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Sökning: WFRF:(Leyden J.)

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1.
  • Carey, L. M., et al. (författare)
  • STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol
  • 2015
  • Ingår i: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 10:4, s. 636-644
  • Tidskriftsartikel (refereegranskat)abstract
    • RationaleStroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AimsOur aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DesignIn a longitudinal cohort study of 200 stroke survivors, the START - STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. Study OutcomesClinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.
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2.
  • Tan, J., et al. (författare)
  • Shortcomings in rosacea diagnosis and classification
  • 2017
  • Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 176:1, s. 197-199
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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4.
  • Jiang, Yan, et al. (författare)
  • Negligible-Pb-Waste and Upscalable Perovskite Deposition Technology for High-Operational-Stability Perovskite Solar Modules
  • 2019
  • Ingår i: Advanced Energy Materials. - : Wiley-VCH Verlagsgesellschaft. - 1614-6832 .- 1614-6840. ; 9:13
  • Tidskriftsartikel (refereegranskat)abstract
    • An upscalable perovskite film deposition method combining raster ultrasonic spray coating and chemical vapor deposition is reported. This method overcomes the coating size limitation of the existing stationary spray, single-pass spray, and spin-coating methods. In contrast with the spin-coating method (>90% Pb waste), negligible Pb waste during PbI2 deposition makes this method more environmentally friendly. Outstanding film uniformity across the entire area of 5 cm x 5 cm is confirmed by both large-area compatible characterization methods (electroluminescence and scattered light imaging) and local characterization methods (atomic force microscopy, scanning electron microscopy, photoluminescence mapping, UV-vis, and X-ray diffraction measurements on multiple sample locations), resulting in low solar cell performance decrease upon increasing device area. With the FAPb(I0.85Br0.15)(3) (FA = formamidinium) perovskite layer deposited by this method, champion solar modules show a power conversion efficiency of 14.7% on an active area of 12.0 cm(2) and an outstanding shelf stability (only 3.6% relative power conversion efficiency decay after 3600 h aging). Under continuous operation (1 sun light illumination, maximum power point condition, dry N-2 atmosphere with <5% relative humidity, no encapsulation), the devices show high light-soaking stability corresponding to an average T-80 lifetime of 535 h on the small-area solar cells and 388 h on the solar module.
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5.
  • Juarez-Perez, Emilio J., et al. (författare)
  • Role of the dopants on the morphological and transport properties of Spiro-MeOTAD hole transport layer
  • 2016
  • Ingår i: Chemistry of Materials. - : American Chemical Society (ACS). - 0897-4756 .- 1520-5002. ; 28:16, s. 5702-5709
  • Tidskriftsartikel (refereegranskat)abstract
    • The use of a solid hole transport layer (HTL) was transformational for the recent perovskite solar cell (PSC) revolution in solar energy technology. Often high efficiency PSC devices employ heavily doped hole transport materials such as spiro-MeOTAD. Independent of HTL chemistry, lithium-bis-trifluoromethanesulfonyl-imide (LiTFSI) and tert-butylpyridine (TBP) are commonly used as additives in HTL formulations for PSCs. LiTFSI and TBP were originally optimized for dye sensitized solar cells, where their roles have been extensively studied. However, in the case of PSCs, the function of TBP is not clearly understood. In this study, properties of the HTL composite deposited on flat silicon substrates were systematically measured at several length scales, e.g., macroscopically (profilometry, 4-point probe conductivity, and thermogravimetrydifferential thermal analysis), microscopically, and at the nanoscale to investigate film morphology, conductivity, and dopant distribution. Microscopic distributions of spiro-MeOTAD, LiTFSI, and TBP were determined using 2D Fourier transform infrared (FTIR) microscopy and electrostatic atomic force microscopy (EFM). Our findings reveal that the main role of TBP is to prevent phase segregation of LiTFSI and Spiro-MeOTAD, resulting in a homogeneous hole transport layer. These properties are critical for charge transport in the HTL bulk film as well as at the perovskite/HTL and HTL/electrode interfaces and for efficient solar cell performance.
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  • Resultat 1-6 av 6

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