| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
- He, YQ, et al.
(författare)
-
A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- 2022
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966-
-
Tidskriftsartikel (refereegranskat)abstract
- Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Khatri, C, et al.
(författare)
-
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
-
Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
|
|
| 34. |
|
|
| 35. |
|
|
| 36. |
- Li, HB, et al.
(författare)
-
Capon estimation of covariance sequences
- 1998
-
Ingår i: CIRCUITS SYSTEMS AND SIGNAL PROCESSING. - : BIRKHAUSER BOSTON INC. - 0278-081X. ; 17:1, s. 29-49
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Estimating the covariance sequence of a wide-sense stationary process is of fundamental importance in digital signal processing (DSP). A new method, which makes use of Fourier inversion of the Capon spectral estimates and is referred to as the Capon metho
|
|
| 37. |
- Li, HB, et al.
(författare)
-
Computationally efficient maximum likelihood estimation of structured covariance matrices
- 1999
-
Ingår i: IEEE TRANSACTIONS ON SIGNAL PROCESSING. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1053-587X. ; 47:5, s. 1314-1323
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- By invoking the extended invariance principle (EXIP), we present herein a computationally efficient method that provides asymptotic (for large samples) maximum likelihood (AML) estimation for structured covariance matrices and will be referred to as the A
|
|
| 38. |
- Li, HB, et al.
(författare)
-
Performance analysis of forward-backward matched-filterbank spectral estimators
- 1998
-
Ingår i: IEEE TRANSACTIONS ON SIGNAL PROCESSING. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1053-587X. ; 46:7, s. 1954-1966
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The problem of complex spectral estimation is of great interest in many applications. This paper studies the general class of the forward-backward matched-filterbank (MAFI) spectral estimators including the widely used Capon as well as the more recently i
|
|
| 39. |
|
|
| 40. |
- Menden, MP, et al.
(författare)
-
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- 2019
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
-
Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
|
|
| 46. |
- Stoica, P, et al.
(författare)
-
A new derivation of the APES filter
- 1999
-
Ingår i: IEEE SIGNAL PROCESSING LETTERS. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1070-9908. ; 6:8, s. 205-206
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We introduce a novel design criterion for data-dependent narrowband filters that are of interest in temporal or spatial spectral analysis applications, The solution to the design problem considered is shown to coincide with the recently introduced amplitu
|
|
| 47. |
- Stoica, P, et al.
(författare)
-
Amplitude estimation of sinusoidal signals: Survey, new results, and an application
- 2000
-
Ingår i: IEEE TRANSACTIONS ON SIGNAL PROCESSING. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1053-587X. ; 48:2, s. 338-352
-
Tidskriftsartikel (refereegranskat)abstract
- This paper considers the problem of amplitude estimation of sinusoidal signals from observations corrupted by colored noise. A relatively large number of amplitude estimators, which encompass Beast Iquares (LS) and weighted squares (WLS) methods,are descr
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
