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Träfflista för sökning "WFRF:(Ley Steven V) "

Search: WFRF:(Ley Steven V)

  • Result 1-4 of 4
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1.
  • 2019
  • Journal article (peer-reviewed)
  •  
2.
  • Hudson, Thomas J., et al. (author)
  • International network of cancer genome projects
  • 2010
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
  • Journal article (peer-reviewed)abstract
    • The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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3.
  • Weinstein, John N., et al. (author)
  • The cancer genome atlas pan-cancer analysis project
  • 2013
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
  • Research review (peer-reviewed)abstract
    • The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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4.
  • Billker, Oliver, et al. (author)
  • Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei
  • 2002
  • In: Journal of Eukaryotic Microbiology. - : Wiley. - 1066-5234 .- 1550-7408. ; 49:6, s. 489-497
  • Journal article (peer-reviewed)abstract
    • Transmission of malaria parasites from vertebrate blood to the mosquito vector depends critically on the differentiation of the gametocytes into gametes. This occurs in response to environmental stimuli encountered by the parasite in the mosquito bloodmeal. Male gametogenesis involves three rounds of DNA replication and endomitosis, and the assembly de novo of 8 motile axonemes. Azadirachtin, a plant limnoid and insecticide with an unkown mode of action, specifically inhibits the release of motile gametes from activated microgametocytes but does not inhibit growth and replication of a sexual blood stages. We have combined confocal laser scanning microscopy and transmission electron microscopy to examine the effect of azadirachtin on the complex reorganisation of the microtubule cytoskeleton during gametogenesis in Plasmodium berghei. Neither the replication of the genome nor the ability of tubulin monomers to assemble into microtubules upon gametocyte activation were prevented by azadirachtin. However, the drug interfered with the formation of mitotic spindles and with the assembly of microtubules into typical axonemes. Our observations suggest that azadarachtin specifically disrupts the patterning of microtubules into more complex structures, such as mitotic spindles and axonemes.
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  • Result 1-4 of 4
Type of publication
journal article (3)
research review (1)
Type of content
peer-reviewed (4)
Author/Editor
Zhang, Wei (2)
Yang, Yang (1)
Kelly, Daniel (1)
Pontén, Fredrik (1)
Bengtsson-Palme, Joh ... (1)
Nilsson, Henrik (1)
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Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
Uhlén, Mathias (1)
Campo, Elias (1)
Jörnsten, Rebecka, 1 ... (1)
Kling, Teresia, 1985 (1)
Sánchez, José, 1979 (1)
Nelander, Sven, 1974 (1)
Liu, Fang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Nettekoven, Gerd (1)
Bardelli, Alberto (1)
Caldas, Carlos (1)
Calvo, Fabien (1)
Kahan, Thomas (1)
Sörelius, Karl, 1981 ... (1)
Egevad, Lars (1)
Chanock, Stephen J (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Estivill, Xavier (1)
Flicek, Paul (1)
Guigo, Roderic (1)
Gut, Ivo (1)
Lehrach, Hans (1)
Stunnenberg, Hendrik ... (1)
Valencia, Alfonso (1)
Backman, Lars (1)
Billker, Oliver (1)
Yan, Hong (1)
Wainwright, Brandon ... (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
Hammerschmidt, Sven (1)
Patil, Chandrashekha ... (1)
Wang, Jun (1)
Pollesello, Piero (1)
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University
University of Gothenburg (2)
Uppsala University (2)
Lund University (2)
Chalmers University of Technology (2)
Karolinska Institutet (2)
Umeå University (1)
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Royal Institute of Technology (1)
Halmstad University (1)
Stockholm University (1)
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Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (4)
Natural sciences (2)

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