superior to other published signatures to accurately predict clinical outcomes for patients in the DS-GVC (area under the curve 0.94, 95% CI 0.9–0.98) and suggests that cure may be achieved with shorter treatment durations for TB patients in the MDR-GIC (mean reduction 218.0 days, 34.2%; p<0.001), the MDR-GVC (mean reduction 211.0 days, 32.9%; p<0.001) and the MDR-RVC (mean reduction of 161.0 days, 23.4%; p=0.001).ConclusionBiomarker-guided management may substantially shorten the duration of therapy for many patients with MDR-TB.
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| 4. |
- Pichler, M. J., et al.
(author)
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Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, associated with protection from colorectal cancer, immune- and metabolic disorders is enigmatic. Here, we describe catabolic pathways that support the growth of Roseburia and Eubacterium members on distinct human milk oligosaccharides (HMOs). The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans. Analyses of 4599 Roseburia genomes underscored the preponderance and diversity of the HMO utilization loci within the genus. The catabolism of HMOs by butyrate-producing Clostridiales may contribute to the competitiveness of this group during the weaning-triggered maturation of the microbiota. The assembly and maturation of the early life microbiome has life-long effects on human health. Here, the authors combine omics, functional assays and structural analyses to characterize the catabolic pathways that support the growth of butyrate producing Clostridiales members from the Roseburia and Eubacterium, on distinct human milk oligosaccharides.
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| 5. |
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| 6. |
- Borge, M. J. G., et al.
(author)
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Elucidating halo structure by beta decay: beta gamma from the Li-11 decay
- 1997
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In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 55:1, s. R8-R11
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Journal article (peer-reviewed)abstract
- New values for the gamma ray intensities following the beta decay of Li-11 are presented. Special emphasis is put on the determination of the Gamow-Teller transition Li-11 --> Be-11 (1/2(-), 320 keV) to the only bound excited state in Be-11. We show that a shell-model calculation can simultaneously reproduce the half-life of Li-11 and the newly measured branching ratio to the 1/2(-) state provided the Li-11 ground state wave function contains about 50% of s-wave neutron components.
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| 7. |
- Borge, M. J. G., et al.
(author)
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Probing the Li-11 halo structure through beta-decay into the Be-11(*) (18 MeV) state
- 1997
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In: Nuclear Physics A. - 0375-9474. ; 613:3, s. 199-208
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Journal article (peer-reviewed)abstract
- An experimental study of beta-delayed charged particles (H, He, Be) from Li-11 shows a beta-feeding to an excited state at 18.15(15) MeV in Be-11 with a large Gamow-Teller strength, B-GT greater than or equal to 1.6. Branching ratios and reduced widths of 2-, 3- and 5- particle decay channels of this state are extracted, A strong suppression of the neutron branch from the 18 MeV state to the Be-10(g.s.) is observed, We suggest that the measured partial width may be sensitive to the (p(1/2))(2) component in the Li-11 halo, A rough estimate indicates that the (p(1/2))(2) component is not the dominant one in the halo wave-function.
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| 8. |
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| 9. |
- Heyckendorf, J, et al.
(author)
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Treatment responses in multidrug-resistant tuberculosis in Germany
- 2018
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In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. - : International Union Against Tuberculosis and Lung Disease. - 1815-7920. ; 22:4, s. 399-
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Journal article (peer-reviewed)
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| 10. |
- Mukha, I., et al.
(author)
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Observation of the Li-11(beta d) decay
- 1996
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In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 367:1-4, s. 65-69
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Journal article (peer-reviewed)abstract
- Experimental data from the decay of Li-11 show for the first time the presence of beta-delayed deuterons with a branching ratio larger than 10(-4). To distinguish between beta d and beta t events the decays of the daughter nuclei Li-9 and Li-8 were identified in the energy and decay time spectra. Furthermore, a time correlation analysis between the beta d events and the subsequent daughter decays was performed.
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| 11. |
- Mukha, I., et al.
(author)
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Super-strong beta-decay of Li-11 into Be-11* (18 MeV) state: A probe for halo p-wave component?
- 1997
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In: Nuclear Physics A. - 0375-9474. ; 616:1-2, s. C201-C207
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Conference paper (peer-reviewed)abstract
- An experimental study of beta-delayed charged particles (H, He, Be), neutrons and gamma-rays that follow the Li-11 beta-decay, clearly indicates a beta-feeding to an exited state at 18.1 MeV in Be-11 with a large Gamow-Teller strength, B-GT greater than or equal to 1.0. The large strength of this beta-transition implies a broad overlap of the Be-11* state at 18.1 MeV and the ground state of Li-11. The deduced width of this resonance is similar or equal to 1 MeV. A strong suppression of the branch from 18.1 MeV state into the Be-10+n channel is observed. This branch, with the largest decay energy, has a partial width less than 1% of the total width. A centrifugal barrier consideration fails to explain this effect. A possible consequence of the observed effect for the Li-11 structure is that the admixture of (p(1/2))(2) configuration in Li-11 might be small.
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